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New Report Finds Near-Term Update to Social Cost of Carbon Unwarranted

There would not be sufficient benefit to updating estimates of the social cost of carbon (SCC) within a year based only on the revision of a specific climate parameter in the existing framework used by the government’s interagency group to measure the SCC, says a new interim report from the National Academies of Sciences, Engineering, and Medicine.




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EnWave signs vacuum purchase agreement with Dole Worldwide Food & Beverage Group

EnWave Corp. announced that it has signed an Equipment Purchase Agreement with Dole Worldwide Food & Beverage Group to supply a 120kW Radiant Energy Vacuum dehydration processing line that will materially increase Dole’s vacuum-microwave processing capabilities.




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PM Profile: Leonard Valve’s David Brakenwagen

Earlier this year, Leonard Valve announced David Brakenwagen as its new chief executive officer. 




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Greenwashing and geothermal HVAC technologies

Greenwashing is deceptive advertising that uses green PR to make products seem eco-friendly and desensitizes consumers to environmental claims. TerraChoice describes "seven sins of greenwashing" to help consumers spot misleading environmental claims.




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James E. Conway Presented with the Albert Nelson Marquis Lifetime Achievement Award by Marquis Who's Who

James E. Conway channels years of expertise into his work with Arbitration & Mediation Services




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Swati Tanwar Celebrated for Dedication to the Field of Product Engineering




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From Music to Mindfulness: Jonathan Block Ascends to Co-CEO at BrainTap, Pioneers in Brainwave Optimization

Jonathan Block Ascends to Co-CEO at BrainTap, Pioneers in Brainwave Optimization




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From Music to Mindfulness: Jonathan Block Ascends to Co-CEO at BrainTap, Pioneers in Brainwave Optimization (UPDATED)

Jonathan Block Ascends to Co-CEO at BrainTap, Pioneers in Brainwave Optimization




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Sherring Hope's "UNSPOKEN: Unwavering Honesty...Poems and Short Stories" Resonates with All Who Have Felt Emotion

A Journey of Resilience and Self-Discovery Through Poetry and Stories




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Spark Sourcing Dedicates Staff and Introduces New Packaging Material to Help the Cannabis Industry Reduce Plastic and Avoid Greenwashing Traps

Eco-shell™ can reduce reduce plastic by up to 50%, carbon by up to 70%, and makes 100% recyclable packaging. Patented, fully certified, and ready to go.




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MbenzGram (MBGRAM) Celebrates Latest Winward Racing Win

Winward Racing made a big win recently. Their sponsor MbenzGram is just as happy about the win as the team is.




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Cindy Margolis and John Mulhern accepting offers on Vintage1859 Steinway piano

Mulhern will consider reasonable offers for the 85 key Concert Grand Steinway




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Committee visits Connswater Community Greenway

The Northern Ireland Assembly Committee for Infrastructure has today visited the Connswater Community Greenway to see how the park is improving the quality of life for local people.




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Updated: Trump says he won’t fire Conway for Hatch Act violations

A federal watchdog agency is recommending that President Donald Trump fire one of his most ardent defenders, counselor Kellyanne Conway, for repeatedly violating a law that limits political activity by government workers

The post Updated: Trump says he won’t fire Conway for Hatch Act violations first appeared on Federal News Network.




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Twitter tests 'soft block' feature to remove unwanted followers as part of moves to improve privacy

Twitter tests 'soft block' feature to remove unwanted followers as part of moves to improve privacy





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From Onesies to Runway: Inside Baby Adopter Dress Up for iOS

In this delightful episode, Ida Grace revisits Baby Adopter Dress Up for iOS. This charming game combines babysitting, fashion costume dress-up, and nursery care for those who adore looking after little ones.

As a player, you have the opportunity to adopt and nurture a cute son or daughter. You can dress up, feed, care for, and acquire various costumes, shoes, and hats for your baby. Keep in mind that certain costumes become available as your baby grows. Some game features include:

  • Game Locations: Venture into different interior rooms and external settings, including the Summer Beach and Winter House.
  • Growth: Your baby will mature after 20 days, unlocking additional costume options. Dress your little one in playful outfits and share their adorable looks on social media.
  • Karma: Reflects your overall gameplay progress and experience.

Embrace the joy of tending to your virtual baby and creating charming outfits! ????????

Baby Adopter Dress Up on the App Store https://apps.apple.com/us/app/baby-adopter-dress-up/id875064928

transcription:

Disclaimer: This transcript is generated by AIKO, an automated transcription service. It is not edited or formatted, and it may not accurately capture the speakers’ names, voices, or content.

Hello AppleViz.

This is Ida Grace and I am here today with a podcast on the baby adopter dress up app.

I want to go through a couple of quick disclaimers before I start.

First of all, I want to say that I did a podcast for this app years ago.

However, it was called Milky Baby at the time and now it is baby adopter dress up and my podcast for that is no longer available on AppleViz at least as far as I've been able to tell.

417 PM.

Ah, I wanted to tell you a disclaimer about the voice I'm using too, but the app has gone through a couple of changes anyway, so I was given the green light to go ahead and make a new podcast.

And the second disclaimer is involving the voice I am using.

I am using American Siri voice 5 because it is pride season and if you all were able to read the article that Apple put out, this voice was recorded by somebody in the LGBT community.

So I thought with pride month approaching fast, I would keep this voice on through pride season.

However, as you'll notice as I demonstrate this app, it does have some delays.

There is a little bit of delay between voiceover speech and voiceover sound.

So you will notice that comma 418 PM and it is 418 PM.

I am on the clock widget right now.

So the first thing I want to let you know is when you first open the baby adopter dress up app, it's going to ask you if you want the app to send you notifications.

I always turn that on, but all they do is notify you every 24 hours if you forget to feed the baby.

So if you don't want the notifications turned on, you don't have to do it.

Just know that if you're using this on an iPad like I am, the baby will cry and you won't get a vibration.

You'll just get because iPads don't have haptics.

So you're just going to get the baby crying if you forget to feed the baby in 24 hours.

I'm also using iPadOS 16 because the Siri voices do not auto delete for voiceover as they do in iOS 17.

They seem to be…




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Issues of the Environment: Ecology Center study finds PFAS in rainwater in Ann Arbor and Southeast Michigan

PFAS contamination has already been a significant concern. Now, there may be reason to add to the worry. A study funded by the Ann Arbor-based Ecology Center finds there is an array of PFAS chemical profiles in rainwater falling over Ann Arbor and Southeast Michigan. WEMU's David Fair spoke with the center’s Erica Bloom about the findings and what it means to the environment and public health.




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“La muerte de Sinwar no va a cambiar nada y Hamás no se acabará”: analista internacional

En 6AM de Caracol Radio estuvo Marcos Peckel, analista internacional, para hablar sobre por qué Israel asegura que la muerte del líder de Hamás, Yahya Sinwar, es el inicio del fin de la guerra en Gaza





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Photos: Berkeley’s Dress Code-Runway Show

As a part of its 125th anniversary celebrations, the Berkeley Educational Society held their ‘Dress Code Runway Show’ — a Tea, Hat, and Fashion show fundraiser — on Sunday [June 11]. Maxine Esdaille, Chair of the Planning Committee, previously said, “The idea behind this event is to recognize and celebrate Berkeley’s contribution, through its students […]




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Glenn Greenwald says the corruption in the U.S. News Media is absolutely pervasive

The problem is the corruption that is absolutely pervasive in the U.S. news media. There are newsrooms all throughout New York and Washington DC, where top editors are explicitly saying they do not want this story investigated. And they're being clear that the reason that they don't want to investigate it is because they think even if there's corruption that's exposed here, in their view Trump is worse. And therefore it would be malfeasance on the part of the media to report corruption on the part of Biden when Trump is so much more corrupt. What they're really saying is they see their role as journalists not as informing the public, to let the public decide which candidate is better and which is worse. They see journalism, the function of it is to defeat Donald Trump and elect Joe Biden. Continue reading




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Glenn Greenwald says that the Democratic Party, NSA, CIA, Neocons, Silicon Valley, Wall Street, mainstream media have united to impose an authoritarian government of censorship and suppression of information

The CIA from the very first days of the Trump administration, even before he was inaugurated, devoted themselves to sabotaging the administration because Donald Trump questioned just a few of their pieties. And that can't be done in Washington. Whoever does that must be destroyed. And so the CIA and the Deep State operatives became heroes of the liberal left, the people who support the Democratic party. They're now in a full union with the neocons, the Bush Cheney operatives, the CIA, Silicon Valley, and Wall Street. That is the union of power along with mainstream media outlets that are fully behind the Democratic party, which is likely to at least take over one branch of government, if not all of them, with the coming election, and that is a very alarming proposition because they're authoritarian, they believe in censorship, and they believe in suppression of information that exposes them in any kind of a critical light. Continue reading




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Mutual Fund Investors Face Unwanted Tax Bills. Are You on the List?




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Alienwarearena Earn 500DRP or 10ARP every day

Update: Alienwarearena Celebrating Intel® Gamer Days event is over. 

 

Alienware Arena

 

New Topic:

Earn up to 1000 Dell Reward Points(DRP) Every Week by playing the spaceship game after completing 4 DAILY QUESTS.

 

Earn additional ARP/DRP by logging daily via the Monthly Advent Calendar reward. (Day 20,26 for DRP)

 

Alienware Reward Points(ARP) can be redeemed for MARKETPLACE rewards for physical/digital products.

 

Tier rewards: You can choose to claim one game each month provided you have enough ARP and Tier status.

 

100 DRP = $1 Dell Credit 

1 APR = up to ~2cents

 Points expire on the 15th day of the 4th month after earn date.
 

*NOTE: Linking reward account

When registering with Alienware make sure to use the same email address that you use for Dell.

 

Extra: Earn 100 DRP by Logging into your Dell Reward profile(Earn once a week, Reset every Monday)

 

 




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In Finland, people get prizes for their unwanted textiles

In the quest for a more sustainable future, the Finnish city of Lahti has taken a remarkable step with an innovative pilot program called the Textile Deposit scheme. This incentivized recycling program aims to encourage locals to actively sort and recycle their textile waste instead of sending it to the landfill. [...]




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PUGC 150th: Gala Concert - Then, Now, and Onwards!

Join Princeton University Glee Club for a three-day celebration of the Glee Club’s past, present and future with a festival of singing, camaraderie and concerts! On November the 16th at 5pm, a massed choir of Glee Clubbers past and present convenes for a Gala Concert which evokes the history of the choir, and which ushers in its future. This performance features the world premiere of “More to Live For” by Shruthi Rajasekar ’18, composed to be sung together by Glee Clubbers of all generations. *** PUGC 150th CELEBRATION - a 3 day festival! Opening Concert: The King Singers with the Princeton University Glee Club Friday November 15th, 7:30pm Richardson Auditorium, Princeton, NJ Gala Concert: PUGC - Then, Now, and Onwards! with the Princeton University Glee Club and PUGC alumni Saturday November 16th, 5pm Richardson Auditorium, Princeton, NJ Glee Club Come-and-Sing: Fauré Requiem with the Princeton University Glee Club and PUGC alumni Sunday November 17th, 2:30pm Princeton University Chapel, Princeton, NJ




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Netanyahu says focus on hostages after Sinwar death

Sinwar, who topped Israel's most-wanted list, was a key figure believed to have been behind the 7 October attacks.




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BBC Verify analyses footage of Hamas leader Yahya Sinwar's killing

The BBC's analysis editor Ros Atkins looks at footage said to show Yahya Sinwar's final moments.




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Why a more inward-looking China is bad news for the world economy

Why a more inward-looking China is bad news for the world economy Expert comment LToremark 16 October 2022

The increased role of geopolitics and ideology in Beijing’s economic decision-making is bad news not just for China but for the world.

We should adhere to self-reliance, put the development of the country and nation on the basis of our own strength, and firmly seize the initiative in development. To build a great modern socialist country in an all-round way and achieve the second Centenary Goal, we must take the road of independent innovation.

President Xi Jinping, August 2022

This quote by President Xi clearly outlines the inward tilt of Chinese economic policymaking that is now becoming increasingly obvious to the rest of the world. But it actually has deep roots. Ever since the 2008 global financial crisis, when the West’s reliability as a trading partner was thrown into question, self-reliance has become a more decisive organizing principle for Chinese officials.

As a result, the export-dependent growth model on which China built its economic rise in recent decades has been fraying. Exports as a share of China’s GDP peaked at 35 per cent in 2007 but had fallen to around 20 per cent by last year, a level not seen since before China’s accession to the WTO in 2001. This shows that net exports no longer make any meaningful contribution to Chinese GDP growth.

Russia’s invasion of Ukraine has provided another geopolitical impetus to China’s pursuit of self-reliance.

Although China’s inward tilt may have started out as a response to purely economic phenomena – the post-crisis global recession, belt-tightening in the West, the eurozone crisis, and a general softening of global trade growth in the post-crisis years – geopolitical considerations are now dominant in shaping this shift toward self-reliance.

The role of geopolitics in pushing China towards a more inward-looking development path became clear in China’s response to the aggressive tariffs and export controls introduced by the Trump administration in the US. Because of these new constraints on China’s access to international markets and technology, Beijing sought to limit its dependence on the rest of the world.   

The most obvious result of this was the introduction of the ‘dual circulation’ strategy in May 2020, which sets out a rebalancing of China’s economy away from a reliance on external demand as a stimulus to growth (‘international circulation’) towards increased self-dependence (‘domestic circulation’). 

Russia’s invasion of Ukraine has provided another geopolitical impetus to China’s pursuit of self-reliance. Since it is not far-fetched to think that China, like Russia, might one day also face coordinated sanctions, Chinese authorities must be thinking hard about how to respond to such a risk. 

Within China itself, a new emphasis on the role of the state is increasingly apparent – and seemingly rooted in ideology. 

The only credible strategy that China can adopt is to reduce its economic dependence on the West by creating, in effect, a kind of economic fortress, as its dependence on imported technology, food, and fossil fuels in particular, has created a substantial strategic vulnerability.

Over the next few years, Chinese policymakers will likely attempt to build up the country’s ability to supply its own semi-conductors, food, and green energy sources.

This new approach to economic policymaking isn’t just about China’s relationship with the rest of the world. Within China itself, a new emphasis on the role of the state is increasingly apparent – and seemingly rooted in ideology. 

The previous National Congress of the Chinese Communist Party (CCP), in October 2017, made a push for ‘stronger, better, and bigger’ state-owned enterprises (SOEs) and the past five years have indeed seen a measurable rise in the role that SOEs play in the Chinese economy. These firms now account for more fixed investment in the economy than private firms, for the first time since 2005.




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The killing of Yahya Sinwar won’t change the course of the Gaza war

The killing of Yahya Sinwar won’t change the course of the Gaza war Expert comment jon.wallace

Israel has larger ambitions for Gaza beyond the Hamas leader’s death and the armed group is still asserting its influence despite its degradation.

After a year of being hunted as one of the most wanted men in the Middle East, Hamas leader Yahya Sinwar was killed by Israeli forces on 17 October, in the city of Rafah in the Gaza Strip.

Hailing from Khan Younis refugee camp, Sinwar was imprisoned in Israel in 1989 for the abduction and killing of two Israeli soldiers. He was freed alongside 1,000 other prisoners during a major 2011 exchange, gradually building a notorious reputation as an intelligent and ruthless political figure.

As Hamas’ Gaza chief since 2017, Sinwar oversaw the consolidation of the movement’s authoritarian rule in the Strip and co-directed its military confrontations with Israel. He is regarded as a chief architect of Hamas’ deadly assault of 7 October, which killed 1,200 Israelis, mostly civilians, in southern communities.

Contrary to some wishful thinking, Sinwar’s death is unlikely to change Israel’s calculus in Gaza.

Many world leaders and pundits were quick to embrace Sinwar’s death as an opportunity to press for a ceasefire in Gaza and secure the release of roughly 100 Israeli hostages still held by Hamas and other groups. It is too early to know the full repercussions of this development, but these hopes are largely misplaced – and reflect a reluctance to confront the larger obstacles and motivations that are preventing an end to the war.

Morale amid aimlessness

For Israelis, Sinwar’s death is undoubtedly a morale booster. It is a symbolic victory over a man deemed responsible for the 7 October massacres, and a tactical success that rids Israel of a formidable foe – one who was also an invested ally of Iran and the Axis of Resistance. Israeli politicians and generals will relish the news as another step towards restoring their reputations after their failure to prevent the 7 October attack.

Yet contrary to some wishful thinking, Sinwar’s death is unlikely to change Israel’s calculus in Gaza. Prime Minister Benjamin Netanyahu, whose popularity has been slowly recovering in recent months, described the news as ‘the beginning of the end’ but warned that ‘the task before us is not yet complete’.

The intensification of Israel’s war with Hezbollah – including a ground invasion of Lebanon, airstrikes across the country, and the displacement of over 1 million people – has shifted Israelis’ focus away from Gaza over the past month, especially as Hezbollah rockets disrupt life in Israel’s central cities as well as the north.

The Israeli military – despite its clashes with the prime minister – is seizing the chance to redraw Israel’s geopolitical environment.

During that time, the Israeli army has begun a major offensive in the northern part of the Strip, implementing what appears to be the first part of the so-called ‘General’s Plan’ – an operation to besiege and force out roughly 300,000 Palestinian civilians who remain in the area. It could also pave the way for Israel’s absorption of part of the territory. (Israel’s military has denied pursuing the plan).

As such, the Israeli government has relegated the importance of the hostages. Netanyahu is eager to divert the public’s frustration with his months-long sabotage of a deal, while the military – despite its clashes with the prime minister – is seizing the chance to redraw Israel’s geopolitical environment. Even if a deal is struck in the wake of Sinwar’s death, Israel’s bombing and carving-up of Gaza and south Lebanon will likely continue.

Dynamic but degraded

For Hamas, the killing of its fiery politburo chief – just over two months after the assassination of his predecessor Ismail Haniyeh in Tehran – is certainly a blow to its leadership and internal stability. But the Islamist movement’s dynamism has not changed. Hamas’s decision-making processes are not pegged to specific individuals, and other figures, whether in Gaza or in exile, will be rotated into senior positions.

It is unclear whether Hamas will promote a leader who shares Sinwar’s hardline orientation, or drift back to a more moderate figure similar to Haniyeh. Regardless, Hamas’s core demands in any ceasefire and hostage negotiations are unlikely to shift significantly. The movement is still seeking a permanent end to the war, and Israel is still refusing to grant it.

Hamas’s military capacity has been severely degraded by the Israeli offensive, not least by the fact that much of Gaza has been made unliveable and ungovernable. But the movement is far from destroyed. Its militants continue to fight a guerrilla war to undermine Israel’s foothold in Gaza, while trying to reassert Hamas control over public order, the war economy, and the distribution of aid.

Moreover, as the history of movements like Hamas and Hezbollah shows, the devastating nature of Israel’s campaigns and occupations are planting the seeds for further militancy among Palestinians, whether organized under Hamas or smaller, decentralized groups. The war has brutally decimated Gaza’s society, and the notion that killing figures like Sinwar will dissuade future recruits to fight Israel is fanciful.

On the Palestinian political level, Hamas and Fatah are still in talks about forming a unity agreement, though negotiations have so far remained fruitless. Even if a pact is made, Israel’s relentless targeting of Hamas personnel, the perception of the Fatah-led Palestinian Authority (PA) as feckless collaborators, and Palestinians’ feeling of total abandonment raise doubts about the parties’ ability to regain popular support or legitimacy – whether to lead an interim government or the wider national movement.

The gravest threat

The killing of Sinwar is a significant marker in the Gaza war, with important ramifications for the movement he led and the conflict he seismically shaped. Israel will portray his death as validation of its aggressive military approach, and a further step in the erosion of Iran’s regional influence – an agenda the US has actively supported.




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Sinwar’s death does not make Hamas–Fatah reconciliation more likely, whoever his successor may be

Sinwar’s death does not make Hamas–Fatah reconciliation more likely, whoever his successor may be Expert comment jon.wallace

The killing may aid Hamas recruitment – but it will not make agreement with Fatah any easier to achieve.

Western political leaders were quick to argue that Israel’s killing of Hamas leader Yahya Sinwar on 17 October presented an opportunity for a ceasefire in Gaza and the return of Israeli hostages.

US President Joe Biden immediately called on Israeli prime minister Benjamin Netanyahu to seize the moment to negotiate, now that Israel has achieved one of its war aims.

However, that ‘moment’ has already passed. Israel’s military assault on Gaza has intensified since Sinwar was killed, leading UN Peace Process Co-ordinator Tor Wennesland to say that ‘nowhere is safe in Gaza’. It is abundantly clear Netanyahu is intent on further degrading Hamas, resetting a new ‘power balance’ and carving out a buffer zone, no matter the cost in Palestinian lives or Israeli hostages. 

But there are other implications of Sinwar’s assassination beyond the zero-sum analysis of will there or won’t there be a ceasefire.

Hamas’s ability to fight

At present, everyone has an opinion on how Sinwar’s killing will affect Hamas and its ability to resist and respond to Israel’s military. His death will have been a major blow – symbolically, operationally, and psychologically. Hamas has been downgraded and its capacity to respond compromised.

But it will recover, regenerate and retaliate in time – and Sinwar’s death will have been no surprise to Palestinians in Gaza or elsewhere. Hamas is accustomed to seeing its leaders assassinated. Since its formation in 1987, it has been ‘decapitated’ many times, only to continue with its mission to ‘liberate Palestine’.

Hamas’s portrayal of Sinwar dying in his fatigues, head wrapped in a keffiyeh and resisting until the end will persuade many young Palestinians that he died as a martyr serving the Palestinian cause. Many will be inspired to join and fortify the ranks of Hamas as a result.

The IDF’s release of drone footage showing Sinwar’s last moments will have done nothing to undermine his credibility. 

On the contrary, it will serve as a rallying call to disaffected and disenfranchised young Palestinians horrified by Israel’s bombing of civilian targets in Gaza and disaffected with Fatah’s inability to prevent Israeli settler expansion and violence in the West Bank.

Reconciliation

Some hope that if Sinwar is replaced by a more ‘moderate’ leader, his killing may smooth the path to Hamas–Fatah reconciliation – and that this could provide a foundation for a patchwork political solution when Israel and Gaza arrive at the ‘day after.’  

Prospective new Hamas leaders such as Khaled al Meshaal and Khalil al-Hayya are based in Qatar (and) their ability to influence events on the ground in Gaza will be limited.

But the idea that a downgraded and ‘leaderless’ Hamas will be susceptible to international pressure to reconcile with Fatah is divorced from reality.  

Prospective new Hamas leaders such as Khaled al Meshaal and Khalil al-Hayya are based in Qatar. 

They may be more pliable to external pressure to reconcile with Fatah in search of a political outcome, but their ability to influence events on the ground in Gaza will be limited. That was demonstrated by the Sinwar-orchestrated attacks on 7 October 2023, which took place without the blessing of the exiled leadership in Doha.

Hamas has long gone to ground in Gaza and become far more decentralized than it was before 7 October. It is now more typical of an insurgency, where Hamas cadres exercise a great degree of operational autonomy.

In other words, the disconnect between Hamas in Gaza and its political leadership in Qatar has only grown wider since this round of conflict started.

International efforts

That will undermine international efforts made by Qatar, Egypt, Saudi Arabia, China, Russia and others to bring about a reconciliation. Moscow and Beijing already hosted reconciliation talks in February and April early this year but made no progress in closing the chasm between the two parties. Saudi Arabia has also hosted talks.

The three Arab states, none of which have so far commented publicly on Sinwar’s killing, will likely view his death as an opportunity to bolster the political wing of Hamas – backing it with pledges of political, diplomatic and financial support.

Hamas’s military wing is not about to concede ground and reconcile with Fatah.

Saudi Arabia and Egypt will have next to no influence over the succession process, but Qatar’s long-established relationship with the political wing of Hamas affords it leverage over the organization, albeit limited. They may be able to strengthen the hand of those based in Doha by promising to work harder at securing a ceasefire, guaranteeing the provision of humanitarian relief, and working towards a political solution.




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Greenwashing assisted dying




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Kir2.1 Interactome Mapping Uncovers PKP4 as a Modulator of the Kir2.1-Regulated Inward Rectifier Potassium Currents [Research]

Kir2.1, a strong inward rectifier potassium channel encoded by the KCNJ2 gene, is a key regulator of the resting membrane potential of the cardiomyocyte and plays an important role in controlling ventricular excitation and action potential duration in the human heart. Mutations in KCNJ2 result in inheritable cardiac diseases in humans, e.g. the type-1 Andersen-Tawil syndrome (ATS1). Understanding the molecular mechanisms that govern the regulation of inward rectifier potassium currents by Kir2.1 in both normal and disease contexts should help uncover novel targets for therapeutic intervention in ATS1 and other Kir2.1-associated channelopathies. The information available to date on protein-protein interactions involving Kir2.1 channels remains limited. Additional efforts are necessary to provide a comprehensive map of the Kir2.1 interactome. Here we describe the generation of a comprehensive map of the Kir2.1 interactome using the proximity-labeling approach BioID. Most of the 218 high-confidence Kir2.1 channel interactions we identified are novel and encompass various molecular mechanisms of Kir2.1 function, ranging from intracellular trafficking to cross-talk with the insulin-like growth factor receptor signaling pathway, as well as lysosomal degradation. Our map also explores the variations in the interactome profiles of Kir2.1WT versus Kir2.1314-315, a trafficking deficient ATS1 mutant, thus uncovering molecular mechanisms whose malfunctions may underlie ATS1 disease. Finally, using patch-clamp analysis, we validate the functional relevance of PKP4, one of our top BioID interactors, to the modulation of Kir2.1-controlled inward rectifier potassium currents. Our results validate the power of our BioID approach in identifying functionally relevant Kir2.1 interactors and underline the value of our Kir2.1 interactome as a repository for numerous novel biological hypotheses on Kir2.1 and Kir2.1-associated diseases.




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Cornwall, the Most Beautiful Place in Britain

One of the most evocative and breathtakingly beautiful coastal landscapes in Britain is the historic county of Cornwall. It’s also a place steeped in legend, including that of Britain’s legendary King Arthur.




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Weekly Covid-19 Update – January 28, 2022: Delaware Remains Vigilant As Downward Case, Hospitalization Trends Continue

DOVER, DE (Jan. 28, 2022) – The Delaware Division of Public Health (DPH) is providing an update on the most recent statistics related to coronavirus disease 2019 (COVID-19) in Delaware, as of Thursday, Jan 27, 2022. DPH reports a 57 percent decrease in the seven-day average of new positive cases reported since the peak of the surge […]




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Weekly COVID-19 Update – February 18, 2022: Cases, Hospitalizations Continue Downward Trend

DOVER, DE (February 18, 2022) – The Delaware Division of Public Health (DPH) is providing an update on the most recent statistics related to coronavirus disease 2019 (COVID-19) in Delaware, as of Thursday, Feb 17, 2022. COVID-19 Cases and Hospitalizations:  Total positive cases since March 11, 2020: 254,719 7-day average of new positive cases: 232.6, a decrease […]




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Alienware 310H gaming headset Review

Read the in depth Review of Alienware 310H gaming headset Gaming. Know detailed info about Alienware 310H gaming headset configuration, design and performance quality along with pros & cons, Digit rating, verdict based on user opinions/feedback.




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Alienware x14 Gaming Laptop Review

Read the in depth Review of Alienware x14 Gaming Laptop Laptops. Know detailed info about Alienware x14 Gaming Laptop configuration, design and performance quality along with pros & cons, Digit rating, verdict based on user opinions/feedback.




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Dell Alienware x14 R2 Gaming Laptop Review

Read the in depth Review of Dell Alienware x14 R2 Gaming Laptop Laptops. Know detailed info about Dell Alienware x14 R2 Gaming Laptop configuration, design and performance quality along with pros & cons, Digit rating, verdict based on user opinions/feedback.




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From Studying In Prison To Heading Hamas Oct 7 Attack: Who Was Yahya Sinwar

The Israel Defense Forces (IDF) and the Israel Security Agency have jointly confirmed that Hamas leader Yahya Sinwar was killed in the Gaza Strip by Israeli soldiers on Wednesday.




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UK regions fight for a share of inward investment

The UK’s prime minister has pledged to rebalance the UK economy away from a dominant London. However, this might require greater incentives for foreign investment in the regions outside of the capital, which are underperforming. 




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Serbia's automotive companies drive inward investment

Foreign investment into Serbia is growing at a healthy pace thanks to its attractive automotive manufacturing industry and highly regarded free zones.




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Adaobi Nwaubani: Humorous writer, journalist

Adaobi Tricia Nwaubani is a writer to reckon with among Nigerian female writers. Her works portrays the Igbo culture and thereby carved a niche for herself in the literary world. She is a novelist, humourist, essayist and journalist. Nwaubani is the first contemporary African writer on the global stage to have an international book deal while still living in her home country. She was born in 1976 in Enugu into the family of Chief Chukwuma Nwaubani and Dame Patricia Nwaubani. And was educated at Federal Government Girls’ College, Owerri. She studied psychology at the University of Ibadan. As a teenager, […]




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Diabetes Drug May Help Kids With Autism Fight Unwanted Pounds

Title: Diabetes Drug May Help Kids With Autism Fight Unwanted Pounds
Category: Health News
Created: 8/24/2016 12:00:00 AM
Last Editorial Review: 8/25/2016 12:00:00 AM




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James J. Conway, MD, 1933-2024




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Alienware celebrates 25 years with revamped Aurora desktop PC

Alienware was born in a garage near Miami in 1996. The first Aurora arrived in 2004.




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Boosting brainwaves in sleep improves rats’ memory

Rats perform better on memory tests when certain brainwave-producing neurons are stimulated while they sleep. If we can boost these brainwaves in people, it could help treat memory impairments in those with dementia




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Rainwater Could Help Satisfy AI’s Water Demands

A few dozen ChatGPT queries cost a bottle’s worth of water. Tech firms should consider simpler solutions, such as harvesting rainwater, to meet AI’s needs




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Macron and Starmer vow 'unwavering' Ukraine support

The leaders' discussions also focused on the Middle East and the problems caused by migration in Europe.