In this episode Michael and Markus talk about patterns. Starting with some of their "most used" patterns, they go into some detail about the history of patterns. They then discuss the various pattern forms as well as some misconceptions about patterns. Other topics include the domains that are covered by patterns as well as pattern languages.

This is the fourth and final episode on the fundamentals of Software Architecture. We talk mainly about architectural styles and patterns, as introduced in the POSA 1 Book. We also discuss a little bit the process of actually using those patterns for architecting systems.

In this episode we talk with Gerard Meszaros about problems and challenges doing unit testing in real-world projects. Starting from a short discussion about the importance of automated unit testing we spend most of this episode to talk about every day problems doing unit testing and how those problems can be solved. Based on this book on xunit testing patterns, Gerard talks about his experiences with unit test smells as an analogy to code smells. He describes an impressive set of unit testing patterns to overcome those difficult testing situations and illustrates them with nice examples everybody doing unit testing will feel familiar with.

In this special Episode we briefly discuss the upcoming Patterns Journal with the two editors, Ralph Johnson and James Noble.

This episode is a discussion with various authors of patterns reviewed at EuroPLoP 2009. Topics include Product Line Engineering, Distributed Development, Open Source and Embedded Systems

Chris Richardson of microservices.io and author of the book Microservice Patterns discuss microservice patterns which constitute a set of best practices and building-block solutions to problems inherent microservice architecture.

Jeffery D Smith, author of Operations Anti-Patterns, DevOps Solutions, talks about how things can go wrong in development organizations and what DevOps has to offer with host Robert Blumen.

Jon Smart, author of the book Sooner Safer Happier: Patterns and Antipatterns for Business Agility, discusses patterns and anti-patterns for the success of enterprise software projects. Host Brijesh Ammanath speaks with him about the various common...

Location: Government Information Storage- HV6793.I8S7 198417-P712SA 2:C929 1976-82

An ancient campsite discovered in the Great Lakes can tell us how these ancient humans used to live.

Math is often described as the science of patterns, which makes it a natural subject to help in the study of the underlying causes of patterns found in nature, for example, bands of vegetation that often occur on gently sloped terrains in certain near-desert ecosystems worldwide. We are starting to learn more about these bands' common properties by using mathematical models built on data, such as rainfall totals and the curvature of the terrain. Mary Silber talks about these mathematical models of vegetation bands.

Yueming Hu
Dec 11, 2020; 0:jlr.RA120000919v1-jlr.RA120000919
Research Articles

Apolipoproteins C-I, C-II and C-III interact with ApoE to regulate lipoprotein metabolism and contribute to Alzheimer’s disease pathophysiology. In plasma, apoC-I and C-II exist as truncated isoforms, while apoC-III exhibits multiple glycoforms. This study aimed to 1. delineate apoC-I, C-II and C-III isoform profiles in CSF and plasma in a cohort of non-demented older individuals (n = 61), and 2. examine the effect of APOE4 on these isoforms and their correlation with CSF Aβ42, a surrogate of brain amyloid accumulation. The isoforms of the apoCs were immunoaffinity enriched and measured with MALDI-TOF mass spectrometry, revealing a significantly higher percentage of truncated apoC-I and apoC-II in CSF compared to matched plasma, with positive correlation between CSF and plasma. A greater percentage of monosialylated and disialylated apoC-III isoforms was detected in CSF, accompanied by a lower percentage of the two non-sialylated apoC-III isoforms, with significant linear correlations between CSF and plasma. Furthermore, a greater percentage of truncated apoC-I in CSF, and apoC-II in plasma and CSF, was observed in individuals carrying at least one apoE E4 allele. Increased apoC-I and apoC-II truncations were  associated with lower CSF Aβ42. Finally, monosialylated apoC-III was lower, and disialylated apoC-III greater in the CSF of E4 carriers. Together, these results reveal distinct patterns of the apoCs isoforms in CSF, implying CSF-specific apoCs processing. These patterns were accentuated in APOE E4 allele carriers, suggesting an association between APOE4 genotype and Alzheimer’s disease pathology with apoCs processing and function in the brain.

Multiple sclerosis (MS) is a CNS disease characterized by immune-mediated demyelination and progressive axonal loss. MS-related CNS damage and its clinical course have two main phases: active and inactive/progressive. Reliable biomarkers are being sought to allow identification of MS pathomechanisms and prediction of its course. The purpose of this study was to identify sphingolipid (SL) species as candidate biomarkers of inflammatory and neurodegenerative processes underlying MS pathology. We performed sphingolipidomic analysis by HPLC-tandem mass spectrometry to determine the lipid profiles in post mortem specimens from the normal-appearing white matter (NAWM) of the normal CNS (nCNS) from subjects with chronic MS (active and inactive lesions) as well as from patients with other neurological diseases. Distinctive SL modification patterns occurred in specimens from MS patients with chronic inactive plaques with respect to NAWM from the nCNS and active MS (Ac-MS) lesions. Chronic inactive MS (In-MS) lesions were characterized by decreased levels of dihydroceramide (dhCer), ceramide (Cer), and SM subspecies, whereas levels of hexosylceramide and Cer 1-phosphate (C1P) subspecies were significantly increased in comparison to NAWM of the nCNS as well as Ac-MS plaques. In contrast, Ac-MS lesions were characterized by a significant increase of major dhCer subspecies in comparison to NAWM of the nCNS. These results suggest the existence of different SL metabolic pathways in the active versus inactive phase within progressive stages of MS. Moreover, they suggest that C1P could be a new biomarker of the In-MS progressive phase, and its detection may help to develop future prognostic and therapeutic strategies for the disease.

Among the virulence factors in Neisseria infections, a major inducer of inflammatory cytokines is the lipooligosaccharide (LOS). The activation of NF-B via extracellular binding of LOS or lipopolysaccharide (LPS) to the toll-like receptor 4 and its coreceptor, MD-2, results in production of pro-inflammatory cytokines that initiate adaptive immune responses. LOS can also be absorbed by cells and activate intracellular inflammasomes, causing the release of inflammatory cytokines and pyroptosis. Studies of LOS and LPS have shown that their inflammatory potential is highly dependent on lipid A phosphorylation and acylation, but little is known on the location and pattern of these posttranslational modifications. Herein, we report on the localization of phosphoryl groups on phosphorylated meningococcal lipid A, which has two to three phosphate and zero to two phosphoethanolamine substituents. Intact LOS with symmetrical hexa-acylated and asymmetrical penta-acylated lipid A moieties was subjected to high-resolution ion mobility spectrometry MALDI-TOF MS. LOS molecular ions readily underwent in-source decay to give fragments of the oligosaccharide and lipid A formed by cleavage of the ketosidic linkage, which enabled performing MS/MS (pseudo-MS³). The resulting spectra revealed several patterns of phosphoryl substitution on lipid A, with certain species predominating. The extent of phosphoryl substitution, particularly phosphoethanolaminylation, on the 4'-hydroxyl was greater than that on the 1-hydroxyl. The heretofore unrecognized phosphorylation patterns of lipid A of meningococcal LOS that we detected are likely determinants of both pathogenicity and the ability of the bacteria to evade the innate immune system.

Study participants with lifelong anosmia sniffed less than those with a normal sense of smell. Future research could shed light on whether this has negative implications for their health

In order to protect consumers' interest, the government has banned use of "dark patterns" on e-commerce platforms which intend to deceive customers or manipulate their choices.

The Delaware Division of the Arts’ Mezzanine Gallery presents 2022 DDOA Individual Artist Fellow Aaron Terry’s exhibition, “Patterns for Saturn,” running June 2-July 28, 2023.  Guests are invited to attend a Meet-the-Artist Reception on Friday, June 2 from 5:00-7:00 p.m.

Allowing for moves that create quantum superpositions makes a quantum version of a Rubik’s cube incredibly complex, but not impossible to solve

Allowing for moves that create quantum superpositions makes a quantum version of a Rubik’s cube incredibly complex, but not impossible to solve

Title: Your Sleep Patterns and Alzheimer's Risk
Category: Health News
Created: 8/24/2020 12:00:00 AM
Last Editorial Review: 8/25/2020 12:00:00 AM

Understanding the evolution of chromatin conformation among species is fundamental to elucidate the architecture and plasticity of genomes. Nonrandom interactions of linearly distant loci regulate gene function in species-specific patterns, affecting genome function, evolution, and, ultimately, speciation. Yet, data from nonmodel organisms are scarce. To capture the macroevolutionary diversity of vertebrate chromatin conformation, here we generate de novo genome assemblies for two cryptodiran (hidden-neck) turtles via Illumina sequencing, chromosome conformation capture, and RNA-seq: Apalone spinifera (ZZ/ZW, 2n = 66) and Staurotypus triporcatus (XX/XY, 2n = 54). We detected differences in the three-dimensional (3D) chromatin structure in turtles compared to other amniotes beyond the fusion/fission events detected in the linear genomes. Namely, whole-genome comparisons revealed distinct trends of chromosome rearrangements in turtles: (1) a low rate of genome reshuffling in Apalone (Trionychidae) whose karyotype is highly conserved when compared to chicken (likely ancestral for turtles), and (2) a moderate rate of fusions/fissions in Staurotypus (Kinosternidae) and Trachemys scripta (Emydidae). Furthermore, we identified a chromosome folding pattern that enables "centromere–telomere interactions" previously undetected in turtles. The combined turtle pattern of "centromere–telomere interactions" (discovered here) plus "centromere clustering" (previously reported in sauropsids) is novel for amniotes and it counters previous hypotheses about amniote 3D chromatin structure. We hypothesize that the divergent pattern found in turtles originated from an amniote ancestral state defined by a nuclear configuration with extensive associations among microchromosomes that were preserved upon the reshuffling of the linear genome.

The role of somatostatin receptor (SSTR) PET/CT, using ⁶⁸Ga-based tracers or [⁶⁴Cu]Cu-DOTATATE (⁶⁴Cu-DOTATATE), in the management of patients with neuroendocrine neoplasm (NEN) is guided by appropriate use criteria (AUC). In this study, we performed systematic analyses of referral patterns and image findings of routine ⁶⁴Cu-DOTATATE PET/CT scans to support AUC development. Methods: We included all clinical routine ⁶⁴Cu-DOTATATE PET/CT scans performed between April 10, 2018 (start of clinical use), and May 2, 2022, at Copenhagen University Hospital–Rigshospitalet. We reviewed the referral text and image report of each scan and classified the indication according to clinical scenarios as listed in the AUC. Results: In total, 1,290 patients underwent 2,249 ⁶⁴Cu-DOTATATE PET/CT scans. Monitoring of patients with NEN seen both on conventional imaging and on SSTR PET without clinical evidence of progression was the most common indication (defined as "may be appropriate" in the AUC) and accounted for 703 (31.3%) scans. Initial staging after NEN diagnosis ("appropriate" in the AUC) and restaging after curative-intent surgery ("may be appropriate" in the AUC) accounted for 221 (9.8%) and 241 (10.7%) scans, respectively. Selection of patients eligible for peptide receptor radionuclide therapy ("appropriate" in the AUC) and restaging after peptide receptor radionuclide therapy completion ("appropriate" in the AUC) accounted for 95 (4.2%) and 115 (5.1%) scans, respectively. The number of scans performed for indications not defined in the AUC was 371 (16.5%). Image result analysis revealed no disease in 669 scans (29.7%), stable disease in 582 (25.9%), and progression in 461 (20.5%). In 99 of the 461 (21.5%) scans, progression was detected on PET but not on CT. Conclusion: Our study provided real-life data that may contribute to support development of ⁶⁴Cu-DOTATATE/SSTR PET/CT guidelines including AUC. Some scenarios listed as "may be appropriate" in the current AUC were frequent in our data. Monitoring of patients with NEN without clinical evidence of progression was the most frequent indication for ⁶⁴Cu-DOTATATE PET/CT, in which disease progression was detected in more than one third, and a large proportion was visible by PET only. We therefore conclude that this scenario could potentially be classified as appropriate.

Physicists found that the music of Johann Sebastian Bach contains mathematical patterns that help convey information

Allowing for moves that create quantum superpositions makes a quantum version of a Rubik’s cube incredibly complex, but not impossible to solve

Chinese scientists found that anomalies in tropical Indian Ocean sea surface temperatures can forecast the severity of global medlinkdengue outbreaks/medlink (!--ref1--).

Truvada, used as pre-exposure prophylaxis to prevent HIV infection (PrEP), can reveal patterns of medication-taking behavior that may put persons at risk of prophylactic failure.

Cambridge, United Kingdom ; New York : Cambridge University Press, 2023.

Crime scene analyst Matthew Steiner teaches the techniques forensics experts use to investigate bloodstain patterns, ranging from easy to difficult. Matthew explains how different types of forces create different bloodstain patterns in the crime scenes, and demonstrates how they can analyze these patterns to figure out how a crime was committed.

To gain and retain customer trust, brands have to focus on ethical online design in their apps

According to the Mondelez International snacking report, Indian consumers are showing an increasing interest in plant-based snacks

National Bureau of Economic Research

National Bureau of Economic Research

National Bureau of Economic Research

National Bureau of Economic Research

In creating energy-efficient cities, India will do well to model its development on its own age-old techniques, says Durganand Balsavar

Union Agriculture Ministry launches Krishi-DSS, a digital platform providing real-time data insights for stakeholders in Indian agriculture