A dairy-based yogurt product having a protein level above 15%, sometimes more than 25%, with a smooth and rich texture and no grittiness. The yogurt product includes a particular selection of dairy proteins and other ingredients to raise the gelation temperature of the dairy proteins and avoid causing gelation or precipitation during pasteurization. Additionally, pasteurization temperatures, times and methods are selected to avoid gelation. Starting dairy proteins generally have relatively higher pH levels and low total acidity (TA) levels to help reduce gelation during pasteurization. Ingredients such as buffering agents and sequestering agents may be utilized to help raise the gelation temperature, as well as higher sugar levels which can control hydration of the proteins.

The invention is directed to a single-step method for rapidly and efficiently preparing protein-polymer conjugates, including an insulin-polymer conjugate. According to the method of the present invention, a protein and hydrophilic polymer are contacted in the presence of at least one organic solvent and at least one metal chelator, under conditions that promote the formation of a conjugate of the protein and polymer. Thus, the invention is directed to the site-specific modification of selected proteins, such as insulin, with poly(ethylene glycol) at residue PheB1. The invention also provides a pharmaceutical formulation for encapsulating the conjugate in a biodegradable polymer.

Disclosed are process for contacting a protein containing material with one or more wet-mill streams. The protein content of the protein containing material is increased.

The present invention relates to a means of dialysis for removing protein-bound substances from a biological fluid, especially blood or blood plasma, which contains at least one means for solubilizing protein-binding substances to be removed into the biological fluid and/or dialysis fluid, and to a process for removing protein-bound substances from a biological fluid.

Variant factor H binding proteins that can elicit antibodies that are bactericidal for at least one strain of Neisseria meningitidis, compositions comprising such proteins, and methods of use of such proteins, are provided.

The present invention relates to methods and compositions for treating, preventing, and diagnosing Alzheimer's Disease or other tauopathies in a subject by administering an immunogenic tau peptide or an antibody recognizing the immunogenic tau epitope under conditions effective to treat, prevent, or diagnose Alzheimer's Disease or other tauopathies. Also disclosed are methods of promoting clearance of aggregates from the brain of the subject and of slowing progression of tau-pathology related behavioral phenotype in a subject.

The present invention provides compositions and methods relating to or derived from antigen binding proteins capable of inducing B-Klotho, and or FGF21-like mediated signaling. In embodiments, the antigen binding proteins specifically bind to a complex comprising β-Klotho and at least one of (i) FGFR1c, (ii) FGFR2c and (iii) FGFR3c. In some embodiments the antigen binding proteins induce FGF21-like signaling. In some embodiments, an antigen binding protein is a fully human, humanized, or chimeric antibodies, binding fragments and derivatives of such antibodies, and polypeptides that specifically bind to a complex comprising β-Klotho and at least one of (i) FGFR1c, (ii) FGFR2c and (iii) FGFR3c. Other embodiments provide nucleic acids encoding such antigen binding proteins, and fragments and derivatives thereof, and polypeptides, cells comprising such polynucleotides, methods of making such antigen binding proteins, and fragments and derivatives thereof, and polypeptides, and methods of using such antigen binding proteins, fragments and derivatives thereof, and polypeptides, including methods of treating or diagnosing subjects suffering from type 2 diabetes, obesity, NASH, metabolic syndrome and related disorders or conditions.

Cysteine engineered antibodies useful for the site-specific conjugation to a variety of agents are provided. Methods for the design, preparation, screening, selection and use of such antibodies are also provided.

The present disclosure provides compositions and methods of use involving binding proteins, e.g., antibodies and antigen-binding fragments thereof, that bind to the matrix metalloproteinase-9 (MMP9) protein (MMP9 is also known as gelatinase-B), such as where the binding proteins comprise an immunoglobulin (Ig) heavy chain (or functional fragment thereof) and an Ig light chain (or functional fragment thereof).

A soy protein product having a protein content of at least 60 wt % (N×6.25) d.b., preferably an isolate having a protein content of at least about 90 wt % (N×6.25) d.b., is formed from the supernatant from the precipitation of a soy protein micellar mass. A calcium salt or other divalent salt is added to the supernatant, before concentration, after initial concentration or after final concentration, to provide a conductivity of about 2 to about 30 mS. Precipitate is removed from the resulting solution and the pH of the clear soy protein solution is optionally adjusted to about 1.5 to about 4.4. The optionally pH-adjusted clear solution is concentrated to a concentration of about 50 to about 400 g/L and the clear concentrated protein solution is optionally diafiltered prior to drying. The soy protein product is soluble in acidic media and produces transparent, heat stable solutions at low pH values and, therefore, may be used for protein fortification of soft drinks and sports drinks.

In sporadic Alzheimer's disease, neurofibrillary lesion formation is preceded by extensive post-translational modification of the microtubule associated protein tau. Immunoassays have been developed recently that detect tau in biological specimens, thus providing a means for pre-mortem diagnosis of Alzheimer's disease, which has remained elusive. These assays have been improved by the analysis of relevant post-translational modifications, such as phosphorylation, however opportunity for improvement remains. The present invention addresses this issue by disclosing synthetic methylated peptides derived from the tau protein of paired helical filaments and non-diseased control brain. Alzheimer's disease specificity is provided by the presence or absence of methyl moieties on lysine residues and differences between mono-, di-, and tri-methylation. The methylated peptide is useful as an antigen and a binding partner for identifying compounds that interact with the peptide and the methylated tau protein, including antibodies that can distinguish non-diseased brain from that affected by Alzheimer's disease. The resulting antibodies are useful diagnostically and therapeutically. The compounds that specifically bind to methylated tau proteins are useful for eliminating abnormally methylated tau.

Bethesda announced today that the Switch version of Wolfenstein II: The New Colossus will launch on Friday, June 29.

During a recent SAG Foundation Conversations at Home interview, the Oscar winner talks about the main differences between what happens to her Jeanne Crandall character and herself in real life.

Julia Osborn guides us through an eerie tale of The Two Harveys.

Steinberg has announced the immediate availability of the Marco Minnemann Studio Drums expansion pack for Groove Agent. With over 4 GB of samples and 12 MIDI styles that were recorded and played in his studio in Los Angeles, Marco Minnemann Studio Drums features his 19-piece DW Purpleheart wood kit, comprising one kick drum, two snares, […]

The post Steinberg releases Marco Minnemann Studio Drums for Groove Agent appeared first on rekkerd.org.

This week, the former film producer Harvey Weinstein was convicted on two counts of sexual assault in a New York court. Weinstein, who has been accused of sexual misconduct by more than ninety women, has become an emblem of misogyny in Hollywood, and of the systems that protect wealthy and powerful men from the consequences of criminal misconduct. Rebecca Solnit joins Dorothy Wickenden to discuss whether the Weinstein verdict is a turning point in the #MeToo movement, and what it takes to expose the lies of those in power in business and politics.

Die Krise reißt vor allem wohlhabenden Gemeinden Löcher in die Kasse. Denn die für Städte so wichtige Gewerbesteuer bricht weg. Doch die größeren Probleme haben die ohnehin schwachen Kommunen. Sie müssen auf einen Faktor hoffen, der nicht in ihrer Hand liegt.

Als Reiseziel wird Deutschland dieses Jahr so gefragt sein wie nie. Interessant sind gerade dann Orte, die noch nicht überlaufen sind. Im ersten Teil unserer neuen Serie stellen wir fünf Städte im Norden des Landes vor.

Der Bundespräsident nennt die Auseinandersetzung mit der NS-Zeit einen „langen, schmerzhaften Weg“ – in seiner Gedenkrede zur Kapitulation der Deutschen Wehrmacht vor 75 Jahren formuliert Frank-Walter Steinmeier schöne Sätze. Doch den Punkt trifft er nicht.

Der Konflikt zwischen seiner Partei und Boris Palmer spitzt sich zu: Die Grünen fordern den Tübinger Oberbürgermeister auf, die Partei zu verlassen, der Beschluss fiel einstimmig. Palmer weist die Forderung entschieden zurück

Endlich Fotos schießen wie die Profis. Mit Spiegelreflexkameras ist das möglich. Doch Sie kennen sich mit den angesagten Kameras noch nicht gut aus? Wir stellen Ihnen die beliebtesten Einsteigermodelle vor.

Obduktionen ergeben, dass viele Covid-19-Patienten an Embolien und Thrombosen sterben. Professor Nils Kucher, Angiologe am Universitätsspital Zürich, erklärt, warum Corona falsch eingeschätzt wurde, und kritisiert eine Entscheidung des RKI. (Video, 9:22 Min.)

„Der Landesvorstand erwartet, dass Boris Palmer unsere Partei verlässt“, teilte der Vorstand der Südwest-Grünen mit. Zuletzt sorgte der Tübinger OB mit einer Wortwahl zum Umgang mit älteren Corona-Patienten für Empörung.

Innerhalb der Grünen-Partei rumort es - auch wegen eines Streits um neuerliche Aussagen Boris Palmers. Ein Parteiausschluss, wie von einigen gefordert, scheint dem Tübinger Oberbürgermeister aber nicht zu drohen.

In Deutschland geht die Reproduktionszahl weiter nach oben. Sorgen macht die Entwicklung in drei Landkreisen in NRW, Schleswig-Holstein und Thüringen. Hohe Fallzahlen werden aus Brasilien und Russland gemeldet. Ein Überblick in interaktiven Karten.

For many lucky enough to still have a job, getting dressed and made-up is a vestige of normalcy in a world that feels upended. For others, gray roots, shaggy beards and chipped nails are the last thing to worry about. But what has this unprecedented period behind closed doors revealed about our self-care and priorities? And what will happen to the beauty market when it’s all over? On Second Thought e xplores these questions, which are particularly pertinent now that Gov. Brian Kemp has given the green light for barbershops and hair and nail salons to re-open. The closure of schools, restaurants and hotels has wreaked havoc on the nation’s food culture, from one end of the supply chain to the other. Jon Jackson, founder of Comfort Farms in Milledgeville, joined On Second Thought to share what they’re dealing with, as well as how he got into farming in the first place. We also learn about StagVets , of which he’s executive director, and how it helps veterans dealing with PTSD.

“The Squad” gets a lot of media attention, but they are just one part of the record number of women elected to Congress in 2018. In fact, it was the most diverse freshman class ever elected: the first Muslim women representatives ever, the first Native women, the first two Latina members from Texas, two black women from New England, and the two youngest members ever elected to the House of Representatives.

Meredith Goldstein is host of the Love Letters podcast, the love advice columnist and entertainment writer for the Boston Globe and one of host Elizabeth McQueen's oldest and dearest friends.  In this episode she explores all the reasons she loves the sexy, pleading desperation of "Father Figure" by George Michael.

Carrie Brownstein explains how "Stay" by Rhianna inspired her to write the last track on Sleater-Kinney's latest record,"Broken." 

Tausende Menschen haben in mehreren deutschen Städten gegen die Einschränkungen zur Eindämmung der Corona-Pandemie demonstriert. Einer der Schwerpunkte war Stuttgart. Auch in Berlin, München und Frankfurt gab es Proteste.

Every inch of this backyard oasis in Phinney Ridge is covered in captivating plants, moss or ground cover.

Track president Phil Ziegler says overall handle increased this season despite 11 fewer races. But he says attendance, the number of horses per race and on-track betting declined.  

Predicting this year's biggest Oscar villains, a Métis comedian addresses Lynn Beyak, how China built two hospitals in two weeks in Wuhan, a profile of the woman defending Harvey Weinstein in court, Nigeria's burgeoning tech sector, the guy who created Comic Sans and more.

Eleanor Wachtel revisits her 1995 conversation with the American literary critic and writer about the power of human speech. He died on Feb. 3, 2020.

Het aantal Nederlandse consumenten dat een vaste telefoonlijn belangrijk vindt, blijft dalen. Een trend die al in 2014 ingezet is. De meest voorkomende reden waarom consumenten nog een vaste telefoonlijn in huis hebben? Omdat de vaste telefoniedienst onderdeel uitmaakt van het internet en bellen abonnement of alles-in-1 pakket. Dat zegt ruim een kwart (26%) van de consumenten in het meest recente telefoniemarkt onderzoek van Telecompaper.

De ACM publiceerde onlangs de meest recente Telecommonitor, een open halfjaarlijkse rapportage, over de status van de telecommarkt in de tweede helft van 2019. Daarin worden naast informatie over marktaandelen en abonnementen in de mobiele- en breedbandmarkt ook de jaaromzetten gepubliceerd die de vaste en mobiele netwerken genereren.

Do cooking shows work in a theatre setting?

Throughout a two hour culinary journey Rick will bring his travels to life, working with his guest chef to prepare an array of dishes, from fishy favourites in Cornwall, to vibrant and colourful Mediterranean cuisine, onwards to the light spicy flavours of South East Asia and culminating in a unique Australian dish. Audiences will also be captivated along the way with stories and footage from his TV series.

Ensemble Theatre's nationally touring production of 'Frankenstein' has opened in Wollongong to remind us of a timeless gothic masterpiece.

Marion von Adlerstein

Researchers have identified all the immune reactive proteins, then mapped and identified the parts causing chronic wheat ailments, giving growers a path to develop new lines.

Helena Rubinstein began her career in Victoria at the turn of the 20th century, and when she died she left a cosmetics empire, philanthropic foundation and a backstory laced with myth.

(California Court of Appeal) - Revived claims brought by members of the band WAR alleging that their music publisher breached a contract by failing to pay them certain song royalties. Reversed a summary judgment ruling.

#architektura #architekt #dom #design

#architektura #architekt #dom #design

(California Court of Appeal) - In an action against two insurance companies, brought by a plaintiff-insured who was denied coverage under a D&O policy because he was convicted of securities fraud, the trial court's judgment sustaining defendants' demurrer and dismissing the complaint is: 1) affirmed in part where the AXIS demurrer was properly sustained because AXIS was a stranger to the HCC policy and owed no duties connected with it; but 2) reversed in part where the HCC demurrer was improperly sustained because when a policy expressly provides coverage for litigation expenses on appeal, an exclusion requiring repayment to the insurer upon a 'final determination' of the insured's culpability applies only after the insured's direct appeals have been exhausted.