Cancer of unknown primary (CUP) represents a heterogeneous group of metastatic tumors for which standardized diagnostic work-up fails to identify the primary site. We aimed to describe the Peter MacCallum Cancer Centre experience with ¹⁸F-FDG PET/CT in extracervical CUP with respect to detection of a primary site and its impact on management. A secondary aim was to compare overall survival (OS) in patients with and without a detected primary site. Methods: CUP patients treated between 2014 and 2020 were identified from medical oncology clinics and ¹⁸F-FDG PET/CT records. Information collated from electronic medical records included the suspected primary site and treatment details before and after ¹⁸F-FDG PET/CT. Clinicopathologic details and genomic analysis were used to determine the clinically suspected primary site and compared against 2 independent masked reads of ¹⁸F-FDG PET/CT images by nuclear medicine specialists to determine sensitivity, specificity, accuracy, and the rate of detection of the primary site. Results: We identified 147 patients, 65% of whom had undergone molecular profiling. The median age at diagnosis was 61 y (range, 20–84 y), and the median follow-up time was 74 mo (range, 26–83 mo). Eighty-two percent were classified as having an unfavorable CUP subtype as per international guidelines.¹⁸F-FDG PET/CT demonstrated a primary site detection rate of 41%, resulted in a change in management in 22%, and identified previously occult disease sites in 37%. Median OS was 16.8 mo for all patients and 104.7 and 12.1 mo for favorable and unfavorable CUP subtypes, respectively (P < 0.0001). Median OS in CUP patients when using ¹⁸F-FDG PET/CT, clinicopathologic, and genomic information was 19.8 and 8.5 mo when a primary site was detected and not detected, respectively (P = 0.016). Multivariable analysis of survival adjusted for age and sex remained significant for identification of a potential primary site (P < 0.001), a favorable CUP (P < 0.001), and an Eastern Cooperative Oncology Group status of 1 or less (P < 0.001). Conclusion: ¹⁸F-FDG PET/CT plays a complementary role in CUP diagnostic work-up and was able to determine the likely primary site in 41% of cases. OS is improved with primary site identification, demonstrating the value of access to diagnostic ¹⁸F-FDG PET/CT for CUP patients.

Kevin Costner says he didn't know about his "Yellowstone" character John Dutton's death until after the episode aired on Sunday.

Did you grow up in a world void of social media platforms? Then, you’re probably the last ‘lucky’ generation. A part of Generation Y and most of Generation Z have been raised alongside the internet and social media. Individuals belonging to the latter have practically been raised by such platforms, as they interact with strangers […]

The post Sacrificing the Human Psyche at the Altar of Social Media? 4 Concerning Ill-Effects to Know first appeared on What is Psychology?.

Data on the usage of educational technology tools can provide districts with a helpful road map for improving student engagement under remote, in-person, or hybrid learning conditions. See how school districts are using such data to make smart, strategic decisions.

Data on the usage of educational technology tools can provide districts with a helpful road map for improving student engagement under remote, in-person, or hybrid learning conditions. See how school districts are using such data to make smart, strategic decisions.

Where did Texas A&M land in the latest CFP bracket? Here’s the College Football Playoff picture for the Aggies and their path to the championship.

Miami landed 9th in the latest CFP bracket. Here’s the College Football Playoff picture for the Hurricanes and path to the championship.

Penn State football landed Xth in the second CFP rankings. Here’s the College Football Playoff picture for the Nittany Lions.

Data on the usage of educational technology tools can provide districts with a helpful road map for improving student engagement under remote, in-person, or hybrid learning conditions. See how school districts are using such data to make smart, strategic decisions.

Part of the Feeding Knowledge platform, an initiative [...]

How do you prefer to read? On your phone, on your tablet, on your computer, or in print? And maybe the way you do it today is not the same [...]

Ahead of the Food Systems Summit, join the Publications team to find out more about where to find FAO publications, the different formats available, how you can re-use the [...]

Ahead of the Food Systems Summit, join the Publications team to find out more about where to find FAO publications, the different formats available, how you can re-use the [...]

Ahead of the Food Systems Summit, join the Publications team to find out more about where to find FAO publications, the different formats available, how you can re-use the [...]

Did you know? The Publications and Library branch and the FSN Forum are teaming up to provide Forum participants with additional references and resources to raise awareness on topics of their contributions.

Who does what 

The Global Forum on Food [...]

In this workshop, we will explore the role of innovation in supporting traditional practices that conserve agricultural heritage systems.  

Traditional agricultural practices, often rooted in the local communities and the knowledge [...]

On March 10, 1933, a major earthquake caught the Los Angeles area by surprise. The devastation was of sufficient scale to spur scientific interest in earthquakes—and how to predict them.

Marc Edwards and Leeanne Walters | Smithsonian Magazine’s 2016 American Ingenuity Award Winners for Social Progress The duo joined forces to protect tens of thousands of people during the disastrous water crisis in Flint, Michigan. Walters, a Flint resident, grew suspicious when her tap water changed color and her family suffered odd maladies. Officials insisted that the problems were limited to her household, but she refused to accept that answer and sought out Edwards, a Virginia Tech civil engineering professor and a veteran of municipal water wars. Combining political action and scientific credibility, the testing initiative undertaken by Walters and Edwards showed that the city’s water supply was contaminated with toxic chemicals—an explosive finding that finally forced state and local officials to address the dangers. Read more about their work: http://smithmag.co/D4dIHy | #IngenuityAwards And more about the American Ingenuity Awards: http://smithmag.co/77xPqy

The American Ingenuity Award winner is using geographic information systems to map history's most iconic landscapes

Some researchers initially dismissed the remains of Palaeopascichnus lineari as teeny turds from a bygone era

While no written records exist, new research has illuminated key details of the battle fought in northern Germany during the 13th century B.C.E.

"Frida: Beyond the Myth" aims to paint an intimate portrait of the artist through dozens of works created by Kahlo and photographs taken by her loved ones

Predicted to bring the northern lights as far south as parts of California and Alabama, a large coronal mass ejection from the sun collided with our planet Thursday morning

Identified as an Arctic fox, the animal is believed to have been kept in captivity far from its native habitat in the tundra. Now, it's receiving care from wildlife officials

Authorities have not yet identified the cause of death for the 12.5-foot-long shark, which was named Koala

Called M136279841, the value belongs to a rare class of prime numbers called Mersenne primes and was found using a supercomputer system spread across 17 countries

The deep penetrations suggest that the feline was pressing its claws into the clay, a behavior sometimes known as "making biscuits"

A new exhibition spotlights the Spanish artist's printmaking talents, which he began honing in his 20s. In the decades that followed, he produced thousands of breathtaking creations

Monday marks the first Remembrance Day ceremony at the National War Memorial in St. John's to include the tomb of the Unknown Soldier. We're proud to present again two documentaries that tell a remarkable story.

Hundreds congregated in downtown St. John's Monday morning to pay tribute to Newfoundland and Labrador's fallen soldiers, and honoured the dead for the first time at the newly refurbished National War Memorial and tomb of the Unknown Solider. 

CBC Newfoundland and Labrador would love to hear your suggestions of folks and organizations who are there when you need them — and all the other times, too.

The new mayor and council are planning big changes for the Cape Breton Regional Municipality, and one of those is at the top of the staff organizational chart now that chief administrative officer Marie Walsh is set to retire.

Newspaper editor Horace Greeley unsuccessfully ran against incumbent Ulysses S. Grant in November 1872. Twenty-four days later, he died of unknown causes at a private mental health facility

When the U.S. Army massacred a Lakota village at Blue Water, dozens of plundered artifacts ended up in the Smithsonian. The unraveling of this long-buried atrocity is forging a path toward reconciliation

The apartment once occupied by the author of Les Miserables is now a museum dedicated to his life and to 19th century Paris

The city said in a news release on Thursday that the Mayor’s Task Force on Transparency, Access and Accountability — which is in charge of reviewing community concerns about openness at the city — is looking for your feedback.

Anna (Germany) and Christina (Canada) are the youngest members of OM Montenegro. They describe how God called them into missions, and led them unexpectedly to Montenegro, a Balkan country neither had heard much about before. Here God is changing them as they prepare for further service...

Robbie and Angela from OM in Montenegro take every opportunity to bring God's love into the lives of lonely elderly people in a care home.

Eliminates the Cost and Complexity of Maintaining Online Parts Catalogs; Improves Search, Navigation, and Communication for Engineers Seeking 3D Part Models

MARE’s BATFish improved speed, size and savings of oceanographic surveys with SolidWorks design technology

SA's tax ombud has had "informal discussions" with its counterpart in Australia over combating refund scams as it investigates the hijacking of eFiling profiles.

When God directed Ellianna to Ireland instead of Austria, she discovered a new opportunity to meet refugees.

65 participants travelled throughout Pakistan's provinces to share the Good News with those who have never heard.

After a trip to repair war damaged churches in the east, construction workers share their experience in order to inspire others to go.

Couple prepares for mission field by working with international students at home, and shares how God’s love impacts Muslims.

President Donald Trump wants to make the biggest cuts in the U.S. Department of Education's budget in about 35 years. Check out the highlights of Trump's plan.

There are some serious questions that still need answers, but there are a few certainties that teachers can hold onto, writes Casey M. Bethel.

In a recent high-profile case, Harvard College rescinded its offer to a school-shooting survivor after racist comments he’d written online surfaced. But how common is it for colleges to take back offers? And do students have any recourse?

No studies sufficiently answer the question, finds the GAO, which means debates over whether newer restorative-justice approaches help or harm safety are likely to continue.