You can now add Fresno to the growing list of cities that are now requiring people to wear face masks in public places.

Background: The management for totally thyroidectomized differentiated thyroid cancer (TT-DTC) patients with unexplained hyperthyroglobulinemia remains indeterminate due to evidence scarcity. This multicenter study aimed at prospectively evaluating the response to radioiodine (¹³¹I) adjuvant therapy (RAT) and its potential role in risk stratification and causal clarification. Methods: TT-DTC patients with stimulated serum thyroglobulin (Tgoff) levels > 10 ng/mL but no structurally evident disease were consecutively enrolled in five tertiary care institutions. After the administration of 5.55 GBq of ¹³¹I, the risk of presence of persistent/recurrent/metastatic DTC (prmDTC) was compared to that before RAT. The causes of hyperthyroglobulinemia were explored and the response to RAT was assessed 6-12 months post RAT. The change in suppressed thyroglobulin (Tgon) level was reported. Results: A cohort of 254 subjects with a median Tgoff of 27.1 ng/mL was enrolled for the analyses. Immediately after RAT, low-, intermediate-, and high-risk were identified in 5.9%, 88.6%, and 5.5% patients, respectively, with no significant difference in risk stratification compared with that before RAT (P = 0.952). During the follow-up (median, 10.6 months), hyperthyroglobulinemia was ultimately attributed to thyroid remnant, biochemical disease, and structural/functional disease in 17.3%, 54.3%, and 28.3% of subjects, respectively. In addition, excellent, indeterminate, biochemical incomplete, and structural/functional incomplete responses were achieved in 18.1%, 27.2%, 36.2%, and 18.5% of patients, respectively. Notably, distribution for either cause of hyperthyroglobulinemia or response to RAT was comparable among the three postoperative risk groups. Tgon levels in patients who merely received RAT declined significantly over time. Conclusion: Our study demonstrated that over 90% of TT-DTC patients with unexplained hyperthyroglobulinemia are stratified as intermediate-high risk, and RAT using 5.55 GBq of ¹³¹I reveals biochemical/functional/structural disease and yields non-structural/functional incomplete response in more than 80% patients, suggesting TT-DTC patients with unexplained hyperthyroglobulinemia as explicit candidates for RAT.

OTTAWA, Canada (CMC): The Confederation of North, Central American and Caribbean Association Football’s (Concacaf) hexagonal round of qualifying for the 2022 FIFA World Cup in Qatar may have to be scrapped because of the disruption the COVID-19...

MADRID, Spain (AP): Rafael Nadal says Novak Djokovic will need to be vaccinated to keep playing if the governing bodies of tennis make coronavirus shots obligatory once they become available. Nadal told the Spanish newspaper La Voz de Galicia this...

Neoadjuvant chemotherapy for breast cancer is a new strategy that was introduced towards the end of the 20th century with the aim of reducing tumour size - rendering an otherwise inoperable tumour operable, allowing more conservative surgery, and hopefully improving overall survival. Although data indicate that the first rationale remains valid,...

London : Scribe, 2019.

Amsterdam : Uitgegeven by Frans Buffa en Zonen, [between 1843 and 1845]

The Anaheim Ducks have re-signed defensemen Christian Djoos and Jani Hakanpaa to one-year contracts. The Ducks announced the deals Wednesday. Djoos had one goal and two assists in nine games with the Ducks after they acquired him from the Washington Capitals on Feb. 24 in a trade for forward Daniel Sprong.

Ducks defensemen Christian Djoos and Jani Hakanpaa will stay with the team through the 2020-21 season after each signed a one-year, one-way contract extension.

Rockville, Maryland : National Institute on Drug Abuse, 1984.

James G. Scott, James O. Berger

Source: Ann. Statist., Volume 38, Number 5, 2587--2619.

Abstract:
This paper studies the multiplicity-correction effect of standard Bayesian variable-selection priors in linear regression. Our first goal is to clarify when, and how, multiplicity correction happens automatically in Bayesian analysis, and to distinguish this correction from the Bayesian Ockham’s-razor effect. Our second goal is to contrast empirical-Bayes and fully Bayesian approaches to variable selection through examples, theoretical results and simulations. Considerable differences between the two approaches are found. In particular, we prove a theorem that characterizes a surprising aymptotic discrepancy between fully Bayes and empirical Bayes. This discrepancy arises from a different source than the failure to account for hyperparameter uncertainty in the empirical-Bayes estimate. Indeed, even at the extreme, when the empirical-Bayes estimate converges asymptotically to the true variable-inclusion probability, the potential for a serious difference remains.

Joseph Antonelli, Giovanni Parmigiani, Francesca Dominici.

Source: Bayesian Analysis, Volume 14, Number 3, 825--848.

Abstract:
In observational studies, estimation of a causal effect of a treatment on an outcome relies on proper adjustment for confounding. If the number of the potential confounders ( $p$ ) is larger than the number of observations ( $n$ ), then direct control for all potential confounders is infeasible. Existing approaches for dimension reduction and penalization are generally aimed at predicting the outcome, and are less suited for estimation of causal effects. Under standard penalization approaches (e.g. Lasso), if a variable $X_{j}$ is strongly associated with the treatment $T$ but weakly with the outcome $Y$ , the coefficient $eta_{j}$ will be shrunk towards zero thus leading to confounding bias. Under the assumption of a linear model for the outcome and sparsity, we propose continuous spike and slab priors on the regression coefficients $eta_{j}$ corresponding to the potential confounders $X_{j}$ . Specifically, we introduce a prior distribution that does not heavily shrink to zero the coefficients ( $eta_{j}$ s) of the $X_{j}$ s that are strongly associated with $T$ but weakly associated with $Y$ . We compare our proposed approach to several state of the art methods proposed in the literature. Our proposed approach has the following features: 1) it reduces confounding bias in high dimensional settings; 2) it shrinks towards zero coefficients of instrumental variables; and 3) it achieves good coverages even in small sample sizes. We apply our approach to the National Health and Nutrition Examination Survey (NHANES) data to estimate the causal effects of persistent pesticide exposure on triglyceride levels.

Press release about the Basel Committee publishing consultation paper on revisions to the credit valuation adjustment risk framework, 28 November 2019.

Source: The Irish Times - Harold Kingston, who runs a dairy farm in Courtmacsharry, Co Cork, with 160 cattle, is typical of the new generation of smart farmers, who have adjusted how they work in response to climate change.

Corticosteroids inhibit the expression of many proinflammatory cytokines released during the course of community-acquired pneumonia infection. Corticosteroids have been found in some studies to be associated with improved clinical outcomes in adults with pneumonia. No studies have investigated corticosteroid use in children with pneumonia.

Results showed that corticosteroid treatment in children with pneumonia is common and its use is highly variable across institutions. Although corticosteroid therapy may benefit children with acute wheezing treated with β-agonists, corticosteroid therapy may lead to worse outcomes for children without wheezing. (Read the full article)

Pneumonia is still a significant problem in young children from developing countries where zinc deficiency is prevalent. Although zinc supplementation reduces the risk of childhood pneumonia, the effect of adjunct zinc on severe pneumonia is unclear with conflicting results.

The overall effect, if any, of zinc as adjuvant therapy for World Health Organization–defined severe pneumonia in young children is small. (Read the full article)

Evaluation of neonatal surgical outcomes is necessary to guide improvements in the quality of care. Meaningful comparisons must adjust for factors that alter outcomes independent of the surgical procedures.

Herein is described a method that permits risk adjustment for the broad range of noncardiac neonatal surgery, regardless of gestational age, to permit useful comparisons for quality improvement. (Read the full article)

The American College of Surgeons National Surgical Quality Improvement Program-Pediatric has examined 30-day risk-adjusted outcomes in children’s surgery. Because of low event rates, initial efforts yielded valid models that did not meaningfully discriminate outcomes among over 20 participating institutions.

Programmatic growth, sampling algorithm refinement, and hierarchical modeling use have resulted in the ability to reliably discriminate performance among hospitals in multiple domains. We report the first actionable peer-reviewed risk-adjusted, multiinstitutional outcome data in children’s surgery. (Read the full article)

Research in the aftermath of large-scale terrorist attacks shows that exposed children experience numerous negative psychological sequelae, including increased emotional difficulties, posttraumatic stress, and significant attack-related life disruptions.

Most research on terrorism-exposed youth examines large-scale terrorism. Limited work examines reactions to terrorism of the scope of the marathon attack, and the extraordinary manhunt and shelter-in-place warning was an unprecedented experience. Understanding adjustment after these events is critical. (Read the full article)

Concerns as well as hopes regarding electronic games have led researchers to study the influence of games on children, yet studies to date have largely examined potential positive and negative effects in isolation and using samples of convenience.

Results from this nationally representative study of children 10 to 15 years indicated low levels of regular daily play related to better psychosocial adjustment, compared with no play, whereas the opposite was true for those engaging in high daily play. (Read the full article)

Children who suffer abusive head trauma (AHT) have lasting health and development problems. AHT can reduce life expectancy dramatically. AHT’s contribution to the burden of disease has been estimated only as part of a broad category of intentional injury.

The DALY burden of a severe AHT case averages 80% of the burden of death, with most survivors dying before age 21 years. Even mild AHT is extremely serious, with lasting sequelae that exceed the DALY burden of a severe burn. (Read the full article)

Many families share genetic cancer risk information with their children, and some parents and providers believe BRCA1/2 testing should be permitted in adolescence. The psychosocial effects and impact on health and risk behaviors of this knowledge is unknown.

In our cohort of 869 mother-daughter pairs, we found no differences in general adjustment, but 10- to 13-year-old girls with breast cancer family histories reported higher breast cancer–specific distress and perceived breast cancer risk. Mother distress was associated with daughter distress. (Read the full article)

Of the three political upheavals that have hit the Maghreb since the beginning of 2011, the Libyan crisis seems to be the most dangerous. First of all for Libya, because the popular uprising has taken the form of an armed rebellion that has cut the country in two; second, for the West, now that NATO, under the cover of United Nations Resolution 1973 (2011) and in order to protect the civilian population, has entered the conflict on the side of the rebels, rashly gambling on a speedy war; and finally, for the region as a whole, because the conflict recently "overflowed" into Tunisia, and neighbouring countries are beginning to feel its humanitarian consequences.

Malware on an air-gapped computer can transmit data like Morse code by changing screen brightness in a way that's invisible to the naked eye but easily recorded with a camera.

T. Michael O'Shea
Jul 1, 1999; 104:15-21
ARTICLES

The Penn State Board of Trustees Committee on Finance, Business and Capital Planning today (May 7) advanced a plan to adjust tuition schedules for the summer 2020 semester due to the ongoing financial challenges many students and families are experiencing as a result of COVID-19 disruptions. The measure will go to the full board for a final vote on Friday, May 8.

029 - Six clubs fulfil conditions set out by CFCB

Source: www.youtube.com - Monday, April 27, 2020

Fly your DJI drone using a first-person perspective up to a range of 2.5 miles and race with up to seven other drones using the same low-latency system.

The DJI Mavic 2 Pro is the best small drone on the market, with superior image and video quality, obstacle avoidance, and excellent battery life.

The DJI Mavic Pro Platinum is the best small drone you can buy, and a fantastic choice for most aerial videographers and YouTubers.

The Mavic Air is DJI's smallest, most portable drone, and is just as full-featured as its larger siblings.

The DJI Mavic Mini weighs just 249 grams, so you can fly it in the US—and many other regions—without having to register it with the government. It has very capable specifications, but also some artificial limitations we're not happy to see.

The leading drone vendor developed the system to address safety and privacy concerns. The US Federal Aviation Administration is also drafting a rule that'll require all consumer drones to offer 'remote identification,' or what's basically an electronic license plate.

The DJI Mavic Mini is a lightweight drone that you don't have to register, but spotty connectivity makes it hard to recommend wholeheartedly.

For Penn State Scranton students, the first couple of weeks of remote learning have proven to be a big adjustment — academically and socially. Several campus students shared their initial thoughts regarding the virtual learning experience and being away from the physical campus.

Investment gains (in absolute terms) depend on the principal corpus invested and the returns delivered by the fund. Returns are a function of the performance of the asset class invested in.

You may avoid double taxation on your income by claiming tax relief if India has signed the Double Taxation Avoidance Treaty (DTAA) with the country of your residence.

After the backlash over his anti-vaxxer stance, Novak Djokovic has faced fresh criticism for suggesting that people can alter the make-up of food and water by using mind power and emotions.
Read Full Article at RT.com

World number one Novak Djokovic said he initially struggled to cope with the uncertainty surrounding when tennis can restart after its shutdown in early March due to the novel coronavirus.

The Anaheim Ducks have re-signed defensemen Christian Djoos and Jani Hakanpaa to one-year contracts, the team announced Wednesday.

Django version 3.0 suffers from a cross site request forgery token bypass vulnerability.

Fred. R. Becker Jr., president and CEO of the National Association of Federal Credit Unions, on Sept. 28, 2011, submitted comments to the Federal Reserve Board's Jennifer Johnson on its interim final rule on the fraud adjustment for debit card interchange fees.

A new approach A recent ruling by Coulson J represents a significant departure from the line of cases which paved the way for “smash and grab” adjudications. Since ISG v Seevic (2014) and Galliford Try v Estura (2015) an employer that fa...

The Groceries Code Adjudicator (the “GCA”) was set up in June 2013 to ensure that large retailers with a turnover of over £1bn comply with the Groceries Supply Code of Practice (the “Code”). This statutory body h...