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Estrogenic activity of plastic nanoparticle mixtures under in vitro settings

Environ. Sci.: Nano, 2024, Advance Article
DOI: 10.1039/D3EN00883E, Paper
Lucija Božičević, Korinna Altmann, Jana Hildebrandt, Xenia Knigge, Valerije Vrček, Nikolina Peranić, Nikolina Kalčec, Ivana Vinković Vrček
This study provides science-based evidence on endocrine disrupting effects of polyethylene, polystyrene and polypropylene nanoparticles and their mixtures indicating the importance of hazard assessment of aggregate exposure to nanoplastics.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Spatial Economics for Granular Settings [electronic journal].

National Bureau of Economic Research




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Α simplified lateral flow immunosensor for the assay of carcinoembryonic antigen in low-resource settings

Anal. Methods, 2024, Accepted Manuscript
DOI: 10.1039/D4AY00381K, Paper
Open Access
Ioanna Tsogka, Electra Mermiga, Varvara Pagkali, Christos Kokkinos, Anastasios Economou
Carcinoembryonic antigen (CEA) is a glycoprotein widely used as a tumor marker. In this work, a colorimetric lateral flow immunosensor is developed for rapid and low-cost quantification of CEA in...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Web@All 1.1 Remote Admin Settings Change Exploit

Web@All versions 1.1 and below remote administrative settings changing exploit.




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How To Find Out Your Ip Address And Other Tcp/ip Settings In Windows




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IPv6 "Custom" Firewall Settings ARRIS TG1682G From Xfinity




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Android phone... says under android settings i have 3rd party with trusted cert




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Best power settings for part time server?




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GamePad App Which Overrides Games With Particular Controller Settings




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New Report on Science Learning at Museums, Zoos, Other Informal Settings

Each year, tens of millions of Americans, young and old, choose to learn about science in informal ways -- by visiting museums and aquariums, attending after-school programs, pursuing personal hobbies, and watching TV documentaries, for example.




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How to Reset The Chrome Browser To Its Default Settings





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Policy settings key to debate over Dutch Wadden Sea

There is an ongoing debate over exploitation of the Dutch Wadden Sea, over issues including gas extraction and cockle fishing. According to a review analysing interactions between scientists and policymakers during these debates, the productivity of such discussions is substantially influenced by the policy setting, i.e. the level of government involved and the key decision-makers.




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PreferenceSettings

#SettingPrefs #PreferencesMacros Preference Settings A preference setting lets you define a simple macro that will be expanded in your output. A preference setting ... (last changed by ProjectContributor)




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Facebook loosens privacy settings for teens

Parents and teens should be on the lookout for this new privacy setting that affects 13- to 17-year-olds.



  • Protection & Safety

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Study Recently Published Includes Results of Full-Endoscopic Laser Spine Technique In Ambulatory Settings

Surgery Technique Produces Life-Changing Results For Patients With Extreme Back Pain




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Skin, Bones, Hearts & Private Parts Hosts Destin, Florida CME Conference in Primary and Specialty Care Settings

Continuing Medical Education for Nurse Practitioners & Physician Assistants




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WordPress Development: Bypassing the Settings API

The following is a guest post by Andy Walpole. There are many parts of the Wordpress API which are fantastic but there are also other parts which, I would argue, are lacking. The Settings API was introduced in version 2.7 to allow the semi-automation of form creation. All credible Content Management Systems and frameworks have their own set of functions or classes for the same purpose. Drupal has a multitude of hooks which can be leveraged, while CodeIgniter uses a combination of the Form Validation Class and the Form Helper . When creating a Wordpress plugin recently I wanted to create a dynamic form to insert data into a field in the option database table. I decided to create a class for this purpose with the intention of creating reusable code for future projects.




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Syncing Local Alexa Skills JSON Files With Alexa Developer Console Settings

In the Alexa Skills for Node.JS ASK SDK development world, the Alexa Skills Kit (ASK) Command-Line Interface (CLI) is one of the most overlooked tools.

Boosting Developer Productivity

With proper use, one could really increase productivity when developing Alexa Skills. This is especially so if you are creating many Alexa Skills, either because you are in the learning process or you are just managing multiple Alexa Skills projects for yourself or your clients.




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Integrating multiple FPGA designs by merging configuration settings

This disclosure relates generally to field-programmable gate arrays (FPGAs). Some implementations relate to methods and systems for transmitting and integrating an intellectual property (IP) block with another user's design. The IP developer can design the IP block to include both a secret portion and a public portion. The IP block developer can send or otherwise provide the IP block to another IP user without disclosing the functional description of the secret portion of the IP block. In some implementations, the IP developer provides the public portion to the IP user at the register-transfer-level (RTL) level, as a hardware description language (HDL)-implemented design, or as a synthesizable netlist. In some implementations, the IP developer provides the secret portion of the IP block to the user in the form of programming bits without providing an HDL, RTL, or netlist implementation of the secret portion.




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Controlling drive settings in a press

In one embodiment, a method for controlling drive settings in a press for printing on a web of media. A drive is provided to receive the web from an upstream location and to transport the received web downstream of the drive at a controllable speed. The speed of the drive is sampled plural times while operating the drive in a tension control mode that varies the speed to maintain a desired tension in the web adjacent the drive. An optimal speed of the drive is calculated from the sampled speeds. The drive is operated in a constant velocity mode at the optimal speed during printing.




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Method and device for controlling the register settings of a printing press

A method for controlling register settings of a printing press, includes rotating imaging cylinders of a first print unit and a second print unit, located downstream of the first print unit in a movement direction of a print medium, at a rotational speed to print an image on the print medium. The method includes of changing a length of the print image to a pre-determined length. The method further includes changing a register setting of the imaging cylinder of the second print unit based on the predetermined change in length of the print image to avoid misalignment of the print image printed by the first and the second print units on the print medium. Changing the register setting is dependent on a length of a section of the print medium between the first and the second print units. A device for controlling register settings of a printing press is also disclosed.




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CBD News: For this year's International Women's Day, I join my voice to the call to action to empower women in all settings, rural and urban, and to draw inspiration from the activists working to achieve women's rights and gender equality.




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Integrating Depression Care With Diabetes Care in Real-World Settings: Lessons From the Robert Wood Johnson Foundation Diabetes Initiative

Daren Anderson
Jan 1, 2007; 20:10-16
Feature Articles




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Impact of 68Ga-PSMA-11 PET/CT on Staging and Management of Prostate Cancer Patients in Various Clinical Settings: A Prospective Single Center Study

The impact of prostate specific membrane antigen (PSMA) PET/CT on management of prostate cancer (PCa) patients with biochemical recurrence (BCR) is well-established. However, whether and how PSMA PET/CT affects the management of patients undergoing scans for other clinical indications remains unknown. The goal of this study was to determine the impact of 68Ga-PSMA-11 PET/CT on initial and subsequent management decisions in a cohort of PCa patients referred for various indications ("basket trial") excluding the two main classical indications: BCR and presurgical staging. Methods: This was a prospective study of 197 patients that aimed to determine the impact of 68Ga-PSMA-11 PET/CT on PCa stage and management. Indications for PSMA PET/CT were: initial staging of non-surgical candidates (30 patients) and re-staging after definitive treatment (n = 168). The re-staging cohort comprised: patients re-staged with known advanced metastatic disease (n = 103), after androgen deprivation therapy only (n = 16), after surgery with serum PSA levels <0.2 ng/ml (n = 13), after radiation therapy (RT) not meeting the Phoenix criteria (n = 22) and after other primary local treatments [i.e. high-intensity focused ultrasound (HIFU), focal laser ablation, cryoablation, hyperthermia or irreversible electroporation] (n = 13). Patients with BCR and candidates for curative surgery were excluded. Impact on management was assessed using pre- and post-PET questionnaires completed by referring physicians, electronic chart review and/or patient telephone encounters. Results: PSMA PET/CT changed disease stage in 135/197 (69%) patients (38% up-stage, 30% down-stage and no changes in stage in 32%). Management was affected in 104/182 (57%) patients. Specifically, PSMA PET/CT impacted management of patients who were re-staged after RT without meeting the Phoenix criteria for BCR, after other definitive local treatments and with advanced metastatic disease in 13/18 (72%), 8/12 (67%) and 59/96 (61%), respectively. Conclusion: PSMA PET/CT has a profound impact on stage and management of PCa patients outside of the two main classical indications (BCR and presurgical staging) across all examined clinical scenarios.




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On Mahalanobis Distance in Functional Settings

Mahalanobis distance is a classical tool in multivariate analysis. We suggest here an extension of this concept to the case of functional data. More precisely, the proposed definition concerns those statistical problems where the sample data are real functions defined on a compact interval of the real line. The obvious difficulty for such a functional extension is the non-invertibility of the covariance operator in infinite-dimensional cases. Unlike other recent proposals, our definition is suggested and motivated in terms of the Reproducing Kernel Hilbert Space (RKHS) associated with the stochastic process that generates the data. The proposed distance is a true metric; it depends on a unique real smoothing parameter which is fully motivated in RKHS terms. Moreover, it shares some properties of its finite dimensional counterpart: it is invariant under isometries, it can be consistently estimated from the data and its sampling distribution is known under Gaussian models. An empirical study for two statistical applications, outliers detection and binary classification, is included. The results are quite competitive when compared to other recent proposals in the literature.




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Improving Antibiotic Prescribing for Pediatric Urinary Tract Infections in Outpatient Settings

OBJECTIVES:

To determine if a multicomponent intervention was associated with increased use of first-line antibiotics (cephalexin or sulfamethoxazole and trimethoprim) among children with uncomplicated urinary tract infections (UTIs) in outpatient settings.

METHODS:

The study was conducted at Kaiser Permanente Colorado, a large health care organization with ~127 000 members <18 years of age. After conducting a gap analysis, an intervention was developed to target key drivers of antibiotic prescribing for pediatric UTIs. Intervention activities included development of new local clinical guidelines, a live case-based educational session, pre- and postsession e-mailed knowledge assessments, and a new UTI-specific order set within the electronic health record. Most activities were implemented on April 26, 2017. The study design was an interrupted time series comparing antibiotic prescribing for UTIs before versus after the implementation date. Infants <60 days old and children with complex urologic or neurologic conditions were excluded.

RESULTS:

During January 2014 to September 2018, 2142 incident outpatient UTIs were identified (1636 preintervention and 506 postintervention). Pyelonephritis was diagnosed for 7.6% of cases. Adjusted for clustering of UTIs within clinicians, the proportion of UTIs treated with first-line antibiotics increased from 43.4% preintervention to 62.4% postintervention (P < .0001). The use of cephalexin (first-line, narrow spectrum) increased from 28.9% preintervention to 53.0% postintervention (P < .0001). The use of cefixime (second-line, broad spectrum) decreased from 17.3% preintervention to 2.6% postintervention (P < .0001). Changes in prescribing practices persisted through the end of the study period.

CONCLUSIONS:

A multicomponent intervention with educational and process-improvement elements was associated with a sustained change in antibiotic prescribing for uncomplicated pediatric UTIs.




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Incidence and Cost of Injury Among Youth in Agricultural Settings, United States, 2001-2006

Several studies have analyzed fatal or nonfatal youth injury incidence in US agricultural settings, but none have combined those estimates to form an overall picture. The only detailed study of costs related to such injuries is restricted to nonfatal injury.

This study provides a comprehensive analysis of the annual incidence and cost of agricultural youth injuries in the United States. It analyzes them from different perspectives: fatal versus nonfatal, at work versus not at work, and requiring hospitalization versus not requiring hospitalization. (Read the full article)




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Infant Outcomes After Maternal Antiretroviral Exposure in Resource-Limited Settings

Information on infant safety after exposure to maternal antiretroviral regimens during pregnancy in international clinical trials is lacking. As antiretroviral drugs are released to populations in resource-limited settings through clinical trials, it becomes critical to collect pediatric outcome data.

The study demonstrates the feasibility of reporting infant outcomes following adult antiretroviral trials in developing countries, provides HIV-free infant survival and prospective growth data in association with maternal parameters, and details morbidity, mortality, and genetic defects following maternal antiretroviral exposure. (Read the full article)




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Secondary Sexual Characteristics in Boys: Data From the Pediatric Research in Office Settings Network

Recent investigations of pubertal onset in US girls suggest earlier maturation. The situation for US boys is unknown, and existing investigations are outdated and lack information on a key physical marker of male puberty: testicular enlargement.

US boys appear to be developing secondary sexual characteristics and achieving testicular enlargement 6 months to 2 years earlier than commonly used norms, with African American boys entering Tanner stages 2 to 4 earlier than white or Hispanic boys. (Read the full article)




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Using Otoacoustic Emissions to Screen Young Children for Hearing Loss in Primary Care Settings

The incidence of permanent hearing loss doubles between birth and school age. Otoacoustic emissions screening has been used successfully in early childhood educational settings to identify children with losses not found through newborn screening.

Using otoacoustic emissions to screen the hearing of young children during routine health care visits is feasible and can lead to the identification of permanent hearing loss overlooked by providers relying solely on subjective methods. (Read the full article)




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A Trigger Tool to Detect Harm in Pediatric Inpatient Settings

Harm occurs at a high rate in adult inpatient populations. One single-center study, applying an adult-based surveillance tool, suggests that a pediatric inpatient population also has a high rate of harm.

Harm occurred frequently in 6 freestanding children’s hospitals. Identification and understanding of the harm is the first step to making necessary improvements and to preventing future harm. (Read the full article)




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Deferred Consent for Randomized Controlled Trials in Emergency Care Settings

Deferral of consent avoids delaying emergency interventions while ensuring consent to ongoing participation and use of data. Deferred consent is particularly important for enabling trials in pediatric settings, where many medicines and devices are unlicensed and untested for use.

Approaches for seeking deferred consent should balance the potential burden of obtaining consent against risk of bias due to outcome-related attrition. Ethics committees could consider approving data use when best efforts to obtain deferred consent are met with no response. (Read the full article)




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Secondary Sexual Characteristics and Menses in Young Girls Seen in Office Practice: A Study from the Pediatric Research in Office Settings Network

Marcia E. Herman-Giddens
Apr 1, 1997; 99:505-512
ARTICLES




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Children With Complex Chronic Conditions in Inpatient Hospital Settings in the United States

Tamara D. Simon
Oct 1, 2010; 126:647-655
ARTICLES




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Attention all Zoom users: New security settings to take effect on May 11

Zoom-bombings have been making headlines across the country this spring, and Penn State is no exception to the increase in security threats and breaches. To address these recent incidents in Zoom meetings, University-wide Zoom default setting changes will be implemented on May 11.




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Governor Carney Requires Delawareans to Wear Face Coverings in Public Settings

Children 2-years-old and younger should not wear face coverings due to suffocation risk WILMINGTON, Del. – Governor John Carney on Saturday issued the thirteenth modification to his State of Emergency declaration, requiring Delawareans to wear face coverings in public settings, including in grocery stores, convenience stores, pharmacies, doctor’s offices, and on public transportation. Governor Carney’s […]




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Allegro System Architect 17.2 Project Settings not Opening

I have been working on a an ASA 17.2 project for the last 6 months.

When I go to Project --> Settings, the settings window does not open. 

The tool indicates that a window is open, as I cannot click on anything else in the project. But it does not show the Settings window.

This has been happening only for the last 2 months. Before that it was working fine.

If I send the project to my colleague, the settings window shows up for him.




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Regarding Save/Restore Settings for Transient Simulation

Hello,

I am running a transient simulation on my circuit and usually my simulation time took me more than a day (The circuit is quite big). I am usually saving specific nodes to decrease the simulation time. My problem is, since it usually took me one day to finish I need to save my trans simulation just in case something bad happens. I am aware that the transient simulation have the options for save/restore. But, when I tried to use it I have some problem. Whenever I restore the save file, it starts where it ends before (expected function) but my data is incomplete. It doesn't save the previous data. Its kind of my data is incomplete. What I did is set the saveperiod and savefile. I hope someone can help me. Thank you!


Regards,

Kiel




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Microsoft Windows Internet Settings Security Feature Bypass

Microsoft Windows suffers from an Internet Settings misconfiguration security feature bypass vulnerability. Versions affected include Windows 7 SP1, 8.0, 8.1 x86 and x64 with full patches up to July 2019.





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HARMAN and IBM Watson IoT Introduce Cognitive Rooms that Bring Connected Experiences to Enterprise Settings

HARMAN Professional Solutions and IBM (NYSE: IBM) Watson Internet of Things (IoT) today unveiled Voice-Enabled Cognitive Rooms. Using IBM's Watson artificial intelligence (AI) technology and HARMAN AKG microphones, JBL speakers and AMX AV control and ...




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Effect of an Interactive Website to Engage Patients in Advance Care Planning in Outpatient Settings [Original Research]

PURPOSE

Online programs may help to engage patients in advance care planning in outpatient settings. We sought to implement an online advance care planning program, PREPARE (Prepare for Your Care; http://www.prepareforyourcare.org), at home and evaluate the changes in advance care planning engagement among patients attending outpatient clinics.

METHODS

We undertook a prospective before-and-after study in 15 primary care clinics and 2 outpatient cancer centers in Canada. Patients were aged 50 years or older (primary care) or 18 years or older (cancer care) and free of cognitive impairment. They used the PREPARE website over 6 weeks, with reminders sent at 2 or 4 weeks. We used the 55-item Advance Care Planning Engagement Survey, which measures behavior change processes (knowledge, contemplation, self-efficacy, readiness) on 5-point scales and actions relating to substitute decision makers, quality of life, flexibility for the decision maker, and asking doctors questions on an overall scale from 0 to 21; higher scores indicate greater engagement.

RESULTS

In total, 315 patients were screened and 172 enrolled, of whom 75% completed the study (mean age = 65.6 years, 51% female, 35% had cancer). The mean behavior change process score was 2.9 (SD 0.8) at baseline and 3.5 (SD 0.8) at follow-up (mean change = 0.6; 95% CI, 0.49-0.73); the mean action measure score was 4.0 (SD 4.9) at baseline and 5.2 (SD 5.4) at follow-up (mean change = 1.2; 95% CI, 0.54-1.77). The effect size was moderate (0.75) for the former and small (0.23) for the latter. Findings were similar in both primary care and cancer care populations.

CONCLUSIONS

Implementation of the online PREPARE program in primary care and cancer care clinics increased advance care planning engagement among patients.




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Characterization of blaCTX-M-27/F1:A2:B20 Plasmids Harbored by Escherichia coli Sequence Type 131 Sublineage C1/H30R Isolates Spreading among Elderly Japanese in Nonacute-Care Settings [Mechanisms of Resistance]

We characterized 29 blaCTX-M-27-harboring plasmids of Escherichia coli sequence type 131 (ST131) sublineage C1/H30R isolates from healthy individuals and long-term-care facility (LTCF) residents. Most (27/29) plasmids were of the FIA, FIB, and FII multireplicon type with the same plasmid multilocus sequence typing (pMLST). Several plasmids (7/23) from LTCF residents harbored only blaCTX-M-27 as the resistance gene; however, their fundamental structures were very similar to those of previously isolated blaCTX-M-27/F1:A2:B20 plasmids, suggesting their prevalence as a newly arising public health concern.




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Security Settings




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How to disable Flipboard notifications through the news service app and your device's settings

You can disable Flipboard notifications directly through the app or by going into your device's settings.To disable notifications through the Flipboard app, determine which categories you no longer want alerts for and turn off the appropriate push notification in the app's settings menu.If you want to disable Flipboard notifications through your device settings, you can opt to switch off all notifications or notifications for only "Sound" or "Badges" through your phone's Settings app. Visit Business Insider's homepage for more stories.Flipboard can help organize your news sources, but these days, the news can get overwhelming. You may also want to browse Flipboard yourself without receiving a notification every time a new story is posted.To disable notifications in the Flipboard app, you can




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How To Reset Network Settings On Windows 10

Network issues occur sometimes when you use the internet on your PC. The network problem doesn't always appear but only when there is a break in the network connection. It can also happen when there is a malfunctioning of the network




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Mental health care services in community settings: discussions on NGO approaches in India / Gayathri Balagopal, Aruna Rose Mary Kapanee

Online Resource




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Pharmacy management : essentials for all practice settings / [edited by] Shane P. Desselle, David P. Zgarrick




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The iOS 11 Privacy and Security Settings You Should Set Up Right Now

Heads up, iPhone owners. iOS 11 comes with a batch of security features that merit your attention.