How to create secure access to services hosted in AWS with Sophos XG Firewall.

The development of the HUPO-PSI's (Proteomics Standards Initiative) standard data formats and MIAPE (Minimum Information About a Proteomics Experiment) guidelines should improve proteomics data sharing within the scientific community. Proteomics journals have encouraged the use of these standards and guidelines to improve the quality of experimental reporting and ease the evaluation and publication of manuscripts. However, there is an evident lack of bioinformatics tools specifically designed to create and edit standard file formats and reports, or embed them within proteomics workflows. In this article, we describe a new web-based software suite (The ProteoRed MIAPE web toolkit) that performs several complementary roles related to proteomic data standards. Firstly, it can verify the reports fulfill the minimum information requirements of the corresponding MIAPE modules, highlighting inconsistencies or missing information. Secondly, the toolkit can convert several XML-based data standards directly into human readable MIAPE reports stored within the ProteoRed MIAPE repository. Finally, it can also perform the reverse operation, allowing users to export from MIAPE reports into XML files for computational processing, data sharing or public database submission. The toolkit is thus the first application capable of automatically linking the PSI's MIAPE modules with the corresponding XML data exchange standards, enabling bidirectional conversions. This toolkit is freely available at http://www.proteored.org/MIAPE/.

Site-specific recombinases, such as Cre, are a widely used tool for genetic lineage tracing in the fields of developmental biology, neural science, stem cell biology, and regenerative medicine. However, nonspecific cell labeling by some genetic Cre tools remains a technical limitation of this recombination system, which has resulted in data misinterpretation and led to many controversies in the scientific community. In the past decade, to enhance the specificity and precision of genetic targeting, researchers have used two or more orthogonal recombinases simultaneously for labeling cell lineages. Here, we review the history of cell-tracing strategies and then elaborate on the working principle and application of a recently developed dual genetic lineage-tracing approach for cell fate studies. We place an emphasis on discussing the technical strengths and caveats of different methods, with the goal to develop more specific and efficient tracing technologies for cell fate mapping. Our review also provides several examples for how to use different types of DNA recombinase–mediated lineage-tracing strategies to improve the resolution of the cell fate mapping in order to probe and explore cell fate–related biological phenomena in the life sciences.

OBJECTIVE

The vast number of antihyperglycemic medications and growing amount of evidence make clinical decision making difficult. The aim of this study was to investigate the safety of antihyperglycemic dual and triple therapies for type 2 diabetes management with respect to major adverse cardiovascular events, severe hypoglycemia, and all-cause mortality in a real-life clinical setting.

Rockville, Maryland : National Institute on Drug Abuse, 1988.

Rockville, Maryland : National Institute on Drug Abuse, 1985.

Rockville, Maryland : National Institute on Drug Abuse, 1977.

Washington, D.C. : Wynne Associates, [1974]

This paper proposes a stochastic variant of the stable matching model from Rasulkhani and Chow [1] which allows microtransit operators to evaluate their operation policy and resource allocations. The proposed model takes into account the stochastic nature of users' travel utility perception, resulting in a probabilistic stable operation cost allocation outcome to design ticket price and ridership forecasting. We applied the model for the operation policy evaluation of a microtransit service in Luxembourg and its border area. The methodology for the model parameters estimation and calibration is developed. The results provide useful insights for the operator and the government to improve the ridership of the service.

Yuan Ke, Stanislav Minsker, Zhao Ren, Qiang Sun, Wen-Xin Zhou.

Source: Statistical Science, Volume 34, Number 3, 454--471.

Abstract:
We provide a survey of recent results on covariance estimation for heavy-tailed distributions. By unifying ideas scattered in the literature, we propose user-friendly methods that facilitate practical implementation. Specifically, we introduce elementwise and spectrumwise truncation operators, as well as their $M$-estimator counterparts, to robustify the sample covariance matrix. Different from the classical notion of robustness that is characterized by the breakdown property, we focus on the tail robustness which is evidenced by the connection between nonasymptotic deviation and confidence level. The key insight is that estimators should adapt to the sample size, dimensionality and noise level to achieve optimal tradeoff between bias and robustness. Furthermore, to facilitate practical implementation, we propose data-driven procedures that automatically calibrate the tuning parameters. We demonstrate their applications to a series of structured models in high dimensions, including the bandable and low-rank covariance matrices and sparse precision matrices. Numerical studies lend strong support to the proposed methods.

"Occupy White Walls" allows players to design their own art galleries—and explore others' out-of-the-box creations

The graphic designer is receiving a Lifetime Achievement Award from Cooper Hewitt for her recognizable computer icons, typefaces and graphics

Adventure Smart says search and rescue incidents increased 35 per cent last week, compared to the same time last year — and during the COVID-19 pandemic, SAR teams have to do extra work for each call.

Brydge on Wednesday launched a new update to improve its Brydge Pro+ keyboard with trackpad that recently starting shipping for iPad Pro. AppleInsider goes hands-on with the latest firmware to see how Brydge's improvements have strengthened the user experience of its flagship product.

More than one-tenth pediatric patients use complementary and alternative medicines (CAM) for their medial conditions in the United States. Traditional Chinese medicine (TCM) is the most commonly used CAM in East Asia but large-scale epidemiologic studies are lacking.

In comparing TCM and non-TCM users among children in Taiwan, children’s age and parental TCM use were strongly associated with TCM use. Additionally, dyspepsia and allergic rhinitis were positively related to increasing TCM use. (Read the full article)

Source: www.businessinsider.com - Saturday, May 09, 2020
Dating apps like Tinder, Bumble, and Hinge have reported increased use amid the coronavirus pandemic, while touting virtual dating alternatives for users instead of meeting up in person. Swaths of users are still encouraging matches to break quarantine to have sex and go on dates, despite social distancing guidelines and fines to comply with them. An illustrator on Instagram has been collecting screenshots of these situations, and told Business Insider that users will brand themselves as "badasses," dispute the effectiveness of isolating, and lash out in anger and hurl abusive language when they're rejected. Spokespeople for Grindr, Tinder and Bumble told Business Insider they've informed users to adhere to social-distancing guidelines, but did not respond to inquiries about actions they're taking against users in places where violating lockdown orders can be against the law. Visit Business Insider's homepage for more stories . As millions remain confined to their homes to prevent the spread of coronavirus, the desire for human contact and connection has risen dramatically and led some to search for ways to break those social distancing rules. Popular dating apps — including Tinder , Bumble , and Hinge — have reported significant increases during the outbreak of swiping activity, matches between users, and messages exchanged. It's also led to the introduction of a breed of users who are interested in shirking lockdown orders, an

Google has made it easier to join the company's Advanced Protection Program, which is designed to stop the most sophisticated hackers from breaking into your Gmail account. Before you needed two security keys to enroll. Now you just need a smartphone.

On Tuesday, Avast responded to a PCMag-Motherboard investigation into the company's browser history collection practices, saying it was entirely legal. Avast users should expect to see a prompt from the antivirus products, asking them to consent to the data harvesting.

Zoom-bombings have been making headlines across the country this spring, and Penn State is no exception to the increase in security threats and breaches. To address these recent incidents in Zoom meetings, University-wide Zoom default setting changes will be implemented on May 11.

On Monday, Pablo Escobar's brother started to take orders for a second foldable phone at the low price of $399. However, users who bought the first foldable phone from the company say their orders have yet to arrive. Instead, what they got was a book and a pamphlet.

Seagate's FireCuda Gaming SSD and BarraCuda Fast SSD will appeal to those looking for a convenient way to give their laptop a boost, starting at less than $100.

Post the NTO implementation, the dynamics have tilted in favour of the broadcasters.

OTT platforms are partnering with travel agencies, airlines and cruises to tap on-the-go audiences

As per a report by BARC India and Nielsen, there has been a 30% increase in the time spent on education apps on smartphones since the lockdown

Facebook.com gets more streamlined when it comes to navigation, enabling easier discovery of videos, games, and even Groups.

Dover – Today, the State of Delaware announced that it appears as No. 56 on the U.S. Environmental Protection Agency’s (EPA’s) National Top 100 list of the largest green power users from the Green Power Partnership. Delaware is using nearly 122 million kilowatt-hours (kWh) of green power annually, which represents 40 percent of its total […]

At SAS Press, we agree with the saying “The best things in life are free.” And one of the best things in life is knowledge. That’s why we offer free e-books to help you learn SAS or improve your skills. In this blog post, we will introduce you to one [...]

Free e-book: SAS Programming for R Users was published on SAS Users.

Other telcos may face the heat in the long term by the nature of partnership which over time may see their high-end subscribers moving on to Jio's network just by the brand pull of WhatsApp.

At SAS Press, we agree with the saying “The best things in life are free.” And one of the best things in life is knowledge. That’s why we offer free e-books to help you learn SAS or improve your skills. In this blog post, we will introduce you to one [...]

Free e-book: SAS Programming for R Users was published on SAS Users.

India, which has imposed the world’s biggest shutdown to battle the spread of the coronavirus, last month launched the Aarogya Setu (Health Bridge) app — a Bluetooth and GPS-based application which alerts users who may have come in contact with people who later test positive for COVID-19.

I was recently honored to share the stage with government and medical leaders to discuss ways to impact the nation’s opioid epidemic. Hosted by The Washington Post, this event included often spirited conversations on ways to solve this national crisis. As the medical director for SAS US Government, I have [...]

The post Washington Post, new SAS user group, highlight need to collaborate on opioid epidemic appeared first on Government Data Connection.

A court document has surfaced showing that Tara Reade – a former Senate staffer for Joe Biden who has accused him of sexual assault – told her then-husband she was harassed while working in his office.
Read Full Article at RT.com

Democrat Senator Dianne Feinstein is being lambasted for apparent double standards after attacking Tara Reade, the former Joe Biden staffer who alleges the Democrat presidential candidate sexually assaulted her.
Read Full Article at RT.com

  Introduction Code51 is the first worldwide mech arena VR game supporting Oculus Rift, HTC Vive, PSVR and Pico VR. It allows up to four versus four combat among worldwide players and is specifically...

The gamified learning app for school students to be relaunched in all subjects.

Google Duo group video calling for web will arrive in the coming weeks starting as a preview on Chrome.

Social media giant Facebook is now rolling out its biggest update for desktop users, after first announcing it at its F8 developer conference last year.

Cred, a credit card payment app founded by ace entrepreneur Kunal Shah in late 2018, is now all set to foray into digital lending niche. Two very interesting fintech products have been launched by Cred for their million+ loyal users, which will help them to cope with the financial crisis unleashed by the coronavirus. Now, […]

The post Cred Will Offer Credit To Credit Card Users; Enables House Rent Payment Using Credit Card At 1.75% Fees first appeared on Trak.in . Trak.in Mobile Apps: Android | iOS.

It’s now official: Perspec System Verifier is rated the #1 product in the #1 category of Portable Stimulus, according to the 2017 EDA User Survey published on Deepchip.com. There were 33 user responses in favor of Perspec as the #1 tool, and dr...(read more)

It’s always good to hear what real users think of products. Here is a very detailed review (~4000 words) by an Anonymous user, nick named Ant-Man (from the movie). Overall it’s a very strong endorsement of Perspec, and summarize...(read more)

Hi Team,

I would like to download "Incisive Metrics Center User Guide", I could not find in the cadence/support/manuals. Can you please provide me the link or path to download the same ? I am doing functional coverage with IMC. 

Thank You,

Mahesh