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Margaret Parker, MD, MCCM, speaks with Mirjana Cvetkovic, FRCA. Dr. Cvetkovic works as a Clinical Fellow at the Children's Acute Transport Service at Great Ormond Street Hospital in London and a Consultant Intensivist in Anesthesia at Leicester Hospital.

A plurality of Field Programmable Gate Arrays (FPGA), high performance transceivers, and memory devices provide a verification module for timing and state debugging of electronic circuit designs. Signal value compression circuits and gigabit transceivers embedded in each FPGA increase the fanout of each FPGA. Ethernet communication ports enable remote software debugging of processor instructions.

Transcranial magnetic stimulation (TMS) is a remarkable tool for probing the brain. However, it is still unclear why specific regions in the cortex are excitable by TMS while others are not. This invention provides methods and tools for the design of efficient magnetic stimulators. Such stimulators can excite neuronal networks that were not sensitive to stimulation until now. Stimulation can be carried out both in-vitro and in-vivo. Novel systems and techniques of this invention will enable both treatment and diagnostics by stimulating regions of the brain or neuronal assemblies that were previously unaffected by TMS.

One embodiment may include an automotive timing chain system component (10, 12) such as a tensioner arm (10) or a chain guide (12) that, during use, bears directly or indirectly against a chain (22) of an automotive timing chain system (14). The component (10, 12) may have an elongated body (16, 116) made into a generally hollow shape by a hydroforming process. The body may have a first open free end (26, 126) and a second open free end (28, 128).

A system for providing an accumulated phase to an interpolator of a read channel, the interpolator configured to provide a digital clock signal. A frequency accumulator is configured to generate a frequency offset based on a difference between the digital clock signal and a desired clock signal. A zero phase start module is configured to, during a zero phase start, output an incremental phase jump. A phase accumulator is configured to generate the accumulated phase based on the difference between the digital clock signal and the desired clock signal, and, during the zero phase start, the incremental phase jump output by the zero phase start module, or the frequency offset generated by the frequency accumulator or a predetermined frequency offset.

Aspects of the disclosure provide a sync mark detector. The sync mark detector includes a first unit configured to decay over time a value indicating a length of a bit format, a second unit configured to compare the decayed value with a detected length of the bit format to determine a new length, and a third unit configured to detect a sync mark based on the detected length and the new length.

A phase control apparatus in a variable cam timing (VCT) system of an engine is described herein. The phase control apparatus includes a locking pin coupled to a vane, the locking pin extending into a locking pin recess in a cover plate in a locked configuration, the locking pin and locking pin recess having a backlash and a housing at least partially enclosing the vane and spaced away from the vane forming a gap in the locked configuration.

A valve timing control device includes: a vane rotor having a plurality of vanes; a housing having the vane rotor inside so that an advance chamber is formed on one side of each vane and a retard chamber is formed on the other side; a lock pin inserted in a cylinder provided in the vane and moves to a lock position and to an unlock position; and a feeding passage for feeding oil into the cylinder from the retard chamber adjacent to the vane provided with the cylinder to make the lock pin move to the unlock position, and controls an oil supplying unit to supply oil to each retard chamber, wherein a flow passage cross sectional area of the branch passage connected with the retard chamber linking with the cylinder is larger than a flow passage cross sectional area of the branch passage connected with the other retard chamber.

In an electrically-driven valve timing control apparatus employing a housing and a cover member axially opposed to each other, a cylindrical-hollow motor output shaft is installed in the housing, and configured to rotate relative to the housing by electricity-feeding to the electric motor, and also configured such that lubricating oil is supplied into the motor output shaft. A plug is fitted to the inner periphery of an axial opening end of the motor output shaft for suppressing a leakage of lubricating oil from the motor output shaft to the outside. One of two opposing faces of the cover member and the plug is formed with a protruding portion configured to prevent the plug's slipping out of the axial opening end. A part of the inside face of the cover member, opposed to the plug, is formed integral with the protruding portion partially disposed within the axial opening end.

A brake system and related components including a metering device are configured to regulate a control signal received from a brake control device such that a control valve delays the supply of a level of requested braking pressure for a prescribed amount of time. The metering device can be an inversion valve and orificed check valve in a control circuit adapted to allow relatively unrestricted flow until a threshold pressure is reached, after which pressure the inversion valve closes and the flow is metered through an orifice. This has the effect of allowing rapid brake actuation to a first level, and then slowing further application of the brake until full requested braking is achieved. An electronic control unit can also be configured to regulate a control signal to delay development of the requested brake pressure.

A fluid-working machine has a working chamber of cyclically varying volume, high and low pressure manifolds, and high and low pressure valves for regulating the flow of fluid between the working chamber and the high and low pressure manifolds respectively. A controller actively controls at least one said valve to determine the net displacement of working fluid of the working chamber on a cycle by cycle basis. At least one said valve is a variable timing valve and the controller causes the valve to open or close at a time determined taking into account one or more properties of the performance of the fluid working machine measured during an earlier cycle of working chamber volume.

In general, this disclosure describes techniques for changing a sampling frequency of a digital signal. In particular, the techniques provide a more accurate way to determining a relative timing between a desired output sample and a corresponding input sample using a non-approximated integer representation of the relative timing. The relative timing between the desired output sample and corresponding input sample may be represented using a first component that identifies a latest input sample of the digital signal used to generate intermediate samples, a second component that identifies an intermediate sample, and a third component that identifies a timing difference between the desired output sample and the intermediate sample. Each of the components may be recursively updated using non-approximated integer values.

This disclosure generally provides a processing system that includes a first controller coupled with a second controller via a first communication link. The first controller is configured to transmit display data and configuration data to the second controller via the first communication link. The second controller is configured to drive, using the display data, one or more coupled display electrodes for performing display updating. The second controller is further configured to operate one or more coupled sensor electrodes using the configuration data to acquire capacitive sensing data, and to transmit the capacitive sensing data to the first controller via the first communication link.

Technologies for controlling timing calibration of a dedicated inter-integrated circuit data bus by a primary microcontroller are disclosed. The primary microcontroller performs a data transfer with a secondary integrated circuit using the dedicated inter-integrated circuit data bus, and determines a duration of the data transfer. If the duration is outside of an acceptable range, the primary microcontroller updates one or more data transfer timing parameters so that the duration of future data transfers are closer to the acceptable range.

A valve timing control apparatus includes: a drive-side rotor rotating in synchronization with a crankshaft of an internal combustion engine; a driven-side rotor arranged to have the same shaft center as the drive-side rotor, rotating in synchronization with a camshaft for opening and closing valves; a fluid pressure chamber formed between the drive-side driven-side rotors; a partitioning portion provided in at least one of the drive-side and driven-side rotors; a timing advance chamber and a timing delay chamber formed by partitioning the fluid pressure chamber by the partitioning portion; a lock mechanism including a lock member and a concave portion a lock release flow path through which operating fluid supplied and discharged to and from the concave portion is circulated; a valve arranged in the middle of the lock release flow path; and a control unit controlling the operation of the valve.

Provided is a timing adjustment system having improved control for achieving a target rotational phase. The valve timing adjustment system includes a displacement mechanism unit that displaces a rotational phase of a camshaft relative to a crankshaft of an internal combustion engine; a locking mechanism unit that locks the rotational phase at an intermediate locked phase positioned within a displacement range of the rotational phase; a hydraulic pathway that hydraulically drives the displacement mechanism unit and the locking mechanism unit; and a control unit including a control system that controls operations of the hydraulic control valve. The control unit changes a temporal responsiveness of the control system based on a displacement force that displaces the rotational phase.

A valve timing adjusting device for and engine includes a sprocket configured to rotate by receiving drive power from a driving shaft, a vane rotor fixed to a driven shaft so as to be rotatable relative to the sprocket, a housing that includes an oil chamber housing the vane rotor and is fixed to one end in a thickness direction of the sprocket, a bolt fixing the sprocket to the housing, and a knock pin inserted into a sprocket hole formed in the sprocket at one end thereof and into a housing hole formed in the housing at the other end thereof to restrict relative relation between the sprocket and the housing. The knock pin abuts against an inner wall of the sprocket hole at one end thereof, and abuts against an inner wall of the housing hole at the other end thereof.

A programmable memory including a self-latching read data path. A sense amplifier senses the voltage level at a bit line, the bit line communicating the data state of a selected memory cell in its associated column. A data latch coupled to the output of the sense amplifier passes the sensed data state. Set-reset logic is provided that receives the output of the data latch in the read data path and, in response to a transition of the data state in a read cycle, latches the data latch and isolates it from the sense amplifier. The set-reset logic resets the data latch at the start of the next read cycle. In some embodiments, a timer is provided so that the latch is reset after a time-out period in a long read cycle in which no data transition occurs.

A brake caliper is provided with a timing and retraction controller, a brake pad and a lock-connection comprising an engaging component and a locking component. The timing and retraction controller adjusts brake timing, eliminates parasitic brake losses and dampens out-of-plane vibration between the brake pad and rotor. The brake caliper includes a housing disposed over a brake rotor; first and second opposing brake pads extendably and retractably mounted on opposite sides of the caliper housing, brake pistons that extend and retract the brake pads into and out of frictional engagement with the rotor, and brake pad timing and retraction controllers disposed on opposite sides of the caliper housing. Each controller includes a Belleville spring or other resilient member with a short compression travel limited to between about 1.50 mm and 0.025 mm. The short stroke Belleville spring of each controller applies a hold-off force against the extension force of the brake pistons that slightly delays brake pad extension and slightly reduces brake pad clamping force against the rotor, thereby advantageously providing a front wheel braking bias when applied to the rear wheels of a vehicle. The restorative force applied by the short stroke Belleville forcefully and uniformly retracts the brake pad from the rotor, eliminating parasitic brake losses, and dampening out-of-plane vibration between the brake pad and rotor.

Methods and systems for time interleaved analog-to-digital converter timing mismatch calibration and compensation may include receiving an analog signal on a chip, converting the analog signal to a digital signal utilizing a time interleaved analog-to-digital-converter (ADC), and reducing a blocker signal that is generated by timing offsets in the time interleaved ADC by estimating complex coupling coefficients between a desired digital output signal and the blocker signal utilizing a decorrelation algorithm on frequencies within a desired frequency bandwidth. The decorrelation algorithm may comprise a symmetric adaptive decorrelation algorithm. The received analog signal may be generated by a calibration tone generator on the chip. An aliased signal may be summed with an output signal from a multiplier. The complex coupling coefficients may be determined utilizing the decorrelation algorithm on the summed signals. A multiplier may be configured to cancel the blocker signal utilizing the determined complex coupling coefficients.

For analog-to-digital converters (ADCs) which utilize a feedback digital-to-analog converter (DAC) for conversion, the final analog output can be affected or distorted by errors of the feedback DAC. A digital measurement technique can be implemented to determine timing mismatch error for the feedback DAC in a continuous-time delta-sigma modulator (CTDSM) or in a continuous-time pipeline modulator. The methodology utilizes cross-correlation of each DAC unit elements (UEs) output to the entire modulator output to measure its timing mismatch error respectively. Specifically, the timing mismatch error is estimated using a ratio based on a peak value and a value for the next tap in the cross-correlation function. The obtained errors can be stored in a look-up table and fully corrected in digital domain or analog domain.

After the bumper here, the review will get into spoiler territory. I will say that if you are a Sonic fan this movie will give you a sense of pride as it is far better than it should have had any right in being. Taking the franchise’s lore and resetting it to tell its own story, but retaining the strong characterization and quip heavy personalities of Sonic and Robotnik that makes their rivalry such a strong one. It also keeps the first entry simple with the hedgehog and doctor being the only two characters from the universe being in the film. This makes the story stronger since it can develop those two far more and not have to worry about any other kind of side character fan service for now.

Hey, at least now Sonic fans can brag to Mario ones that Mario may still be the king of games, but Sonic blew the plumber’s cinematic pieces out of the water. Not that that was a high bar I suppose. Then again, having better quality games than Sonic these days isn’t one either (the author quips while using a quote from Sonic Forces for his review’s headline).

In the video game Sonic the Hedgehog, timing is everything. While at the heart of the game is a fast paced platformer, its foundation has always been learning the layout of a level and timing your actions appropriately. In a twist, the timing of this film and its release had quite a bit of impact on my view of it.

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DFT (Design for testing) Engineer: 4-6 years of experience Experience with Synopsys Toolset is mandatory. Scan insertion, Debug DRC, ATPG patterns Gate Level Simulation ( timing and no-timing) Knowledge in P1500 and JTAG is an advantage. Knowledge in MBIST is an advantage. Phy

1 May 2020

Have you ever come across a section of a book where it felt like everything happened at breakneck speed, and you could only just barely read fast enough to keep up? Or have you seen the opposite, where it’s all nice and slow and mellow, and where you’re able to really take your time and enjoy the beauty of the words?

That’s the kind of thing I’ll be musing on today. Prose and pacing. Time and reading.

Do note, this is not about how to pace your story, that’s an entirely different topic.

The Basics

Most writers will at one point or another have heard that a full stop is a signal for the reader to breathe. The shorter the sentences are, the quicker the breathing becomes, like when you’re excited. With longer sentences, the breaths grow longer, and deeper, and you calm down.

And when you write really long sentences and don’t include any commas or other forms of punctuation your reader might just run out of breath and begin to feel a little panicked.

There’s no ideal sentence length to strive for – rather the opposite.

Continue reading Pace Your Prose — Three Thoughts on Timing at Mythic Scribes.

1 May 2020

1 May 2020

Prevention of aberrant cutaneous wound repair and appropriate regeneration of an intact and functional integument require the coordinated timing of fibroblast and keratinocyte migration. Here, we identified a mechanism whereby opposing cell-specific motogenic functions of a multifunctional intracellular and extracellular protein, the receptor for hyaluronan-mediated motility (RHAMM), coordinates fibroblast and keratinocyte migration speed and ensures appropriate timing of excisional wound closure. We found that, unlike in WT mice, in Rhamm-null mice, keratinocyte migration initiates prematurely in the excisional wounds, resulting in wounds that have re-surfaced before the formation of normal granulation tissue, leading to a defective epidermal architecture. We also noted aberrant keratinocyte and fibroblast migration in the Rhamm-null mice, indicating that RHAMM suppresses keratinocyte motility but increases fibroblast motility. This cell context–dependent effect resulted from cell-specific regulation of extracellular signal-regulated kinase 1/2 (ERK1/2) activation and expression of a RHAMM target gene encoding matrix metalloprotease 9 (MMP-9). In fibroblasts, RHAMM promoted ERK1/2 activation and MMP-9 expression, whereas in keratinocytes, RHAMM suppressed these activities. In keratinocytes, loss of RHAMM function or expression promoted epidermal growth factor receptor–regulated MMP-9 expression via ERK1/2, which resulted in cleavage of the ectodomain of the RHAMM partner protein CD44 and thereby increased keratinocyte motility. These results identify RHAMM as a key factor that integrates the timing of wound repair by controlling cell migration.

(Keck School of Medicine of USC) A new USC study suggests that temporarily suppressing the body's immune system during the early stages of COVID-19 could help a patient avoid severe symptoms. That's because the research shows that an interaction between the body's two main lines of defense may be causing the immune system to go into overdrive in some patients.

1 May 2020

Prevention of aberrant cutaneous wound repair and appropriate regeneration of an intact and functional integument require the coordinated timing of fibroblast and keratinocyte migration. Here, we identified a mechanism whereby opposing cell-specific motogenic functions of a multifunctional intracellular and extracellular protein, the receptor for hyaluronan-mediated motility (RHAMM), coordinates fibroblast and keratinocyte migration speed and ensures appropriate timing of excisional wound closure. We found that, unlike in WT mice, in Rhamm-null mice, keratinocyte migration initiates prematurely in the excisional wounds, resulting in wounds that have re-surfaced before the formation of normal granulation tissue, leading to a defective epidermal architecture. We also noted aberrant keratinocyte and fibroblast migration in the Rhamm-null mice, indicating that RHAMM suppresses keratinocyte motility but increases fibroblast motility. This cell context–dependent effect resulted from cell-specific regulation of extracellular signal-regulated kinase 1/2 (ERK1/2) activation and expression of a RHAMM target gene encoding matrix metalloprotease 9 (MMP-9). In fibroblasts, RHAMM promoted ERK1/2 activation and MMP-9 expression, whereas in keratinocytes, RHAMM suppressed these activities. In keratinocytes, loss of RHAMM function or expression promoted epidermal growth factor receptor–regulated MMP-9 expression via ERK1/2, which resulted in cleavage of the ectodomain of the RHAMM partner protein CD44 and thereby increased keratinocyte motility. These results identify RHAMM as a key factor that integrates the timing of wound repair by controlling cell migration.

Guo-qiang Bi
Dec 15, 1998; 18:10464-10472
Articles

Necrotizing enterocolitis (NEC) can present within the first week of life in term infants. In preterm infants, NEC usually appears after commencement of feeds and can occur between 2 and 3 weeks of life.

Among infants <33 weeks’ gestation, NEC appears to occur at mean age of 7 days in more mature infants, whereas onset of NEC is delayed to 32 days of age in smaller, lower gestational age infants. (Read the full article)

Many children are vaccinated against measles with a delay. This may influence effective measles vaccine coverage even in countries with high overall immunization levels. Official vaccine coverage statistics do not usually report on the impact of timeliness of measles vaccination.

Delayed measles vaccination results in 48.6% effective coverage in children aged 6 months to 2 years when 84.5% of 25-month-olds are up-to-date for 1 measles vaccination. Analyzing patterns of measles vaccination could help to address low coverage in infants and toddlers. (Read the full article)

In a previous randomized trial, infants from a low-resource country exclusively breastfed for 6 months had lower iron stores at 6 months compared with breastfeeding infants receiving solid foods. Randomized trials of exclusive breastfeeding in high-income countries are lacking.

In a high-income country, infants who receive complementary foods in addition to breast milk from 4 months of age had higher iron stores at 6 months compared with those exclusively breastfed for 6 months. (Read the full article)

Some Western studies show early introduction of solid food is associated with subsequent obesity. However, introduction of solid food and obesity share social patterning, making these observations vulnerable to residual confounding.

In a non-Western developed setting, there was no clear association of the early introduction of solid food with childhood obesity. Studies in populations with a different confounding structure may be valuable in clarifying and reconciling potentially confounded epidemiologic associations. (Read the full article)

Infants born late-preterm and early-term are at higher risk of morbidity and mortality compared with term infants. Home care practices recommended for all infants include supine sleep position, no smoke exposure, and breastfeeding to optimize health outcomes.

Our study provides new findings on the timing of hospital discharge, outpatient follow-up, and home care of late-preterm and early-term infants compared with term infants in the United States. (Read the full article)

Clamping and cutting of the umbilical cord at birth is the most prevalent of all operations; however, the optimal timing of cord clamping is still a controversial issue, with different timings offering advantages and disadvantages.

Our findings suggest a protective effect of late cord clamping, increasing the antioxidant capacity and decreasing the inflammatory-mediated effects induced during delivery of term neonates. (Read the full article)

Earlier adiposity rebound may increase fatness in later life; however, there is limited evidence from large cohorts of contemporary children with direct measures of fatness in adolescence or adulthood.

Early adiposity rebound is strongly associated with increased BMI and fatness in adolescence. Future preventive interventions should consider targeting early childhood to delay timing of adiposity rebound. (Read the full article)

Current recommendations for the first outpatient visit for newborns are based on known health risks during the first week of life. Knowledge of the relationship between early well child visits and hospital readmissions may inform newborn health policy interventions.

Newborns who have a first well child visit within the recommended time period after hospital discharge are substantially less likely be readmitted. Obstacles to early follow-up should be addressed to reduce the risk of readmission in this population. (Read the full article)

Patients with sickle cell disease frequently express dissatisfaction with emergency department treatment of painful crises. Time to opioid administration has been suggested as a quality of care measure for painful crises.

Although not associated with hospital admission, time to opioid administration in sickle cell disease painful crises was associated with secondary outcomes including improvement between the first 2 pain scores, decreased pain score area under the curve at 4 hours, decreased emergency department length of stay, and increased total opioids. (Read the full article)

Many studies have suggested that autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) are commonly co-occuring neurodevelopmental conditions.

In children with co-occurring ASD and ADHD, an initial ADHD diagnosis may be associated with delayed ASD diagnosis and a higher likelihood of ASD diagnosis older than 6 years of age. Clinicians should consider ASD when evaluating young children presenting with ADHD symptoms. (Read the full article)

Cesar Gomes Victora
Mar 1, 2010; 125:e473-e480
ARTICLES

David’s role on the Riverboat is to act as a homeless man. In reality, he is acting out a familiar life he used to lead.

<strong>New Delhi:</strong> Delhi Government's Odd-Even scheme has come into effect from today and will continue till November 15. In a bid to control the deteriorating air quality in the national capital, this is the third Odd-Even car rationing scheme that has kicked off from Monday. A flagship scheme of the

The longer you stay in the markets, the more you are likely to earn returns by letting the magic of compounding work for you.

One of the major lunar events India is going to witness this week is a Pink Super Moon. This appearance of the moon is considered as the brightest and the biggest.

Did you miss last month's Pink Supermoon? Don’t worry! You can witness another supermoon today.

Hello, i am a student who is studying Allegro tool with SKILL.

I have a question about SKILL axlSegDelayAndZ0. The reference says this function "returns the delay and impedance of a cline segment."

I want to know how many components does this tool consider when calculating timing delay from the length. 

How steep is input signal's rise transition? Is rise transition shape isosceles trapezoid or differential increasing shape?

Also, if it is a multi fan-out, the rise transition time will be different net by net. How can this tool can calculate in this case?

I want to hear answers about these questions.

Thank you for reading this long boring questions, and i will be waiting for answers.