The present invention relates to a novel method for producing a pyridazinone compound and an intermediate thereof as shown in the following scheme: wherein the symbols are as defined in the specification.

The present invention is concerned with a process for preparing 5-(2{[6-(2,2-difluoro-2-phenylethoxy)hexyl]amino}-1(R)-hydroxyethyl)-8-hydroxyquinolin-2(1H)-one or a pharmaceutically acceptable salt thereof.

The present disclosure relates to a novel benzindocyanine compound for labeling biomolecules and a method for preparing the same.

The present invention relates to methods for synthesizing compounds of formula I or pharmaceutically acceptable salts thereof: I wherein each of X, Alk1, Alk2, and W are as defined and described herein.

A rotation transmitting apparatus includes a first shaft on which multiple external teeth are formed so as to be arranged in a circumferential direction, and a second shaft in which multiple internal teeth are formed so as to be arranged in the circumferential direction, the second shaft being fitted to the first shaft so as to be slidable relative to the first shaft in the axial direction and so as to be engageable with the first shaft in a rotational direction through the use of the external teeth and the internal teeth. A protrusion is formed on the tooth flank of one of the external tooth and the internal tooth, the protrusion being projected toward the corresponding tooth flank of the other of the external tooth and the internal tooth. The protrusion is made of a resin that is more elastically deformable than the tooth flank.

The present invention relates to compounds suitable as modulators of protein misfolding and/or protein aggregation. The compounds are particularly suitable as inhibitors of amyloid aggregate formation and/or modulators of amyloid surface properties, and/or as activators of degradation or reduction of amyloid aggregates.

A perpendicular magnetic recording disk has a graded-anisotropy recording layer (RL) formed of at least two ferromagnetically exchange coupled CoPtCr-oxide magnetic layers (MAG1 and MAG2) with two nucleation films (NF1 and NF2) between the magnetic layers. NF1 is a metal film, preferably Ru or a Ru-based alloy like RuCr, sputter deposited on MAG1 at low pressure to a thickness between about 0.1-1.5 nm. NF2 is a metal oxide film, preferably an oxide of Ta, sputter deposited on NF1 at high pressure to a thickness between about 0.2-1.0 nm. MAG2 is sputter deposited over NF2. NF1 and NF2 provide a significant reduction in average grain size in the RL from a graded-anisotropy RL without nucleation films between MAG1 and MAG2, while also assuring that MAG1 and MAG2 are strongly exchange coupled.

An adapter for front forks of a front loading commodity collection truck allows the truck to collect from rear load and side load style containers. An intermediate container is carried on the forks of the truck. An engagement apparatus is mounted on the intermediate container and is laterally extendible to engage the commercial container at curbside and draw the container to the intermediate container. The engagement apparatus will lift the commercial container and tip it over the intermediate container. Controls in the cab of the truck control operation of the adapter. The adapter can be removed easily from the forks when a front loading refuse container is encountered.

A robot includes an arm having a base end portion rotatably installed through a joint part and a tip end portion in which an output shaft is installed; and a drive mechanism arranged within the arm and configured to drive the output shaft at a reduced speed. The drive mechanism includes a motor having a motor shaft, a driving pulley attached to the motor shaft, a driven pulley attached to the output shaft, at least one intermediate pulley provided between the driving pulley and the driven pulley, and a plurality of belts for operatively interconnecting the driving pulley and the driven pulley through the intermediate pulley.

A very-low intermediate frequency (VLIF) receiver and a method of controlling a VLIF receiver. The method comprises receiving a first signal, the first signal including one or both of an on-channel signal portion and an adjacent channel interferer (ACI) portion; determining that the first signal includes a portion having a strength that is above a threshold; in response to determining that the first signal includes a portion having a strength that is above the threshold, estimating one or more IQ imbalance parameters for at least a portion of the first signal; and compensating for an IQ imbalance in at least the portion of the first signal using the one or more IQ imbalance parameters.

The invention relates to a device (10) for handling notes of value, comprising a sensor unit (300) for detection of at least one feature of each note of value, and a control unit (28) which classifies the notes of value into accepted notes of value and sheet-shaped media to be returned, dependent on the feature to be detected by the sensor unit (300). A sorting gate (400) is arranged downstream the sensor unit (300), wherein the control unit (28) controls the sorting gate (400) to supply notes of value classified as accepted notes of value to a first intermediate storage (32), and notes of value classified as sheet-shaped media to be returned to a second intermediate storage (500).

The invention relates to a cluster arm arrangement for the intermediate roll sets of 18 HS roll stands, wherein arranged between the chock at the operating side and the chock at the drive side are cluster arms which are pivotable laterally of the intermediate roll and in which the lateral backing rolls are integrated for support of the working rolls in the stand. In that case, arranged between the chock (1) and the cluster arm (2) is a pivot pin (3), which is fixedly connected with the cluster arm and about the axis of which the cluster arm (2) is pivotable, and a locking means for the cluster arm (2) as well as an abutment (6) with a restoring spring (6) are operatively arranged on the pivot pin (3) as a compact unit in the region between the cluster arm (2) and chock (1).

The invention relates to a device for actuating a clutch-controlled transfer case having a two-stage intermediate gearing and a clutch-controlled transfer case that has a two-stage intermediate gearing and that is equipped with such a device. The device comprises: a rotatably driven selector shaft,a drive for rotating the selector shaft,a clutch cam disk, which can be rotated about a clutch cam disk axis by means of the selector shaft, andat least one scissor lever, wherein: one end (06) of at least one scissor lever is guided in a gate provided on the clutch cam disk,the gate has a curved path for each scissor lever, in which curved path the end of the scissor lever associated with the curved path is guided,the curved path winds around the clutch cam disk axis by at least 360°,the curved path has at least one helical segment having a continuously increasing or decreasing distance from the clutch cam disk axis, along which segment one end of a scissor lever guided therein experiences a continuously increasing or decreasing change in deflection with respect to the clutch cam disk axis during a rotation of the clutch cam disk with increasing angle of rotation, andthe clutch cam disk is disposed in such a way that the clutch cam disk can be rotated with respect to the selector shaft between two stops by an angle-of-rotation range such that, by means of rotation of the selector shaft within the angle-of-rotation range situated between said stops, shifting back and forth between the shifting stages of the intermediate gearing occurs, and, by means of rotation of the selector shaft beyond the angle-of-rotation range, the end of the at least one scissor lever experiences a deflection for actuating the clutch while a selected shifting stage is maintained.

An intermediate support structure for an escalator or moving walk having a dampening device with slots formed therein allowing a supported escalator truss to be free to move laterally to accommodate lateral displacement caused by story drift during an earthquake or seismic event.

The plans need to be approved by the U.S. Forest Service.

The production of formate from CO2 is considered an attractive strategy for the long-term storage of solar renewable energy in chemical form.

Cytochrome c oxidase (CcO) reduces O2 to water, coupled with a proton-pumping process. The structure of the O2-reduction site of CcO contains two reducing equivalents, Fea32+ and CuB1+, and suggests that a peroxide-bound state (Fea33+–O−–O−–CuB2+) rather than an O2-bound state (Fea32+–O2) is the initial catalytic intermediate. Unexpectedly, however, resonance Raman spectroscopy results have shown that the initial intermediate is Fea32+–O2, whereas Fea33+–O−–O−–CuB2+ is undetectable. Based on X-ray structures of static noncatalytic CcO forms and mutation analyses for bovine CcO, a proton-pumping mechanism has been proposed. It involves a proton-conducting pathway (the H-pathway) comprising a tandem hydrogen-bond network and a water channel located between the N- and P-side surfaces. However, a system for unidirectional proton-transport has not been experimentally identified. Here, an essentially identical X-ray structure for the two catalytic intermediates (P and F) of bovine CcO was determined at 1.8 Å resolution. A 1.70 Å Fe–O distance of the ferryl center could best be described as Fea34+ = O2−, not as Fea34+–OH−. The distance suggests an ∼800-cm−1 Raman stretching band. We found an interstitial water molecule that could trigger a rapid proton-coupled electron transfer from tyrosine-OH to the slowly forming Fea33+–O−–O−–CuB2+ state, preventing its detection, consistent with the unexpected Raman results. The H-pathway structures of both intermediates indicated that during proton-pumping from the hydrogen-bond network to the P-side, a transmembrane helix closes the water channel connecting the N-side with the hydrogen-bond network, facilitating unidirectional proton-pumping during the P-to-F transition.

Cytochrome c oxidase (CcO) reduces O2 to water, coupled with a proton-pumping process. The structure of the O2-reduction site of CcO contains two reducing equivalents, Fea32+ and CuB1+, and suggests that a peroxide-bound state (Fea33+–O−–O−–CuB2+) rather than an O2-bound state (Fea32+–O2) is the initial catalytic intermediate. Unexpectedly, however, resonance Raman spectroscopy results have shown that the initial intermediate is Fea32+–O2, whereas Fea33+–O−–O−–CuB2+ is undetectable. Based on X-ray structures of static noncatalytic CcO forms and mutation analyses for bovine CcO, a proton-pumping mechanism has been proposed. It involves a proton-conducting pathway (the H-pathway) comprising a tandem hydrogen-bond network and a water channel located between the N- and P-side surfaces. However, a system for unidirectional proton-transport has not been experimentally identified. Here, an essentially identical X-ray structure for the two catalytic intermediates (P and F) of bovine CcO was determined at 1.8 Å resolution. A 1.70 Å Fe–O distance of the ferryl center could best be described as Fea34+ = O2−, not as Fea34+–OH−. The distance suggests an ∼800-cm−1 Raman stretching band. We found an interstitial water molecule that could trigger a rapid proton-coupled electron transfer from tyrosine-OH to the slowly forming Fea33+–O−–O−–CuB2+ state, preventing its detection, consistent with the unexpected Raman results. The H-pathway structures of both intermediates indicated that during proton-pumping from the hydrogen-bond network to the P-side, a transmembrane helix closes the water channel connecting the N-side with the hydrogen-bond network, facilitating unidirectional proton-pumping during the P-to-F transition.

Cytochrome c oxidase (CcO) reduces O2 to water, coupled with a proton-pumping process. The structure of the O2-reduction site of CcO contains two reducing equivalents, Fea32+ and CuB1+, and suggests that a peroxide-bound state (Fea33+–O−–O−–CuB2+) rather than an O2-bound state (Fea32+–O2) is the initial catalytic intermediate. Unexpectedly, however, resonance Raman spectroscopy results have shown that the initial intermediate is Fea32+–O2, whereas Fea33+–O−–O−–CuB2+ is undetectable. Based on X-ray structures of static noncatalytic CcO forms and mutation analyses for bovine CcO, a proton-pumping mechanism has been proposed. It involves a proton-conducting pathway (the H-pathway) comprising a tandem hydrogen-bond network and a water channel located between the N- and P-side surfaces. However, a system for unidirectional proton-transport has not been experimentally identified. Here, an essentially identical X-ray structure for the two catalytic intermediates (P and F) of bovine CcO was determined at 1.8 Å resolution. A 1.70 Å Fe–O distance of the ferryl center could best be described as Fea34+ = O2−, not as Fea34+–OH−. The distance suggests an ∼800-cm−1 Raman stretching band. We found an interstitial water molecule that could trigger a rapid proton-coupled electron transfer from tyrosine-OH to the slowly forming Fea33+–O−–O−–CuB2+ state, preventing its detection, consistent with the unexpected Raman results. The H-pathway structures of both intermediates indicated that during proton-pumping from the hydrogen-bond network to the P-side, a transmembrane helix closes the water channel connecting the N-side with the hydrogen-bond network, facilitating unidirectional proton-pumping during the P-to-F transition.

Frederick J. Bloom
Jul 1, 2010; 23:165-169
From Research to Practice

Björn Morén
Apr 15, 2020; 0:jlr.ILR120000808v1-jlr.ILR120000808
Images in Lipid Research

Tumor cells can spread to distant sites through their ability to switch between mesenchymal and amoeboid (bleb-based) migration. Because of this difference, inhibitors of metastasis must account for each migration mode. However, the role of vimentin in amoeboid migration has not been determined. Because amoeboid leader bleb–based migration (LBBM) occurs in confined spaces and vimentin is known to strongly influence cell-mechanical properties, we hypothesized that a flexible vimentin network is required for fast amoeboid migration. To this end, here we determined the precise role of the vimentin intermediate filament system in regulating the migration of amoeboid human cancer cells. Vimentin is a classic marker of epithelial-to-mesenchymal transition and is therefore an ideal target for a metastasis inhibitor. Using a previously developed polydimethylsiloxane slab–based approach to confine cells, RNAi-based vimentin silencing, vimentin overexpression, pharmacological treatments, and measurements of cell stiffness, we found that RNAi-mediated depletion of vimentin increases LBBM by ∼50% compared with control cells and that vimentin overexpression and simvastatin-induced vimentin bundling inhibit fast amoeboid migration and proliferation. Importantly, these effects were independent of changes in actomyosin contractility. Our results indicate that a flexible vimentin intermediate filament network promotes LBBM of amoeboid cancer cells in confined environments and that vimentin bundling perturbs cell-mechanical properties and inhibits the invasive properties of cancer cells.

Chris Englund
Jan 5, 2005; 25:247-251
BRIEF COMMUNICATION

The higher the predischarge bilirubin percentile reading on the hour of life–specific nomogram, the higher becomes that infant's risk of developing significant hyperbilirubinemia. Neonates in the low-risk zones (≤75th percentile) have a low risk of developing hyperbilirubinemia.

Thirty-two percent of newborns readmitted for hyperbilirubinemia had low-risk zone predischarge bilirubin percentile values, predominantly in the intermediate low-risk zone (41st–75th percentile). The intermediate low-risk zone may not be as low risk as previously thought. (Read the full article)

Westmark (Lettings) Limited v Elizabeth Peddle and others [2017] UKUT 449 (LC) Here, the Upper Tribunal had to decide on the issue of when “relevant costs” are incurred for the purposes of Section 20(B)(1) of the Landlord and Tenant Act ...

Isoprene has the highest emission into Earth’s atmosphere of any nonmethane hydrocarbon. Atmospheric processing of alkenes, including isoprene, via ozonolysis leads to the formation of zwitterionic reactive intermediates, known as Criegee intermediates (CIs). Direct studies have revealed that reactions involving simple CIs can significantly impact the tropospheric oxidizing capacity, enhance...

Tumor cells can spread to distant sites through their ability to switch between mesenchymal and amoeboid (bleb-based) migration. Because of this difference, inhibitors of metastasis must account for each migration mode. However, the role of vimentin in amoeboid migration has not been determined. Because amoeboid leader bleb–based migration (LBBM) occurs in confined spaces and vimentin is known to strongly influence cell-mechanical properties, we hypothesized that a flexible vimentin network is required for fast amoeboid migration. To this end, here we determined the precise role of the vimentin intermediate filament system in regulating the migration of amoeboid human cancer cells. Vimentin is a classic marker of epithelial-to-mesenchymal transition and is therefore an ideal target for a metastasis inhibitor. Using a previously developed polydimethylsiloxane slab–based approach to confine cells, RNAi-based vimentin silencing, vimentin overexpression, pharmacological treatments, and measurements of cell stiffness, we found that RNAi-mediated depletion of vimentin increases LBBM by ∼50% compared with control cells and that vimentin overexpression and simvastatin-induced vimentin bundling inhibit fast amoeboid migration and proliferation. Importantly, these effects were independent of changes in actomyosin contractility. Our results indicate that a flexible vimentin intermediate filament network promotes LBBM of amoeboid cancer cells in confined environments and that vimentin bundling perturbs cell-mechanical properties and inhibits the invasive properties of cancer cells.

Exports (Bop) - Farm, Fishing And Intermediate Food Products in Canada increased to 3582.20 CAD Million in March from 3156.80 CAD Million in February of 2020. Exports (Bop) - Farm, Fishing And Intermediate Foo in Canada averaged 1529.37 CAD Million from 1988 until 2020, reaching an all time high of 3597.90 CAD Million in June of 2019 and a record low of 441.70 CAD Million in February of 1988. This page includes a chart with historical data for Canada Exports of (bop) - Farm, Fishing And Intermediate.

Exports (Bop) - Food And Tobacco Intermediate Products in Canada increased to 534.20 CAD Million in March from 459 CAD Million in February of 2020. Exports (Bop) - Food And Tobacco Intermediate Prod in Canada averaged 249.03 CAD Million from 1988 until 2020, reaching an all time high of 617.40 CAD Million in February of 2016 and a record low of 37 CAD Million in December of 1989. This page includes a chart with historical data for Canada Exports of (bop) - Food And Tobacco Intermediate.

Exports of (bop) - Intermediate Metal Products in Canada increased to 4249.60 CAD Million in March from 4223.10 CAD Million in February of 2020. Exports of (bop) - Intermediate Metal Products in Canada averaged 2539.84 CAD Million from 1988 until 2020, reaching an all time high of 5201.60 CAD Million in November of 2019 and a record low of 978.60 CAD Million in January of 1988. This page includes a chart with historical data for Canada Exports of (bop) - Intermediate Metal Products.

Imports (Bop) - Food And Tobacco Intermediate Products in Canada increased to 307.40 CAD Million in March from 257 CAD Million in February of 2020. Imports (Bop) - Food And Tobacco Intermediate Prod in Canada averaged 177.85 CAD Million from 1988 until 2020, reaching an all time high of 329.30 CAD Million in April of 2014 and a record low of 55.10 CAD Million in September of 1988. This page includes a chart with historical data for Canada Imports of (bop) - Food And Tobacco Intermediate.

Non-Oil Retained Imports - Intermediate Good (Nori) in Singapore increased to 7381.35 SGD Million in March from 6638 SGD Million in February of 2020. Non-Oil Retained Imports - Intermediate Good (Nori in Singapore averaged 5208.98 SGD Million from 2014 until 2020, reaching an all time high of 7381.35 SGD Million in March of 2020 and a record low of 1841.37 SGD Million in January of 2015. This page includes a chart with historical data for Singapore Non-oil Retained Imports of Intermediate Good (no.

Imports To Extra-Ea18-Intermediate Goods(Unit Value %mom) In the Euro Area increased to 1.40 percent in January from 1.20 percent in December of 2019. Imports To Extra-Ea18-Intermediate Goods(Unit Valu in the Euro Area averaged 0.23 percent from 2000 until 2020, reaching an all time high of 4.50 percent in July of 2005 and a record low of -7.50 percent in December of 2008. This page includes a chart with historical data for Euro Area Imports of Extra-ea18-intermediate Goods(unit Val.

Imports To Extra-Ea18 - Intermediate Goods (Volume %mom) In the Euro Area increased to 2.10 percent in January from -1.70 percent in December of 2019. Imports To Extra-Ea18 - Intermediate Goods (Volume in the Euro Area averaged 0.14 percent from 2000 until 2020, reaching an all time high of 7.90 percent in March of 2010 and a record low of -6.50 percent in June of 2011. This page includes a chart with historical data for Euro Area Imports of Extra-ea18 - Intermediate Goods (volum.

Imports To Extra-Ea18 - Intermediate Goods (Trade Value %mom) In the Euro Area increased to 3.50 percent in January from -0.50 percent in December of 2019. Imports To Extra-Ea18 - Intermediate Goods (Trade in the Euro Area averaged 0.49 percent from 1999 until 2020, reaching an all time high of 10.60 percent in March of 2010 and a record low of -10.80 percent in December of 2008. This page includes a chart with historical data for Euro Area Imports of Extra-ea18 - Intermediate Goods (trade.

Imports of Extra-ea18 - Intermediate Goods In the Euro Area increased to 103434.80 EUR Million in January from 88845 EUR Million in December of 2019. Imports of Extra-ea18 - Intermediate Goods in the Euro Area averaged 73814.95 EUR Million from 1999 until 2020, reaching an all time high of 112743.70 EUR Million in October of 2018 and a record low of 30491.30 EUR Million in January of 1999. This page includes a chart with historical data for Euro Area Imports of Extra-ea18 - Intermediate Goods.

Exports of Extra-ea18 - Intermediate Goods In the Euro Area increased to 90970.70 EUR Million in January from 83190.70 EUR Million in December of 2019. Exports of Extra-ea18 - Intermediate Goods in the Euro Area averaged 63859.46 EUR Million from 1999 until 2020, reaching an all time high of 100467.30 EUR Million in October of 2018 and a record low of 26826.30 EUR Million in January of 1999. This page includes a chart with historical data for Euro Area Exports of Extra-ea18 - Intermediate Goods.

Exports To Extra-Ea18 - Intermediate Goods (Trade Value %mom) In the Euro Area increased to 1.30 percent in January from 0.80 percent in December of 2019. Exports To Extra-Ea18 - Intermediate Goods (Trade in the Euro Area averaged 0.47 percent from 1999 until 2020, reaching an all time high of 10.80 percent in May of 2000 and a record low of -8.80 percent in November of 2008. This page includes a chart with historical data for Euro Area Exports of Extra-ea18 - Intermediate Goods (trade.

Exports To Extra-Ea18 - Intermediate Goods (Volume %mom) In the Euro Area increased to 0 percent in January from -0.30 percent in December of 2019. Exports To Extra-Ea18 - Intermediate Goods (Volume in the Euro Area averaged 0.25 percent from 2000 until 2020, reaching an all time high of 9.80 percent in May of 2000 and a record low of -8.20 percent in November of 2008. This page includes a chart with historical data for Euro Area Exports of Extra-ea18 - Intermediate Goods (volum.

Exports To Extra-Ea18-Intermediate Goods(Unit Value %mom) In the Euro Area increased to 1.30 percent in January from 1 percent in December of 2019. Exports To Extra-Ea18-Intermediate Goods(Unit Valu in the Euro Area averaged 0.15 percent from 2000 until 2020, reaching an all time high of 2.60 percent in October of 2000 and a record low of -2.20 percent in January of 2009. This page includes a chart with historical data for Euro Area Exports of Extra-ea18-intermediate Goods(unit Val.

Imports of Semi-manufactures & Intermediate Prds. in Switzerland increased to 3393.78 CHF Million in March from 3104.67 CHF Million in February of 2020. Imports of Semi-manufactures & Intermediate Prds. in Switzerland averaged 3263.72 CHF Million from 2014 until 2020, reaching an all time high of 3935.75 CHF Million in March of 2019 and a record low of 2550.58 CHF Million in December of 2016. This page includes a chart with historical data for Switzerland Imports of Semi-manufactures & Intermediate Prds.

Exports of Intermediate Goods in Spain increased to 12331880 EUR THO in February from 12123686 EUR THO in January of 2020. Exports of Intermediate Goods in Spain averaged 5485568.84 EUR THO from 1981 until 2020, reaching an all time high of 14668336 EUR THO in October of 2018 and a record low of 310987 EUR THO in January of 1981. This page includes a chart with historical data for Spain Exports of Intermediate Goods.

Exports of Intermediate Goods - Agriculture in Spain increased to 169552.88 EUR THO in February from 152284.38 EUR THO in January of 2020. Exports of Intermediate Goods - Agriculture in Spain averaged 64391.17 EUR THO from 1981 until 2020, reaching an all time high of 203554.87 EUR THO in October of 2018 and a record low of 1698 EUR THO in September of 1982. This page includes a chart with historical data for Spain Exports of Intermediate Goods - Agriculture.

Exports of Intermediate Goods - Energy Products in Spain decreased to 945736.92 EUR THO in February from 1088802.55 EUR THO in January of 2020. Exports of Intermediate Goods - Energy Products in Spain averaged 411557.81 EUR THO from 1981 until 2020, reaching an all time high of 2039833.47 EUR THO in October of 2011 and a record low of 10603.70 EUR THO in January of 1981. This page includes a chart with historical data for Spain Exports of Intermediate Goods - Energy Products.

Exports of Intermediate Goods - Industrial in Spain increased to 11216590.50 EUR THO in February from 10882598.93 EUR THO in January of 2020. Exports of Intermediate Goods - Industrial in Spain averaged 5009619.87 EUR THO from 1981 until 2020, reaching an all time high of 12857472.04 EUR THO in October of 2018 and a record low of 295351 EUR THO in January of 1981. This page includes a chart with historical data for Spain Exports of Intermediate Goods - Industrial.

Exports of Intermediate Goods - Non Energy Produc in Spain increased to 11386143.37 EUR THO in February from 11034883.31 EUR THO in January of 2020. Exports of Intermediate Goods - Non Energy Produc in Spain averaged 5074011.02 EUR THO from 1981 until 2020, reaching an all time high of 13061026.91 EUR THO in October of 2018 and a record low of 300382.96 EUR THO in January of 1981. This page includes a chart with historical data for Spain Exports of Intermediate Goods - Non Energy Produc.

Imports of Intermediate Goods in Italy decreased to 11391 EUR Million in February from 11677 EUR Million in January of 2020. Imports of Intermediate Goods in Italy averaged 10890.96 EUR Million from 2014 until 2020, reaching an all time high of 12247 EUR Million in August of 2018 and a record low of 9698 EUR Million in May of 2014. This page includes a chart with historical data for Italy Imports of Intermediate Goods.