rtu Chromatin proteomics to study epigenetics - challenges and opportunities [Review] By www.mcponline.org Published On :: 2020-10-15T08:35:17-07:00 Regulation of gene expression is essential for the functioning of all eukaryotic organisms. Understanding gene expression regulation requires determining which proteins interact with regulatory elements in chromatin. Mass spectrometry-based analysis of chromatin has emerged as a powerful tool to identify proteins associated with gene regulation, as it allows studying protein function and protein complex formation in their in vivo chromatin-bound context. Total chromatin isolated from cells can be directly analysed using mass spectrometry or further fractionated into transcriptionally active and inactive chromatin prior to MS-based analysis. Newly formed chromatin that is assembled during DNA replication can also be specifically isolated and analysed. Furthermore, capturing specific chromatin domains facilitates the identification of previously unknown transcription factors interacting with these domains. Finally, in recent years, advances have been made towards identifying proteins that interact with a single genomic locus of interest. In this review, we highlight the power of chromatin proteomics approaches and how these provide complementary alternatives compared to conventional affinity purification methods. Furthermore, we discuss the biochemical challenges that should be addressed to consolidate and expand the role of chromatin proteomics as a key technology in the context of gene expression regulation and epigenetics research in health and disease. Full Article
rtu Ethical principles, opportunities and constraints in clinical proteomics [Research] By www.mcponline.org Published On :: 2021-01-04T06:35:18-08:00 Recent advances in MS-based proteomics have vastly increased the quality and scope of biological information that can be derived from human samples. These advances have rendered current workflows increasingly applicable in biomedical and clinical contexts. As proteomics is poised to take an important role in the clinic, associated ethical responsibilities increase in tandem with the impact on the health, privacy, and well-being of individuals. Here we conducted and report a systematic literature review of ethical issues in clinical proteomics. We add our perspectives from a background of bioethics, the results of our accompanying paper extracting individual-sensitive results from patient samples, and the literature addressing similar issues in genomics. The spectrum of potential issues ranges from patient re-identification to incidental findings of clinical significance. The latter can be divided into actionable and unactionable findings. Some of these have the potential to be employed in discriminatory or privacy-infringing ways. However, incidental findings may also have great positive potential. A plasma proteome profile, for instance, could inform on the general health or disease status of an individual regardless of the narrow diagnostic question that prompted it. We suggest that early discussion of ethical issues in clinical proteomics is important to ensure that eventual regulations reflect the considered judgment of the community as well as to anticipate opportunities and problems that may arise as the technology matures further. Full Article
rtu Mugabe’s Departure Ushers in a Heady New Era for Zimbabwe By www.chathamhouse.org Published On :: Thu, 23 Nov 2017 09:49:08 +0000 Mugabe’s Departure Ushers in a Heady New Era for Zimbabwe Expert comment sysadmin 23 November 2017 The country is experiencing an almost unprecedented convergence, with traditional political, economic and social fault lines bridged as Zimbabweans make common cause for change. — People celebrate Mugabe’s resignation in Harare. Photo: Getty Images. The ecstatic scenes said it all – Zimbabweans around the world are celebrating the resignation of Robert Mugabe as president. In January 1980, hundreds of thousands of Zimbabweans thronged Zimbabwe Grounds stadium in Highfields township, Harare, to welcome Mugabe back from exile. In March 1980, with reggae icon Bob Marley and Britain’s Prince Charles in attendance, thousands filled Rufaro Stadium to witness the handover from Rhodesia to the new nation of Zimbabwe. Thirty-seven years later, the largest crowds Harare has ever witnessed flooded the streets once again; not to welcome Mugabe in, but to see him out. One simple, taut phrase summed up the day’s events: ‘This is our second independence day.’ How did it come to this? History has been put on fast-forward, and left Zimbabwe – and the world – shaken. Just two weeks ago, it seemed to be the height of folly to think that Mugabe would leave office on any but his own terms. Emmerson Mnangagwa had been sacked as vice president, and his followers had been purged. Grace Mugabe, with ringing endorsements from the women’s and youth leagues, looked set to be elevated to the vice presidency at the ZANU-PF congress in less than a month’s time. Mugabe was expected to stay until the 2018 elections, after which he would hand over the presidency to his wife. It was the prospect of Grace Mugabe becoming Zimbabwe’s next president which brought in the military. Aware that they had three weeks or less to prevent a dynastic succession and a looming purge of the military itself, Zimbabwe’s military chose, not the audacity of hope, but the hope of audacity, and launched Operation Restore Legacy to stop the rot. What has happened in Zimbabwe is not a people’s revolution in the traditional sense. The Bourbons in France, the Romanov dynasty in Russia, the Shah of Iran, and the autocrats of north Africa’s Arab Spring were all felled by continuous street protests which ultimately received the support of the military. In Zimbabwe it has been the military who have been the drivers of revolutionary change. What has happened is that an internal party-factional power struggle has inadvertently led to a military-guided popular revolution and the ousting of the Mugabes. Zimbabwe’s military, often seen as the guardians of the state, became instead the guardians of the people. They are seen, for now at least, as liberators, and national heroes. This has been a very Zimbabwean revolution. So what next? These are heady days. Zimbabwe is experiencing an almost unprecedented national convergence, with traditional political, economic and social fault lines bridged as Zimbabweans make common cause for change. It is not quite a ‘Zimbabwe Spring’, but it is perhaps a ‘Zimbabwe Sunrise’. Parliament, which on Tuesday had met to impeach Robert Mugabe, is now installing, through constitutional procedures, Emmerson Mnangagwa as president, who will be given the mandate to form an interim government. Mnangagwa will be further ratified at the ZANU-PF Congress in December where he will be named and acclaimed as ZANU-PF’s candidate for the next general elections, which constitutionally are due by mid-2018 (although it is unclear whether this will indeed be the case). Mnangagwa has a full in-tray. He needs to form a government quickly and has to balance the need for inclusivity and consultation, with the undoubted pressure to reward his followers. With Zimbabwe’s economy nearing paralysis, Zimbabwe’s new president will be under pressure to deliver. Although many are nervous about his history as Mugabe’s ally and his reputation for toughness, Mnangagwa is also an astute political survivor, and has been pro-business and supportive of Zimbabwe’s ongoing re-engagement with the global community. Zimbabwe has become a cashless society not by design, but by default; with formal unemployment at 80 per cent and with a largely informalized economy in which much of Zimbabwe’s citizenry have been reduced to penury and classic short-termism, there is plenty for Zimbabwe’s next president to think about. Activists wonder whether he will try to introduce systemic change, or merely go through the motions. He may well face a binary choice between government or governance. And yet there are also positives. Zimbabwe’s institutions have proven to be resilient, and there is still a reservoir of dedicated and competent professionals in both public and private sectors. Although still laggardly, Zimbabwe had begun to progress in ‘ease of doing business’ indices. There is a large diaspora who have continued to engage with Zimbabwe; and Zimbabwe’s recent ‘Look East’ and de facto ‘Look West’ re-engagement policies can be built upon. Many are urging caution and saying that Zimbabwe needs a second, truly democratic revolution. Perhaps. But right now, Mnangagwa should be given a chance. Farai, a friend of mine in Harare, said this: ‘Yes we know this euphoria may be short-lived. But even if it turns out that we were only happy for a day, let’s make it a brilliant day. Rega tifare nhasi (Let us be happy today).’ A version of this article was first published by the Guardian. Full Article
rtu Virtual breakfast: The state of the EU in 2023 By www.chathamhouse.org Published On :: Wed, 05 Apr 2023 10:52:14 +0000 Virtual breakfast: The state of the EU in 2023 3 May 2023 — 8:30AM TO 9:30AM Anonymous (not verified) 5 April 2023 Online In this breakfast discussion, we will explore the current state of play in the EU with one the most prominent experts on European politics. While the European Union has come together in its response to the invasion of Ukraine, significant divisions remain on other issues. East-West tensions remain high and troublesome German-French relations are hampering the bloc’s traditional engine of integration. Furthermore, the EU is pushing through legislation at breakneck speed, including in its attempts to kickstart green industrial policy with its responses to the American Inflation Reduction Act. At the same time, the main players within the EU continue to disagree on what the bloc’s fiscal rules should look like. What are the implications of the recent wave of protests in France against President Macron’s pension reforms? What is the outlook of EU-UK relations following the successful completion of the Windsor Framework? Where are the fiscal rules likely to land and when will they be back in place? Are we seeing the emergence of a new Central and Eastern European power bloc within the EU? In short, despite having avoided an energy crisis over the winter, the EU continues to face significant challenges. In this breakfast event, we will explore the current state of play in the EU with one of the most prominent experts on European politics. Full Article
rtu NSF Issues Next Solicitation and More Detail on National Quantum Virtual Laboratory By www.hpcwire.com Published On :: Wed, 10 Jul 2024 14:20:57 +0000 After percolating for roughly a year, NSF has issued the next solicitation for the National Quantum Virtual Lab program — this one focused on design and implementation phases of the […] The post NSF Issues Next Solicitation and More Detail on National Quantum Virtual Laboratory appeared first on HPCwire. Full Article Features NSF NSF NQVL QED-C
rtu Have chronic low back pain? Try virtual yoga, study suggests By www.upi.com Published On :: Fri, 01 Nov 2024 14:33:48 -0400 Virtual yoga can be a successful and accessible way to manage chronic low back pain -- a common ailment with major consequences, a new study suggests. Full Article
rtu NASA offers virtual launch attendance, guest passport for next SpaceX supply mission By www.upi.com Published On :: Fri, 01 Nov 2024 15:41:27 -0400 NASA is inviting pubic participation in some virtual activities to watch the SpaceX space station resupply mission scheduled for a Monday night liftoff from NASA's Kennedy Space Center in Florida. Full Article
rtu The rise of virtual humans — and what they mean for the future | Sara Giusto By www.ted.com Published On :: Tue, 17 Sep 2024 14:56:27 +0000 Sara Giusto is a talent manager, but not in the sense you might imagine. Her biggest client is imma, an influencer with pink hair ... who isn't human. Giusto discusses what the rise of "virtual humans" means for the real world — and invites imma onstage to explore an important question: In an increasingly digital world, what's really real? Full Article Higher Education
rtu Educational Opportunities and Performance in Montana By www.edweek.org Published On :: Wed, 16 Jan 2019 00:00:00 +0000 This Quality Counts 2019 Highlights Report captures all the data you need to assess your state's performance on key educational outcomes. Full Article Montana
rtu Educational Opportunities and Performance in Montana By www.edweek.org Published On :: Tue, 21 Jan 2020 00:00:00 +0000 This Quality Counts 2020 Highlights Report captures all the data you need to assess your state's performance on key educational outcomes. Full Article Montana
rtu Educational Opportunities and Performance in Pennsylvania By www.edweek.org Published On :: Wed, 16 Jan 2019 00:00:00 +0000 This Quality Counts 2019 Highlights Report captures all the data you need to assess your state's performance on key educational outcomes. Full Article Pennsylvania
rtu Educational Opportunities and Performance in Pennsylvania By www.edweek.org Published On :: Tue, 21 Jan 2020 00:00:00 +0000 This Quality Counts 2020 Highlights Report captures all the data you need to assess your state's performance on key educational outcomes. Full Article Pennsylvania
rtu Philadelphia schools will stay virtual as virus cases spike By www.edweek.org Published On :: Wed, 11 Nov 2020 00:00:00 +0000 Full Article Pennsylvania
rtu Teachers union: More Pennsylvania schools should go virtual By www.edweek.org Published On :: Thu, 12 Nov 2020 00:00:00 +0000 Full Article Pennsylvania
rtu Educational Opportunities and Performance in Rhode Island By www.edweek.org Published On :: Wed, 16 Jan 2019 00:00:00 +0000 This Quality Counts 2019 Highlights Report captures all the data you need to assess your state's performance on key educational outcomes. Full Article Rhode_Island
rtu Educational Opportunities and Performance in Rhode Island By www.edweek.org Published On :: Tue, 21 Jan 2020 00:00:00 +0000 This Quality Counts 2020 Highlights Report captures all the data you need to assess your state's performance on key educational outcomes. Full Article Rhode_Island
rtu School Workers in Oregon Sue Union Over Window of Opportunity to Quit By www.edweek.org Published On :: Tue, 18 Jun 2019 00:00:00 +0000 Three Oregon school employees sued their union in federal court last week, arguing it's unfair that the teachers' union only lets members drop out and stop paying dues during the month of September. Full Article Oregon
rtu Educational Opportunities and Performance in Oregon By www.edweek.org Published On :: Wed, 16 Jan 2019 00:00:00 +0000 This Quality Counts 2019 Highlights Report captures all the data you need to assess your state's performance on key educational outcomes. Full Article Oregon
rtu Educational Opportunities and Performance in Oregon By www.edweek.org Published On :: Tue, 21 Jan 2020 00:00:00 +0000 This Quality Counts 2020 Highlights Report captures all the data you need to assess your state's performance on key educational outcomes. Full Article Oregon
rtu Educational Opportunities and Performance in North Dakota By www.edweek.org Published On :: Wed, 16 Jan 2019 00:00:00 +0000 This Quality Counts 2019 Highlights Report captures all the data you need to assess your state's performance on key educational outcomes. Full Article North_Dakota
rtu Educational Opportunities and Performance in North Dakota By www.edweek.org Published On :: Tue, 21 Jan 2020 00:00:00 +0000 This Quality Counts 2020 Highlights Report captures all the data you need to assess your state's performance on key educational outcomes. Full Article North_Dakota
rtu Educational Opportunities and Performance in Ohio By www.edweek.org Published On :: Wed, 16 Jan 2019 00:00:00 +0000 This Quality Counts 2019 Highlights Report captures all the data you need to assess your state's performance on key educational outcomes. Full Article Ohio
rtu Educational Opportunities and Performance in Ohio By www.edweek.org Published On :: Tue, 21 Jan 2020 00:00:00 +0000 This Quality Counts 2020 Highlights Report captures all the data you need to assess your state's performance on key educational outcomes. Full Article Ohio
rtu Educational Opportunities and Performance in Wyoming By www.edweek.org Published On :: Wed, 16 Jan 2019 00:00:00 +0000 This Quality Counts 2019 Highlights Report captures all the data you need to assess your state's performance on key educational outcomes. Full Article Wyoming
rtu Educational Opportunities and Performance in Wyoming By www.edweek.org Published On :: Tue, 21 Jan 2020 00:00:00 +0000 This Quality Counts 2020 Highlights Report captures all the data you need to assess your state's performance on key educational outcomes. Full Article Wyoming
rtu Philadelphia schools will stay virtual as virus cases spike By www.teachermagazine.org Published On :: 2020-11-10T19:41:25-05:00 Full Article Education
rtu Teachers union: More Pennsylvania schools should go virtual By www.teachermagazine.org Published On :: 2020-11-11T23:22:40-05:00 Full Article Education
rtu Non-English speakers face challenges in virtual learning By www.teachermagazine.org Published On :: 2020-11-14T14:42:29-05:00 Full Article Education
rtu Rapid City area schools move to all virtual instruction By www.teachermagazine.org Published On :: 2020-11-17T11:37:57-05:00 Full Article Education
rtu WVa education group seeks virtual learning until year's end By www.teachermagazine.org Published On :: 2020-11-16T20:12:14-05:00 Full Article Education
rtu Educational Opportunities and Performance in Maryland By www.edweek.org Published On :: Wed, 16 Jan 2019 00:00:00 +0000 This Quality Counts 2019 Highlights Report captures all the data you need to assess your state's performance on key educational outcomes. Full Article Maryland
rtu Educational Opportunities and Performance in Maryland By www.edweek.org Published On :: Tue, 21 Jan 2020 00:00:00 +0000 This Quality Counts 2020 Highlights Report captures all the data you need to assess your state's performance on key educational outcomes. Full Article Maryland
rtu Educational Opportunities and Performance in Massachusetts By www.edweek.org Published On :: Wed, 16 Jan 2019 00:00:00 +0000 This Quality Counts 2019 Highlights Report captures all the data you need to assess your state's performance on key educational outcomes. Full Article Massachusetts
rtu Educational Opportunities and Performance in Massachusetts By www.edweek.org Published On :: Tue, 21 Jan 2020 00:00:00 +0000 This Quality Counts 2020 Highlights Report captures all the data you need to assess your state's performance on key educational outcomes. Full Article Massachusetts
rtu Educational Opportunities and Performance in Kentucky By www.edweek.org Published On :: Wed, 16 Jan 2019 00:00:00 +0000 This Quality Counts 2019 Highlights Report captures all the data you need to assess your state's performance on key educational outcomes. Full Article Kentucky
rtu Educational Opportunities and Performance in Kentucky By www.edweek.org Published On :: Tue, 21 Jan 2020 00:00:00 +0000 This Quality Counts 2020 Highlights Report captures all the data you need to assess your state's performance on key educational outcomes. Full Article Kentucky
rtu Educational Opportunities and Performance in West Virginia By www.edweek.org Published On :: Wed, 16 Jan 2019 00:00:00 +0000 This Quality Counts 2019 Highlights Report captures all the data you need to assess your state's performance on key educational outcomes. Full Article Virginia
rtu Educational Opportunities and Performance in Virginia By www.edweek.org Published On :: Wed, 16 Jan 2019 00:00:00 +0000 This Quality Counts 2019 Highlights Report captures all the data you need to assess your state's performance on key educational outcomes. Full Article Virginia
rtu Educational Opportunities and Performance in West Virginia By www.edweek.org Published On :: Tue, 21 Jan 2020 00:00:00 +0000 This Quality Counts 2020 Highlights Report captures all the data you need to assess your state's performance on key educational outcomes. Full Article Virginia
rtu Educational Opportunities and Performance in Virginia By www.edweek.org Published On :: Tue, 21 Jan 2020 00:00:00 +0000 This Quality Counts 2020 Highlights Report captures all the data you need to assess your state's performance on key educational outcomes. Full Article Virginia
rtu WVa education group seeks virtual learning until year's end By www.edweek.org Published On :: Tue, 17 Nov 2020 00:00:00 +0000 Full Article Virginia
rtu Educational Opportunities and Performance in Nevada By www.edweek.org Published On :: Wed, 16 Jan 2019 00:00:00 +0000 This Quality Counts 2019 Highlights Report captures all the data you need to assess your state's performance on key educational outcomes. Full Article Nevada
rtu Educational Opportunities and Performance in Nevada By www.edweek.org Published On :: Tue, 21 Jan 2020 00:00:00 +0000 This Quality Counts 2020 Highlights Report captures all the data you need to assess your state's performance on key educational outcomes. Full Article Nevada
rtu Educational Opportunities and Performance in North Carolina By www.edweek.org Published On :: Tue, 21 Jan 2020 00:00:00 +0000 This Quality Counts 2020 Highlights Report captures all the data you need to assess your state's performance on key educational outcomes. Full Article North_Carolina
rtu Educational Opportunities and Performance in Oklahoma By www.edweek.org Published On :: Wed, 16 Jan 2019 00:00:00 +0000 This Quality Counts 2019 Highlights Report captures all the data you need to assess your state's performance on key educational outcomes. Full Article Oklahoma
rtu Educational Opportunities and Performance in Oklahoma By www.edweek.org Published On :: Tue, 21 Jan 2020 00:00:00 +0000 This Quality Counts 2020 Highlights Report captures all the data you need to assess your state's performance on key educational outcomes. Full Article Oklahoma
rtu Educational Opportunities and Performance in Maine By www.edweek.org Published On :: Wed, 16 Jan 2019 00:00:00 +0000 This Quality Counts 2019 Highlights Report captures all the data you need to assess your state's performance on key educational outcomes. Full Article Maine
rtu Educational Opportunities and Performance in Maine By www.edweek.org Published On :: Tue, 21 Jan 2020 00:00:00 +0000 This Quality Counts 2020 Highlights Report captures all the data you need to assess your state's performance on key educational outcomes. Full Article Maine
rtu Educational Opportunities and Performance in New York By www.edweek.org Published On :: Tue, 21 Jan 2020 00:00:00 +0000 This Quality Counts 2020 Highlights Report captures all the data you need to assess your state's performance on key educational outcomes. Full Article New_York
rtu Educational Opportunities and Performance in Nebraska By www.edweek.org Published On :: Wed, 16 Jan 2019 00:00:00 +0000 This Quality Counts 2019 Highlights Report captures all the data you need to assess your state's performance on key educational outcomes. Full Article Nebraska