orphan What the Orphan Drug Act Has Done Lately for Children With Rare Diseases: A 10-Year Analysis By pediatrics.aappublications.org Published On :: 2012-02-27T00:08:27-08:00 Rare diseases in childhood can be debilitating and require lifelong care. Since 1983, the Orphan Drug Act incentives have stimulated the development and significantly improved the availability of treatment products for patients with rare diseases.We report an increasing pediatric orphan product designations and approvals from 2000 to 2009. The trend indicates that the Orphan Drug Act has continued to address this important unmet need. (Read the full article) Full Article
orphan Pediatric Orphan Drug Indications: 2010-2018 By pediatrics.aappublications.org Published On :: 2020-04-01T01:00:57-07:00 BACKGROUND: Orphan drug development is crucial for children, who are disproportionately affected by rare diseases. Data are lacking on the number, nature, and benefit of recently approved pediatric orphan indications. METHODS: We classified the 402 orphan indications the US Food and Drug Administration approved between 2010 and 2018 as "pediatric" if they were approved for children only or targeted pediatric diseases. We determined the number of unique diseases targeted by pediatric orphan indications and calculated the proportion that were for (1) novel drugs, (2) non-novel drugs approved to treat ≥1 common disease, and (3) non-novel drugs approved only to treat rare diseases. Among pediatric orphan indications eligible for US Food and Drug Administration breakthrough designation (granted to drugs potentially representing major therapeutic advances), we calculated the proportion receiving this designation. RESULTS: Of the 402 orphan indications, 136 (33.8%) were pediatric. These 136 indications targeted 87 unique diseases; 21 diseases were targeted by ≥1 indication. Of the 136 pediatric orphan indications, 60 (44.1%) were for novel drugs, 45 (33.1%) were for non-novel drugs approved to treat ≥1 common disease, and 31 (22.8%) were for non-novel drugs approved only to treat rare diseases. Among 97 indications eligible for breakthrough designation, 20 (20.6%) received this designation. CONCLUSIONS: Recent orphan drug development has increased the availability of treatments for pediatric rare diseases. Most pediatric orphan indications expanded use of existing drugs, and many targeted the same disease. Some indications may represent breakthroughs, but substantial unmet need for treatments remains for most pediatric rare diseases. Full Article
orphan COVID-19 leading to shortage of orphan drugs in Russia By www.thepharmaletter.com Published On :: Tue, 05 May 2020 10:09:00 +0100 The ongoing spread of COVID-19 in Russia is leading to shortages of drugs against orphan diseases in… Full Article Anti-virals/Coronavirus/Focus On/From our correspondent/Hydroxychloroquine/In Depth/Pharmaceutical/Public health/Rare diseases/Russia/Russian market
orphan US states want idled workers to plug orphan wells By www.argusmedia.com Published On :: 08 May 2020 21:32 (+01:00 GMT) Full Article Crude oil Natural gas North America US Politics
orphan Owlet orphaned by fallen tree gets adopted by new family (video) By www.treehugger.com Published On :: Thu, 03 Oct 2019 09:54:44 -0400 Here's what happens when kind humans and open-armed owls encounter an orphaned owlet. Full Article Science
orphan Coronavirus Lockdown: Nagpur Police steps in as orphan bride's family, wins hearts on Twitter By www.mid-day.com Published On :: 7 May 2020 10:24:43 GMT In a heartwarming gesture, Nagpur Police stepped up to stand in as a orphan bride’s family on her wedding day after her relatives could not attend the ceremony due to the restrictions imposed as part of the nationwide lockdown due to the coronavirus outbreak. The officers of the police department showed up for the wedding to bless the couple so that the bride does not miss her family on her special day. They shared a post about the moment on Twitter with the photo of the newlyweds with officers. The post said that the bride’s parents had died and her relatives could not attend the wedding due moment restrictions. “The bride's parents had passed away. There was no one from her family to attend her marriage due to movement restrictions. #NagpurPolice tried to fulfill this absence.PI and staff were present to bless the newly wedded couple at #Nagpur,” said the tweet by the police, with the hashtag #alwaysthereforyou. The bride's parents had passed away. There was no one from her family to attend her marriage due to movement restrictions. #NagpurPolice tried to fulfill this absence.PI and staff were present to bless the newly wedded couple at #Nagpur.#LockdownStories#alwaysthere4u pic.twitter.com/5tvBNt4EyF — Nagpur City Police (@NagpurPolice) May 6, 2020 The post that went viral on Wednesday garnered 757 likes and was retweeted 81 times and counting. Users commenting on the post praised the Nagpur police for their noble deed. Thank you for helping citizens.Because of people like u we are assured that the city is safe!!God bless you n ur family!! #goodkarma #safecity ðÂÂÂÂÂÂð»ðÂÂÂÂÂÂð» — mon_naturelover (@NatureloverMon) May 6, 2020 Much love to you all â¤ï¸Â for working day and night going beyond the line to help everyone. — Papabear ð» (@GanuYogesh) May 6, 2020 We proud you. — SANJIV M (@sansar1970) May 6, 2020 Great gesture by Nagpur Police ðÂÂÂÂÂÂð»ðÂÂÂÂÂÂð» — Rohit dubey (@RDroxx20) May 6, 2020 What do you think about the post? Catch up on all the latest Crime, National, International and Hatke news here. Also download the new mid-day Android and iOS apps to get latest updates. Mid-Day is now on Telegram. Click here to join our channel (@middayinfomedialtd) and stay updated with the latest news Full Article
orphan Australian mum and daughter are making pouches for baby joeys and bats orphaned by bushfires By www.dailymail.co.uk Published On :: Fri, 10 Jan 2020 07:20:36 GMT An estimated one billion animals have been killed as massive bushfires ravage across Australia. Full Article
orphan Mercenaries could be drafted in to extract three British orphans from Syria By www.dailymail.co.uk Published On :: Sun, 27 Oct 2019 03:19:22 GMT Initial plans to use UK special forces to repatriate the children of a dead Islamic State fighter were met with strong resistance from the Cabinet, prompting a Foreign Office rethink. Full Article
orphan British children orphaned after their family travelled to Syria back in the UK with relatives By www.dailymail.co.uk Published On :: Tue, 26 Nov 2019 13:10:59 GMT The judge, who has looked at issues relating to the children's welfare at private hearings in the Family Division of the High Court in London, revealed detail of their return in a ruling published today. Full Article
orphan Orphan raised by drug traffickers was part of Australia's biggest ever heroin importation By www.dailymail.co.uk Published On :: Wed, 20 Nov 2019 06:01:19 GMT Singapore-based drug smuggler Wee Quay Tan, 48, who also has a large tattoo of a dragon inked over his shoulders and chest, found himself in the middle of the biggest drug bust in Australian history. Full Article
orphan Proud 'foster mother' orangutan begins new life in wild with her adopted orphaned infant By www.dailymail.co.uk Published On :: Thu, 20 Feb 2020 11:35:16 GMT Monti and three-year-old infant Anggun, who were both rescued from human captivity, were released into the jungle of Bukit Baka Bukit Raya National Park in West Borneo earlier this month. Full Article
orphan Orphaned puppy is rescued from the rubble of ISIS leader's compound By www.dailymail.co.uk Published On :: Thu, 31 Oct 2019 22:23:33 GMT A puppy (pictured) orphaned by the destruction of the Syrian compound which housed abu Bakr al-Baghdadi has been rescued after being found next to its dead mother. Full Article
orphan Unwilling parents, unwary orphans By indiatogether.org Published On :: Fri, 22 Jun 2007 00:00:00 +0000 In Anantapur, farm suicides are fewer than they were in 2002. But they still happen and could rise again in this fragile region. As elsewhere, agriculture is plagued by uncertainty, writes P Sainath. Full Article
orphan Orphans of our society By indiatogether.org Published On :: Sat, 11 May 2013 00:00:00 +0000 Ignored by the government, shunned by society and caught in a time-warp of their own, the nomadic castes and tribes of India are almost "non citizens" of the land. R. Akhileshwari describes the abysmal plight of such people from Andhra Pradesh and highlights the injustice and neglect that they are subject to. Full Article
orphan Orphans of Williamsburg By podcast.history.org Published On :: Mon, 13 Jan 2014 11:00:29 +0000 Historian Cathy Hellier describes the poignant histories of children left without parents. The question of providing for colonial orphans was split between the courts and the children’s caretakers. Listen this week to learn how colonial society looked after its littlest citizens. Full Article Children Government
orphan Design FX - How Orphan Black Creates Convincing Clones By www.wired.com Published On :: Fri, 16 Sep 2016 20:40:00 +0000 Design FX dives into the incredible special effects of BBC America's Orphan Black. Mike Seymour breaks down how the team at Intelligent Creatures and Emmy Award nominated actress Tatiana Maslany work together to create convincing clones; with a combination of visual effects, rotoscoping, and incredible acting ability. Full Article
orphan Expert opinion on orphan drugs [electronic journal]. By encore.st-andrews.ac.uk Published On :: London : Informa Healthcare Full Article
orphan The Nociceptin/Orphanin FQ peptide receptor / editors, Mei-Chuan Ko and Girolamo Caló By library.mit.edu Published On :: Sun, 18 Aug 2019 09:32:39 EDT Online Resource Full Article
orphan Dextromethorphan-Quinidine for Agitation in Patients With Alzheimer Disease By dx.doi.org Published On :: Tue, 22 Sep 2015 14:59:00 +0000 Interview with Jeffrey L. Cummings, MD, ScD, author of Effect of Dextromethorphan-Quinidine on Agitation in Patients With Alzheimer Disease Dementia: A Randomized Clinical Trial Full Article
orphan Young Wild West locating a lode, or, The orphans of Bowie Bar By digital.lib.usf.edu Published On :: Fri, 13 Oct 2017 10:08:18 -0400 Full Article
orphan Young Wild West locating a lode, or, The orphans of Bowie Bar By digital.lib.usf.edu Published On :: Fri, 07 Feb 2020 11:50:20 -0400 Full Article
orphan Bill Graham’s American Journey: A Rock & Roll Mastermind Started Life as an Orphaned World War II Refugee By behindthescenes.nyhistory.org Published On :: Thu, 06 Feb 2020 15:13:56 +0000 Bill Graham once said he didn’t remember much about his childhood. Maybe that’s because he preferred to forget. One of the most influential rock & roll promoters of all time, Graham was quite literally the man behind the music. The manager of the legendary Fillmore Auditorium in San Francisco and the Fillmore East in New... The post Bill Graham’s American Journey: A Rock & Roll Mastermind Started Life as an Orphaned World War II Refugee appeared first on Behind The Scenes. Full Article Exhibitions General Now on View bill graham and the rock & roll revolution exhibitions music now on view
orphan Orphans of Williamsburg By feeds.history.org Published On :: Mon, 13 Jan 2014 11:00:29 +0000 Historian Cathy Hellier describes the poignant histories of children left without parents. The question of providing for colonial orphans was split between the courts and the children’s caretakers. Listen this week to learn how colonial society looked after its littlest citizens. Full Article Children Government
orphan UP: 3 held for ‘raping’ orphanage inmate By indianexpress.com Published On :: Sat, 05 Oct 2019 23:26:45 +0000 Full Article India