Shady Habash, whose video mocked the president, "mistook hand sanitiser for water", prosecutors say.

Carbon monoxide (CO) remains the most common cause of human poisoning. The consequences of CO poisoning include cardiac dysfunction, brain injury, and death. CO causes toxicity by binding to hemoglobin and by inhibiting mitochondrial cytochrome c oxidase (CcO), thereby decreasing oxygen delivery and inhibiting oxidative phosphorylation. We have recently developed a CO antidote based on human neuroglobin (Ngb-H64Q-CCC). This molecule enhances clearance of CO from red blood cells in vitro and in vivo. Herein, we tested whether Ngb-H64Q-CCC can also scavenge CO from CcO and attenuate CO-induced inhibition of mitochondrial respiration. Heart tissue from mice exposed to 3% CO exhibited a 42 ± 19% reduction in tissue respiration rate and a 33 ± 38% reduction in CcO activity compared with unexposed mice. Intravenous infusion of Ngb-H64Q-CCC restored respiration rates to that of control mice correlating with higher electron transport chain CcO activity in Ngb-H64Q-CCC–treated compared with PBS-treated, CO-poisoned mice. Further, using a Clark-type oxygen electrode, we measured isolated rat liver mitochondrial respiration in the presence and absence of saturating solutions of CO (160 μm) and nitric oxide (100 μm). Both CO and NO inhibited respiration, and treatment with Ngb-H64Q-CCC (100 and 50 μm, respectively) significantly reversed this inhibition. These results suggest that Ngb-H64Q-CCC mitigates CO toxicity by scavenging CO from carboxyhemoglobin, improving systemic oxygen delivery and reversing the inhibitory effects of CO on mitochondria. We conclude that Ngb-H64Q-CCC or other CO scavengers demonstrate potential as antidotes that reverse the clinical and molecular effects of CO poisoning.

Carbon monoxide (CO) remains the most common cause of human poisoning. The consequences of CO poisoning include cardiac dysfunction, brain injury, and death. CO causes toxicity by binding to hemoglobin and by inhibiting mitochondrial cytochrome c oxidase (CcO), thereby decreasing oxygen delivery and inhibiting oxidative phosphorylation. We have recently developed a CO antidote based on human neuroglobin (Ngb-H64Q-CCC). This molecule enhances clearance of CO from red blood cells in vitro and in vivo. Herein, we tested whether Ngb-H64Q-CCC can also scavenge CO from CcO and attenuate CO-induced inhibition of mitochondrial respiration. Heart tissue from mice exposed to 3% CO exhibited a 42 ± 19% reduction in tissue respiration rate and a 33 ± 38% reduction in CcO activity compared with unexposed mice. Intravenous infusion of Ngb-H64Q-CCC restored respiration rates to that of control mice correlating with higher electron transport chain CcO activity in Ngb-H64Q-CCC–treated compared with PBS-treated, CO-poisoned mice. Further, using a Clark-type oxygen electrode, we measured isolated rat liver mitochondrial respiration in the presence and absence of saturating solutions of CO (160 μm) and nitric oxide (100 μm). Both CO and NO inhibited respiration, and treatment with Ngb-H64Q-CCC (100 and 50 μm, respectively) significantly reversed this inhibition. These results suggest that Ngb-H64Q-CCC mitigates CO toxicity by scavenging CO from carboxyhemoglobin, improving systemic oxygen delivery and reversing the inhibitory effects of CO on mitochondria. We conclude that Ngb-H64Q-CCC or other CO scavengers demonstrate potential as antidotes that reverse the clinical and molecular effects of CO poisoning.

United Kingdom, c.1935.

United Kingdom, c.1935.

England, 1935.

The exact molecule behind the Minamata mercury disaster, caused by a chemical plant’s wastewater, remains a point of disagreement

Refugee children arriving in the United States have had higher rates of elevated blood lead levels than US-born children. The Centers for Disease Control and Prevention recommends blood lead screening of all refugee children within 3 months after their arrival in the United States.

This is the first investigation we are aware of to examine and identify risk factors for lead poisoning among US-bound refugee children living in camps overseas, before their arrival in the United States. (Read the full article)

Medication ingestions are increasing among children despite a number of public health interventions. The majority of these poisonings are related to prescription as opposed to over-the-counter medications.

Rising rates of poisonings in children are strongly correlated with rising use of hypoglycemics, antihyperlipidemics, β-blockers, and opioids among adults. These events are associated with considerable health care utilization, both in terms of emergency department visits and hospital admissions. (Read the full article)

Title: Teens With History of Self-Poisoning Face Greater Suicide Risk
Category: Health News
Created: 4/25/2015 12:00:00 AM
Last Editorial Review: 4/27/2015 12:00:00 AM

Title: Take Precautions to Prevent Child Poisonings
Category: Health News
Created: 4/22/2016 12:00:00 AM
Last Editorial Review: 4/25/2016 12:00:00 AM

Title: Food Poisoning Cases Rise in U.S.
Category: Health News
Created: 4/26/2019 12:00:00 AM
Last Editorial Review: 4/29/2019 12:00:00 AM

Carbon monoxide (CO) remains the most common cause of human poisoning. The consequences of CO poisoning include cardiac dysfunction, brain injury, and death. CO causes toxicity by binding to hemoglobin and by inhibiting mitochondrial cytochrome c oxidase (CcO), thereby decreasing oxygen delivery and inhibiting oxidative phosphorylation. We have recently developed a CO antidote based on human neuroglobin (Ngb-H64Q-CCC). This molecule enhances clearance of CO from red blood cells in vitro and in vivo. Herein, we tested whether Ngb-H64Q-CCC can also scavenge CO from CcO and attenuate CO-induced inhibition of mitochondrial respiration. Heart tissue from mice exposed to 3% CO exhibited a 42 ± 19% reduction in tissue respiration rate and a 33 ± 38% reduction in CcO activity compared with unexposed mice. Intravenous infusion of Ngb-H64Q-CCC restored respiration rates to that of control mice correlating with higher electron transport chain CcO activity in Ngb-H64Q-CCC–treated compared with PBS-treated, CO-poisoned mice. Further, using a Clark-type oxygen electrode, we measured isolated rat liver mitochondrial respiration in the presence and absence of saturating solutions of CO (160 μm) and nitric oxide (100 μm). Both CO and NO inhibited respiration, and treatment with Ngb-H64Q-CCC (100 and 50 μm, respectively) significantly reversed this inhibition. These results suggest that Ngb-H64Q-CCC mitigates CO toxicity by scavenging CO from carboxyhemoglobin, improving systemic oxygen delivery and reversing the inhibitory effects of CO on mitochondria. We conclude that Ngb-H64Q-CCC or other CO scavengers demonstrate potential as antidotes that reverse the clinical and molecular effects of CO poisoning.

Michael Warren and Natacha Pisarenko from The Associated Press have a blockbuster piece of reporting on the dozens of ways Monsanto's chemical fertilizers and pesticides are poisoning the people of Argentina.

The Southern Poverty Law Center says “It is time to call out Agenda 21conspiracy theories and the people spreading them.”

Playing It Safe with Eggs

Playing It Safe with Eggs

Visit www.foodsafety.gov to find more food safety tips.

The government of Nigeria has issued a warning over the use of chloroquine to treat COVID-19, after three people got overdosed, and hospitalized due to poisoning.

Experts discuss the raised risk of carbon monoxide (CO) poisoning in the winter and during travel as recently, around 25 people were hospitalized for

Sensitive and specific assay to detect different serotypes of Salmonella has been developed, which would paving the way for rapid serotyping directly from specimens.

Skin-whitening or skin-bleaching is a way to lighten the skin tone with the help of chemical substances. Several people opt for cosmetics that claim to

Sixty girls in a Zarbia Girl School in Afghanistan's Eastern Parwan Province have been mysteriously poisoned. They were rushed to the hospital right after the incident.

A Perth mother accused of trying to murder her baby boy by pouring bleach into his formula will stand trial.

The children were identified as Wendi Morales-Garcia, 12; Yakelin Morales-Garcia, 11; Gudalupe Morales-Garcia, 8; Johnathan Garcia-Garcia, 4; and Nattaly Garcia-Garcia, 3.

The spike in radiation in Russia yesterday may have been caused when one of Vladimir Putin's top secret Zircon hypersonic missiles exploded during tests, according to news reports in the country.

NORMAN BAKER: If Putin wanted to kill him, why not get him back to Russia first? As for his daughter Yulia, she had only arrived in Britain 24 hours earlier and had been living in Moscow for years.

Policewoman Katie Miles, 38, could lose her job after being caught out trying to claim over a fake bout of food poisoning on a holiday in Sharm-el-Sheik, Eygpt. Ms Miles is pictured above riding on a camel.

Public Health England has said people are returning from the Hurghada region on the east coast of Egypt with a Shia toxin-producing strain of the food poisoning bug E.coli, which can turn deadly.

Sarah McCormick, 37, a bookkeeper from Wimborne, Dorset, feared her ex-Army corporal husband Thomas, 42, would die after being so badly affected by salmonella and shigella.

A new study has highlighted the world's food poisoning hotspots and top of the list is Hurghada in Egypt - 380 cases have been reported since the start of 2017.

Just over 600 people died from alcohol poisoning in January, a 37 per cent drop compared to the same month last year. And average temperatures in Moscow were more than 20F higher than last year.

In the Nandesari industrial area and surrounding it, the chemical pollution that has accompanied years of industrial growth has ravaged agriculture and public health. Surekha Sule reports.

Damaged soil, ill-effects from pesticides, and falling water tables are the legacy of practices that were once thought great for the state. Ramesh Menon reports.

Air pollution has detrimental effects on our body. Sometimes air pollution occurs inside our house and it is very risky compared to the air pollution outside. This is due to the fact that we spent a considerable amount of time in

The U.S. Department of Agriculture’s (USDA) Food Safety and Inspection Service (FSIS) is urging everyone to be food safe as they cook out this Fourth of July by to keep the celebration free from illness-causing bacteria.