OPEC and the U.S. can help ease oil prices in case there is disruption in supply due to a full-blown conflict between Israel and Iran; while OPEC has enough spare capacity to compensate for the loss of Iranian supplies, much of that capacity is in the Gulf region and potentially vulnerable to attack

The National Water Commission (NWC) says a loss in power supply forced the shutdown of the Dinthill facility today, leaving some northern St Catherine communities without water.  The affected communities are: Linstead,...

The UK’s tallest mountain is Ben Nevis in Scotland. Recently, it became one metre taller, standing now at 1 345m rather than 1 344m above sea level. Of course, the mountain did not actually grow. Rather, the team of Ordnance Survey experts who re-measured it for the first time since 1949 were able to do so more accurately because of improvements in technology, and specifically through the use of GPS.

This guidance document was originally published in 2012 and updated in 2018 to reflect new and updated OECD test guidelines, as well as reflect on scientific advances in the use of test methods and assessment of the endocrine activity of chemicals. The document is intended to provide guidance for evaluating chemical using standardised test guidelines.

Sadoun: “This is how I work: I go fast, I take risk, I learn, I correct if it’s not good”

The likes of Christian Eriksen and Victor Wanyama were expected to leave in the summer but both have remained in north London, with Pochettino insisting they are in his plans.

As sales and exports of fish crash, another huge crisis is staring at Sri Lanka’s fisherfolk.

Our expert panel discusses the landscape of tech disruption in insurance, as well as what brokers can expect from technology in the future

A new study finds that sleep disruptions are particularly common--and particularly problematic--among children with asthma; these findings have won the attention of immunologist Dr. Jesse Stoff.

Into The Sun Entertainment Is Named One Of The Sponsors For David Lynch's Upcoming "Festival of Disruption"

The HBS sage and McKinsey head discuss how to stay on top in a rapidly changing industry.

R. "Ray" Wang, author of "Disrupting Digital Business" on how business is transforming.

Organizations are struggling to implement an immediate crisis response mechanism while exploring long term sustainability solutions to build resilience against future black swan events.

Federal authorities announced today that an ongoing cooperative effort between law enforcement and a number of private-sector companies, including multiple internet domain providers and registrars, has disrupted hundreds of internet domains used to exploit the COVID-19 pandemic to commit fraud and other crimes.

A system that may be used as an initiation disruption system (IDS) according to one embodiment includes an explosive charge; a plurality of particles in a layer at least partially surrounding the explosive charge; and a fire suppressant adjacent the plurality of particles. A method for disabling an object according to one embodiment includes placing the system as recited above near an object; and causing the explosive charge to initiate, thereby applying mechanical loading to the object such that the object becomes disabled. Additional systems and methods are also presented. A device according to another embodiment includes a plurality of particles bound by a binder thereby defining a sidewall having an interior for receiving an explosive; and a fire suppressant adjacent the plurality of particles and binder. Additional systems and methods are also presented.

Aspects of the present disclosure include a navigation system and computer-implemented methods for detecting traffic disruption events based on an analysis of input component data obtained from navigation-enabled devices of vehicles near a particular location. Traffic disruption events are events such as accidents, construction road closures, police and speed traps, or road hazards that cause a decrease in the flow of traffic along a particular route and thus, added time delays for occupants of vehicles traveling along those routes. The navigation system scores the input component data associated with each vehicle and aggregates the scored input component data to obtain a frustration score associated with the vehicle. The navigation system may detect traffic disruption events based on a number of vehicles near a particular area having associated frustration scores above a certain threshold.

Coming on the heels of the AB5 trauma, the coronavirus lockdown poses an extra economic threat. The COVID-19 pandemic has affected all facets of life in California and the world.…

HAMPSHIRE rail users can expect a week of disruptions.

World's gold demand during the first quarter of 2019 stood at 1070.8 tonne, according to WGC's Q1 Gold Demand Trends report.

Macy's, like many retailers, has had to close its stores, furlough employees, suspend dividend and tap into credit facilities to survive the financial hit caused by the lockdowns.

The Mayors of DeKalb and Rockford responded to the statewide minimum wage hike that was signed into law last week. The measure will raise the state's minimum wage to $15 per hour by 2025. DeKalb Mayor Jerry Smith worries about the effect this may have on small businesses. Smith says he would have preferred that the increase be done more incrementally. "I would have liked to have seen something that was written into law that mandated perhaps a one or two year step, and then let's take a look at it," he said. "You know, economies change." But he says the law taking effect means businesses know what to expect. "If you know that you're going to be paying nine and a quarter next year and ten the following year, or whatever the case may be, the smart businesses -- small or large -- are going to make those adjustments that are necessary so the bottom line is still black," he said. Smith says the City of DeKalb already pays its employees at a level where the wage hike's effect on city

Food production has been seriously disrupted to the coronavirus pandemic. It has forced producers, including dairy farmers, to dispose of more of their supplies, which has led to more food waste. Joe Diglio, president/CEO of the Michigan Milk Producers Association, has a conversation with WEMU's David Fair about how the problems are being addressed in this week's "Issues of the Environment."

Food production has been seriously disrupted to the coronavirus pandemic. It has forced producers, including dairy farmers, to dispose of more of their supplies, which has led to more food waste. Joe Diglio, president/CEO of the Michigan Milk Producers Association, has a conversation with WEMU's David Fair about how the problems are being addressed in this week's "Issues of the Environment."

QBE's chief executive says the eventual recovery from COVID-19 will hasten the trend of digital disruption that was underway before the pandemic began.

Digital disruption has changed the craft of writing, and crime writing in particular, according to those in the industry, but has not caused the death of print books.

The sizzle of a steak on a barbecue may soon sound a little different as Australia's $16.8 billion beef industry prepares to adapt to demands from 'locavores' and technological change.

While marketing and sales professionals increasingly find themselves drowning in data, a new IBM study finds that nearly two thirds—64 percent--of surveyed CMOs and sales leaders believe their industries will be ready to adopt cognitive technologies in the next three years. However despite this stated readiness, the study finds that only 24 percent of those surveyed believe they have strategy in place to implement these technologies today.

Etude IBM : les directions Marketing doivent adopter la « disruption créative » pour fidéliser leurs clients La nouvelle étude IBM révèle les principaux axes de priorités des directions Marketing pour 2016

The latest episode of the "She Roars" podcast features Wendy Kopp, Class of 1989, reflecting on her experience as a groundbreaking social entrepreneur — which she has been since long before the term was invented.

The outbreak of the coronavirus has dealt a shock to the global economy with unprecedented speed as it continues to spread across the world. Here is a look at some of the latest developments Wednesday related to the global economy, particular economic sectors, and the workplace.

CSU Chancellor Timothy P. White and the presidents of the Northridge and East Bay campuses say they will stay on through fall 2020.

A lawsuit announced Tuesday seeks refunds for students who, as a result of the coronavirus closures, lost out on in-person instruction, housing, meals and other elements of campus life and were not paid back tuition and fees.

Fire crews attended around 160 weather related incidents in a 12 hour period.

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Nica M. Borradaile
Dec 1, 2006; 47:2726-2737
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The coach and rail journey app has launched a new AI voice app for automated disruption alerts

(Kudos Innovations Ltd) Kudos helps researchers maximize reach and visibility of research by opening up Kudos Pro. The platform helps showcase work to a range of target audiences, supporting researchers in fields where conferences have been cancelled -- and those with COVID-19-relevant work that needs rapid communication. Over 2,000 researchers have already signed up.

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A Smarter Balanced testing vendor has released completion rates in three states that had serious challenges giving the common-core aligned exam.

Synaptic dysfunction provoking dysregulated cortical neural circuits is currently hypothesized as a key pathophysiological process underlying clinical manifestations in Alzheimer's disease and related neurodegenerative tauopathies. Here, we conducted PET along with postmortem assays to investigate time course changes of excitatory and inhibitory synaptic constituents in an rTg4510 mouse model of tauopathy, which develops tau pathologies leading to noticeable brain atrophy at 5-6 months of age. Both male and female mice were analyzed in this study. We observed that radiosignals derived from [¹¹C]flumazenil, a tracer for benzodiazepine receptor, in rTg4510 mice were significantly lower than the levels in nontransgenic littermates at 2-3 months of age. In contrast, retentions of (E)-[¹¹C]ABP688, a tracer for mGluR5, were unaltered relative to controls at 2 months of age but then gradually declined with aging in parallel with progressive brain atrophy. Biochemical and immunohistochemical assessment of postmortem brain tissues demonstrated that inhibitory, but not excitatory, synaptic constituents selectively diminished without overt loss of somas of GABAergic interneurons in the neocortex and hippocampus of rTg4510 mice at 2 months of age, which was concurrent with enhanced immunoreactivity of cFos, a well-characterized immediate early gene, suggesting that impaired inhibitory neurotransmission may cause hyperexcitability of cortical circuits. Our findings indicate that tau-induced disruption of the inhibitory synapse may be a critical trigger of progressive neurodegeneration, resulting in massive neuronal loss, and PET assessments of inhibitory versus excitatory synapses potentially offer in vivo indices for hyperexcitability and excitotoxicity early in the etiologic pathway of neurodegenerative tauopathies.

SIGNIFICANCE STATEMENT In this study, we examined the in vivo status of excitatory and inhibitory synapses in the brain of the rTg4510 tauopathy mouse model by PET imaging with (E)-[¹¹C]ABP688 and [¹¹C]flumazenil, respectively. We identified inhibitory synapse as being significantly dysregulated before brain atrophy at 2 months of age, while excitatory synapse stayed relatively intact at this stage. In line with this observation, postmortem assessment of brain tissues demonstrated selective attenuation of inhibitory synaptic constituents accompanied by the upregulation of cFos before the formation of tau pathology in the forebrain at young ages. Our findings indicate that selective degeneration of inhibitory synapse with hyperexcitability in the cortical circuit constitutes the critical early pathophysiology of tauopathy.

Poor health in children is associated with exposure to family violence and disruption. Telomere length has been hypothesized to be a lasting biological indicator of exposure to early adversity and potentially predictive of negative health outcomes throughout the life course.

Telomere length reflects exposure to family violence and disruption and may be an early indicator of the biological impact of early adversity. Children exposed to interpersonal violence and family disruptions had significantly shorter telomeres. Gender moderated these associations. (Read the full article)

While four of the MPC members voted in favour of the eventual 75-basis point (bps) cut, external members Chetan Ghate and Pami Dua argued for a 50-bps cut, the minutes, released on Monday, showed.

Join us today, May 5 — Coronavirus and Supply Chains Disruption Panel Broadcast at: 7:45 am PCT, 10:45 am EST, 3:45 pm BST and 4:45 pm CET COVID-19 has caused severe supply chain disruptions and has affected almost every facet of our daily lives. What will the landscape look like after this disease passes and […]

Professional pyrotechnician Zack James is lighting his next fuse under the tractor market. The founder of Rabbit Tractors develops autonomous farm robots intended for multiple tasks and to be scaled up in number as needed, challenging traditional tractors. Based in northwest Indiana, Rabbit Tractors is a so-called swarm farming startup among a field of like-minded Read article >

The post Field Day: AI Startup Cultivates Robo Tractors for ‘Swarm Farming’ Disruption appeared first on The Official NVIDIA Blog.

The European guide to strikes and other industrial action has been created by Eversheds Sutherland to provide you with a quickand easy reference when responding to threats of industrial action in 15 European countries. Click here to download the pub...