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Assam Governor attends Sainik school Goalpara's Diamond Jubilee celebrations




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DRDO conducts maiden flight test of Long-Range Land Attack Cruise Missile (LRLACM)




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HC modifies the status quo order on maintaining constructions for Tent City in two islands of Lakshadweep




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HC quashes magistrate court’s directive to register FIR against police officers

Magistrate court’s order to file FIR against police officers, including IPS officer and former Malappuram Superintendent of Police Sujith Das, in connection with an alleged sexual assault case quashed




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China's largest air show takes off with fighter jets, attack drones

China has poured resources into modernising and expanding its aviation capabilities as it faces off against the United States and others around regional flashpoints like Taiwan.




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COP29: India, other developing countries demand fair climate finance commitments

India, LMDCs advocate for equitable climate finance at COP29, pushing for transparency, fairness, and flexibility in financial commitments




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Lebanon media claims Israeli strike hit apartment south of Beirut

Israeli warplanes launched a strike at dawn targeting a residential apartment in a building in the Dawhet




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IndiGo, Air India cancel flights to Bali following volcanic eruption

The Mount Lewotobi Laki Laki volcano located in a remote island in East Nusa Tenggara province erupted earlier this month and has resulted in ash clouds




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Senior Russian naval officer killed in car bombing claimed by Kyiv

Russia's state Investigative Committee said in a statement that an improvised explosive device had detonated in an act of terrorism, killing a serviceman whom it did not identify




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Chemical synthetic approaches to mimic the TRAIL: promising cancer therapeutics

RSC Med. Chem., 2024, 15,3639-3651
DOI: 10.1039/D4MD00183D, Review Article
Abdullah-Al Masum, Shin Aoki, Md. Mahbubur Rahman, Yosuke Hisamatsu
TRAIL induced apoptosis signalling by death receptors (DR4/DR5).
The content of this RSS Feed (c) The Royal Society of Chemistry




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New ATP-competitive inhibitors of E. coli GyrB obtained from the mapping of the hydrophobic floor at the binding site: synthesis and biological evaluation

RSC Med. Chem., 2024, 15,3759-3777
DOI: 10.1039/D4MD00498A, Research Article
Lucas Gutierrez, Peter Peršolja, Rodrigo Tosso, Nace Zidar, Danijel Kikelj, Ricardo D. Enriz
A diagram of the active site of E. coli gyrase B, highlighting the hydrophobic subsite, including key residues relevant to ligand binding.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Discovery of hybrid Glypromate conjugates with neuroprotective activity against paraquat-induced toxicity

RSC Med. Chem., 2024, 15,3711-3727
DOI: 10.1039/D4MD00584H, Research Article
Sara C. Silva-Reis, Vera M. Costa, Daniela Correia da Silva, David M. Pereira, Xavier Cruz Correia, Xerardo García-Mera, José E. Rodríguez-Borges, Ivo E. Sampaio-Dias
A series of bicyclic-based Glypromate conjugates with reduction of protein aggregation elicited by Aβ25–35 and neuroprotective activity against paraquat-induced toxicity is reported, paving the way for the discovery of novel neurotherapeutics.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Stachydrine, a pyrrole alkaloid with promising therapeutic potential against metabolic syndrome and associated organ dysfunction

RSC Med. Chem., 2024, 15,3652-3673
DOI: 10.1039/D4MD00425F, Review Article
Semim Akhtar Ahmed, Prasenjit Manna, Jagat Chandra Borah
Metabolic syndrome is a multifaceted condition marked by interconnected risk factors, significantly increasing the risk of serious diseases like cardiovascular disease, type 2 diabetes, and stroke.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Asymmetric imidazole-4,5-dicarboxamide derivatives as SARS-CoV-2 main protease inhibitors: design, synthesis and biological evaluation

RSC Med. Chem., 2024, 15,3880-3888
DOI: 10.1039/D4MD00414K, Research Article
Phuong Nguyen Hoai Huynh, Phatcharin Khamplong, Minh-Hoang Phan, Thanh-Phuc Nguyen, Phuong Ngoc Lan Vu, Quang-Vinh Tang, Phumin Chamsodsai, Supaphorn Seetaha, Truong Lam Tuong, Thien Y. Vu, Duc-Duy Vo, Kiattawee Choowongkomon, Cam-Van T. Vo
Novel asymmetric imidazole-4,5-dicarboxamide derivatives were synthesized, evaluated for SARS-CoV-2 MPro inhibitory activity in vitro, and investigated for binding ability in silico.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Design and synthesis of novel 8-(azaindolyl)-benzoazepinones as potent and selective ROCK inhibitors

RSC Med. Chem., 2024, 15,3862-3879
DOI: 10.1039/D4MD00313F, Research Article
Daniele Pala, David Clark, Christine Edwards, Elisa Pasqua, Laura Tigli, Barbara Pioselli, Piotr Malysa, Fabrizio Facchinetti, Fabio Rancati, Alessandro Accetta
This study reports a novel, potent and selective series of ROCK inhibitors based on 8-(azaindolyl)-benzoazepinones identified through a core-hopping strategy.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Advances in Detecting Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Using Molecular Receptors and Nanostructured Assemblies

RSC Med. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4MD00661E, Review Article
Avijit Kumar Das
The detection and quantification of non-steroidal anti-inflammatory drugs (NSAIDs) are crucial due to their widespread use and potential impact on human health and the environment. This review provides a comprehensive...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Supreme Court stays order for CBI probe into sexual assault of minor in Chennai

Calls for a list of five to seven direct recruit IPS officers, including three women, who hail from other States but are now serving in Tamil Nadu cadre




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AIADMK will not form an alliance with BJP in 2026 polls, reiterates Palaniswami

“During the Lok Sabha election, it was said at the party headquarters and in press bytes that the AIADMK will not have alliance with the BJP in the [2026] Assembly election,” he said




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Southern Railway refuses to share inquiry report of Perumon train tragedy

105 people had died in after several coaches of the Island Express fell into the Ashtamudi Lake in 1988




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Delhi airport sees seven flight diversions owing to bad weather

The IMD reported that very dense fog began forming at around 5.30 a.m., resulting in a thick haze over various parts of Delhi




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Delhi’s air quality turns ‘severe’ for first time this season: CPCB

According to Central Pollution Control Board data, Delhi’s air quality reaches ‘severe’ levels with AQI of 418




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Arvinder Singh Sahney is new chairman of Indian Oil 




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Free and fair inquiry sought into death of snakebite victim in Srikakulam district

Son of the victim alleges that local medical and health officials misleading higher-ups regarding the incident




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Fervour marks ‘Kaisika Dwadasi’ at Tirumala




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Incessant rains cause landslides on Tirumala ghat road




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Target is to to make 30,000 MT of sand available every day in East Godavari district, says Collector

P. Prasanthi warns boatmen associations of stringent action if they attempt to prevent vehicles transporting sand from the sand reaches




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PAG report points out Andhra Pradesh govt.’s failure to disclose quantum of off-budget borrowings in Budget

Principal amount outstanding in 2019-20 was ₹67,171 crore, and it touched ₹1,54,797 crore in 2023-24, says the PAG report released by the I&PR Department




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RLDA invites bids for commercial land use in Tirupati railway station

The station is being developed on a massive scale, providing commuting area on the southern side, in view of the crammed locality on the northern side




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Jagan dares govt. to arrest him, says will continue to ‘expose failures’




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Police book Sri Reddy for posting ‘defamatory content’ against Chandrababu Naidu, Pawan Kalyan




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Andhra Pradesh High Court strikes down PIL seeking to restrain police from taking action on ‘abusive content on social media’




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Supreme Court sets pan-India guidelines against ‘bulldozer justice,’ calls demolitions without due process unconstitutional

The Apex court maintains that these guidelines do not apply in cases of unauthorized public land construction or where demolition is mandated by a court ruling




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Peddapalli goods train derailment: Several trains cancelled or diverted

Three railway lines were affected in the derailment. Some trains skipped stoppages.




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Hyderabad Airport wins global recognition for digital innovations




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Metro Rail services to be extended to Medchal and other parts of northern Hyderabad under Phase-III: Telangana CM




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Doctor stabbed at Kalaignar Centenary Super Speciality Hospital in Chennai; one arrested

The oncologist who was attacked has been identified as Balaji Jagannath. He has been admitted in the ICU, and his condition is said to be critical




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COP29: India, other developing countries demand fair climate finance commitments

India, LMDCs advocate for equitable climate finance at COP29, pushing for transparency, fairness, and flexibility in financial commitments




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Karnataka Chief Minister Siddaramaiah says no proposal to ease night traffic ban through Bandipur

Deputy Chief Minister D.K. Shivakumar had stated, in Wayanad in Kerala, that the government would take all possible measures to lift night traffic ban through Bandipur, which had riled wildlife conservationists in Karnataka




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ED’s investigation into MUDA case is based on false allegations, says Siddaramaiah




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Illegal export of iron ore from Belekeri port: Karnataka High Court suspends sentence and grants bail to MLA Satish Sail and five other convicts




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FIR registered against Snehamayi Krishna




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Only education can empower women: Siddaramaiah




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Marakumbi atrocity case: 99 persons granted bail by High Court Dharwad Bench




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Mysuru to host conference on AI and Deeptech




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MUDA ‘scam’: Raichur MP Kumar Naik, CM’s PA questioned by ED




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After hosting World Cup, Qatar praised by U.N. rights body for labour law reforms but urged to do more

In Qatar, better labour law protections have been passed in recent years relating to a minimum wage, freedom to change employers and combating forced labor and trafficking




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Why US chess champ Levon Aronian is connecting with the Armenian community in Chennai

Chess champion Levon Aronian, who competed in Chennai Grand Masters recently, on future Indian chess superstars




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Comeback man Shami hogs the spotlight as MP takes honours on opening day against Bengal




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Ranji Trophy | Tamil Nadu has Railways under the cosh with dominant show

CRICKET | Skipper Jagadeesan’s decision to field pays off handsomely as Ajith Ram and Gurjapneet take quick wickets; Ahuja, Saif and Merai hold out with half centuries




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Siddhant Banthia sails past Siddharth Vishwakarma in ITF men’s tennis tournament

Siddhant Banthia broke serve dropping one point, and served out at love in the next game, to gain a stranglehold over the proceedings. He ran up a 5-1 lead in the second set before closing it out without any trouble