In the five months since her house was destroyed, Tod Adams has been at war with government agencies because the Fires Near Me app suggests her home was not affected.

Conservative skepticism toward both science and government intervention has shifted from an ideology to a pathology.

The startup anti-patterns section of my blog summarizes the repeatable ways startups waste time & money and, often, fail. Learning from startup failure is valuable because there are many more examples of failures that successes. (Anti-)Patterns become more noticeable and … Continue reading →

Research Event

Event participants

Alan Doss, President, Kofi Annan Foundation
 

Next week, Nicola Sturgeon is promising to outline her proposals for lifting the lockdown. Good luck with that. She is unlikely to open the schools because she can't rely on parents to send their children.

In late 2008, the Financial Services Authority (FSA) reviewed how firms had implemented key aspects of the Markets in Financial Instruments Directive (MiFID). It has now published the results of that review. Generally the FSA has been encouraged by ...

 Amy Sadro, Principal Associate in Eversheds Sutherland’s Environment, Health and Safety Team and Dr Chris Nelson, a Principal Consultant and specialist in noise and vibration at Finch Consulting give their views on recent HAVS prosecutio...

Investors and lawmakers in Hong Kong are urging regulators to seek compensation for people who lose money when listed companies collapse shortly after their initial public offerings.Under the current system, when banks sponsoring IPOs are found to have fallen short in their due diligence duties, the proceeds of any fine imposed by the watchdog goes to the government, not investors. Those fines amount to almost HK$1 billion (US$130 million) over the last 20 years, according to calculations by…

PURPOSE

Operational failures are system-level errors in the supply of information, equipment, and materials to health care personnel. We aimed to review and synthesize the research literature to determine how operational failures in primary care affect the work of primary care physicians.

Etravirine (ETR) is a nonnucleoside reverse transcriptase inhibitor (NNRTI) used in treatment-experienced individuals. Genotypic resistance test-interpretation systems can predict ETR resistance; however, genotype-based algorithms are derived primarily from HIV-1 subtype B and may not accurately predict resistance in non-B subtypes. The frequency of ETR resistance among recombinant subtype C HIV-1 and the accuracy of genotypic interpretation systems were investigated. HIV-1_LAI containing full-length RT from HIV-1 subtype C-positive individuals experiencing virologic failure (>10,000 copies/ml and >1 NNRTI resistance-associated mutation) were phenotyped for ETR susceptibility. Fold change (FC) was calculated against a composite 50% effective concentration (EC₅₀) from treatment-naive individuals and three classifications were assigned: (i) <2.9-FC, susceptible; (ii) ≥2.9- to 10-FC, partially resistant; and (iii) >10-FC, fully resistant. The Stanford HIVdb-v8.4 was used for genotype predictions merging the susceptible/potential low-level and low-level/intermediate groups for 3 x 3 comparison. Fifty-four of a hundred samples had reduced ETR susceptibility (≥2.9-FC). The FC correlated with HIVdb-v8.4 (Spearman’s rho = 0.62; P < 0.0001); however, 44% of samples were partially (1 resistance classification difference) and 4% completely discordant (2 resistance classification differences). Of the 34 samples with an FC of >10, 26 were HIVdb-v8.4 classified as low-intermediate resistant. Mutations L100I, Y181C, or M230L were present in 27/34 (79%) of samples with an FC of >10 but only in 2/46 (4%) of samples with an FC of <2.9. No other mutations were associated with ETR resistance. Viruses containing the mutation K65R were associated with reduced ETR susceptibility, but 65R reversions did not increase ETR susceptibility. Therefore, genotypic interpretation systems were found to misclassify ETR susceptibility in HIV-1 subtype C samples. Modifications to genotypic algorithms are needed to improve the prediction of ETR resistance for the HIV-1 subtype C.

Police in New York broke up a "4/20" marijuana party in Manhattan after receiving a tip that nearly 40 people were not practising social distancing during the coronavirus outbreak.

The government has blamed "technical issues" in labs for its failure to reach its coronavirus test target for four consecutive days.

Jenson Button complained of a lack of front end grip for his disappointing 12th place finish in the Korean Grand Prix that almost certainly rules him out of the title race

Perhaps the school should offer a course on parenting instead, so this problem is solved for the next generation.

He has flattered to deceive on umpteen occasions but highly-rated wicketkeeper-batsman Sanju Samson says he has learnt to accept his failures in pursuit of the calm demeanour that former India captain Mahendra Singh Dhoni possesses. The 25-year-old from Kerala has always been talked about by the likes of Rahul Dravid and Gautam Gambhir but it hasn't translated into international success with only four T20 Internationals in his kitty in the last five years.

"I have learnt to understand and focus more on my strengths and (be more) accepting (of) the failures. I try to contribute to the team's cause and try to take the team over the line. I am learning to focus and control my emotions while batting like MS Dhoni," Samson said during a podcast organised by Rajasthan Royals. He recently made a comeback in India's T20 side and it was a worthy experience for him. "It was great to be a part of the Indian team again. To be a part of one of the best teams in the world, surrounded by players like Virat bhai and Rohit bhai, it was a fantastic experience," Samson said. In one of the games in New Zealand, Samson was sent to bat in the Super Over, something which made him feel wanted in the Indian set-up. "It was a great feeling to be trusted by the players such as Virat bhai and Rohit bhai to go out there and bat in the crucial moments. It's a great feeling when the team and the players consider you to be a match winner." On a lighter note, Samson revealed that he refers to Steve Smith as "chachu" (uncle) after Brad Hodge once started calling him by that name.

"I share a very good relationship with 'Chachu' Steve Smith. He is one of the best brains in world cricket and we all enjoy a lot playing under him." Asked what's the back story of the nickname, Samson said: "It started with Brad Hodge, he used to call Smith 'Chachu', then when Hodgy left, I started calling Smith 'Chachu'. In return Smith also started calling me 'Chachu'. We both really enjoy and continue calling each other that." While Dhoni is his idol, he also loves watching Jos Buttler in Royals and makes notes on how the star Englishman prepares for games. "I observe Jos especially given he too is a wicketkeeper-batsman. He's always working on his skills and his game and never sits idle. "He's either working on his keeping, batting in the nets or running around the park. I love to observe and know how he thinks and prepares as a keeper before a game."

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There are no targeted therapies or immunotherapies proven effective to treat pediatric brain cancer better than chemotherapy. In fact, chemotherapy has

Appearing on Lorraine on Wednesday, the former EastEnders actress, 48, discussed her fertility issues, the death of mum, and explained how she keeps her mental health in check

Two-time London marathon winner Kenyan Wilson Kipsang has been provisionally suspended for whereabouts failures and tampering with samples, the Athletics Integrity Unit revealed.

When five-time Ballon d'Or winner and Barcelona star Lionel Messi eventually hangs up his boots, he might just have one huge regret lingering in the back of his mind.

The framework for assessing the environmental impact of new projects has in the past served to merely facilitate projects getting started. It was hoped that revisions proposed recently would change that, but there is little evidence of a new course, writes Shripad Dharmadhikary.

Despite being feted as a huge success, the flagship programme of the government for the universalisation of primary education leaves much to be desired. Ironically, the easy availability of the funds for a supposedly successful scheme may be preventing it from being as productive as it could otherwise be. Kalpana Misra reports.

The recently released CAG audit report on Maharashtra has heavily criticized the time and cost overruns in Gosikhurd irrigation project in Vidarbha. Himanshu Upadhyaya analyses the report to list the shortcomings of the project.

Dewey Library - JZ5675.S686 2019

Online Resource

Interview with Mario Castro, MD, author of Effect of Vitamin D₃ on Asthma Treatment Failures in Adults With Symptomatic Asthma and Lower Vitamin D Levels