ISLAMABAD: Federal Minister for Planning, Development, Reforms, and Special Initiatives Asad Umer Friday said Pakistan would be manufacturing its own ventilators in next two months. Talking in a private news channel programme, he said Pakistan had taken all possible measures to fight against the...

Healthcare systems need to prepare for the extensive physiotherapy and mental rehabilitation that people put on ventilators for covid-19 will need as they recover

Title: ECMO: Technology That Might Help COVID Patients When Ventilators Can't
Category: Health News
Created: 5/1/2020 12:00:00 AM
Last Editorial Review: 5/1/2020 12:00:00 AM

BACKGROUND:Ventilator-associated pneumonia (VAP) is a common and serious complication of mechanical ventilation. We conducted a meta-analysis of published randomized controlled trials to evaluate the efficacy and safety of probiotics for VAP prevention in patients who received mechanical ventilation.METHODS:We searched a number of medical literature databases to identify randomized controlled trials that compared probiotics with controls for VAP prevention. The results were expressed as odds ratios (OR) or mean differences with accompanying 95% CIs. Study-level data were pooled by using a random-effects model. Data syntheses were accomplished by using statistical software.RESULTS:Fourteen studies that involved 1,975 subjects met our inclusion criteria. Probiotic administration was associated with a reduction in VAP incidence among all 13 studies included in the meta-analysis (OR 0.62, 95% CI 0.45–0.85; P = .003; I2 = 43%) but not among the 6 double-blinded studies (OR 0.72, 95% CI 0.44–1.19; P = .20; I2 = 55%). We found a shorter duration of antibiotic use for VAP (mean difference −1.44, 95% CI −2.88 to −0.01; P = .048, I2 = 30%) in the probiotics group than in the control group, and the finding comes from just 2 studies. No statistically significant differences were found between the groups in terms of ICU mortality (OR 0.95, 95% CI 0.67–1.34; P = .77; I2 = 0%), ICU stay (mean difference –0.77, 95% CI –2.58 to 1.04; P = .40; I2 = 43%), duration of mechanical ventilation (mean difference –0.91, 95% CI –2.20 to 0.38; P = .17; I2 = 25%), or occurrence of diarrhea (OR 0.72, 95% CI 0.45–1.15; P = .17; I2 = 41%).CONCLUSIONS:The meta-analysis results indicated that the administration of probiotics significantly reduced the incidence of VAP. Furthermore, our findings need to be verified in large-scale, well-designed, randomized, multi-center trials.

Nosocomial pneumonia (NP), including ventilator-associated pneumonia (VAP), is increasingly associated with multidrug-resistant Gram-negative pathogens. This study describes the in vitro activity of ceftazidime-avibactam, ceftazidime, and relevant comparator agents against bacterial pathogens isolated from patients with NP, including VAP, enrolled in a ceftazidime-avibactam phase 3 trial. Gram-positive pathogens were included if coisolated with a Gram-negative pathogen. In vitro susceptibility was determined at a central laboratory using Clinical and Laboratory Standards Institute broth microdilution methods. Of 817 randomized patients, 457 (55.9%) had ≥1 Gram-negative bacterial pathogen(s) isolated at baseline, and 149 (18.2%) had ≥1 Gram-positive pathogen(s) coisolated. The most common isolated pathogens were Klebsiella pneumoniae (18.8%), Pseudomonas aeruginosa (15.8%), and Staphylococcus aureus (11.5%). Ceftazidime-avibactam was highly active in vitro against 370 isolates of Enterobacteriaceae, with 98.6% susceptible (MIC₉₀, 0.5 μg/ml) compared with 73.2% susceptible for ceftazidime (MIC₉₀, >64 μg/ml). The percent susceptibility values for ceftazidime-avibactam and ceftazidime against 129 P. aeruginosa isolates were 88.4% and 72.9% (MIC₉₀ values of 16 μg/ml and 64 μg/ml), respectively. Among ceftazidime-nonsusceptible Gram-negative isolates, ceftazidime-avibactam percent susceptibility values were 94.9% for 99 Enterobacteriaceae and 60.0% for 35 P. aeruginosa. MIC₉₀ values for linezolid and vancomycin (permitted per protocol for Gram-positive coverage) were within their respective MIC susceptibility breakpoints against the Gram-positive pathogens isolated. This analysis demonstrates that ceftazidime-avibactam was active in vitro against the majority of Enterobacteriaceae and P. aeruginosa isolates from patients with NP, including VAP, in a phase 3 trial. (This study has been registered at ClinicalTrials.gov under identifier NCT01808092.)

COMPUTER services company PTC is using augmented reality , the enhanced visual technology seen in Pokemon Go smartphone games and Iron Man movies, to produce ventilators in record time for the NHS.

If there's a ventilator shortage, doctors and ethicists say priority should be given to people with the best chance of recovery and most years likely left to live

Healthcare systems need to prepare for the extensive physiotherapy and mental rehabilitation that people put on ventilators for covid-19 will need as they recover

Read our live updates on coronavirus HERE Coronavirus: The symptoms

Read our live coronavirus updates HERE Coronavirus: The symptoms

Follow our live coronavirus updates HERE Coronavirus: The symptoms

The Foreign Office's top civil servant has backtracked after saying ministers took a "political decision" not to take part in an EU scheme to get vital coronavirus equipment.

Ten years worth of ventilators are to be made in around just ten weeks to cope with demand during the coronavirus outbreak, the head of a consortium of manufacturers has said.

Stephen Hawking's ventilator has been donated to the NHS to help treat coronavirus patients at a hospital in Cambridge.

The Health Secretary has been forced to deny the UK's failure to take part in an EU scheme to get vital ventilators for the coronavirus crisis was politically motivated.

A nurse has died with coronavirus in the London hospital where she worked alongside her sister — who is now fighting for life in intensive care.

Around two-thirds of coronavirus patients who required advanced respiratory support in intensive care have died, according to a study of critical care outcomes.

A "dedicated and loving" nurse with coronavirus has tragically died five weeks after first being placed on a ventilator.

Specialist London hospital receives working medical equipment used in BBC drama

Innovations are taking place around the country as doctors and entrepreneurs turn their ingenuity to solving the country's ventilator shortage.

An Australian-made ventilator that costs a tenth of the price of existing models is brought to life in just four weeks, which could revolutionise intensive care capability in the fight against COVID-19.

Supercar engineers are taking their skills from the racetrack to the ICU ward by creating a ventilator prototype to help during the coronavirus crisis.

The Trump administration appears to be conditioning coronavirus assistance in Central America on immigration policy

The Dyson CoVent ventilators are no longer required in the UK, according to a statement from Sir James Dyson.

Prisym ID, a provider of data-led label and artwork management solutions, is offering instant access to its Prisym 360 SaaS medical devices labelling solution, to support medtech manufacturers’ response to Covid-19.

The UK government has announced it will be ending support for four devices in the Ventilator Challenge.

AdvaMed has announced the launch of a new platform, which will attempt to connect ventilator companies with component suppliers to ensure quick scale production and distribution of these devices during the Covid-19 pandemic.

The U.S. Food and Drug Administration approved a new high-pressure ventilator developed by NASA to treat coronavirus or COVID-19 patients. The space agency is offering the designs for licensing on a royalty-free basis during the time of the pandemic, hoping to increase the availability of life-saving medical devices.

We speak with Dr. Richard Levitan, an emergency physician based in Littleton, New Hampshire, who volunteered at Bellevue Hospital in Manhattan for 10 days at the height of the COVID-19 surge in April. Based on what he saw, he argues patients should be going to hospitals sooner and that medical professionals could use a small device you clip on your fingertip, called a pulse oximeter, to help detect the virus earlier by revealing oxygenation problems and elevated heart rates. "A pulse oximeter is just a measure of identifying how well the lungs are working, and, I believe, can be basically an early warning system in terms of patients to know who has COVID pneumonia," says Dr. Levitan.

Healthcare systems need to prepare for the extensive physiotherapy and mental rehabilitation that people put on ventilators for covid-19 will need as they recover

The 211 machines were purchased from a US firm, Mexico's foreign minister said.

Singer Rihanna's father Ronald Fenty tested positive for coronavirus in his home country of Barbados but has now beat COVID-19 thanks to the superstar's help.

According to Page Six, Rihanna's father recently shared with The Sun, "My daughter Robyn was checking in on me every day. I thought I was going to die to be honest. I have to say, I love you so much, Robyn. She did so much for me. I appreciate everything she has done."

The 32-year-old songstress sent a ventilator to his Caribbean home and gave him "more than enough" to battle the illness that left him feeling weak and frightened for his life.

"I got a fever up inside of my nose. I had a fever across my lips. It was just a lot of fever," Fenty revealed. "I feared the worst. I thought I was going to die, honestly."

The Fenty Beauty founder's father was quarantined for two weeks after at the Paragon Isolation Center, after which he was declared virus-free. He is now resting in his St. James home.

Fenty asked of the public to stay at home and said, "I want everybody to stay home. This is a serious situation. More serious than people realize. Please stay home."

The 'Work' songstress is also using her time and money to help those globally affected by COVID-19, and she has donated 5 million USD to the cause via her Clara Lionel Foundation. She and Jay-Z also teamed up to donate 1 million USD each to those affected in Los Angeles and New York.

Twitter boss Jack Dorsey is also collaborating with Rihanna to help domestic abuse survivors who may have been displaced during the coronavirus pandemic.

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Having higher levels of wakefulness and experiencing the same depth of sleep on both right and left brains can help in successfully weaning critically-ill

Around 880,000 more ventilators are in demand globally because of COVID-19 pandemic, revealed GlobalData analysis. According to GlobalData analysis,

Warning of potential harm from tendency to use invasive equipment too quickly

Strategic decisions by chief executive make the Dutch company a safe bet

The U.S. Food and Drug Administration (FDA) has authorized the manufacture of the Coventor ventilator, a new hardware design first developed by the University of Minnesota. The project sought to create a ventilator that could provide the same level of life-saving care as existing ventilator models, but with a much lower cost to help ramp […]

Nvidia Chief Scientist Bill Dally has released an open-source ventilator hardware design he developed in order to address the shortage resulting from the global coronavirus pandemic. The mechanical ventilator design developed by Dally can be assembled quickly, using off-the-shelf parts with a total cost of around $400 — making it an accessible and affordable alternative […]

Two-thirds of machines to go to NHS following order from UK government

Ministers’ challenge to manufacturers sets basic specifications that are not suitable to task, say experts 

DR MARTIN SCURR: Yet another sign of the impact the Covid-19 crisis has had on us is how much talk there is, even among the public, about the number of ventilators at the NHS's disposal.

The former Coronation Street star, 36, took to Instagram on Thursday and told fans he grandfather is 'really, really poorly'.

New York City doctors in residence have said that coronavirus patients are dying while they being made to work on intensive care units with no prior training in the field.

Jayden Hardowar had complained of a fever and diarrhea just five days before his heart failed and he was placed on a ventilator at a New York City medical center.

Social media star Sahar Tabar, 22, whose real name is Fatemeh Khishvand, from Tehran, shot to prominence after posting images of her eerily gaunt face.