Sam Howell tells New Scientist why NASA is so keen to visit Jupiter’s fourth-largest moon, Europa, and how the mission could help us figure out the likelihood of life elsewhere in the cosmos

Past observations have indicated that the icy moon of Jupiter has a vast subsurface ocean. Launching in October, NASA’s Europa Clipper will go there in search of evidence that it could support life

A 6000-kilogram spacecraft will embark on a six-year journey to Jupiter to explore whether its icy moon Europa has the conditions to support life

The huge spacecraft is headed toward the icy moon Europa, where it will use an array of instruments to survey for geologic activity, magnetism and more

[s.l.] : A. Francke Verlag, 2022.

München ; Wien : De Gruyter Oldenbourg, [2023]

IMAGES from the Europa League matches played on Thursday

The win leaves United in 15th place in the Europa League standings on six points from four games.

Embarking on a 1.8 million-mile journey from Kennedy Space Centre, the spacecraft is set to reach Jupiter in 5 1/2 years, utilising gravity assists from Mars and Earth

[Germany] : Elite Film AG, [2013]

99% is not enough, You have to give 100%. You have kill the game. You have to finish it off, says Manchester United manager Erik ten Hag

The record 20-time English champions are off to their joint-worst start in the Premier League era, collecting just seven points from six games and scoring a mere five goals

Substitute Harry Maguire came from the bench late to salvage a 3-3 draw for 10-man Manchester United at Porto in the Europa League

Chelsea routed Panathinaikos 4-1 in Athens to make it two wins from two in the third-tier Conference League.

The win leaves United in 15th place in the Europa League standings on six points from four games.

The win leaves United in 15th place in the Europa League standings on six points from four games.

The development of Green Infrastructure (GI) in a UK case study has been researched in a recent study. Some issues caused by an imbalance in stakeholder power and conflicting roles played by major stakeholders were identified with the project. Stakeholder participation is central to the concept of GI and the research reiterates the importance for those implementing GI to ensure that participation is effective and balanced.

The White House budget proposal for NASA in 2016 calls for a $500 million boost over the 2015 enacted budget and would keep NASA on its path to Mars.

Studio Europa LEICHT, San Diego's exclusive LEICHT dealer, announces the opening of its second LEICHT showroom in San Diego. Located at 2064 Kettner Blvd, the showroom will feature the latest premium kitchen and home concepts from LEICHT.

Studio Europa LEICHT announces the grand opening of its second LEICHT showroom in San Diego, featuring the latest kitchen and home concepts from LEICHT and premium appliances from our partners Gaggenau, Miele, Bosch, and Thermador.

San Diego-based, Studio Europa LEICHT takes 1st Place in the 2018 LEICHT Global Kitchen Design Competition for the best kitchen design in the US. The award honors the exceptional design and planning that went into the winning San Diego kitchen.

Low-level Light Therapy Provides a No Drug Approach to a Chronic Condition

Dallas Doctor Uses Non-Surgical Innovative Procedures to Help Relieve Neuropathy Symptoms with Great Success

Margaret M. Parker, MD, MCCM, speaks with Rakesh Lodha, MD, on his article titled Polyneuropathy in Critically Ill Mechanically Ventilated Children: Experience from Tertiary Care Hospital in North India, published the September issue of Pediatric Critical Care Medicine

The invention relates to human medicine and to the use of epidermal growth factor (EGF) for preparing a pharmaceutical composition which is administered by infiltration into the periphery of nerve ganglia and/or trunks for the morphofunctional restoration of peripheral nerves in painful sensory-motor neuropathy as well as manifestations of ischemic neuritis. The invention also includes a composition containing EGF which can be formulated together with anesthetics or analgesics or encapsulated in microspheres and to the use thereof for the morphofunctional restoration of peripheral nerves in painful sensitive-motor-type diabetic neuropathy and the manifestations of ischemic neuritis.

The present invention is relevant to human medicine, and, in particular, to the use of Epidermal Growth Factor (EGF) in a pharmaceutical composition, said composition is administered through infiltration at the periphery of nerve trunks and/or ganglia, for the morphofunctional restoration of peripheral nerves in painful, sensory-motor neuropathy, as well as ischemic neuritis. It is also relevant to an EGF containing composition, where this molecule can be formulated together with anesthetic or analgesic drugs, or encapsulated in microspheres, and their use for the morphofunctional restoration of peripheral nerves in painful, sensory-motor neuropathy, as well as in ischemic neuritis.

Bayer Leverkusen sporting director Simon Rolfes has urged Uefa to allow his side to play Rangers behind closed doors - to ensure the tournament is completed this season.

Finanzhilfen für besonders von der Krise getroffene Länder wie Italien? Die Erfahrung mit der deutschen Währungsunion zeigt, dass das allein nicht reichen wird. Es gilt, die Wirtschaftsstruktur anzupassen. Dazu braucht es relative Preisänderungen.

12-Jan-2015 12:11.

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Was ist nur aus dem großen Friedensprojekt Europa geworden? Für Alexander Göbel ist es eine Liebe mit herben Enttäuschungen, immer wieder zum Haare-Raufen. Und trotz der "Fortwurschtelei" ist es alternativlos.

Die Spitzen der EU haben sich besorgt gezeigt über den Zustand der Gemeinschaft. Durch die Corona-Krise drohe eine Schwächung Europas - zulasten der Ärmsten. Erhebliche Kritik gibt es an den Grenzschließungen.

Jewel beetles iridescent camouflage, better talk on climate change and flying west

Treating neuropathic pain is challenging and novel non–opioid-based medicines are needed. Using unbiased receptomics, transcriptomic analyses, immunofluorescence, and in situ hybridization, we found that the expression of the orphan GPCR Gpr160 and GPR160 increased in the rodent dorsal horn of the spinal cord following traumatic nerve injury. Genetic and immunopharmacological approaches demonstrated that GPR160 inhibition in the spinal cord prevented and reversed neuropathic pain in male and female rodents without altering normal pain response. GPR160 inhibition in the spinal cord attenuated sensory processing in the thalamus, a key relay in the sensory discriminative pathways of pain. We also identified cocaine- and amphetamine-regulated transcript peptide (CARTp) as a GPR160 ligand. Inhibiting endogenous CARTp signaling in spinal cord attenuated neuropathic pain, whereas exogenous intrathecal CARTp evoked painful hypersensitivity through GPR160-dependent ERK and cAMP response element–binding protein (CREB). Our findings de-orphanize GPR160, identify it as a determinant of neuropathic pain and potential therapeutic target, and provide insights into its signaling pathways. CARTp is involved in many diseases including depression and reward and addiction; de-orphanization of GPR160 is a major step forward understanding the role of CARTp signaling in health and disease.

Scientists have gotten their best look to date at three chaotic patches on the icy surface of Jupiter's moon Europa thanks to decade-old images from a long-defunct spacecraft.

We should have taken it as a sign of what was to come a gruff taxi driver who reeked of cigarette smoke greeted us with little more than a grunt and yelled out arschloch half a dozen times during our short journey to the train station. One scary frau

A couple of days ago, Thomas Dolby posted this video to Twitter and YouTube of a track called "Corona and the Pirate Twins," a spoof of his 1982 hit, "Europa and the Pirate Twins." The song is credited to Dolby Kids. Thomas included the following note:

"This is what my mischievous offspring have been getting up to during the Lockdown."

Here is the original video for "Europa..."

Bonus track:

And here is Thomas Dolby doing a touching home solo version of his achingly beautiful "Screen Kiss" from 1984's Flat Earth. He did it as a tribute to Matthew Seligman, the celebrated bassist who recently died of COVID-19. Seligman played bass on Dolby's recordings, including Flat Earth, and also played for Bowie, Robyn Hitchcock, Peter Murphy, and countless others. He was also a member of the Soft Boys.

Image: YouTube Read the rest

Barbara H. Braffett
May 1, 2020; 69:1000-1010
Complications

Christer S. Andreassen
Mar 1, 2006; 55:806-812
Complications

Schwann cell–derived exosomes communicate with dorsal root ganglia (DRG) neurons. The current study investigated the therapeutic effect of exosomes derived from healthy Schwann cells (SC-Exos) on diabetic peripheral neuropathy (DPN). We found that intravenous administration of SC-Exos to type 2 diabetic db/db mice with peripheral neuropathy remarkably ameliorated DPN by improving sciatic nerve conduction velocity and increasing thermal and mechanical sensitivity. These functional improvements were associated with the augmentation of epidermal nerve fibers and remyelination of sciatic nerves. Quantitative RT-PCR and Western blot analysis of sciatic nerve tissues showed that SC-Exo treatment reversed diabetes-reduced mature form of miRNA (miR)-21, -27a, and -146a and diabetes-increased semaphorin 6A (SEMA6A); Ras homolog gene family, member A (RhoA); phosphatase and tensin homolog (PTEN); and nuclear factor-B (NF-B). In vitro data showed that SC-Exos promoted neurite outgrowth of diabetic DRG neurons and migration of Schwann cells challenged by high glucose. Collectively, these novel data provide evidence that SC-Exos have a therapeutic effect on DPN in mice and suggest that SC-Exo modulation of miRs contributes to this therapy.

Studies on magnetic resonance neurography (MRN) in diabetic polyneuropathy (DPN) have found proximal sciatic nerve lesions. The aim of this study was to evaluate the functional relevance of sciatic nerve lesions in DPN, with the expectation of correlations with the impairment of large-fiber function. Sixty-one patients with type 2 diabetes (48 with and 13 without DPN) and 12 control subjects were enrolled and underwent MRN, quantitative sensory testing, and electrophysiological examinations. There were differences in mechanical detection (Aβ fibers) and mechanical pain (A fibers) but not in thermal pain and thermal detection clusters (C fibers) among the groups. Lesion load correlated with lower Aα-, Aβ-, and A-fiber but not with C-fiber function in all participants. Patients with lower function showed a higher load of nerve lesions than patients with elevated function or no measurable deficit despite apparent DPN. Longer diabetes duration was associated with higher lesion load in patients with DPN, suggesting that nerve lesions in DPN may accumulate over time and become clinically relevant once a critical amount of nerve fascicles is affected. Moreover, MRN is an objective method for determining lower function mainly in medium and large fibers in DPN.

Andrew J.M. Boulton
Jan 1, 2005; 23:9-15
Feature Articles

OBJECTIVE

To assess the contemporaneous prevalence of diabetic peripheral neuropathy (DPN) in people with type 1 diabetes (T1D) in Scotland and study its cross-sectional association with risk factors and other diabetic complications.

Catherine L. Martin
Jan 1, 2014; 37:31-38
DCCT/EDIC 30th Anniversary Summary Findings

OBJECTIVE

To evaluate the contemporary prevalence of diabetic peripheral neuropathy (DPN) in participants with type 1 diabetes in the T1D Exchange Clinic Registry throughout the U.S.

OBJECTIVE

Corneal nerve fiber length (CNFL) represents a biomarker for diabetic distal symmetric polyneuropathy (DSP). We aimed to determine the reference distribution of annual CNFL change, the prevalence of abnormal change in diabetes, and its associated clinical variables.

OBJECTIVE

To investigate the association of metabolic and lifestyle factors with possible diabetic polyneuropathy (DPN) and neuropathic pain in patients with early type 2 diabetes.

Andrew J.M. Boulton
Jan 1, 2005; 23:9-15
Feature Articles