The UAE has announced the introduction of 'Palm ID' technology, a payment solution that utilises the unique vein patterns in individuals' palms for...

Overall cigar consumption has increased since the 1990s, but there is limited research on “premium” cigars. A new report examines the short- and long-term health effects of premium cigars, who is using them and how often, and marketing practices and consumer perceptions.

In 1998, the National Cancer Institute undertook a review of available knowledge about cigars. A new National Academies consensus study report provides a comprehensive update to the 1998 report. Steven Teutsch, the chair of the committee that wrote the report, shared some of the report’s key findings and research recommendations to move the field forward.

PITTSBURGH (September 2, 2016) ... The potential to develop "materials that compute" has taken another leap at the University of Pittsburgh's Swanson School of Engineering, where researchers for the first time have demonstrated that the material can be designed to recognize simple patterns. This responsive, hybrid material, powered by its own chemical reactions, could one day be integrated into clothing and used to monitor the human body, or developed as a skin for "squishy" robots.

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This article is really about putting all of the concepts in the previous articles together to come up with what will hopefully be the most significant change in thinking so far.

With all baby boomers at least 65 or older by 2030, beverage-makers should consider what this demographic needs as their shopping habits evolve.

Learn how to use Template Part and Query Loop patterns to provide users with more design options.

Zebra Patterns: Every Mirrorless Photographer Needs Them. Most Sony Alpha Mirrorlesss Cameras have the option...

The post Zebra Patterns: Every Mirrorless Photographer Needs Them! appeared first on Alphatracks.

RNA does many things in the body. Now, scientists have shown that RNA in blood samples can be used as a diagnostic indicator.

RNA does many things in the body. Now, scientists have shown that RNA in blood samples can be used as a diagnostic indicator.

RNA does many things in the body. Now, scientists have shown that RNA in blood samples can be used as a diagnostic indicator.

Proteomic scores and dietary patterns  Nature.com

Any compressor that gets too hot or is overheated is subject to premature wear between its internal moving parts.

In this episode Michael and Markus talk about patterns. Starting with some of their "most used" patterns, they go into some detail about the history of patterns. They then discuss the various pattern forms as well as some misconceptions about patterns. Other topics include the domains that are covered by patterns as well as pattern languages.

This is the fourth and final episode on the fundamentals of Software Architecture. We talk mainly about architectural styles and patterns, as introduced in the POSA 1 Book. We also discuss a little bit the process of actually using those patterns for architecting systems.

In this Episode we talked about the new POSA 4 book which has recently been published. We talk to two of the authors, Kevlin Henney and Frank Buschmann (the third author, Doug Schmidt was not available - and he had also been on the podcast a couple of times :-)). The book contains a pattern language for distributed systems. It contains 114 patterns that had been published before by many different other authors. The patterns have been rewritten to form a consistent language. We basically talked through the different sections of the book, which gives a really good overview over the challenges and the solutions of building distributed systems. These sections include From Mud to Structure, Distribution Infrastructure, Event Demultiplexing and Dispatching, Interface Partitioning, Component Patitioning, Application Contrl, Concurrency, Synchronization, Object Interaction, Adaptazion and Extension, Modal Behaviour, Resource Management and finally, Database Access. The book references several other previous works (as listed below). Interestingly, many of these referenced works and authors have also been discussed previously on the podcast. Here are the back references:

• Domain Driven Design, Eric Evans
• Messaging Patterns, Gregor Hohpe
• POSA 2 Patterns, Doug Schmidt
• Concurrency: Part 1, Part 2, Part 3 and the interview with Goetz and Holmes
• Remoting Patterns Part 1 and Part 2
• POSA3, Resource Management

In this episode we talk with Gerard Meszaros about problems and challenges doing unit testing in real-world projects. Starting from a short discussion about the importance of automated unit testing we spend most of this episode to talk about every day problems doing unit testing and how those problems can be solved. Based on this book on xunit testing patterns, Gerard talks about his experiences with unit test smells as an analogy to code smells. He describes an impressive set of unit testing patterns to overcome those difficult testing situations and illustrates them with nice examples everybody doing unit testing will feel familiar with.

In this special Episode we briefly discuss the upcoming Patterns Journal with the two editors, Ralph Johnson and James Noble.

This episode is a discussion with various authors of patterns reviewed at EuroPLoP 2009. Topics include Product Line Engineering, Distributed Development, Open Source and Embedded Systems

Chris Richardson of microservices.io and author of the book Microservice Patterns discuss microservice patterns which constitute a set of best practices and building-block solutions to problems inherent microservice architecture.

Jeffery D Smith, author of Operations Anti-Patterns, DevOps Solutions, talks about how things can go wrong in development organizations and what DevOps has to offer with host Robert Blumen.

Jon Smart, author of the book Sooner Safer Happier: Patterns and Antipatterns for Business Agility, discusses patterns and anti-patterns for the success of enterprise software projects. Host Brijesh Ammanath speaks with him about the various common...

Venkat Subramaniam previews his upcoming session at Oracle Developer Live Java Innovations — The Elegance of Pattern Matching in Modern Java. The conversation was recorded via Zoom on Tuesday February 15, 2022.

Venkat Subramaniam, Founder, Agile Developer

@venkat_s on Twitter https://twitter.com/venkat_s

Background on Pattern Marching

JEP 305: Pattern Matching for instanceof (Preview)
Pattern Matching with Gavin Bierman — Inside Java Podcast 17
Pattern Matching in Java 17 and Beyond

Java Development & Community

OpenJDK https://openjdk.java.net/
Inside Java https://inside.java/
Dev.Java https://dev.java/
@java Twitter https://twitter.com/java

Duke's Corner Podcast

Jim Grisanzio, Host, Java Developer Relations
@jimgris on Twitter https://twitter.com/jimgris

PredictHQ has announced its Demand Impact Pattern for severe weather events, with data sets to help businesses prepare for major weather events and mitigate overall impact by integrating into machine learning models for demand forecasting.

Location: Government Information Storage- HV6793.I8S7 198417-P712SA 2:C929 1976-82

An ancient campsite discovered in the Great Lakes can tell us how these ancient humans used to live.

Hops fashion pantyhose from Sarah Borghi. 20 deniers. Sheer to waist with cotton gusset. Flat seams. Footless. All colored fabrics are seamlessly woven (not printed or sewn) to ensure durability of colors as well as comfort. Note: See the complete Sarah Borghi Spring/Summer 2004 Fashion Collection. Vivace color only. Sizes 1,2,3,4. See Sizechart. Price: USD10.49

Sarah Borghi Zelig - women fashion tights. 15 denier elastane patterned fashion tights. Sheer to waist. Cotton gusset. Flat seams. Patterned with words "Beautiful Glamourous Cool Fashionable". Sizes 1,2,3,4. See Sizechart. Price: USD10.49

A new collection of bodystocking by MusicLegs®.

Semi-opaque diamond patterned bodystocking. Low cut with elastic spaghetti straps. Open crotch for convenience. Suitable for workout.

Gabriella Fantasia Exclusive fashion patterned tights. Braided with LYCRA®, this pantyhose is highly stretchable and durable.

Sheer to waist. Flat seam. No heel pocket, suits any foot length.

See sizechart at:
http://www.newlook.com.sg/sizechart.asp?style=GBP711A

I'm very interested in eLearning designs that try to entwine content and exercise so thoroughly that the learner almost constructs their instruction – even if...

Looking for the simplest Waldorf kite paper star pattern? You’ve found it! Anyone can make a beautiful sun catcher for their window out of translucent paper. This pattern gives young children the delight of creating their own decoration, while practicing fine motor skills. Please note though – it may be a bit tricky for kids […]

The post The Simplest Waldorf Star Pattern – Beautiful and Easy Decoration appeared first on Joyful Abode.

Histone recognition by “reader” modules serves as a fundamental mechanism in epigenetic regulation. Previous studies have shown that Spindlin1 is a reader of histone H3K4me3 as well as “K4me3-R8me2a” and promotes transcription of rDNA or Wnt/TCF4 target genes. Here we show that Spindlin1 also acts as a potent reader of histone H3 “K4me3-K9me3/2” bivalent methylation pattern. Calorimetric titration revealed a binding affinity of 16 nm between Spindlin1 and H3 “K4me3-K9me3” peptide, which is one to three orders of magnitude stronger than most other histone readout events at peptide level. Structural studies revealed concurrent recognition of H3K4me3 and H3K9me3/2 by aromatic pockets 2 and 1 of Spindlin1, respectively. Epigenomic profiling studies showed that Spindlin1 colocalizes with both H3K4me3 and H3K9me3 peaks in a subset of genes enriched in biological processes of transcription and its regulation. Moreover, the distribution of Spindlin1 peaks is primarily associated with H3K4me3 but not H3K9me3, which suggests that Spindlin1 is a downstream effector of H3K4me3 generated in heterochromatic regions. Collectively, our work calls attention to an intriguing function of Spindlin1 as a potent H3 “K4me3-K9me3/2” bivalent mark reader, thereby balancing gene expression and silencing in H3K9me3/2-enriched regions.

Math is often described as the science of patterns, which makes it a natural subject to help in the study of the underlying causes of patterns found in nature, for example, bands of vegetation that often occur on gently sloped terrains in certain near-desert ecosystems worldwide. We are starting to learn more about these bands' common properties by using mathematical models built on data, such as rainfall totals and the curvature of the terrain. Mary Silber talks about these mathematical models of vegetation bands.

Visual Abstract

Yueming Hu
Dec 11, 2020; 0:jlr.RA120000919v1-jlr.RA120000919
Research Articles

Apolipoproteins C-I, C-II and C-III interact with ApoE to regulate lipoprotein metabolism and contribute to Alzheimer’s disease pathophysiology. In plasma, apoC-I and C-II exist as truncated isoforms, while apoC-III exhibits multiple glycoforms. This study aimed to 1. delineate apoC-I, C-II and C-III isoform profiles in CSF and plasma in a cohort of non-demented older individuals (n = 61), and 2. examine the effect of APOE4 on these isoforms and their correlation with CSF Aβ42, a surrogate of brain amyloid accumulation. The isoforms of the apoCs were immunoaffinity enriched and measured with MALDI-TOF mass spectrometry, revealing a significantly higher percentage of truncated apoC-I and apoC-II in CSF compared to matched plasma, with positive correlation between CSF and plasma. A greater percentage of monosialylated and disialylated apoC-III isoforms was detected in CSF, accompanied by a lower percentage of the two non-sialylated apoC-III isoforms, with significant linear correlations between CSF and plasma. Furthermore, a greater percentage of truncated apoC-I in CSF, and apoC-II in plasma and CSF, was observed in individuals carrying at least one apoE E4 allele. Increased apoC-I and apoC-II truncations were  associated with lower CSF Aβ42. Finally, monosialylated apoC-III was lower, and disialylated apoC-III greater in the CSF of E4 carriers. Together, these results reveal distinct patterns of the apoCs isoforms in CSF, implying CSF-specific apoCs processing. These patterns were accentuated in APOE E4 allele carriers, suggesting an association between APOE4 genotype and Alzheimer’s disease pathology with apoCs processing and function in the brain.

Multiple sclerosis (MS) is a CNS disease characterized by immune-mediated demyelination and progressive axonal loss. MS-related CNS damage and its clinical course have two main phases: active and inactive/progressive. Reliable biomarkers are being sought to allow identification of MS pathomechanisms and prediction of its course. The purpose of this study was to identify sphingolipid (SL) species as candidate biomarkers of inflammatory and neurodegenerative processes underlying MS pathology. We performed sphingolipidomic analysis by HPLC-tandem mass spectrometry to determine the lipid profiles in post mortem specimens from the normal-appearing white matter (NAWM) of the normal CNS (nCNS) from subjects with chronic MS (active and inactive lesions) as well as from patients with other neurological diseases. Distinctive SL modification patterns occurred in specimens from MS patients with chronic inactive plaques with respect to NAWM from the nCNS and active MS (Ac-MS) lesions. Chronic inactive MS (In-MS) lesions were characterized by decreased levels of dihydroceramide (dhCer), ceramide (Cer), and SM subspecies, whereas levels of hexosylceramide and Cer 1-phosphate (C1P) subspecies were significantly increased in comparison to NAWM of the nCNS as well as Ac-MS plaques. In contrast, Ac-MS lesions were characterized by a significant increase of major dhCer subspecies in comparison to NAWM of the nCNS. These results suggest the existence of different SL metabolic pathways in the active versus inactive phase within progressive stages of MS. Moreover, they suggest that C1P could be a new biomarker of the In-MS progressive phase, and its detection may help to develop future prognostic and therapeutic strategies for the disease.

Among the virulence factors in Neisseria infections, a major inducer of inflammatory cytokines is the lipooligosaccharide (LOS). The activation of NF-B via extracellular binding of LOS or lipopolysaccharide (LPS) to the toll-like receptor 4 and its coreceptor, MD-2, results in production of pro-inflammatory cytokines that initiate adaptive immune responses. LOS can also be absorbed by cells and activate intracellular inflammasomes, causing the release of inflammatory cytokines and pyroptosis. Studies of LOS and LPS have shown that their inflammatory potential is highly dependent on lipid A phosphorylation and acylation, but little is known on the location and pattern of these posttranslational modifications. Herein, we report on the localization of phosphoryl groups on phosphorylated meningococcal lipid A, which has two to three phosphate and zero to two phosphoethanolamine substituents. Intact LOS with symmetrical hexa-acylated and asymmetrical penta-acylated lipid A moieties was subjected to high-resolution ion mobility spectrometry MALDI-TOF MS. LOS molecular ions readily underwent in-source decay to give fragments of the oligosaccharide and lipid A formed by cleavage of the ketosidic linkage, which enabled performing MS/MS (pseudo-MS³). The resulting spectra revealed several patterns of phosphoryl substitution on lipid A, with certain species predominating. The extent of phosphoryl substitution, particularly phosphoethanolaminylation, on the 4'-hydroxyl was greater than that on the 1-hydroxyl. The heretofore unrecognized phosphorylation patterns of lipid A of meningococcal LOS that we detected are likely determinants of both pathogenicity and the ability of the bacteria to evade the innate immune system.

Study participants with lifelong anosmia sniffed less than those with a normal sense of smell. Future research could shed light on whether this has negative implications for their health

In order to protect consumers' interest, the government has banned use of "dark patterns" on e-commerce platforms which intend to deceive customers or manipulate their choices.

The Delaware Division of the Arts’ Mezzanine Gallery presents 2022 DDOA Individual Artist Fellow Aaron Terry’s exhibition, “Patterns for Saturn,” running June 2-July 28, 2023.  Guests are invited to attend a Meet-the-Artist Reception on Friday, June 2 from 5:00-7:00 p.m.

Hi,

I have a string "[@global_vddi:%:vddi!]" which I need to process to remove "@[]" chars. The desired result is "global_vddi:%:vddi!". I tried the following in CIW

netExpr = "[@global_vddi:%:vddi!]"
rexCompile("\([a-zA-Z0-9_:!%]+\)")
t
rexExecute(netExpr)
t
rexSubstitute( "\0" )
"global_vddi:%:vddi!"

and I achieved the desired value. I added the same code to my script but it didn't work. In my script rexExecute returns 't' but rexSubstitute returns 'nil' 

Here is the snippet from my script

netExpr = dbGetTermNetExpr(term)
if(netExpr then
rexCompile("\([a-zA-Z0-9_:!%]+\)")
rexExecute(netExpr)
netExpr1 = rexSubstitute( "\0" )

...

. ..)  and trace log showing the variable values as the code executes

stopped before evaluating dbGetTermNetExpr(term)
after evaluating dbGetTermNetExpr(term)==> "[@global_vddi:%:vddi!]"
after evaluating (netExpr = dbGetTermNetExpr(term))==> "[@global_vddi:%:vddi!]"
stopped before evaluating if(netExpr then rexCompile("\([a-zA-Z0-9_:!%]+\)") rexExecute(netExpr) (netExpr1 = rexSubstitute("\0")) ... )
stopped before evaluating rexCompile("\([a-zA-Z0-9_:!%]+\)")
after evaluating rexCompile("\([a-zA-Z0-9_:!%]+\)")==> t
stopped before evaluating rexExecute(netExpr)
after evaluating rexExecute(netExpr)==> t
stopped before evaluating (netExpr1 = rexSubstitute("\0"))
stopped before evaluating rexSubstitute("\0")
after evaluating rexSubstitute("\0")==> nil
|[2]netExpr1 set to nil, was nil

Any help or suggestions as to why the code executes differently in CIW and when called from a SKILL script file will be much appreciated.

I also tried a different approach using rexReplace instead of rexSubstitute but couldn't get the regex pattern correct. The code I tried in CIW using rexReplace is as follows

a = "[@global_vddi:%:vddi!]"
"[@global_vddi:%:vddi!]"
rexCompile("\([@\[\]]*\)")
t
rexReplace(a "" 0)
"global_vddi:%:vddi!]"

Only '@[' get replaced and ']' is still present. The regex pattern contains '\]' to match the closing square bracket yet it is not replaced. Please let me know what I'm missing in these 2 scenarios.

Any help is much appreciated!!

Regards,

Confused SKILL user 

The symbols and mathematical operations used in the laws of physics follow a pattern that could reveal something fundamental about the universe

Allowing for moves that create quantum superpositions makes a quantum version of a Rubik’s cube incredibly complex, but not impossible to solve

El Niño and La Niña cycles driven by ocean temperatures in the Pacific can influence weather in the North Atlantic 12 months later – a finding that could improve long-range forecasts

Allowing for moves that create quantum superpositions makes a quantum version of a Rubik’s cube incredibly complex, but not impossible to solve

Title: Your Sleep Patterns and Alzheimer's Risk
Category: Health News
Created: 8/24/2020 12:00:00 AM
Last Editorial Review: 8/25/2020 12:00:00 AM