en Method of, and apparatus for, processing sheets of different formats By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT An apparatus for processing sheets of different formats, the apparatus including a feeding device that feed sheets of different formats in a feeding direction one behind the other, and at a certain conveying speed, at least two collecting drums disposed downstream of the feeding device, the at least two collecting drums having cylindrical lateral surfaces that rotate about an axis of rotation, securing means for temporarily securing the fed sheets on a circumference of the at least two collecting drums, a drive device that drives the collecting drums in rotation at a circumferential speed that corresponds to the conveying speed of the feeding device, and a sensing device for sensing the sheets of different formats moving past is arranged along the conveying path and senses the leading edge of the sheets of different formats, as seen in the feeding direction, or markings applied to the sheets of different formats. Full Article
en Semiconductor device for restraining creep-age phenomenon and fabricating method thereof By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT The present invention relates generally to a semiconductor device and, more specifically, to optimizing the creep-age distance of the power semiconductor device and a preparation method thereof. The power semiconductor device includes a chip mounting unit with a die paddle and a plurality of leads arranged side by side located close to one side edge of the die paddle in a non-equidistant manner, a semiconductor chip attached on the die paddle, and a plastic packaging body covering the die paddle, the semiconductor chip, where the plastic packing body includes a plastic extension portion covering at least a part of a lead shoulder of a lead to obtain better electrical safety distance between the terminals of the semiconductor device, thus voltage creep-age distance of the device is increased. Full Article
en Land grid array package capable of decreasing a height difference between a land and a solder resist By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT A land grid array (LGA) package including a substrate having a plurality of lands formed on a first surface of the substrate, a semiconductor chip mounted on a second surface of the substrate, a connection portion connecting the semiconductor chip and the substrate, and a support layer formed on part of a surface of a first land. Full Article
en Method to increase I/O density and reduce layer counts in BBUL packages By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT An apparatus including a die including a dielectric material on a device side, an insulating layer surrounding a die area and embedding a thickness dimension of the die; and a carrier including a plurality of layers of conductive material disposed on the device side of the die, a first one of the layers of conductive materials being formed on the insulating layer and patterned into traces at least a portion of which are connected to respective contact points on the die. A method including disposing a die on a sacrificial substrate with a device side of the die opposite the sacrificial substrate; disposing a mold on the sacrificial substrate around; introducing an insulating material into a chase of the mold; removing the mold; forming a carrier on the insulating material adjacent a device side of a die; and separating the die and the carrier from the sacrificial substrate. Full Article
en Chip arrangement and a method of manufacturing a chip arrangement By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT In various embodiments, a chip arrangement is provided. The chip arrangement may include a chip carrier and a chip mounted on the chip carrier. The chip may include at least two chip contacts and an insulating adhesive between the chip and the chip carrier to adhere the chip to the chip carrier. The at least two chip contacts may be electrically coupled to the chip carrier. Full Article
en Camera module for tilt balance of lens By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT The present invention relates to a camera module including: a lens unit mounted with at least one or more lenses; an image sensor mounted with an image pickup device for converting a light converged through the lenses to an electric signal; a PCB (Printed Circuit Board) mounted with the image sensor; and a holder accommodated inside the lens unit for supporting the lens unit, wherein the lens unit is bonded and fixed at an inner surface of the holder, whereby the lens unit mounted with a plurality of lenses is bonded to a lateral surface of a holder to prevent generation of vertical tilting phenomenon at the lens unit caused by a conventional improper coating of epoxy, and particularly, the coating of epoxy on the lateral surface of the holder advantageously enhances adhesive power to increase a bonded area. Full Article
en Methods and systems for global knowledge sharing to provide corrective maintenance By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT Described herein are methods and systems for providing corrective maintenance using global knowledge sharing. A method to provide corrective maintenance with a CM system includes performing a query to generate a ranking of fixable causes based on factors (e.g., symptoms, configuration, test). The ranking may be determined based on a fixable cause percent match with the factors. The ranking of fixable causes may be associated with one or more solutions for each fixable cause. The ranking can be updated based on performing tests or solutions. Full Article
en Method for fabricating sensor By www.freepatentsonline.com Published On :: Tue, 02 Jun 2015 08:00:00 EDT A method for fabricating a sensor includes: forming, on a base substrate, a pattern of a source electrode and a drain electrode, a pattern of a data line, a pattern of a receiving electrode, a pattern of a photodiode, and a pattern of a transparent electrode disposed by using a first patterning process; forming a pattern of an ohmic layer by using a second patterning process; forming a pattern of an active layer by using a third patterning process; forming a pattern of a gate insulating layer by using a fourth patterning process, wherein the gate insulating layer has a via hole above the transparent electrode; and forming a pattern of a gate electrode, a pattern of a gate line, and a pattern of a bias line connected to the transparent electrode via the via hole above the transparent electrode by using a fifth patterning process. Full Article
en Package-on-package assembly with wire bonds to encapsulation surface By www.freepatentsonline.com Published On :: Tue, 28 Jul 2015 08:00:00 EDT A method of making a microelectronic package includes forming a dielectric encapsulation layer on an in-process unit having a substrate having a first surface and a second surface remote therefrom. A microelectronic element is mounted to the first surface of the substrate, and a plurality of conductive elements exposed at the first surface, at least some of which are electrically connected to the microelectronic element. Wire bonds have bases joined to the conductive elements and end surfaces remote from the bases and define an edge surface extending away between the base and the end surface. The encapsulation layer is formed to at least partially cover the first surface and portions of the wire bonds with unencapsulated portions of the wire bonds being defined by at least one of the end surface or a portion of the edge surface that is uncovered thereby. Full Article
en Semiconductor element and method for manufacturing the same By www.freepatentsonline.com Published On :: Tue, 27 Oct 2015 08:00:00 EDT An object is to provide a thin film transistor and a method for manufacturing the thin film transistor including an oxide semiconductor with a controlled threshold voltage, high operation speed, a relatively easy manufacturing process, and sufficient reliability. An impurity having influence on carrier concentration in the oxide semiconductor layer, such as a hydrogen atom or a compound containing a hydrogen atom such as H2O, may be eliminated. An oxide insulating layer containing a large number of defects such as dangling bonds may be formed in contact with the oxide semiconductor layer, such that the impurity diffuses into the oxide insulating layer and the impurity concentration in the oxide semiconductor layer is reduced. The oxide semiconductor layer or the oxide insulating layer in contact with the oxide semiconductor layer may be formed in a deposition chamber which is evacuated with use of a cryopump whereby the impurity concentration is reduced. Full Article
en Semiconductor device and method of forming interconnect structure for encapsulated die having pre-applied protective layer By www.freepatentsonline.com Published On :: Tue, 02 Feb 2016 08:00:00 EST A semiconductor device has a protective layer formed over an active surface of a semiconductor wafer. The semiconductor die with pre-applied protective layer are moved from the semiconductor wafer and mounted on a carrier. The semiconductor die and contact pads on the carrier are encapsulated. The carrier is removed. A first insulating layer is formed over the pre-applied protective layer and contact pads. Vias are formed in the first insulating layer and pre-applied protective layer to expose interconnect sites on the semiconductor die. An interconnect structure is formed over the first insulating layer in electrical contact with the interconnect sites on the semiconductor die and contact pads. The interconnect structure has a redistribution layer formed on the first insulating layer, a second insulating layer formed on the redistribution layer, and an under bump metallization layer formed over the second dielectric in electrical contact with the redistribution layer. Full Article
en Enhanced patterning uniformity of gate electrodes of a semiconductor device by late gate doping By www.freepatentsonline.com Published On :: Tue, 08 Mar 2016 08:00:00 EST When forming sophisticated semiconductor-based gate electrode structures of transistors, the pre-doping of one type of gate electrode structure may be accomplished after the actual patterning of the electrode material by using an appropriate mask or fill material for covering the active regions and using a lithography mask. In this manner, a high degree of flexibility is provided with respect to selecting an appropriate patterning regime, while at the same time a uniform and superior cross-sectional shape for any type of gate electrode structure is obtained. Full Article
en ***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST***Electroconductive sheet and touch panel By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT The present invention provides an electroconductive sheet and a touch panel which do not impair visibility in a vicinity of an electrode terminal in a sensing region. In an electroconductive sheet which has an electrode pattern constructed of a metal thin wire and an electrode terminal that is electrically connected to an end of the electrode pattern, a transmittance of the electrode pattern is 83% or more, and when the transmittance of the electrode pattern is represented by a %, a transmittance of the electrode terminal is controlled to be (a-20)% or more and (a-3)% or less. Full Article
en Semiconductor device including a current mirror circuit By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT In a semiconductor device, where, with respect to a parasitic resistor in a current mirror circuit, a compensation resistor for compensating the parasitic resistor is provided in the current mirror circuit, the current mirror circuit includes at least two thin film transistors. The thin film transistors each have an island-shaped semiconductor film having a channel formation region and source or drain regions, a gate insulating film, a gate electrode, and source or drain electrodes, and the compensation resistor compensates the parasitic resistor of any one of the gate electrode, the source electrode, and the drain electrode. In addition, each compensation resistor has a conductive layer containing the same material as the gate electrode, the source or drain electrodes, or the source or drain regions. Full Article
en Sensor substrate, method of manufacturing the same and sensing display panel having the same By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT A sensor substrate includes a blocking pattern disposed on a base substrate, a first electrode disposed on the base substrate and overlapping the blocking pattern, the first electrode including a plurality of first unit parts arranged in a first direction, each of the first unit parts including a plurality of lines connected to each other in a mesh-type arrangement, a color filter layer disposed on the base substrate, a plurality of contact holes defined in the color filter layer and exposing the first unit parts, and a bridge line between and connected to first unit parts adjacent to each other in the first direction, through the contact holes. Full Article
en Display device including a lens module By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT A display device includes a display panel including a plurality of pixels arranged in a matrix form, each pixel including a plurality of sub-pixels, a lens module on the display panel, the lens module including a plurality of lenses having a pitch that corresponds to a horizontal pitch of the plurality of sub-pixels, and a driving unit configured to drive the display panel and the lens module to provide an image displayed by the display panel to a left eye of a viewer at a first frame and to provide the image displayed by the display panel to a right eye of the viewer at a second frame. Full Article
en Liquid crystal display element and liquid crystal module By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT A liquid crystal display element disclosed includes: a first substrate; a second substrate; a liquid crystal layer sandwiched between the first substrate and the second substrate; a first transparent electrode provided at a display region of the first substrate; and a second transparent electrode provided at a display region of the second substrate, at least one of d1 and d2 being not larger than 60 nm, where d1 represents a thickness of the first transparent electrode and d2 represents a thickness of the second transparent electrode. Full Article
en Back plate component having reflective sheet reinforcing structure and liquid crystal display device including the same By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT Provided is a back plate component having reflective sheet reinforcing structure. The back plate component includes: a frame, a reflective sheet and a plurality of supporting film sheets. The frame includes a plurality of lateral beams and vertical beams, and at least one hollow part is included between the lateral beams and the vertical beams. The reflective sheet is attached to the frame, and includes a reflective surface and a back surface corresponding to the reflective surface. A portion of the back surface covers the whole hollow part. The plurality of supporting film sheets is attached to the back surface at a region corresponding to the hollow part, and includes a material the same as that of the reflective sheet. A liquid crystal display device is further disclosed herein. Full Article
en Optical compensated bending mode liquid crystal display panel and method for manufacturing the same By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT The present invention provides an optical compensated bending (OCB) mode liquid crystal display (LCD) panel and a method for manufacturing the same. The method comprises the following steps: forming alignment layers on substrate, respectively; forming a liquid crystal layer between the alignment layers to form a liquid crystal cell; applying an electrical signal across the liquid crystal cell; and irradiating light rays to or heating the liquid crystal cell, so as to form a first polymer alignment layer and a second polymer alignment layer, respectively. The present invention can reduce a phase transition time of liquid crystal molecules from a splay state to a bent state. Full Article
en Display device substrate, display device substrate manufacturing method, display device, liquid crystal display device, liquid crystal display device manufacturing method and organic electroluminescent display device By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT The present invention provides a display device substrate, a display device substrate manufacturing method, a display device, a liquid crystal display device, a liquid crystal display device manufacturing method and an organic electroluminescent display device that allow suppressing faults derived from occurrence of gas and/or bubbles in a pixel region. The present invention is a display device substrate that comprises: a photosensitive resin film; and a pixel electrode, in this order, from a side of an insulating substrate. The display device substrate has a gas-barrier insulating film, at a layer higher than the photosensitive resin film, for preventing advance of a gas generated from the photosensitive resin film, or has a gas-barrier insulating film, between the photosensitive resin film and the pixel electrode, for preventing advance of gas generated from the photosensitive resin film. Full Article
en Display apparatus having spacers with different heights and different upper and lower surface areas By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT A display apparatus includes a lower substrate, an upper substrate, a spacer and an image display layer. The spacer includes a main spacer, a first sub-spacer and a second sub-spacer. The main spacer has a height greater than that of the first and second sub-spacers. The second sub-spacer has an area wider than that of the main spacer and the first sub-spacer. Full Article
en Constant-temperature equipment By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT Constant-temperature equipment wherein mechanical and electrical structures are eliminated from the inside of a temperature-controlled chamber (15) by using a non-contact magnetic arrangement as a drive transmission for a sample table (5) and a sample table drive mechanism (6), thus reducing failure and enhancing maintainability. In addition, a conveyance mechanism (11) is provided with a pass box adjacent which sliding shielding plates (9) are stacked vertically, and the shielding plates (9) are linked with the conveyance mechanism (11) by an engaging mechanism provided in the conveyance mechanism (11) to allow the plates to be opened and closed by a travel mechanism (12), thus simplifying the structure and minimizing change in atmosphere during conveying. The sample table drive mechanism (6) and the conveyance mechanism (11) can be attached removably to the temperature-controlled chamber (15) to permit sterilization at high temperature. Full Article
en Constant-temperature equipment By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT Provided is constant-temperature equipment wherein maintenance is facilitated with the least failure, and highly reliable culturing and testing can be carried out. Mechanical and electrical structures are eliminated from the inside of a temperature-controlled chamber (15) by using a non-contact magnetic arrangement as a drive transmission for a sample table (5) and a sample table drive (6), thus reducing failure and enhancing maintainability. In addition, a conveyor (11) is provided with a pass box to minimize change in atmosphere during conveying. The sample table drive (6) and the conveyor (11) can be attached removably to the temperature-controlled chamber (15) to permit sterilization at high temperature. Full Article
en Plasmid vector, method for detecting gene promoter activity, and assay kit By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT According to one embodiment, a first gene encodes a reporter protein. The first gene is disposed at the downstream of the gene promoter. A second gene is disposed at the downstream of the gene promoter and encodes a replication origin-binding protein. An internal ribosome entry site is disposed between the first gene and the second gene. The transcription termination signal sequence encodes a signal for terminating the transcription of the first gene and the second gene. A replication origin sequence is recognized by the replication origin-binding protein. Full Article
en Production of viral vaccines in suspension on avian embryonic derived stem cell lines By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT The present invention relates to the development and manufacturing of viral vaccines. In particular, the invention relates to the field of industrial production of viral vectors and vaccines, more in particular to the use of avian embryonic stem cells, preferably the EBx® cell line derived from chicken embryonic stem cells, for the production of viral vectors and viruses. The invention is particularly useful for the industrial production of viral vaccines to prevent viral infection of humans and animals. Full Article
en Methods of expanding embryonic stem cells in a suspension culture By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT A method of expanding and maintaining human embryonic stem cells (ESCs) in an undifferentiated state by culturing the ESCs in a suspension culture under culturing conditions devoid of substrate adherence is provided. Also provided are a method of deriving ESC lines in the suspension culture and methods of generating lineage-specific cells from ESCs which were expanded in the suspension culture of the present invention. Full Article
en Method of selecting stem cells having high chondrogenic differentiation capability By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT Thrombospondin 1 (TSP-1), TSP-2, interleukin 17B receptor (IL-17BR) and heparin-binding epidermal growth factor-like growth factor (HB-EGF) associated with stem cell activity and use thereof. Full Article
en Generating a mucin-producing cell from an umbilical cord amniotic membrane epithelial stem cell By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT The present invention relates to the generation of a mucin-producing cell using stem/progenitor cells obtained from the amniotic membrane of umbilical cord and therapeutic uses of such mucin-producing cells. Full Article
en Method of washing adherent cell using trehalose-containing cell-washing solution By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT Methods of washing adherent cells, capable of effectively suppressing cell death due to proteolytic enzyme treatment for detaching the adherent cell from a culture vessel and subsequent cell treatment; cell-washing solutions used for the washing method; methods of producing cell suspensions for transplantation using the cell-washing solution; and kits comprising the cell-washing solution. Trehalose or its derivative or a salt thereof is added to physiological aqueous solutions to prepare cell-washing solutions containing trehalose or its derivative or a salt thereof as an active ingredient. The cell-washing solutions can be used to wash adherent cells before detaching the adherent cells from a culture vessel by proteolytic enzyme treatment to suppress cell death due to the proteolytic enzyme treatment. The concentration of trehalose applied to the cell-washing solution may be a concentration capable of suppressing the cell death due to the proteolytic enzyme treatment, such as 0.1 to 20 (w/v) %. Full Article
en Genetically modified Streptococcus thermophilus bacterium By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT Methods and compositions for targeted delivery of biotherapeutics are provided. The compositions comprise bile-sensitive St. thermophilus bacteria modified to release a biotherapeutic agent following bile exposure. Biotherapeutic agents released by the St. thermophilus bacteria disclosed herein include AQ and AQR rich peptides. Methods of the invention comprise administering to a subject a St. thermophilus bacterium modified to release a biotherapeutic agent following bile exposure. Administration of the St. thermophilus bacterium promotes a desired therapeutic response. The bacterium may be modified to express and release AQ or AQR rich peptides which subsequently inhibit cellular apoptosis or reduce mucosal damage. Thus, methods of the invention find use in treating or preventing a variety of gastrointestinal disorders including C. difficile infection and antibiotic-associated diarrhea. Full Article
en General composition framework for ligand-controlled RNA regulatory systems By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT The invention provides an improved design for the construction of extensible nucleic acid-based, ligand-controlled regulatory systems, and the nucleic acid regulatory systems resulting therefrom. The invention contemplates improving the design of the switches (ligand-controlled regulatory systems) through the design of an information transmission domain (ITD). The improved ITD eliminates free-floating ends of the switching and the competing strands, and localizes competitive hybridization events to a contiguous strand of competing and switching strands in a strand-displacement mechanism-based switch, thereby improving the kinetics of strand-displacement. The improved regulatory systems have many uses in various biological systems, including gene expression control or ligand-concentration sensing. Full Article
en Monoclonal thyroid stimulating or blocking antibodies, peptide sequences corresponding to their variable regions, and their uses in diagnostic, preventive and therapeutic medicine By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT Monoclonal antibodies (mAbs) having thyroid stimulating activity (TSAb), especially full or considerably agonistic activity, or thyroid blocking activity (TBAb), which are obtainable by genetic immunization of mice, or fragments (F(ab')2, Fab or Fv) or humanized forms of such monoclonal antibodies or single chain forms (SCA; scFv) of such fragments, which antibodies, or their fragments, compete with bovine TSH for epitopes of the human TSHr, compete with autoantibodies from sera from Graves' patients as well as with autoantibodies from sera from patients harboring blocking autoantibodies for epitopes of the human TSHr, bind to conformational epitopes of the human TSHr located in the first 281 amino acids of the human TSHr, and usually also bind to TSFR receptors (TSHr) from different animals. Various uses of such antibodies, or of peptides corresponding to variable regions of such antibodies, are also described and claimed. Full Article
en Compositions and methods for enhancing resistance to northern leaf blight in maize By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT The invention relates to methods and compositions for identifying and selecting maize plants with enhanced resistance to northern leaf blight. Maize plants generated by the methods of the invention are also a feature of the invention. Full Article
en Plants having altered agronomic characteristics under nitrogen limiting conditions and related constructs and methods involving genes encoding LNT1 polypeptides and homologs thereof By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT Isolated polynucleotides and polypeptides and recombinant DNA constructs particularly useful for altering agronomic characteristics of plants under nitrogen limiting conditions, compositions (such as plants or seeds) comprising these recombinant DNA constructs, and methods utilizing these recombinant DNA constructs. The recombinant DNA construct comprises a polynucleotide operably linked to a promoter functional in a plant, wherein said polynucleotide encodes an LNT1 polypeptide. Full Article
en Recombinant DNA constructs encoding ribonuclease cleavage blockers and methods for modulating expression of a target gene By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT This invention provides recombinant DNA constructs and methods for manipulating expression of a target gene that is regulated by a small RNA, by interfering with the binding of the small RNA to its target gene. More specifically, this invention discloses recombinant DNA constructs encoding cleavage blockers, 5-modified cleavage blockers, and translational inhibitors useful for modulating expression of a target gene and methods for their use. Further disclosed are miRNA targets useful for designing recombinant DNA constructs including miRNA-unresponsive transgenes, miRNA decoys, cleavage blockers, 5-modified cleavage blockers, and translational inhibitors, as well as methods for their use, and transgenic eukaryotic cells and organisms containing such constructs. Full Article
en Genes regulating plant branching, promotors, genetic constructs containing same and uses thereof By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT The invention relates to genes coding for TCP family transcription factors and having a biological role in the development of axillary buds and branch growth. Furthermore, the invention relates to the promoters of the transcription of said genes, to the genetic constructs containing same and to the uses thereof, including the use of agents that modulate the expression of these genes in order to modify plant architecture. Full Article
en Chimeric T1R taste receptor polypeptides and nucleic acid sequences encoding and cell lines that express said chimeric T1R polypeptides By www.freepatentsonline.com Published On :: Tue, 28 Jul 2015 08:00:00 EDT The invention relates to compounds that specifically bind a T1R1/T1R3 or T1R2/T1R3 receptor or fragments or sub-units thereof. The present invention also relates to the use of hetero-oligomeric and chimeric taste receptors comprising T1R1/T1R3 and T1R2/T1R3 in assays to identify compounds that respectively respond to umami taste stimuli and sweet taste stimuli. Further, the invention relates to the constitutive of cell lines that stably or transiently co-express a combination of T1R1 and T1R3; or T1R2 and T1R3; under constitutive or inducible conditions. The use of these cells lines in cell-based assays to identify umami and sweet taste modulatory compounds is also provided, particularly high throughput screening assays that detect receptor activity by use of fluorometric imaging. Full Article
en Method of determining the nucleotide sequence of oligonucleotides and DNA molecules By www.freepatentsonline.com Published On :: Tue, 04 Aug 2015 08:00:00 EDT The present invention relates to a novel method for analyzing nucleic acid sequences based on real-time detection of DNA polymerase-catalyzed incorporation of each of the four nucleotide bases, supplied individually and serially in a microfluidic system, to a reaction cell containing a template system comprising a DNA fragment of unknown sequence and an oligonucleotide primer. Incorporation of a nucleotide base into the template system can be detected by any of a variety of methods including but not limited to fluorescence and chemiluminescence detection. Alternatively, microcalorimetic detection of the heat generated by the incorporation of a nucleotide into the extending template system using thermopile, thermistor and refractive index measurements can be used to detect extension reactions. Full Article
en Method for detecting the presence of a nucleic acid in a sample By www.freepatentsonline.com Published On :: Tue, 06 Oct 2015 08:00:00 EDT An automated method for detecting the presence of a nucleic acid in a sample, where the method is performed within a housing of a self-contained, stand-alone analyzer. The method includes purifying the nucleic acid after it has been immobilized on a magnetically-responsive solid support. A pipette of the analyzer is used to form a reaction mixture comprising the purified nucleic acid and all reagents required to perform a nucleic acid amplification. Amplification products are synthesized that include a nucleotide sequence contained in the nucleic acid or the complement of the nucleic acid. The amplification products are exposed to a probe in a mixture, where the probe forms a hybrid with one of the amplification products. The formation of the hybrid in the mixture provides an indication of the presence of the nucleic acid in the sample. Full Article
en Mutant receptors and their use in a nuclear receptor-based inducible gene expression system By www.freepatentsonline.com Published On :: Tue, 20 Oct 2015 08:00:00 EDT This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to novel substitution mutant receptors and their use in a nuclear receptor-based inducible gene expression system and methods of modulating the expression of a gene in a host cell for applications such as gene therapy, large scale production of proteins and antibodies, cell-based high throughput screening assays, functional genomics and regulation of traits in transgenic organisms. Full Article
en Protein concentrate and an aqueous stream containing water-soluble carbohydrates By www.freepatentsonline.com Published On :: Tue, 05 Jan 2016 08:00:00 EST Disclosed are process for contacting a protein containing material with one or more wet-mill streams. The protein content of the protein containing material is increased. Full Article
en Method of regulating gene expression By www.freepatentsonline.com Published On :: Tue, 23 Feb 2016 08:00:00 EST The present invention relates, in general, to gene expression and, in particular, to a method of inhibiting the expression of a target gene and to constructs suitable for use in such a method. Full Article
en Premium class aircraft passenger suite By www.freepatentsonline.com Published On :: Tue, 19 May 2015 08:00:00 EDT A premium class passenger suite that includes a main seat positioned in the suite together with separate bed. The bed has a flexible mattress of predetermined dimensions and is movable between a stowed position to one side of the main seat and a deployed position above and separate from the main seat. A drive apparatus is provided for driving the bed between the stowed and deployed positions. The main seat is configured to be movable between a seating position when the bed is stowed, and a stowed position with a lowered seat back when the bed is deployed for use. Full Article
en Driven infant seat By www.freepatentsonline.com Published On :: Tue, 19 May 2015 08:00:00 EDT An infant rocking seat includes a base; a track provided on the base having a first arc-shaped portion and a second arc-shaped portion meeting at a crest; a carriage having a body portion, a first pair of wheels positioned at a first end of the body portion, and a second pair of wheels positioned at a second end of the body portion; and a drive mechanism configured to move the carriage along the track. The carriage is positioned within a central portion of the base and is configured to ride along the track. A distance between the first pair of wheels and the second pair of wheels is less than a distance between centers of curvature of the first arc-shaped portion and the second arc-shaped portion. Full Article
en Vertical back support health-enhancing device By www.freepatentsonline.com Published On :: Tue, 19 May 2015 08:00:00 EDT An ergonomic back support device utilizing one or multiple vertical components that include layers (28,36), pressure distributing layers (34,38,50), and a single notched layer (48). These layers provide primary back support located behind and conforming to the Erector spinae muscles (124). The vertical components form an open channel (24) that is parallel to the prime neurological pathway of the spinal column (100). The vertical conforming support components and open channel facilitate physiological functions that promote health. The device accomplishes support without using any transverse, hard or continuous components across or against the back. Other embodiments include the following additional vertical components: a lateral pressure-adjusting device (14), heating layers (40,46), circulation stimulating layers (42,44), and massage layers (52,54). Embodiments include portable and permanently installed versions that can be utilized in the following applications, including, but not limited to, furniture, vehicles, trains, aircraft, boats, ships, and backpacks. Full Article
en Chair, a support, and components By www.freepatentsonline.com Published On :: Tue, 19 May 2015 08:00:00 EDT A chair has a seat support (101), a seat portion (13), a back portion (15), and a supporting frame. The supporting frame is formed by a castored base (11), a height adjustment mechanism (17), and a main transom (21). The seat portion (13) is selectively moveable relative to the supporting frame, with the seat portion having a locked configuration and a released configuration. The back portion has a back frame (25) and a compliant cover (61). The back frame has hook features for receiving a portion of the compliant cover (61). The back portion (15) is reclinable relative to the supporting frame between an upright position and a reclined position. A recline mechanism has deformable members operatively connecting the seat portion and the supporting frame. A recline resistance mechanism is selectively engageable to resist movement of the back portion toward the reclined position. Full Article
en Vehicle seat assembly having a hardness gradient via surface intrusions and/or protrusions By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT A method of making a vehicle seat assembly comprising providing a cushion having an “A” surface, a “B” surface, a central portion, and two bolster areas, with each bolster area being adjacent the central portion, the cushion having a plurality of intrusions extending from the “A” surface towards the “B” surface to form a hardness gradient between at least one of the bolster areas and the central portion of between 8% to 25%, securing the cushion to a frame, and covering cushion with a trim member. Full Article
en Seat extension seamless gap fill By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT A vehicle seating assembly includes a seatpan coupled with a track assembly that has a rail and a slide. The vehicle seating assembly also includes a cushion assembly that has a movable cushion and a base cushion with a slot. The movable cushion is slidable between a forward position and a rearward position on the seatpan. In addition, the vehicle seating assembly includes a coverstock with a first portion that is disposed over a movable cushion. The coverstock also has a second portion that is disposed between the seatpan and the cushion assembly. The second portion of the coverstock is withdrawn through the slot when the movable cushion moves to the forward position. A gap is defined by the area between the base cushion and the movable cushion in the forward position. The gap is concealed by the coverstock when the movable cushion is in the forward position. Full Article
en Height adjustment mechanism suitable for a footring By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT A mechanism for vertically adjusting a component on a shaft has a collet sleeve riding on the shaft. A spiral track of the component's hub receives a radially outwardly projecting pin on the collet sleeve. The outer surface of the collet sleeve and the inner surface of the hub are tapered so that the hub can rotated one direction to advance the hub on the collet sleeve and compress the collet sleeve onto the shaft to frictionally lock the collet sleeve to the shaft. Because the hub is joined to the collet sleeve by the pin, this also locks the vertical position of the component. Conversely, the hub can be oppositely rotated to release the compression of the collet sleeve so that the collet sleeve, and therefore the vertical component, is slidable on the shaft. Full Article
en Air bag enabling car seat cover By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT The present disclosure describes a method of manufacture and a structure for an automobile seat cover that includes a seat cover body with an outer perimeter, a seat cover skirt with a first edge sewn with an overlock stitch to the seat cover body for a majority of the outer perimeter, and a second edge, distal from the first edge, comprising a tie element extending for a majority of the second edge around a seat opening in the seat cover. A portion of the seat cover skirt and the seat cover body corresponding to a location of at least one airbag installed in an automobile seat cover over which the seat cover is to be placed are sewn together with one of a straight stitch and a lock stitch instead of the overlock stitch. In some implementations, the thread used is a brightly colored string. Full Article