Some people collect cars, mugs or sports memorabilia. Hayden Peters collects jewellery made from the hair of dead people.

If the 'Star of the South' wind farm is approved, you will see the turbines off the pier

Police have charged a man with the wilful murder of Sarah Spiers, a victim of the so-called Claremont serial killings in Perth in the 1990s.

A major work by influential German avant-garde artist Joseph Beuys is back on display at the National Gallery, and is taking the space usually occupied by Jackson Pollock's Blue Poles.

Five years ago up to 10,000 magpie geese helped themselves to fruit on a mango farm. Now the birds deliberately fly around the property.

Researchers from five Indigenous language groups have spent days scouring 19th-century archives for traces of lost words, as a new study suggests more than half of all living languages worldwide are endangered.

Of the almost 3,000 magpie attacks reported in Australia this year, only one was in Tasmania. So why are these notoriously angry birds so much more relaxed on the Apple Isle?

Computers have traditionally excelled at mathematical tasks, and are now better than humans at games such as chess, but some AI experts believe they could one day produce literature to rival Shakespeare himself.

The massive yacht crushed several smaller boats as it came to a juddering halt at the Cairns Marlin Marina in Queensland.

Massive wins for Geelong and Brisbane over North Melbourne and Gold Coast respectively have them closing in on a top two finish, while the Bombers are completely dismantled by the Bulldogs.

Young men detained for assault, theft and drug offences are training guide dogs in a program they say is changing their lives.

Connor Drum admits he steals food from the supermarket to supplement the Newstart payments he receives unable to find work, some in the Federal Government say he should leave the support networks he has in Canberra to search for a job in regional Australia.

(United States Ninth Circuit) - In an action in which a street performer-plaintiff and her friend, both dressed in 'sexy cop' costumes, posed with pedestrians on the Las Vegas Strip and accepted tips in exchange for photos, alleging plaintiff was unlawfully arrested for conducting business without a license, in violation of her First Amendment rights, the district court's summary judgment in favor of Las Vegas Metropolitan Police Department officers is reversed in part where: 1) the full First Amendment protections accorded to plaintiff's own activities did not lapse because of what her friend said or did without plaintiff's direct participation; and 2) plaintiff associated with her friend only for expressive activity protected under Berger v. City of Seattle, 569 F. 3d 1029 (9th Cir. 2009) (en banc), and the district court erred by deciding that the officers had probable cause to arrest plaintiff despite the First Amendment protections afforded to her expressive association.

(United States Fifth Circuit) - Denied in part, dismissed in part. A Haitian national's petition for review of a Board of Immigration Appeals denial of asylum and cancellation of removal was dismissed for lack of jurisdiction. His arguments that the court lacked jurisdiction and violated due process were denied.

(United States Ninth Circuit) - Reversing the district court's dismissal of claims under the False Claims Act by realtors against their former employer who made false statements about its compliance with FDA regulations regarding certain HIV drugs resulting in the receipt of billions of dollars from the federal government and alleging retaliation against the complaining realtor, holding that the realtors adequately pled a claim for retaliation.

(California Court of Appeal) - Affirmed. Defendant, a chiropractor, was convicted of charges stemming from a scheme to defraud workers’ compensation insurance carriers. On appeal, Defendant claimed several errors at trial including a sentencing error. The appeals court found no abuse of discretion or prejudicial error.

(California Court of Appeal) - Affirmed. Defendant, a chiropractor, was convicted of charges stemming from a scheme to defraud workers’ compensation insurance carriers. On appeal, Defendant claimed several errors at trial including a sentencing error. The appeals court found no abuse of discretion or prejudicial error.

(United States Fifth Circuit) - Affirmed. Investors who alleged that Pier 1 Imports was a trend-based fashion retailer with inventory that carried a significant markdown risk they failed to disclose were unable to adequately plead scienter.

Finnish Alt-rock Five-piece Planet Case Are Ready To Unveil Their Debut EP ‘Simple Thoughts’, Out On 24th May Via Up And Coming Finnish Label Soit Se Silti.

Halo On The Radio Will Broadcast For Three Hours, Seven Days A Week.

Capitol Hill bar Sancho's Broken Arrow has received a notice from the city requiring it to be vacated immediately and remain empty until the city's stay-at-home order is lifted.

(United States Third Circuit) - Held that unpaid highway tolls are not the type of debt that can support a claim under the federal Fair Debt Collection Practices Act (FDCPA). A driver who failed to pay tolls on the New Jersey Turnpike because his electronic payment account was in arrears filed a class-action complaint alleging that a debt collection agency used impermissible means to collect the debt. Affirming dismissal of his complaint, the Third Circuit held that highway tolls are a legal obligation in the nature of a tax that falls outside the scope of the FDCPA.

Now that Colorado is homebound for a while, here are three regional books to read during the coronavirus outbreak.

Sponsored by Credit Karma.

The WNBA star talks about his Mamba mentality

"Patti, I have to say, girl, you did it with this pie."

Everybody wants a piece of Ms. LaBelle.

Schneider Electric patches vulns after Trustwave raises alarm

Two Schneider Electric SCADA products had vulnerabilities similar to the ones exploited in the Iran-bothering Stuxnet worm, an infosec outfit has claimed.…

Contes de fées aux enfants - Octo-Puce la pieuvre et Craby-la-Pince le crabe.

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Alterations in calcium signaling in pancreatic acinar cells can result in pancreatitis. Although pressure changes in the pancreas can elevate cytosolic calcium (Ca2+) levels, it is not known how transient pressure-activated elevations in calcium can cause prolonged calcium changes and consequent pancreatitis. In this issue of the JCI, Swain et al. describe roles for the mechanically activated plasma membrane calcium channels Piezo1 and transient receptor potential vanilloid subfamily 4 (TRPV4) in acinar cells. The authors used genetic deletion models and cell culture systems to investigate calcium signaling. Notably, activation of the Piezo1-dependent TRPV4 pathway was independent of the cholecystokinin (CCK) stimulation pathway. These results elegantly resolve an apparent discrepancy in calcium signaling and the pathogenesis of pancreatitis in pancreatic acinar cells.

Elevated pressure in the pancreatic gland is the central cause of pancreatitis following abdominal trauma, surgery, endoscopic retrograde cholangiopancreatography, and gallstones. In the pancreas, excessive intracellular calcium causes mitochondrial dysfunction, premature zymogen activation, and necrosis, ultimately leading to pancreatitis. Although stimulation of the mechanically activated, calcium-permeable ion channel Piezo1 in the pancreatic acinar cell is the initial step in pressure-induced pancreatitis, activation of Piezo1 produces only transient elevation in intracellular calcium that is insufficient to cause pancreatitis. Therefore, how pressure produces a prolonged calcium elevation necessary to induce pancreatitis is unknown. We demonstrate that Piezo1 activation in pancreatic acinar cells caused a prolonged elevation in intracellular calcium levels, mitochondrial depolarization, intracellular trypsin activation, and cell death. Notably, these effects were dependent on the degree and duration of force applied to the cell. Low or transient force was insufficient to activate these pathological changes, whereas higher and prolonged application of force triggered sustained elevation in intracellular calcium, leading to enzyme activation and cell death. All of these pathological events were rescued in acinar cells treated with a Piezo1 antagonist and in acinar cells from mice with genetic deletion of Piezo1. We discovered that Piezo1 stimulation triggered transient receptor potential vanilloid subfamily 4 (TRPV4) channel opening, which was responsible for the sustained elevation in intracellular calcium that caused intracellular organelle dysfunction. Moreover, TRPV4 gene–KO mice were protected from Piezo1 agonist– and pressure-induced pancreatitis. These studies unveil a calcium signaling pathway in which a Piezo1-induced TRPV4 channel opening causes pancreatitis.

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