En el programa 6AM Hoy por Hoy de Caracol Radio, el Ministro del interior no guarda sus palabras al señalar al exfuncionario Olmedo López

En 6AM Hoy por Hoy de Caracol Radio estuvo Luis Fernando Velasco, exministro de Interior, para hablar en qué consiste la propuesta que planteó para aliviar la coyuntura que hoy enfrenta el país y el sector transportador.

[Written by Stephen Wright] Boxer Nikki Bascome will face American Rashad Kilpatrick in the co-main event at The Shed in Dockyard on March 30. Kilpatrick, who has lost two of his nine professional contests, defeated Juan de la Cruz Rodriguez [11-22-1], of El Salvador, by unanimous decision in Baltimore in September last year in his […]

[Written by Stephen Wright] Boxer Nikki Bascome insists he is still as hungry as ever as he gears up for his professional bout against American Rashad Kilpatrick at The Shed in Dockyard next Saturday [May 25]. Bascome, who will face Rashad in an eight-round welterweight contest, has not fought since defeating Filipino Alvin Lagumbay on […]

Boxer Nikki Bascome claimed a unanimous points win over American Rashad Kilpatrick in the co-main event at The Shed in Dockyard yesterday [May 25]. Bascome dominated his opponent throughout the eight-round welterweight contest to improve his record in the paid ranks to 14 wins and one defeat. The 33-year-old wrote on Instagram: “Thank you God […]

[Written by Stephen Wright] Boxer Nikki Bascome says he has more fights left in the tank after his unanimous points win over American Rashad Kilpatrick in the co-main event at The Shed in Dockyard on Saturday [May 25]. Bascome improved his professional record to 13 wins from 14 bouts after a controlled display in his […]

He was trying to get the attention of a mascot.

Ascot announced today the appointment of Ian Grayson as Chief Information Officer for UK/ Bermuda. A spokesperson said, “In this newly created role, Ian is responsible for developing and executing a technology transformation strategy and driving technology-based innovation and growth to support the company’s robust UK and Bermuda platforms. He will report to Owen Williams, […]

Ascot Group Limited announced that Kewsong Lee, the Founder and CEO of BellTower Partners [BellTower], will be appointed Chairman of the Ascot Board of Directors. A spokesperson said, “Ascot Group Limited, the Bermuda-based global specialty insurance company, announced that Kewsong Lee, the Founder and CEO of BellTower Partners [BellTower], will be appointed Chairman of the […]

Flora Of Bermuda, owned by Bermuda Racing, claimed a third-place finish at Ascot in the prestigious Group One Qipco British Champions Sprint Stakes in England last weekend. Drawn in stall 20 in the 20-strong field, the three-year-old, who went off a 25-1, ran strongly on the soft ground under jockey Oisin Murphy. Simon Scupham, founder […]

The Boston AIGA selected Bermudian Daren Bascome, Managing Director of Proverb Agency, as one of three recipients of the 2024 Fellows award for his significant contributions to the local design community. A spokesperson said, “The Boston AIGA [American Institute of Graphic Artists] selects Bermuda native Daren Bascome, Managing Director of award-winning branding and advertising firm […]

Bermudian Daren Bascome spoke at the 2024 AIGA Boston Fellow Awards Celebration, with Mr. Bascome himself among the event’s three awardees. A spokesperson said, “‘Being a great designer isn’t about what you know, it’s about what you notice,’ said Daren Bascome, Managing Director of Proverb Agency on Tuesday at the 2024 AIGA Boston Fellow Awards […]

Nikki Bascome – who is well known for his skills in the boxing ring — is showcasing another one of his talents, this time his musical ability, with Mr Bascome releasing a new music video and song entitled “Picture Me”. Related Stories Video: Performing Arts Camp Cup Match Song Devaune Ratteray Releases ‘Dark & Stormy’ […]

By Wallace White Los Angeles County District Attorney George Gascon lost his seat in a landslide to independent challenger Nathan Hochman, The Associated Press and Los Angeles Times reported. Gascon is projected to lose against Hochman in a crucial seat in one of America’s most crime-ridden cities, according to the AP and the LA Times […]

The post Soros-Backed George Gascon Loses Los Angeles DA Race In Landslide appeared first on Liberty Unyielding.

Global design firm cuts development time and costs in half

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

Even by the already-painfully-embarrassingly-low standards of clinical trial enrollment in general, patient enrollment in cancer clinical trials is slow. Horribly slow. In many cancer trials, randomizing one patient every three or four months isn't bad at all – in fact, it's par for the course. The most
commonly-cited number is that only 3% of cancer patients participate in a trial – and although exact details of how that number is measured are remarkably difficult to pin down, it certainly can't be too far from reality.

Ultimately, the cost of slow enrollment is borne almost entirely by patients; their payment takes the form of fewer new therapies and less evidence to support their treatment decisions.

So when a couple dozen thousand of the world's top oncologists fly into Chicago to meet, you'd figure that improving accrual would be high on everyone’s agenda. You can't run your trial without patients, after all.

But every year, the annual ASCO meeting underdelivers in new ideas for getting more patients into trials. I suppose this a consequence of ASCO's members-only focus: getting the oncologists themselves to address patient accrual is a bit like asking NASCAR drivers to tackle the problems of aerodynamics, engine design, and fuel chemistry.

Nonetheless, every year, a few brave souls do try. Here is a quick rundown of accrual-related abstracts at this year’s meeting, conveniently sorted into 3 logical categories:

1. As Lord Kelvin may or may not have said, “If you cannot measure it, you cannot improve it.”

• Abstract e15572: Inadequate data availability on clinical trial accrual and its effect on progress in cancer research

Probably the most sensible of this year's crop, because rather than trying to make something out of nothing, the authors measure exactly how pervasive the nothing is. Specifically, they attempt to obtain fairly basic patient accrual data for the last three years' worth of clinical trials in kidney cancer. Out of 108 trials identified, they managed to get – via search and direct inquiries with the trial sponsors – basic accrual data for only 43 (40%).

That certainly qualifies as “terrible”, though the authors content themselves with “poor”.

Interestingly, exactly zero of the 32 industry-sponsored trials responded to the authors' initial survey. This fits with my impression that pharma companies continue to think of accrual data as proprietary, though what sort of business advantage it gives them is unclear. Any one company will have only run a small fraction of these studies, greatly limiting their ability to draw anything resembling a valid conclusion.

• Abstract TPS6645: Predictors of accrual success for cooperative group trials: The Cancer and Leukemia Group B (Alliance) experience

CALGB investigators look at 110 trials over the past 10 years to see if they can identify any predictive markers of successful enrollment. Unfortunately, the trials themselves are pretty heterogeneous (accrual periods ranged from 6 months to 8.8 years), so finding a consistent marker for successful trials would seem unlikely.

And, in fact, none of the usual suspects (e.g., startup time, disease prevalence) appears to have been significant. The exception was provision of medication by the study, which was positively associated with successful enrollment.

The major limitation with this study, apart from the variability of trials measured, is in its definition of “successful”, which is simply the total number of planned enrolled patients. Under both of their definitions, a slow-enrolling trial that drags on for years before finally reaching its goal is successful, whereas if that same trial had been stopped early it is counted as unsuccessful. While that sometimes may be the case, it's easy to imagine situations where allowing a slow trial to drag on is a painful waste of resources – especially if results are delayed enough to bring their relevance into question.

Even worse, though, is that a trial’s enrollment goal is itself a prediction. The trial steering committee determines how many sites, and what resources, will be needed to hit the number needed for analysis. So in the end, this study is attempting to identify predictors of successful predictions, and there is no reason to believe that the initial enrollment predictions were made with any consistent methodology.

2. If you don't know, maybe ask somebody?

• Abstract 8592: Strategies to overcome barriers to accrual (BtA) to NCI-sponsored clinical trials: A project of the NCI-Myeloma Steering Committee Accrual Working Group (NCI-MYSC AWG)
  
• Abstract 1596: Rapid online feedback to improve clinical trial accrual: CODEL anaplastic glioma (AG) (NCCTG/Alliance N0577) as a model

With these two abstracts we celebrate and continue the time-honored tradition of alchemy, whereby we transmute base opinion into golden data. The magic number appears to be 100: if you've got 3 digits' worth of doctors telling you how they feel, that must be worth something.

In the first abstract, a working group is formed to identify and vote on the major barriers to accrual in oncology trials. Then – and this is where the magic happens – that same group is asked to identify and vote on possible ways to overcome those barriers.

In the second, a diverse assortment of community oncologists were given an online survey to provide feedback on the design of a phase 3 trial in light of recent new data. The abstract doesn't specify who was initially sent the survey, so we cannot tell response rate, or compare survey responders to the general population (I'll take a wild guess and go with “massive response bias”).

Market research is sometimes useful. But what cancer clinical trial do not need right now are more surveys are working groups. The “strategies” listed in the first abstract are part of the same cluster of ideas that have been on the table for years now, with no appreciable increase in trial accrual.

3. The obligatory “What the What?” abstract

• Abstract 6564: Minority accrual on a prospective study targeting a diverse U.S. breast cancer population: An analysis of Wake Forest CCOP research base protocol 97609

The force with which my head hit my desk after reading this abstract made me concerned that it had left permanent scarring.

If this had been re-titled “Poor Measurement of Accrual Factors Leads to Inaccurate Accrual Reporting”, would it still have been accepted for this year’s meeting? That's certainly a more accurate title.

Let’s review: a trial intends to enroll both white and minority patients. Whites enroll much faster, leading to a period where only minority patients are recruited. Then, according to the authors, “an almost 4-fold increase in minority accrual raises question of accrual disparity.” So, sites will only recruit minority patients when they have no choice?

But wait: the number of sites wasn't the same during the two periods, and start-up times were staggered. Adjusting for actual site time, the average minority accrual rate was 0.60 patients/site/month in the first part and 0.56 in the second. So the apparent 4-fold increase was entirely an artifact of bad math.

This would be horribly embarrassing were it not for the fact that bad math seems to be endemic in clinical trial enrollment. Failing to adjust for start-up time and number of sites is so routine that not doing it is grounds for a presentation.

The bottom line

What we need now is to rigorously (and prospectively) compare and measure accrual interventions. We have lots of candidate ideas, and there is no need for more retrospective studies, working groups, or opinion polls to speculate on which ones will work best.  Where possible, accrual interventions should themselves be randomized to minimize confounding variables which prevent accurate assessment. Data needs to be uniformly and completely collected. In other words, the standards that we already use for clinical trials need to be applied to the enrollment measures we use to engage patients to participate in those trials.

This is not an optional consideration. It is an ethical obligation we have to cancer patients: we need to assure that we are doing all we can to maximize the rate at which we generate new evidence and test new therapies.

[Image credit: Logarithmic turtle accrual rates courtesy of Flikr user joleson.]

1. The Appellant filed an RTI application dated 16.05.2023 seeking information on the following points:

"Please provide the specific information / clarification on Central Civil Services (Leave) Rules, 1972. (updated as on 19.09.2022)

(i) Please inform who are 'such Government Servant' referred under Rule 63 (2)(a) above

(ii) Please clarify whether Rule 63(2)(a) is applicable to only to those Government servants refereed 63(1)(a) and (b)

(iii) Whether both the actual amount of leave salary (Rule 63(1)) and study leave conversion to regular leave (Rule 63 (2) (a) are applicable to all government servants referred in 63 (1) and 63 (2)

Just hours after President Donald Trump announced that he intends to withdraw the United States from Paris Climate Agreement, three state governors announced the formation of the United States Climate Alliance, a union that will work to reduce greenhouse gas emissions, even as national leadership on climate change falters.

For now, the alliance includes California, New York and Washington State. The governors of those states, Jerry Brown, Andrew Cuomo, and Jay Inslee, respectively, released a statement on Thursday describing how the new alliance will build state-level partnerships to continue aggressive American action on climate change and uphold the goals and standards of the Paris Agreement.

"The president has already said climate change is a hoax, which is the exact opposite of virtually all scientific and worldwide opinion," said Governor Brown in the statement. "I don't believe fighting reality is a good strategy—not for America, not for anybody. If the president is going to be AWOL in this profoundly important human endeavor, then California and other states will step up."

Governor Cuomo echoed that sentiment. Trump's "reckless decision to withdraw from the Paris Climate Agreement has devastating repercussions not only for the United States, but for our planet," he said. "This administration is abdicating its leadership and taking a backseat to other countries in the global fight against climate change."

California, New York, and Washington combined are home nearly 70 million people, about 20 percent of the US population. And their governments have already begun to take action. For example, the California State Senate passed legislation on Wednesday that mandates California to develop 100 percent of its electricity from renewable resources by 2045.

So far, no other states have signed on to the alliance, though 61 American mayors also pledged on Thursday that their cities will uphold the tenets of the Paris Climate Agreement.

Lotus technical chief Mike Gascoyne said his team's performance in Canada was a 'massive step forward'

VERSUS ASCON AGRO PRODUCTS EXPORTERS AND BUILDERS PRIVATE LIMITED BEFORE The Hon'ble Justice SHAMPA SARKAR Date: 28th April, 2020 Apperance Mr. Saunak Ghosh, Adv. with Mr. Rajib Mullick, Adv.

..for the decree holder Mr. Dipanjan Roy, Adv (in person) ..for the judgment debtor The Court: GA No.803 of 2020 is an application filed by the decree holder for non-prosecution of the Execution Case no.302 of 2019 arising out of a judgment and decree dated July 26, 2017 passed in CS No.115 of 2013, in view of settlement arrived at by and between the parties.

Alex Morgan welcomed her first child with husband Servando Carrasco, 31, a daughter named Charlie, on Thursday.

The creator of Tabasco sauce is often credited with a proliferation of large rodents called nutria in the swamps of Louisiana.

DL-820 offers exceptional value and host of features

DC-7600 and DC-3300 to be officially launched at GITEX

Card identification printers to be sold "direct-to-consumer" at www.dascomcardprinters.com

New Offering is 20% faster than brand's current fastest models

AUTOCROP system now re-branded as HYVE™ to be most descriptive of company's indoor farming products.

Franklin fiasco will not have any bearing on other mutual funds: Nilesh Shah

The Franklin Templeton Mutual Fund fiasco seems to have hit the debt mutual fund space very hard. The data released by Association of Mutual Funds in India or Amfi reveals that most debt mutual fund categories have witnessed outflows in the last month.

Eclipse Award-winning jockey Jose Ortiz will be headed to Royal Ascot on a strong pair of contenders, reports the TDN. In the Group 1 Queen Anne Stakes, he will be astride recent G1 winner Yoshida for trainer Bill Mott. In the G1 King's Stand, Ortiz will ride Grade 2 winner Bucchero for trainer Tim Glyshaw. “Jose […]

The post Jose Ortiz To Ride Yoshida, Bucchero At Royal Ascot appeared first on Horse Racing News | Paulick Report.

The present disclosure relates to compositions comprising at least one fluoroolefin and an effective amount of a stabilizer comprising at least one ascorbic acid, terephthalate, or nitromethane, or mixtures thereof. The stabilized compositions may be useful in cooling apparatus, such as refrigeration, air-conditioning, chillers and heat pumps, as well as in applications as foam blowing agents, solvents, aerosol propellants, fire extinguishants, and sterilants.

Stories of when things go wrong. Really wrong. When you leave the normal realm of human error, fumble, mishap, and mistake and enter the territory of really huge breakdowns. Fiascos. Things go so awry that normal social order collapses.

Very bad reviews have been a siren call for people who believe they know how to salvage an irretrievably weird movie, at least for themselves: by doing drugs first. It was unclear, on balance, whether getting high made "Cats" better, or much, much worse.

Most people are still in quarantine due to the novel coronavirus, and UW's live mascot Dubs II is no exception. But this adorable Alaskan malamute -- and UW's social media team -- are providing much-needed cute dog content when all of us need it most.

Gerald Ford was president. It was 1976. A mysterious new strain of swine flu turned up, and Ford raced to come up with a response. Every American, he said, would be vaccinated. Here's how that turned out.

Most people are still in quarantine due to the novel coronavirus, and UW's live mascot Dubs II is no exception. But this adorable Alaskan malamute -- and UW's social media team -- are providing much-needed cute dog content when all of us need it most.

Nikki Bascome has released an inspirational video titled “The Restoration: A Comeback Story,” where the professional boxer discusses the aftermath of loss in November 2017 and pays tribute to the late Allan ‘Forty’ Rego. In the video, Mr. Bascome says, “I’d be lying if I said I didn’t want to hang up the gloves and […] (Click to read the full article)

The Bermuda Boxing Federation [BBF] has joined forces with Heart of A Lion Productions and Pulse Entertainment to promote the upcoming IBA International Welterweight Title “Redemption Fight Night”, with the main event set to take place on Saturday, 24 November at the Fairmont Southampton, featuring professional Bermudian boxer Nikki Bascome, taking on David “Popeye” Martinez […] (Click to read the full article)

Professional boxer Nikki Bascome has been training with Jeff Mayweather in Las Vegas in advance of his IBA International Welterweight fight against Mexico’s David Martinez, which is set to take place on Saturday, 24 November at the Fairmont Southampton. “One thing when Nicky he’s got power in both hands, good skills and good movement,” Mr […] (Click to read the full article)

[Written by Patrick Bean] A Las Vegas like stage has been set for Bermudian boxer Nikki Bascome to redeem himself from his last fight loss, with the Fairmont Southampton’s Poinciana Room set up as one might witness at the famous MGM Grand or Caesar’s Palace among the Nevada Desert oasis that is ‘Sin City’. Redemption […] (Click to read the full article)

[Updating] A number of boxers will be in the ring this evening [Nov 24], as the ‘Redemption Fight Night’ event takes place at the Fairmont Southampton Hotel, with the headline fight to see professional Bermudian boxer Nikki Bascome take on David Martinez of Mexico. According to the fight card released by the Bermuda Boxing Federation, fighters in […] (Click to read the full article)

Professional boxer Nikki Bascome brought the crowd to their feet last night [Nov 24], as the Bermudian boxer defeated David Martinez from Mexico to claim the International Boxing Association [IBA] Welterweight Championship Title. The match was the title fight in last night’s ‘Redemption Fight Night’ at the Fairmont Southampton, which saw a number of bouts […] (Click to read the full article)