Will Smith, Will Ferrell, Wanda Sykes, Stephen Colbert and Colin Quinn are among the latest additions.

The series was previously scheduled to roll out Thursday, April 2 on sibling Science Channel.

Owlet started learning about Beethoven in music class at school just before March break. She ran to meet me at the school gate and this is the conversation we had: OWLET: Mummy, do you know Beethoven? ME: Not personally, but I know his music. OWLET: Why not? ME: Well, honey, he’s dead. OWLET: WHAT. He […]

There has been a lot of talk about how this moment in history is going to be remembered -- and as Professor Jay Rosen has been saying, a key part is going to be an effort by the many people who failed to respond properly to rewrite the history of everything that happened:

There is going to be a campaign to prevent Americans from understanding what happened within the Trump government during the critical months of January to April, 2020. Many times Donald Trump told the nation that it has nothing to worry about because he and his people have the spread of the SARS-CoV-2 virus well in hand. They did not. He misled the country about that.

“It’s one person coming in from China, and we have it under control,” he told CNBC on January 22. “We pretty much shut it down coming in from China,” he told Sean Hannity on February 2. On February 24, Trump tweeted that “the Coronavirus is very much under control in the USA.”

He misled the country. This basic fact is so damning, the evidence for it so mountainous, and the mountain of evidence so public — and so personally attached to Donald Trump — that the only option is to create confusion about these events, and about the pandemic generally, in hopes that people give up and conclude that the public record does not speak clearly and everything is propaganda.

The battle over rewriting history is going to take many forms in many different ways -- and so it's good to see a company like Twitter making it easier for researchers to look at the actual history of the public conversation during these months.

To further support Twitter’s ongoing efforts to protect the public conversation, and help people find authoritative health information around COVID-19, we’re releasing a new endpoint into Twitter Developer Labs to enable approved developers and researchers to study the public conversation about COVID-19 in real-time.

This is a unique dataset that covers many tens of millions of Tweets daily and offers insight into the evolving global public conversation surrounding an unprecedented crisis. Making this access available for free is one of the most unique and valuable things Twitter can do as the world comes together to protect our communities and seek answers to pressing challenges. 

It would be interesting to see if others (cough Facebook cough) would do the same thing as well. How the history of these times is written is going to be important in seeing how we deal with the next such crisis.

I largely gave up political blogging after November 8, 2016, when it became obvious that I have no idea what...

iGiant not only screwed up the wiring, it knew it was shipping dodgy gear, it is claimed

Apple is potentially facing a class-action lawsuit over the failure of displays on its MacBook Pro line.…

-Album Details- Title: Distant Worlds: music from FINAL FANTASY JIRITSU Publisher: Square Enix Music Catalog Number: SQEX-10659~60 Release Date: September 20th, 2018 Ripped by: dancey -Info- Nothing new or revelatory here other than it was only available at TGS2018, enjoy nonetheless.

Hello, friends. We haven’t been releasing albums in quite a while, but we are still running our Discord server. We’ve been building a community for people who are interested in video game music, video games, and other assorted media, but are tired of the constant cynicism and negativity that permeate many communities with those interests. […]

Limit your exposure!

Chronic pancreatitis (CP) is considered an irreversible fibroinflammatory pancreatic disease. Despite numerous animal model studies, questions remain about local immune characteristics in human CP. We profiled pancreatic immune cell characteristics in control organ donors and CP patients including those with hereditary and idiopathic CP undergoing total pancreatectomy with islet autotransplantation. Flow cytometric analysis revealed a significant increase in the frequency of CD68+ macrophages in idiopathic CP. In contrast, hereditary CP samples showed a significant increase in CD3+ T cell frequency, which prompted us to investigate the T cell receptor β (TCRβ) repertoire in the CP and control groups. TCRβ sequencing revealed a significant increase in TCRβ repertoire diversity and reduced clonality in both CP groups versus controls. Interestingly, we observed differences in Vβ-Jβ gene family usage between hereditary and idiopathic CP and a positive correlation of TCRβ rearrangements with disease severity scores. Immunophenotyping analyses in hereditary and idiopathic CP pancreases indicate differences in innate and adaptive immune responses, which highlights differences in immunopathogenic mechanisms of disease among subtypes of CP. TCR repertoire analysis further suggests a role for specific T cell responses in hereditary versus idiopathic CP pathogenesis, providing insights into immune responses associated with human CP.

BACKGROUND Since December 2019, an outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan, and is now becoming a global threat. We aimed to delineate and compare the immunological features of severe and moderate COVID-19.METHODS In this retrospective study, the clinical and immunological characteristics of 21 patients (17 male and 4 female) with COVID-19 were analyzed. These patients were classified as severe (11 cases) and moderate (10 cases) according to the guidelines released by the National Health Commission of China.RESULTS The median age of severe and moderate cases was 61.0 and 52.0 years, respectively. Common clinical manifestations included fever, cough, and fatigue. Compared with moderate cases, severe cases more frequently had dyspnea, lymphopenia, and hypoalbuminemia, with higher levels of alanine aminotransferase, lactate dehydrogenase, C-reactive protein, ferritin, and D-dimer as well as markedly higher levels of IL-2R, IL-6, IL-10, and TNF-α. Absolute numbers of T lymphocytes, CD4+ T cells, and CD8+ T cells decreased in nearly all the patients, and were markedly lower in severe cases (294.0, 177.5, and 89.0 × 106/L, respectively) than moderate cases (640.5, 381.5, and 254.0 × 106/L, respectively). The expression of IFN-γ by CD4+ T cells tended to be lower in severe cases (14.1%) than in moderate cases (22.8%).CONCLUSION The SARS-CoV-2 infection may affect primarily T lymphocytes, particularly CD4+ and CD8+ T cells, resulting in a decrease in numbers as well as IFN-γ production by CD4+ T cells. These potential immunological markers may be of importance because of their correlation with disease severity in COVID-19.TRIAL REGISTRATION This is a retrospective observational study without a trial registration number.FUNDING This work is funded by grants from Tongji Hospital for the Pilot Scheme Project, and partly supported by the Chinese National Thirteenth Five Years Project in Science and Technology for Infectious Disease (2017ZX10202201).

Prenatal alcohol exposure (PAE) affects at least 10% of newborns globally and leads to the development of fetal alcohol spectrum disorders (FASDs). Despite its high incidence, there is no consensus on the implications of PAE on metabolic disease risk in adults. Here, we describe a cohort of adults with FASDs that had an increased incidence of metabolic abnormalities, including type 2 diabetes, low HDL, high triglycerides, and female-specific overweight and obesity. Using a zebrafish model for PAE, we performed population studies to elucidate the metabolic disease seen in the clinical cohort. Embryonic alcohol exposure (EAE) in male zebrafish increased the propensity for diet-induced obesity and fasting hyperglycemia in adulthood. We identified several consequences of EAE that may contribute to these phenotypes, including a reduction in adult locomotor activity, alterations in visceral adipose tissue and hepatic development, and persistent diet-responsive transcriptional changes. Taken together, our findings define metabolic vulnerabilities due to EAE and provide evidence that behavioral changes and primary organ dysfunction contribute to resultant metabolic abnormalities.

Brown and beige adipose tissues contain thermogenic fat cells that can be activated by β3-adrenergic receptor agonists. In rodents, such drugs both diminish obesity and improve glucose homeostasis. In this issue of the JCI, O’Mara et al. and Finlin and Memetimin et al. report that chronic administration of the approved β3 agonist mirabegron to human subjects was without effect on body weight or fat mass, but improved several measures of glucose homeostasis. Though the mechanisms mediating these metabolic effects are uncertain, the data suggest that β3 agonists could have therapeutic utility in disorders of glucose homeostasis.

Amazon is taking up to $100 off the Apple Watch Series 5 this week, with prices starting at $299.99 for the 40mm GPS models. Only the Gold Aluminum Case with Pink Sport Band is available at this price. If you order today, the Apple Watch should arrive sometime next week.

Note: MacRumors is an affiliate partner with Amazon. When you click a link and make a purchase, we may receive a small payment, which helps us keep the site running.

The Apple Watch Series 5 was released in September 2019 with a new OLED screen that supports an always-on feature, which represents the biggest change to the Series 5 models. The newest Apple Watch is available in 40mm and 44mm sizes, and it has the overall same design as the Series 4 models.

$100 OFF

Apple Watch S5 (40mm, GPS) for $299.99

If you're shopping for a cellular model, there are also a few solid discounts on Amazon for these devices. You can get the Gold Aluminum Case with Pink Sport Band (40mm) for $399.00, down from $499.00. Likewise, the Silver Aluminum Case with White Sport Band (40mm) is $399.00 right now.

For the 44mm cellular models, a solid deal is the Space Gray Aluminum Case with Black Sport Band at $429.00, down from $529.00. You'll find the same price on the Silver Aluminum Case with White Sport Band and the Gold Aluminum Case with Pink Sport Band.

Across the board, these sales are either new low prices on the Apple Watch Series 5, or they're matching previous low prices seen on these models on Amazon. There are a few other deals going on for different Series 5 models as well, including numerous 44mm cellular devices that are about $50 off Apple's original prices. Be sure to head to Amazon to check out the full sale before these prices expire, or the retailer runs out of stock.

Keep up with all of this week's best discounts on Apple products and related accessories in our dedicated Apple Deals roundup.
This article, "Deals: Apple Watch Series 5 Models Discounted by Up to $100 on Amazon" first appeared on MacRumors.com

Discuss this article in our forums

A nationwide class action lawsuit filed against Apple in Northern California court this week accuses the company of knowingly concealing a defect with a display-related flex cable on recent 13-inch and 15-inch MacBook Pro models.


As discovered by repair website iFixit last year, some MacBook Pro models released in 2016 and 2017 have experienced issues with uneven backlighting caused by a delicate flex cable that can wear out and break after repeated opening and closing of the display. Impacted notebooks can exhibit uneven lighting at the bottom of the screen, which has been described as a "stage light" effect, and the backlighting system can eventually fail entirely.

Since the issue often takes time to manifest, the affected ‌MacBook Pro‌ units can be outside of Apple's one-year warranty period when they start exhibiting symptoms, resulting in an out-of-warranty repair fee of up to $850.

"Imagine spending more than $2,500 on a laptop only for it to fail shortly after the manufacturer's warranty expires," said PARRIS Law Firm attorney R. Rex Parris. "What's even more appalling is Apple requiring customers to spend an additional $600 to $850 to replace the screen."

Apple seemingly fixed the issue by extending the length of the flex cable by 2mm in the 2018 MacBook Pro. It also launched a free repair program in May 2019, but the program only applies to 13-inch MacBook Pro models released in 2016.

iFixit found the 2018 MacBook Pro flex cable on the left to be 2mm longer
The class action lawsuit seeks restitution for all costs attributable to replacing or replacing the affected MacBook Pro units, and calls for Apple to expand its repair program to cover the 15-inch MacBook Pro. The proposed class is defined as all persons within the United States who purchased a 2016 or newer MacBook Pro.

Related Guide: "Flexgate" Display Issues Affecting 2016 MacBook Pro and Later
This article, "Apple Faces Class Action Lawsuit Over 'Flexgate' Issue With MacBook Pro Displays" first appeared on MacRumors.com

Discuss this article in our forums

Disney has announced that it will be producing a new Robin Hood movie.

Yes, that Robin Hood.

read more

Senator Max Baucus, Chairman of the U.S. Senate Committee on Finance, releases a staff discussion draft on international business tax reform. Continue reading →

When longtime independent Senator Bernie Sanders lost his bid for the Democratic presidential nomination, he concluded his campaign by endorsing Hillary Clinton instead of a third-party candidate. "This huge, wonderful effort that he launched is now aborted," says our guest, four-time former presidential candidate Ralph Nader. "Sanders hasn’t returned a call from me in 18 years. He is a lone ranger. He doesn’t like to be pushed into more progressive action than he is willing to adhere to. As a result, millions of his voters now are in disarray. They don’t know where to go." Nader has a new book titled "Breaking Through Power: It’s Easier Than We Think." Continue reading →

Jimmy Dore: The intelligence agencies have been releasing the reports to convince us that we should be upset at Russia because they hacked our election. First of all, who gives a shit if they did? The United States tapped Angela Merkel’s … Continue reading →

Connecticut General Assembly Majority Leader Joe Aresimowicz speaking at the 2014 CEUI Convention. Joe Aresimowicz, in speaking to a governmental employee union group in 2014, assured governmental union employees that he would be looking out for them: "You guys have one of your own that sits in the caucus room of the General Assembly. You cannot replicate that." "I will never allow an anti-collective bargaining bill to be called to the House floor. I'm the majority leader. I can make that guarantee." "Please, stand together, stand as brothers and sisters, and be a family. And make sure we are looking out for our own." Continue reading →

With only 37 days until Britain leaves the EU, its biggest foreign and trade policy shift in more than 40 years, divisions over Brexit are redrawing the political landscape.

We are all keeping our social distance these days, and many of us, other than the superheroes in the medical profession and restocking grocery stores, are spending all of our time in our homes. The delightful ladies of Drunk Austen have thus put together a Virtual JaneCon to be held this weekend, March 28 and…

IBM Research today opened its second research location on the African continent and announced several new project collaborations in the areas of data driven healthcare, digital urban ecosystems and astronomy.

An updated Disaster Resilience Scorecard to help cities and local government agencies improve their preparedness and reduce risks from disasters was launched today at the Global Platform for Disaster Risk Reduction. Developed for the UN Office for Disaster Risk Reduction by AECOM, IBM with support from USAID and the European Commission, the Scorecard gives better access to information, knowledge resources, and tools to effectively reduce risks from the impacts of natural hazards and climate change.

Plus more ways to support comics creators and new authors launching their books worldwide while social distancing!

The post Social Distancing Roundup: JOHN WICK Livestream, Neil Gaiman reads CORALINE, and an X-MEN ’92 watchalong appeared first on The Beat.

DC made a good choice in moving away from Diamond.

The post The Coronavirus Journal: Alternative Distribution Will Help Us Survive appeared first on The Beat.

The media name and shame people breaking the rules on social distancing and self-isolation.

Disappointing results for malaria drug hydroxychloroquine which has been favoured by Donald Trump and some in the media as a possible treatment for coronavirus.

IBM and West Virginia University’s Center for Disability Inclusion (CDI) today announced they are developing a first generation mobile workplace accommodation case management app to help U.S. businesses create inclusive workplaces for employees with disabilities.

I went out to interview the players hunting in the park at night

If your timing is just exactly right, you can experience a Disneyland ghost town

Photos and Descriptions of where to find Electrical Outlets in the Magic Kingdom

Photos of Menu Signs from 2011-2019

A batch of advice for visiting Disneyland with two young teens

IBM Security today released a global study examining consumer perspectives around digital identity and authentication, which found that people now prioritize security over convenience when logging into applications and devices. Generational differences also emerged showing that younger adults are putting less care into traditional password hygiene, yet are more likely to use biometrics, multifactor authentication and password managers to improve their personal security.

While marketing and sales professionals increasingly find themselves drowning in data, a new IBM study finds that nearly two thirds—64 percent--of surveyed CMOs and sales leaders believe their industries will be ready to adopt cognitive technologies in the next three years. However despite this stated readiness, the study finds that only 24 percent of those surveyed believe they have strategy in place to implement these technologies today.

IBM (NYSE: IBM) reinventa hoy el correo electrónico empresarial con una nueva oferta de colaboración social freemium que utiliza la tecnología de analítica integrada para dar a los empleados una nueva forma de conversar, encontrar a las personas y la información correcta rápidamente, y hacer su trabajo de manera eficiente. IBM Verse es el resultado de una inversión de US$100 millones en diseño e innovación, y reúne las plataformas líderes cloud, analytics, social y de seguridad de la compañía para transformar el futuro del trabajo.

IBM (NYSE: IBM) reveló hoy una serie de nuevos servidores diseñados para potenciar las cargas de trabajo cognitivas y elevar la eficiencia en el centro de cómputo. Con un nuevo chip, la línea basada en Linux incorpora innovaciones de la comunidad OpenPOWER que ofrecen mayores niveles de desempeño y mayor eficiencia de cómputo que los disponibles en cualquier servidor basado sobre x86.

IBM and Health Benefits Limited announce agreement to introduce National Infrastructure Platform to District Health Boards, based on IBM Cloud.

Dans ce monde où les business model des entreprises et encore plus les technologies sont en rupture, le challenge est le même : rester en contact avec le consommateur hyper connecté d’aujourd’hui. Ce challenge peut être vu comme un véritable cauchemar ou à l’inverse, considéré comme la prochaine grande opportunité pour les entreprises. Elles sont obligées d’aller au-delà des prévisions, en identifiant et capitalisant sur des opportunités que d’autres entreprises ne voient pas.

L’entité sécurité d’IBM a annoncé aujourd'hui les résultats d'une étude mondiale sondant le niveau de préparation des organisations en matière de résistance à une cyberattaque et de récupération ensuite. L'étude, menée par le Ponemon Institute et sponsorisée par IBM Resilient, a révélé qu'une grande majorité des organisations interrogées ne sont toujours pas prêtes à répondre de façon adéquate aux incidents de cybersécurité, 77% des personne interrogées indiquant qu'ils n'ont pas de plan de réponse aux incidents de cybersécurité appliqué de manière cohérente dans l’ensemble de l'organisation.

@IBM et Hardis Group signent un accord mondial pour transformer la chaîne logistique à l'heure du #client connecté #smartercommerce

Etude IBM : les directions Marketing doivent adopter la « disruption créative » pour fidéliser leurs clients La nouvelle étude IBM révèle les principaux axes de priorités des directions Marketing pour 2016

North Queensland capital Townsville is among the first cities globally to use a new United Nations&rsquo; Office for Disaster Risk Reduction (UNISDR) disaster resilience scorecard developed jointly by global fully integrated infrastructure firm AECOM and IBM.</p>

The IBM Research findings achieve the highest recorded accuracy of 86 percent by using deep learning and pathology insights to identify the severity of diabetic retinopathy.