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First responder: On Maldives-India ties
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Over the borderline: On the India-China deal
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Escalation ladder: On conflict between Israel and Iran
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Towards Europe: On the India visits by the leaders of Germany, Spain
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Synthesis of a celastrol derivative as a cancer stem cell inhibitor through regulation of the STAT3 pathway for treatment of ovarian cancer
RSC Med. Chem., 2024, 15,3433-3443
DOI: 10.1039/D4MD00468J, Research Article
DOI: 10.1039/D4MD00468J, Research Article
Meijuan Liu, Na Li, Zhaoxue Wang, Shuo Wang, Shaoda Ren, Xiaojing Li
A synthetic celastrol derivative (Cel-N) attenuates cancer cell stemness, inhibits the STAT3 pathway, and exerts anti-ovarian cancer effects in cell and mouse models.
The content of this RSS Feed (c) The Royal Society of Chemistry
A synthetic celastrol derivative (Cel-N) attenuates cancer cell stemness, inhibits the STAT3 pathway, and exerts anti-ovarian cancer effects in cell and mouse models.
The content of this RSS Feed (c) The Royal Society of Chemistry
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Pyridazinone-based derivatives as anticancer agents endowed with anti-microbial activity: molecular design, synthesis, and biological investigation
RSC Med. Chem., 2024, 15,3529-3557
DOI: 10.1039/D4MD00481G, Research Article
DOI: 10.1039/D4MD00481G, Research Article
Mohamed K. S. El-Nagar, Mai I. Shahin, Mohammed F. El-Behairy, Ehab S. Taher, Mohamed F. El-Badawy, Marwa Sharaky, Dalal A. Abou El Ella, Khaled A. M. Abouzid, Mai Adel
Discovery of novel pyridazinone derivatives with dual antimicrobial and anticancer activities.
The content of this RSS Feed (c) The Royal Society of Chemistry
Discovery of novel pyridazinone derivatives with dual antimicrobial and anticancer activities.
The content of this RSS Feed (c) The Royal Society of Chemistry
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Design, synthesis, and structure–activity relationship studies of 6H-benzo[b]indeno[1,2-d]thiophen-6-one derivatives as DYRK1A/CLK1/CLK4/haspin inhibitors
RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00537F, Research Article
DOI: 10.1039/D4MD00537F, Research Article
Open Access
This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.
Abdelfattah Faouzi, Alexandre Arnaud, François Hallé, Jean Roussel, Mandy Aymard, Vincent Denavit, Cong Viet Do, Angélique Mularoni, Mohamed Salah, Ahmed ElHady, Thanh-Nhat Pham, Alexandre Bancet, Marc Le Borgne, Raphaël Terreux, Roland Barret, Matthias Engel, Thierry Lomberget
A series of sulfur-containing tetracycles was designed and evaluated for their ability to inhibit protein kinase DYRK1A, a target known to have several potential therapeutic applications including cancers, Down syndrome or Alzheimer's disease.
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The content of this RSS Feed (c) The Royal Society of Chemistry
A series of sulfur-containing tetracycles was designed and evaluated for their ability to inhibit protein kinase DYRK1A, a target known to have several potential therapeutic applications including cancers, Down syndrome or Alzheimer's disease.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry
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Inhibition of monoamine oxidases by heterocyclic derived conjugated dienones: synthesis and in vitro and in silico investigations
RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00608A, Research Article
DOI: 10.1039/D4MD00608A, Research Article
Sunil Kumar, Bishnu Prasad Pandey, Mohamed A. Abdelgawad, Mohammed M. Ghoneim, Rania B. Bakr, Hoon Kim, Bijo Mathew
A total of 18 heterocyclic derived conjugated dienones (CD1–CD18) were evaluated for their potential monoamine oxidase (MAO)-A/-B inhibitory activity.
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The content of this RSS Feed (c) The Royal Society of Chemistry
A total of 18 heterocyclic derived conjugated dienones (CD1–CD18) were evaluated for their potential monoamine oxidase (MAO)-A/-B inhibitory activity.
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Development, biological evaluation, and molecular modelling of some benzene-sulfonamide derivatives as protein tyrosine phosphatase-1B inhibitors for managing diabetes mellitus and associated metabolic disorders
RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00594E, Research Article
DOI: 10.1039/D4MD00594E, Research Article
Nagat Ghareb, Khaled M. Darwish, Mohamed S. Nafie, Ranwa Elrayess, Noha M. Abourobe, Shaimaa A. Fattah, Reem M. Hazem, Eman T. Mehanna, Ranza Elrayess
One benzene-sulfonamide derivative exhibited potent protein tyrosine phosphatase-1B inhibition for managing diabetes mellitus and associated metabolic disorders.
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One benzene-sulfonamide derivative exhibited potent protein tyrosine phosphatase-1B inhibition for managing diabetes mellitus and associated metabolic disorders.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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Design, synthesis and mechanistic insights into triclosan derived dimers as potential anti-plasmodials
RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00494A, Research Article
DOI: 10.1039/D4MD00494A, Research Article
Shekhar, Shefali Chowdhary, Joel Mosnier, Isabelle Fonta, Bruno Pradines, Vipan Kumar
In pursuit of novel anti-plasmodial agents, a library of triclosan-based dimers both with and without a 1H-1,2,3 triazole core were designed, synthesized and evaluated in order to achieve a multitargeted approach.
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The content of this RSS Feed (c) The Royal Society of Chemistry
In pursuit of novel anti-plasmodial agents, a library of triclosan-based dimers both with and without a 1H-1,2,3 triazole core were designed, synthesized and evaluated in order to achieve a multitargeted approach.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry
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Human microbiome derived synthetic antimicrobial peptides with activity against Gram-negative, Gram-positive, and antibiotic resistant bacteria
RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00383G, Research Article
DOI: 10.1039/D4MD00383G, Research Article
Open Access
This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.
Walaa K. Mousa, Ashif Y. Shaikh, Rose Ghemrawi, Mohammed Aldulaimi, Aya Al Ali, Nour Sammani, Mostafa Khair, Mohamed I. Helal, Farah Al-Marzooq, Emilia Oueis
An AMP-derived short 15-mer peptide and its cyclic derivatives have low micromolar broad spectrum antibacterial activity, with rapid onset of bactericidal effect and a membrane-targeting mode of action.
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The content of this RSS Feed (c) The Royal Society of Chemistry
An AMP-derived short 15-mer peptide and its cyclic derivatives have low micromolar broad spectrum antibacterial activity, with rapid onset of bactericidal effect and a membrane-targeting mode of action.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry
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Azo derivatives of monoterpenes as anti-Helicobacter pylori agents: from synthesis to structure-based target investigation
RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00511B, Research Article
DOI: 10.1039/D4MD00511B, Research Article
Open Access
This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.
Francesco Melfi, Marialuigia Fantacuzzi, Simone Carradori, Ilaria D'Agostino, Alessandra Ammazzalorso, Noemi Mencarelli, Marialucia Gallorini, Mattia Spano, Paolo Guglielmi, Mariangela Agamennone, Sazan Haji Ali, Ali Al-Samydai, Francesca Sisto
Monoterpene-derived azo benzenes showed selective antibacterial activity against Helicobacter pylori with a safe profile. An in silico investigation highlighted the inosine 5'-monophosphate dehydrogenase enzyme as the putative target.
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The content of this RSS Feed (c) The Royal Society of Chemistry
Monoterpene-derived azo benzenes showed selective antibacterial activity against Helicobacter pylori with a safe profile. An in silico investigation highlighted the inosine 5'-monophosphate dehydrogenase enzyme as the putative target.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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Medicinal chemistry-based perspective on thiophene and its derivatives: Exploring the structural insights to discover plausible druggable leads
RSC Med. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4MD00450G, Review Article
DOI: 10.1039/D4MD00450G, Review Article
Shikha Thakur, Devendra Kumar, shivani jaiswal, Kapil Kumar Goel, Pramod Rawat, Vivek Srivastava, Sonia Dhiman, Hemant R Jadhav, Ashish Ranjan Dwivedi
Thiophene is a privileged pharmacophore in medicinal chemistry owing to its diversified biological attributes. The thiophene moiety has been ranked 4th in US FDA drug approval of small drug molecules,...
The content of this RSS Feed (c) The Royal Society of Chemistry
Thiophene is a privileged pharmacophore in medicinal chemistry owing to its diversified biological attributes. The thiophene moiety has been ranked 4th in US FDA drug approval of small drug molecules,...
The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis and anti-tumor activity of new benzofuran-based chalcone derivatives as potent VEGFR-2 inhibitors
RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00621F, Research Article
DOI: 10.1039/D4MD00621F, Research Article
Chunfei Zhang, Yixin Liu, Xiao Zhang, Chunping Wan, Zewei Mao
A series of novel benzofuran-based chalcone derivatives could be considered as potent VEGFR-2 inhibitors.
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The content of this RSS Feed (c) The Royal Society of Chemistry
A series of novel benzofuran-based chalcone derivatives could be considered as potent VEGFR-2 inhibitors.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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Novel quinoxaline-derived derivatives: design, synthesis, bioactive evaluation, SARs and preliminary antibacterial mechanism
RSC Med. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4MD00670D, Research Article
DOI: 10.1039/D4MD00670D, Research Article
Yuting Liu, Pengju Yang, Yunyun Zhou, Zhiwen Zhou
In the current study, we have designed and prepared a series of quinoxaline-based compounds, which were derived from o-phenylenediamine. Among which, compounds 5m-p displayed good to moderate antibacterial activity with...
The content of this RSS Feed (c) The Royal Society of Chemistry
In the current study, we have designed and prepared a series of quinoxaline-based compounds, which were derived from o-phenylenediamine. Among which, compounds 5m-p displayed good to moderate antibacterial activity with...
The content of this RSS Feed (c) The Royal Society of Chemistry
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Design and synthesis of (E)-3-benzylideneindolin-2-one derivatives as potential allosteric inhibitors of Aurora A kinase
RSC Med. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4MD00373J, Research Article
DOI: 10.1039/D4MD00373J, Research Article
YongLai Jiao, Jie Zhong, Jin-Fang Xu, Shaobo Ning, Taigang Liang, Mingzhu Zhao, Jian Zhang
The mitotic kinase Aurora A, a pivotal regulator of cell cycle, is overexpressed in various cancers and has emerged as one of the most promising targets for anticancer drug discovery....
The content of this RSS Feed (c) The Royal Society of Chemistry
The mitotic kinase Aurora A, a pivotal regulator of cell cycle, is overexpressed in various cancers and has emerged as one of the most promising targets for anticancer drug discovery....
The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis, in silico and bio-evaluation studies of new isothiocyanate derivatives with respect to COX inhibition and H2S release profiles
RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00495G, Research Article
DOI: 10.1039/D4MD00495G, Research Article
Yakup Berkay Yilmaz, Tuğba Güngör, Serhat Dönmez, Hazal Nazlıcan Atalay, Pınar Siyah, Serdar Durdağı, Mehmet Ay, Tugba Boyunegmez Tumer
New isothiocyanate derivatives (I1–3 and I1a–e) were synthesized and screened for their anti-inflammatory activities and H2S-releasing capacities. Compounds I1 and I1c demonstrated the most potent and selective COX-2 inhibition.
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The content of this RSS Feed (c) The Royal Society of Chemistry
New isothiocyanate derivatives (I1–3 and I1a–e) were synthesized and screened for their anti-inflammatory activities and H2S-releasing capacities. Compounds I1 and I1c demonstrated the most potent and selective COX-2 inhibition.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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Synthesis and antifungal evaluation of new azole derivatives containing 1,2,3-triazole
RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00724G, Research Article
DOI: 10.1039/D4MD00724G, Research Article
Zhengxiao Huang, Hongjie Chen, Xiao Zhang, Ruirui Wang, Chunyan Hu, Zewei Mao
A series of novel azole derivatives containing 1,2,3-triazole have been synthesized with good antifungal effects on sensitive and drug-resistant C. albicans.
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The content of this RSS Feed (c) The Royal Society of Chemistry
A series of novel azole derivatives containing 1,2,3-triazole have been synthesized with good antifungal effects on sensitive and drug-resistant C. albicans.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry
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Will decide on sharing stage with actor Vijay in consultation with VCK leaders: Thirumavalavan
Mr. Thirumavalavan told reporters in Tiruchi that the book release event was not something that was planned recently, and that he had consented to take part in it almost a year ago
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Heavy weed growth at Kasi Viswanathar Temple tank prevents replenishing of underground water table, say Tiruchi residents
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HR&CE plans to bring properties around the Vennaimalai Temple under tenants list
The HR&CE department has cleared 34 properties around the Balasubramanyaswamy Temple at Vennaimalai in Karur district as per the High Court orders
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557: ChatGPT, Conferences, Fidgets on the Web, and Modern CSS in Real Life
When will AI be able to tell you the risk / reward of cleaning up trees? Are conferences back? Bringing fidgets to the web, internet as an anxiety machine, and Chris is working on talk on modern CSS in real life.
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564: Render ATL, New Colors Available, Gradients, HDR, and More
Chris previews a bit of his Render ATL 2023 talk, and then we mouth blog some color ideas, thoughts, and shame you for your non-HD websites.
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569: Apple’s Web Apps, Meta Quest and Vision Pro, and Missing Sticky Headers
How do you point out things in a UI? Are Arc Boosts the end of the web? What do you think of VR and AR / Vision Pro and Meta Quest? And what do you do when the sticky header goes missing?
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573: Google Reader, Sticky and Overflow, and Figma Thoughts
Chris breaks out his banjo, some thoughts on making music vs recording music, what happened to Google Reader and social reading, what black box properties can't Dave or Chris remember, follow up for dev teams communicating with designers, and what's Adobe going to do about Figma?
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622: Website Rendering, Updating Software, and Edge Gets Faster
We're talking website rendering, server side rendering, Astro's server islands, perf hits for navigation elements, updating software because the docs aren't available for older versions, and a new Microsoft Edge was released.
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The pros and cons of spouses teaming up as co-founders
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RNT: Judging a leader’s true nature
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The last thing business founders need is a wasteful public spat
As entrepreneurship explodes in India, we need more iconic founders who not only build sustainable firms but also retain their humility
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Founders who firefight non-stop, risking their mental health
There is unbelievable pressure on entrepreneurs as they work hard non-stop to create bigger, better, faster businesses
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Delhi riots case: HC dismisses plea by Khalid Saifi against attempt to murder charge
Mr. Saifi submitted that once the offences under the Arms Act were dropped against him and neither any weapon was recovered nor the alleged gunshot was attributed to him, the charge of attempt to murder could not be framed
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Lawyer sent to jail for 4 months from Delhi HC for ‘derogatory’ remarks against judges
The court directed the police to take Sanjeev Kumar into custody directly from the court and sent him to jail
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Provide medical aid to jailed separatist leader Yasin Malik: Delhi HC to Tihar jail
In his plea before the high court, Malik claimed to be a patient of “serious cardiac and kidney ailments”, currently facing a “life and death situation”
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Three juveniles held for murder in Delhi; political row erupts over city’s crime rate
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Dribbling past gender stereotypes in rural Odisha
Odisha takes a lead in inspiring and training young tribal boys and girls to play mixed-gender football matches and drive social change in the State
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Delhi Assembly elections | Congress leader Mateen Ahmed joins AAP, AAP leader Harsharan Singh Balli returns to BJP
Setback for Congress as five-time MLA Mateen Ahmed jumps ship to Aam Aadmi Party, days after his son, daughter-in-law join Kejriwal-led party; former Minister Balli quits AAP and returns to BJP
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1984 anti-Sikh riots case: Delhi HC says murder trial to continue against Congress leader Jagdish Tytler
Justice Manoj Kumar Ohri was hearing a plea filed by Mr. Tytler seeking a stay on the trial proceedings taking place against him in a Delhi court. The court would continue with the hearing on November 29
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Delhi HC says murder trial to continue against Jagdish Tytler in 1984 riots case
Justice Manoj Kumar Ohri was hearing a plea filed by Mr. Tytler seeking a stay on the trial proceedings taking place against him in a Delhi court. The court will continue with the hearing on November 29
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Dream Rig Contest Underway
The 5th annual Youth "Dream Rig" Essay Contest has begun to accept submissions.
The contest is sponsored by The Intrepid-DX Group, a U.S.-based 501 (c) (3) nonprofit organization that promotes amateur radio activities around the world and recognizes the importance of including youth in the amateur radio hobby.
Contestants must be USA or Canadian amateur radio license holders aged 19 or younger. A...
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The code to uncommon leadership
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16 leaders, as many economic verities
Vince Cable profiles 16 personalities who rung in deep rooted economic change in their societies
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The journey to leadership roles
The author, citing his own experiences, delves into the qualities required to become a good leader
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Leadership in a WFH world
Relationships, accountability, motivation and processes are vital for a high performance team
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Book Review: Demystifying Leadership: Unveiling the Mahabharata Code by Asha Kaul and Vishal Gupta
The Mahabharata shows that leaders need to navigate moral codes that are as complex, varied, and subtle as the situations in which they find themselves