The number of hospitalisations in 20 days since the Omicron variant was discovered was relatively lower than the pace observed during the Delta wave in Gauteng in South Africa

Experts believe that the markets may consolidate in the near term, with key support levels at 23,800-24,000 for the Nifty 50

The government said it's distributing the promising coronavirus drug, remdesivir, to some hard-hit states. Eventually, all 50 states should get it.

The OECD LEED Programme launches this "Call for Initiatives" to extract what local authorities and other actors know works, what the new scenario is demanding and how equipped they are to respond. We are interested in learning from the experiences of EU member countries, the wider OECD area as well as other countries.

The OECD LEED Programme launches this "Call for Initiatives" to extract what local authorities and other actors know works, what the new scenario is demanding and how equipped they are to respond. We are interested in learning from the experiences of EU member countries, the wider OECD area as well as other countries.

The OECD LEED Programme launches this "Call for Initiatives" to extract what local authorities and other actors know works, what the new scenario is demanding and how equipped they are to respond. We are interested in learning from the experiences of EU member countries, the wider OECD area as well as other countries.

Following recommendations from a National Academies of Sciences, Engineering, and Medicine report released earlier this year, the National Academies’ Gulf Research Program (GRP) is developing a long-term research campaign to improve understanding and prediction of the Gulf of Mexico Loop Current System (LCS).

Transport policies that produce physically segregated cycle lanes on main roads, combined with low-speed local streets, will boost numbers of cyclists and provide the best financial return on investment, new research suggests. Using Auckland, New Zealand as a case study the researchers showed that the economic benefits of this policy can outweigh the costs by more than 20 times.

From Michael Jordan to J.K. Rowling, these superstars prove the value of perseverance.

Baladna Food Industries, a subsidiary of Power International Holding, announced on October 17, 2019 to raise about QR1.42bn ($382m) in an initial public offering (IPO)

Former astronaut Leland Melvin encourages students to persevere as they continue to build and test their rockets

AP Photo/Alex Brandon

• The federal government on Saturday announced initial plans for distributing a promising coronavirus drug, remdesivir.
• The drug, manufactured by Gilead Sciences, was authorized for emergency use last week, but doctors and hospitals weren't sure how they were going to get it.
• The Department of Health and Human Services now say the drug is first being distributed to health departments in some hard-hit states, and the departments can distribute it to hospitals as they see fit. 
• Eventually, HHS expects the drug to be delivered to all 50 states, terrorities, the Veterans Health Administration and the Indian Health Service. 
• Visit Business Insider's homepage for more stories.

The federal government released its initial distribution plans today for the promising coronavirus drug, remdesivir, which was approved for emergency use last week. 

The drug, donated by manufacturer Gilead Sciences, "will be used to treat hospitalized COVID-19 patients in areas of the country hardest hit by the pandemic," the US Department of Health and Human Services' Office of the Assistant Secretary for Preparedness and Response (ASPR) said in a press release.

See the rest of the story at Business Insider

NOW WATCH: How the Navy's largest hospital ship can help with the coronavirus

See Also:

• The coronavirus drug remdesivir was OK'd for emergency use a week ago. The plan to get it to patients is still mired in confusion.
• Dispensed: Hospitals are stuck waiting for a promising coronavirus treatment
• 'It's hard to pay off your medical school loans in this kind of a job': Doctors who can protect the world against pandemics are in short supply

California passed legislation to allow college athletes to be compensated for their likeness. Under this new legislation, schools would not compensate student athletes, but athletes would be allowed to profit off their likeness via third party businesses. This law would… Read More

The post NCAA Passes Initial Steps for Student Athletes to Benefit from their Likeness appeared first on Anders CPAs.

Forex traders said stimulus measures announced by the RBI and FPIs turning net buyers in capital markets boosted investor sentiment.

The National Park Service (NPS) has announced that the Initial Bison Herd Reduction Environmental Assessment (EA), which evaluates management actions related to bison on Grand Canyon’s North Rim, is available for public review and comment. https://www.nps.gov/grca/learn/news/bison-ea.htm

The NPS has announced that it will extend the public comment period on the Initial Bison Herd Reduction Environmental Assessment (EA). The EA will now be available for public review and comment through June 14, 2017. https://www.nps.gov/grca/learn/news/initial-bison-herd-ea.htm

The Aquatic Conservation Strategy (ACS) of the Northwest Forest Plan guides management of riparian and aquatic ecosystems on federal lands in western Oregon, western Washington, and northern California.

NIELSEN HOLDINGS has filed an initial Form 10 Registration Statement with the U.S. SECURITIES AND EXCHANGE COMMISSION in connection with the Company's proposed separation of the NIELSEN … more

The Firefox DevTools underlying code, which is written with JavaScript and HTML, is a complex application. Due to the complexity and amount of work going on, the DevTools team has done everything they can to load as little as possible. Furthermore the team has a system of lazily importing and initializing objects when they’re needed. […]

The post Lazy Object Initialization appeared first on David Walsh Blog.

One proves the existence and uniqueness of a generalized (mild) solution for the nonlinear Fokker--Planck equation (FPE) egin{align*} &u_t-Delta (eta(u))+{mathrm{ div}}(D(x)b(u)u)=0, quad tgeq0, xinmathbb{R}^d, d e2, \ &u(0,cdot)=u_0,mbox{in }mathbb{R}^d, end{align*} where $u_0in L^1(mathbb{R}^d)$, $etain C^2(mathbb{R})$ is a nondecreasing function, $bin C^1$, bounded, $bgeq 0$, $Din(L^2cap L^infty)(mathbb{R}^d;mathbb{R}^d)$ with ${ m div}, Din L^infty(mathbb{R}^d)$, and ${ m div},Dgeq0$, $eta$ strictly increasing, if $b$ is not constant. Moreover, $t o u(t,u_0)$ is a semigroup of contractions in $L^1(mathbb{R}^d)$, which leaves invariant the set of probability density functions in $mathbb{R}^d$. If ${ m div},Dgeq0$, $eta'(r)geq a|r|^{alpha-1}$, and $|eta(r)|leq C r^alpha$, $alphageq1,$ $alpha>frac{d-2}d$, $dgeq3$, then $|u(t)|_{L^infty}le Ct^{-frac d{d+(alpha-1)d}} |u_0|^{frac2{2+(m-1)d}},$ $t>0$, and the existence extends to initial data $u_0$ in the space $mathcal{M}_b$ of bounded measures in $mathbb{R}^d$. The solution map $mumapsto S(t)mu$, $tgeq0$, is a Lipschitz contractions on $mathcal{M}_b$ and weakly continuous in $tin[0,infty)$. As a consequence for arbitrary initial laws, we obtain weak solutions to a class of McKean-Vlasov SDEs with coefficients which have singular dependence on the time marginal laws.

We consider two special cases of the connection problem for the second Painlev'e equation (PII) using the method of uniform asymptotics proposed by Bassom et al.. We give a classification of the real solutions of PII on the negative (positive) real axis with respect to their initial data. By product, a rigorous proof of a property associate with the nonlinear eigenvalue problem of PII on the real axis, recently revealed by Bender and Komijani, is given by deriving the asymptotic behavior of the Stokes multipliers.

A process for the production of aromatics through the reforming of a hydrocarbon stream is presented. The process utilizes the differences in properties of components within the hydrocarbon stream to increase the energy efficiency. The differences in the reactions of different hydrocarbon components in the conversion to aromatics allows for different treatments of the different components to reduce the energy used in reforming process.

Methods using a sequence of externally generated magnetic fields to initialize the magnetization directions of each of the layers in perpendicular MTJ MRAM elements for data and reference bits when the required magnetization directions are anti-parallel are described. The coercivity of the fixed pinned and reference layers can be made unequal so that one of them can be switched by a magnetic field that will reliably leave the other one unswitched. Embodiments of the invention utilize the different effective coercivity fields of the pinned, reference and free layers to selectively switch the magnetization directions using a sequence of magnetic fields of decreasing strength. Optionally the chip or wafer can be heated to reduce the required field magnitude. It is possible that the first magnetic field in the sequence can be applied during an annealing step in the MRAM manufacture process.

Disclosed herein are a pre-fill system to improve brake feel and a method of increasing an initial flux using the same which may reduce an invalid travel distance of a brake pedal. The pre-fill system includes a first housing connected with the master cylinder and provided with a first bore having a smaller-diameter portion and a larger-diameter portion, a second housing provided with a stepped second bore communicating with the first bore to be coupled with the first housing to define a hydraulic pressure chamber, a piston arranged in the first bore and provided with an oil channel unit, and a valve assembly adapted to open and close the oil channel unit of the piston according to the hydraulic brake pressure, wherein the piston applies pressure to the hydraulic pressure chamber through the piston to supply hydraulic pressure to the disc brake.

A method and apparatus for initializing a radio frequency identification tag are disclosed. For example, the method receives an optical signal having a unique identifier and an encryption key from a display by a radio frequency identification repeater associated with the radio frequency identification tag, wherein the radio frequency identification repeater comprises an optical reader. The method then transmits a communication comprising radio frequency identification information associated with the radio frequency identification tag and the unique identifier via the radio frequency identification repeater to a wireless access point, wherein the communication is encrypted using the encryption key.

This invention relates to a multi-room air conditioning system with a plurality of indoor expansion valves. A method for sequencing the initialization of each indoor expansion valve upon system startup is disclosed. The method includes the following steps: 1. Initializing expansion valves corresponding to active indoor units,2. Turning on the compressor,3. Adjusting the indoor expansion valves corresponding to active indoor units,4. Initializing and adjusting indoor expansion valves corresponding to inactive indoor units.

A method of reducing an initial stress on a cable includes stretching the cable to a first length to thereby define the initial stress. The cable has a central longitudinal axis, and includes a plurality of wires each twisted around the axis and formed from a shape memory alloy transitionable in response to a signal between a first state wherein each of the wires has a first temperature-dependent length, and a second state wherein each of the wires has a second temperature-dependent length that is less than the first. After stretching, the method includes activating the alloy by exposing the alloy to the signal such that the alloy transitions from the first to the second temperature-dependent state. Concurrent to activating, the method includes elongating the cable to a second length that is greater than the first to define a second stress on the cable that is less than the first.

After coming under pressure early in the session, stocks have regained some ground over the course of morning trading on Monday. The major averages have bounced well off their lows of the session, with the tech-heavy Nasdaq climbing into positive territory.

The major U.S. index futures are currently pointing to a sharply higher opening on Friday, with stocks likely to add to the gains posted in the previous session.

The major U.S. index futures are currently pointing to a lower opening on Monday, with stocks likely to give back ground following the strong upward move seen last week.

The major U.S. index futures are currently pointing to a higher opening on Thursday, with stocks likely to regain some ground following the sharp pullback seen in the previous session.

The major U.S. index futures are currently pointing to a lower opening on Thursday, with stocks likely to give back some ground following the rally seen in the previous session.

The major U.S. index futures are currently pointing to a higher open on Tuesday, with stocks likely to extend the rebound seen over the course of the previous session.

A senior manager of a Melbourne aged care home initially refused to act on video footage of elder abuse for a month due to the Christmas break, the aged care royal commission hears.

France has accused Beijing of concealing facts, while Germany has suggested it could demand compensation.

A Victorian family at risk of being deported back to their homeland Ireland after their son was diagnosed with cystic fibrosis will now be able to stay in Australia.

On Monday, Denver dispensaries saw their biggest sales day of the year so far, according to data firm Flowhub. Sales were up 140% compared to an average Monday, the company reported.

the Indiana Democratic State Central Committee decided to push back the noon Tuesday deadline to 10 a.m. Friday.

Nearly 120,000 more Indiana workers filed for unemployment, but the amount is less than the week before, signaling some encouragement.

New data from the U.S. Department of Labor reflects the continued toll of the coronavirus on Indiana workers.

strataconf: Read our initial findings of @amplab's open source benchmark for tracking large-scale Query Engines http://t.co/rGgOVeTHQ8 #strataconf

Alma L. Burlingame
Apr 1, 2020; 19:571-571
Editorial

Introduction: Aromatase inhibitors are the mainstay of hormonal therapy in estrogen receptor positive, postmenopausal breast cancer, although response rate is just over 50%. The goal of the present study was to validate and optimize positron emission tomography (PET) with ¹¹C-vorozole for measuring aromatase expression in postmenopausal breast cancer. Methods: Ten newly diagnosed, postmenopausal women with biopsy confirmed breast cancer were administered ¹¹C-vorozole intravenously and PET emission data collected between 40 – 90 minutes post-injection. Tracer injection and scanning were repeated 2 hours after ingestion of 2.5mg letrozole p.o. Mean and maximal standard uptake values and ratios to non-tumor tissue (SUVs, SUVRs) were calculated for tumor and non-tumor regions at baseline and after letrozole. Biopsy specimens from the same tumors were stained for aromatase using immunohistochemistry and evaluated for stain intensity and the percentage of immune-positive cells. Results: Seven of the 10 women (70%) demonstrated increased focal uptake of tracer (SUVR>1.1) coinciding with the mammographic location of the lesion. The other 3 women (30%) did not show increased uptake in the tumor (SUVR <1.0). All of the cases with SUVR above 1.1 had SUVs above 2.4 and there was no overlap in SUV between the two groups, with mean SUV in tumors overexpressing aromatase (SUVR>1.1) ranging from 2.47 to 13.6, while tumors not overexpressing aromatase (SUVR<1) ranged from 0.8 to 1.8. Pretreatment with letrozole reduced tracer uptake in the majority of subjects; although the %blocking varied across and within tumors. Tumors with high SUV in vivo also showed high staining intensity on IHC. Conclusion: PET with ¹¹C-vorozole is a useful technique for measuring aromatase expression in individual breast lesions, enabling a non-invasive quantitative measurement of baseline and post-treatment aromatase availability in primary tumors and metastatic lesions.

Background: Accurate definition of the extent and severity of left-ventricular assist device (LVAD) infection may facilitate therapeutic decision making and targeted surgical intervention. Here, we explore the value of ¹⁸F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) for guidance of patient management. Methods: Fifty-seven LVAD-carrying patients received 85 whole-body ¹⁸F-FDG PET/CT scans for the work-up of device infection. Clinical follow-up was obtained over a period of up to two years. Results: PET/CT showed various patterns of infectious involvement of the 4 LVAD components: driveline entry point (77% of cases), subcutaneous driveline path (87%), pump pocket (49%) and outflow tract (58%). Driveline smears revealed staphylococcus or pseudomonas strains as the underlying pathogen in a majority of cases (48 and 34%, respectively). At receiver-operating characteristics analysis, an ¹⁸F-FDG standardized uptake value (SUV) >2.5 was most accurate to identify smear-positive driveline infection. Infection of 3 or all 4 LVAD components showed a trend towards lower survival vs infection of 2 or less components (P = 0.089), while involvement of thoracic lymph nodes was significantly associated with adverse outcome (P = 0.001 for nodal SUV above vs below median). Finally, patients that underwent early surgical revision within 3 months after PET/CT (n = 21) required significantly less inpatient hospital care during follow-up when compared to those receiving delayed surgical revision (n = 11; p<0.05). Conclusion: Whole-body ¹⁸F-FDG PET/CT identifies the extent of LVAD infection and predicts adverse outcome. Initial experience suggests that early image-guided surgical intervention may facilitate a less complicated subsequent course.

Purpose: This prospective study evaluated the imaging performance of a novel immunological pretargeting positron-emission tomorgraphy (immuno-PET) method in patients with HER2-negative, carcinoembryonic antigen (CEA)-positive, metastatic breast cancer (BC), compared to computed tomography (CT), bone magnetic resonance imaging (MRI), and ¹⁸Fluorodeoxyglucose PET (FDG-PET). Patients and Methods: Twenty-three patients underwent whole-body immuno-PET after injection of 150 MBq ⁶⁸Ga-IMP288, a histamine-succinyl-glycine peptide given following initial targeting of a trivalent anti-CEA, bispecific, anti-peptide antibody. The gold standards were histology and imaging follow-up. Tumor standard uptake values (SUV_max and SUVmean) were measured, and tumor burden analyzed using Total Tumor Volume (TTV) and Total Lesion Activity (TLA). Results: Total lesion sensitivity of immuno-PET and FDG-PET was 94.7% (1116/1178) and 89.6% (1056/1178), respectively. Immuno-PET had a somewhat higher sensitivity than CT and FDG-PET in lymph nodes (92.4% vs 69.7% and 89.4%, respectively) and liver metastases (97.3% vs 92.1% and 94.8%, respectively), whereas sensitivity was lower for lung metastases (48.3% vs 100% and 75.9%, respectively). Immuno-PET showed higher sensitivity than MRI and FDG-PET for bone lesions (95.8% vs 90.7% and 89.3%, respectively). In contrast to FDG-PET, immuno-PET disclosed brain metastases. Despite equivalent tumor SUV_max, SUVmean, and TTV, TLA was significantly higher with immuno-PET compared to FDG PET (P = 0.009). Conclusion: Immuno-PET using anti-CEA/anti-IMP288 bispecific antibody, followed by ⁶⁸Ga-IMP288, is a potentially sensitive theranostic imaging method for HER2-negative, CEA-positive, metastatic BC patients, and warrants further research.

Wien : L.W. Seidel, 1875.