The Delaware Division of the Arts is thrilled to announce the highly anticipated exhibition, Award Winners XXIII, showcasing the exceptional talents of 17 artists who have been named the 2023 Individual Artist Fellows. This extraordinary exhibition is curated and hosted by the Biggs Museum of American Art in Dover, Delaware.

This holiday season the Delaware Public Archives will present an exhibit “Celebrating Emily Bissell: The Christmas Seal Story.” The exhibit chronicles the beginning of Christmas Seals, and presents historic Christmas Seals, scrap books, photographs and documents related to Ms. Bissell’s efforts to foster public interest and gain support to raise funds to battle tuberculosis.

Wilmington, Del. (February 26, 2024) – The Delaware Division of the Arts’ Mezzanine Gallery presents Aaron Keith Hoffer’s exhibition, “Unspoken Trajectories,” on view from March 1-28, 2024. Guests are invited to attend a Meet-the-Artist Reception on Friday, March 1 from 5:00-7:00 p.m. Hoffer’s show will include dozens of abstract paintings ranging in size from large […]

  Wilmington, Del. (April 1, 2024) – The Delaware Division of the Arts’ Mezzanine Gallery presents E. Schwinn’s exhibition, “Within the Intimate Realm,” on view from April 5-26, 2024. Guests are invited to attend a Meet-the-Artist Reception on Friday, April 5 from 5:00-7:00 p.m. Schwinn creates patterned collages that incorporate found images, saved fragments, half-finished […]

Unique program highlights creativity of Delaware state employees   Dover, Del. (April 15, 2024) – The Delaware Division of the Arts held the 13th Annual Delaware State Employee Art Exhibition from February 27 to March 22, 2024 at the Art Center/Gallery at Delaware State University, Dover. This year, 180 State of Delaware employees and their […]

Twenty Delaware artists receive significant award from the Delaware Division of the Arts   Dover, Del. (April 22, 2024) – The Biggs Museum of American Art has opened the exhibition, Award Winners XXIV, marking the 24th consecutive year of hosting this exhibition in partnership with the Delaware Division of the Arts. Showcasing the exceptional work […]

  Wilmington, Del. (May 3, 2024) – The Delaware Division of the Arts’ Mezzanine Gallery presents Gregg Silvis’ exhibition, “15,000 Dowels,” on view from May 3-31, 2024. Guests are invited to attend a Meet-the-Artist Reception on Friday, May 3 from 5:00-7:00 p.m. The title of the exhibition comes from the essential material in this body […]

Attorney General Kathy Jennings announced Wednesday that 41-year-old Keith Gibson was declared a Habitual Offender and sentenced in New Castle County Superior Court to seven life terms, plus 296 years in prison for 22 convictions, including four counts of murder, relating to a brutal crime spree in the summer of 2021 that claimed the lives […]

It is definitely in the fitness of things that while striking the right chord, the Bombay High Court while batting most zealously for protecting the legal rights of the prisoners in a most learned, laudable, landmark, logical and latest judgment titled Balaji Puyad vs State of Maharashtra in Crimina

At the announcement Thursday morning at Rose Hill Community Center near New Castle (from left): Habitat for Humanity of New Castle County CEO Kevin L. Lewis, Division of Services for Aging and Adults with Physical Disabilities (DSAAPD) Chief Administrator Cynthia Mercer, DSAAPD Director Melissa Smith, state Representative Franklin Cooke, state Senator Darius Brown, DSAAPD Deputy […]

The Delaware Division of the Arts’ Mezzanine Gallery presents 2022 DDOA Individual Artist Fellow Maia Palmer’s exhibition, "Making the Invisible, Visible", running November 4-25, 2022.

Wilmington, DE, May 31, 2024 – Habitat for Humanity of New Castle County (HFHNCC) and Delaware State Housing Authority (DSHA), in partnership with Governor John Carney’s office, are proud to announce a press conference to highlight their efforts in supporting homeownership and community development across Wilmington and the entire state of Delaware. The press conference, […]

Wilmington, Del.  – The Delaware Division of the Arts’ Mezzanine Gallery presents Don James’ exhibition, “Beyond the Facade: Architectural Portraits,” on view from June 7-28, 2024. Guests are invited to attend a Meet-the-Artist Reception on Friday, June 7 from 5:00-7:00 p.m. Don James, from Milton, Delaware, is a photographer who finds inspiration in natural, industrial, […]

The Delaware Department of Justice has secured five years in prison followed by probation for a Wilmington woman who stole thousands of dollars worth of goods from Delaware retail chains between 2023 and 2024.      On July 10, Jasmine Williams, 36, was sentenced to five years of Level V prison followed by one year of […]

“Mercado Kitsch México” presents a vibrant and eclectic exhibition inspired by the rich visual and cultural heritage of kitsch art in Mexico City. Zavala celebrates the creativity and artistic expression of the working class, who, with ingenuity and passion, combine textures, colors, and shapes to reflect their unique essence. Her Mexican heritage “has been and will continue to be my strongest inspiration. Everything about our art, culture, and traditions inspires me.”

The Delaware Division of the Arts’ Mezzanine Gallery presents 2024 Emerging Artist Fellow Brandan Henry’s exhibition, “Ebon Solus” on view from October 4-25, 2024. Guests are invited to attend a Meet-the-Artist Reception on Friday, October 4 from 5:00-7:00 p.m.

Any State Bank of India account holder in order to activate their ATM card or a debit card can go to the online portal of SBI and do so by clicking on the e-services tab.

I am not able to open 64bit version of simvision using the following :

simvision -64 -wav "path to wav"

This throws the error "  /lib64/libc.so.6: version `GLIBC_2.14' not found"

I am only able to open it without the -64 option.

As a result I am not able to use the source browser feature since the simulation was run in 64 bit mode.

Need suggestion on how to resolve this. Thanks.

Despite its thriving automotive sector, Gothenburg is vulnerable to global economic pressures. However, local authorities are confident that their strategies will see the city ride out the uncertainties related to Brexit and the US-China trade wars.

Despite nurturing its R&D capacity, the city of Braunschweig lags its German peers in attracting FDI. Now it hopes a focus on the mobility sector will mean its technical skills are matched with investment.

The development of its agribusiness sector is one of Kazakhstan’s key priorities, and a first wave of foreign investors from Europe and Asia is looking at the country as a base to supply major markets in the regions. 

Make this year’s resolution stick with Kwit’s lifetime subscription plan, packed with tools and support to help you quit smoking for good.

Themed “Clean Energy for a Clean World”, ACES 2023 will take place from 24-26 October in Singapore. The event supports the region’s net zero ambitions and the need to accelerate just clean energy transition with appropriate technologies, policies and financing. Gain access to insightful sessions, networking with industry leaders, and exploring the latest advancements in clean energy.

LONDON — British writer Samantha Harvey won the Booker Prize for fiction on Tuesday with "Orbital," a short, wonder-filled novel set aboard the International Space Station that ponders the beauty and fragility of the Earth. Harvey was awarded the 50,000-pound ($64,000) prize for what she has called a "space pastoral" about six orbiting astronauts, which she began writing during COVID-19 pandemic lockdowns. The confined characters loop through 16 sunrises and 16 sunsets over the course of a day, trapped in one another's company and transfixed by the globe's ever-changing vistas. "To look at the Earth from space is like a child looking into a mirror and realizing for the first time that the person in the mirror is herself," said Harvey, who researched her novel by reading books by astronauts and watching the space station's live camera. "What we do to the Earth we do to ourselves." She said the novel "is not exactly about climate change, but implied in the view of the Earth is the fact of human-made climate change." She dedicated the prize to everyone who speaks "for and not against the Earth, for and not against the dignity of other humans, other life." "All the people who speak for and call for and work for peace — this is for you," she said. Writer and artist Edmund de Waal, who chaired the five-member judging panel, called "Orbital" a "miraculous novel" that "makes our world strange and new for us." Gaby Wood, chief executive of the Booker Prize Foundation, noted that "in a year of geopolitical crisis, likely to be the warmest year in recorded history," the winning book was "hopeful, timely and timeless." Harvey, who has written four previous novels and a memoir about insomnia, is the first British writer since 2020 to win the Booker. The prize is open to English-language writers of any nationality and has a reputation for transforming writers' careers. Previous winners include Ian McEwan, Margaret Atwood, Salman Rushdie and Hilary Mantel. De Waal praised the "crystalline" writing and "capaciousness" of Harvey's succinct novel — at 136 pages in its U.K. paperback edition, one of the shortest-ever Booker winners. "This is a book that repays slow reading," he said. He said the judges spent a full day picking their winner and came to a unanimous conclusion. Harvey beat five other finalists from Canada, the United States, Australia and the Netherlands, chosen from among 156 novels submitted by publishers. American writer Percival Everett had been the bookies' favorite to win with "James," which reimagines Mark Twain's "Huckleberry Finn" from the point of view of its main Black character, the enslaved man Jim. The other finalists were American writer Rachel Kushner's spy story "Creation Lake"; Canadian Anne Michaels' poetic novel "Held"; Charlotte Wood's Australian saga "Stone Yard Devotional"; and "The Safekeep" by Yael van der Wouden, the first Dutch author to be shortlisted for the Booker. Harvey is the first female Booker winner since 2019, though one of five women on this year's shortlist, the largest number in the prize's 55-year history. De Waal said issues such as the gender or nationality of the authors were "background noise" that did not influence the judges. "There was absolutely no question of box ticking or of agendas or of anything else. It was simply about the novel," he said before the awards ceremony at Old Billingsgate, a grand former Victorian fish market in central London. Founded in 1969, the Booker Prize is open to novels originally written in English published in the U.K. or Ireland. Last year's winner was Irish writer Paul Lynch for post-democratic dystopia "Prophet Song." Lynch handed Harvey her Booker trophy at the ceremony, warning her that her life was about to change dramatically because of the Booker publicity boost. Harvey said she was "overwhelmed" but remained down-to-earth about spending her prize money. She said she'd disburse "some of it on tax. I want to buy a new bike. And then the rest — I want to go to Japan."

PORT-AU-PRINCE, Haiti — The Federal Aviation Administration announced Tuesday that it will prohibit U.S. airlines from flying to Haiti for 30 days after gangs shot a Spirit Airlines flight. The United Nations also said it will suspend flights, "obviously limiting the flow of humanitarian aid and humanitarian personnel into the country."  The bullets hit the plane when it was about to land Monday in the country's capital, Port-au-Prince, injuring a flight attendant. It was part of a wave of violence that erupted in Haiti as the country swore in its new prime minister after a politically tumultuous process.  Life in much of Haiti's capital was frozen after the wave of violence, which came to a head when gangs shot the Spirit Airlines airplane Monday, forcing the airport to shut down. Photos and videos obtained by The Associated Press show bullet holes dotting the interior of a plane. A number of airlines suspended flights to Haiti through Thursday, but it was unclear how long closures could drag on.  Neither the former interim prime minister, Garry Conille, nor the newly inaugurated Alix Didier Fils-Aime commented on the violence.  But Luis Abinader, who as president of the neighboring Dominican Republic has cracked down on Haitian migration, called firing on the airplane terrorism.  "This was a terrorist act; the countries that are following and helping Haiti should declare these armed gangs as terrorist groups," Abinader said in a news conference.  On Tuesday, heavily armed police in armored cars outside the airport checked trucks used for public transportation passing by.  Schools were closed, as were banks and government offices. The streets, where just a day before gangs and police were locked in a fierce firefight, were eerily empty.  The sound of heavy gunfire was heard in the streets in the afternoon — a reminder that despite political maneuvering by Haiti's elites and a strong push by the international community to restore peace, the country's toxic slate of gangs kept its firm hold on much of the Caribbean nation.  The United Nations estimates that gangs control 85% of the capital. A U.N.-backed mission led by Kenyan police to quell gang violence struggles with a lack of funding and personnel, prompting calls for a U.N. peacekeeping mission.

[The Edelstam Foundation] The Edelstam Prize 2024 is awarded to Mr. Dawit Isaak for his outstanding contributions and exceptional courage in standing up for freedom of expression, one's beliefs, and in the defence of Human Rights. The prize will be awarded during a ceremony at the House of Nobility in Stockholm, Sweden, on 19th November 2024. As Dawit Isaak is a prisoner of conscience and the longest-held detained journalist in the world, he cannot be present. His daughter, Betlehem Isaak, will receive the prize on his behalf.

This exquisite stuffed rabbit recipe from Ta' Marija restaurant, renowned for traditional Maltese cuisine, brings a flavourful twist to a classic dish. Infused with aromatic herbs, honey, and spices, it’s a deliciously unique way to enjoy rabbit

DELHI — A surge in Bitcoin has paused as traders assess the remaining market impact of United States President-elect Donald Trump's rhetorical support for crypto.

The International Space Station will burn up and splash down into the Pacific sometime around 2030. What could possibly go wrong? And will we ever see anything like the ISS again?

Two strange, high-density blobs buried more than a kilometre underground may have come from the ancient world Theia, which is thought to have slammed into Earth to create the moon

The dynamics of how plants and animals change Earth is central to this last book in a trilogy by Other Minds author and "scuba-diving philosopher" Peter Godfrey-Smith

Samantha Harvey has won the UK's top fiction prize for a novel that takes place over 24 hours on the International Space Station

An arm bone from an ancient human that lived 700,000 years ago on the island of Flores is the smallest ever found from an adult hominin, adding a new piece to the puzzle of Homo floresiensis

Title: bitolterol mesylate
Category: Medications
Created: 12/31/1997 12:00:00 AM
Last Editorial Review: 5/20/2022 12:00:00 AM

Title: 4 Eating Habits May Help Older Women Maintain Weight Loss
Category: Health News
Created: 8/28/2012 2:05:00 PM
Last Editorial Review: 8/29/2012 12:00:00 AM

Title: More Baby Boomers Opting to Cohabit, Not Marry
Category: Health News
Created: 8/31/2012 10:05:00 AM
Last Editorial Review: 8/31/2012 12:00:00 AM

Title: Summer Bug Bite? Expert Gives Answers on Care
Category: Health News
Created: 7/30/2022 12:00:00 AM
Last Editorial Review: 8/1/2022 12:00:00 AM

Title: ACE Inhibitors
Category: Medications
Created: 4/19/2001 12:00:00 AM
Last Editorial Review: 7/22/2022 12:00:00 AM

Solute carrier family 6 member 19 (SLC6A19) inhibitors are being studied as therapeutic agents for phenylketonuria. In this work, a potent SLC6A19 inhibitor (RA836) elevated rat kidney uremic toxin indoxyl sulfate (IDS) levels by intensity (arbitrary unit) of 13.7 ± 7.7 compared with vehicle 0.3 ± 0.1 (P = 0.01) as determined by tissue mass spectrometry imaging analysis. We hypothesized that increased plasma and kidney levels of IDS could be caused by the simultaneous inhibition of both Slc6a19 and a kidney IDS transporter responsible for excretion of IDS into urine. To test this, we first confirmed the formation of IDS through tryptophan metabolism by feeding rats a Trp-free diet. Inhibiting Slc6a19 with RA836 led to increased IDS in these rats. Next, RA836 and its key metabolites were evaluated in vitro for inhibiting kidney transporters such as organic anion transporter (OAT)1, OAT3, and breast cancer resistance protein (BCRP). RA836 inhibits BCRP with an IC₅₀ of 0.045 μM but shows no significant inhibition of OAT1 or OAT3. Finally, RA836 analogs with either potent or no inhibition of SLC6A19 and/or BCRP were synthesized and administered to rats fed a normal diet. Plasma and kidney samples were collected to quantify IDS using liquid chromatography–mass spectrometry. Neither a SLC6A19 inactive but potent BCRP inhibitor nor a SLC6A19 active but weak BCRP inhibitor raised IDS levels, whereas compounds inhibiting both transporters caused IDS accumulation in rat plasma and kidney, supporting the hypothesis that rat Bcrp contributes to the excretion of IDS. In summary, we identified that inhibiting Slc6a19 increases IDS formation, while simultaneously inhibiting Bcrp results in IDS accumulation in the kidney and plasma.

The CYP3A7 enzyme accounts for ~50% of the total cytochrome P450 (P450) content in fetal and neonatal livers and is the predominant P450 involved in neonatal xenobiotic metabolism. Additionally, it is a key player in healthy birth outcomes through the oxidation of dehydroepiandrosterone (DHEA) and DHEA-sulfate. The amount of the other hepatic CYP3A isoforms, CYP3A4 and CYP3A5, expressed in neonates is low but highly variable, and therefore the activity of individual CYP3A isoforms is difficult to differentiate due to their functional similarities. Consequently, a better understanding of the contribution of CYP3A7 to drug metabolism is essential to identify the risk that drugs may pose to neonates and developing infants. To distinguish CYP3A7 activity from CYP3A4/5, we sought to further characterize the selectivity of the specific CYP3A inhibitors CYP3cide, clobetasol, and azamulin. We used three substrate probes, dibenzylfluorescein, luciferin-PPXE, and midazolam, to determine the IC₅₀ and metabolism-dependent inhibition (MDI) properties of the CYP3A inhibitors. Probe selection had a significant effect on the IC₅₀ values and P450 inactivation across all inhibitory compounds and enzymes. CYP3cide and azamulin were both identified as MDIs and were most specific for CYP3A4. Contrary to previous reports, we found that clobetasol propionate (CP) was not an MDI of CYP3A5 but was more selective for CYP3A5 over CYP3A4/7. We further investigated CYP3cide and CP’s ability to differentiate CYP3A7 activity in an equal mixture of recombinant CYP3A4, CYP3A5, and CYP3A7, and our results provide confidence of CYP3cide’s and CP’s ability to distinguish CYP3A7 activity in the presence of the other CYP3A isoforms.

The -aminobutyric acid type A (GABA_A) receptor is modulated by a number of neuroactive steroids. Sulfated steroids and 3β-hydroxy steroids inhibit, while 3α-hydroxy steroids typically potentiate the receptor. Here, we have investigated inhibition of the α1β32L GABA_A receptor by the endogenous neurosteroid 3α-hydroxy-5β-pregnan-20-one (3α5βP) and the synthetic neuroactive steroid 3α-hydroxy-5α-androstane-17β-carbonitrile (ACN). The receptors were expressed in Xenopus oocytes. All experiments were done using two-electrode voltage-clamp electrophysiology. In the presence of low concentrations of GABA, 3α5βP and ACN potentiate the GABA_A receptor. To reveal inhibition, we conducted the experiments on receptors activated by the combination of a saturating concentration of GABA and propofol to fully activate the receptors and mask potentiation, or on mutant receptors in which potentiation is ablated. Under these conditions, both steroids inhibited the receptor with IC₅₀s of ~13 μM and maximal inhibitory effects of 70–90%. Receptor inhibition by 3α5βP was sensitive to substitution of the α1 transmembrane domain (TM) 2-2' residue, previously shown to ablate inhibition by pregnenolone sulfate. However, results of coapplication studies and the apparent lack of state dependence suggest that pregnenolone sulfate and 3α5βP inhibit the GABA_A receptor independently and through distinct mechanisms. Mutations to the neurosteroid binding sites in the α1 and β3 subunits statistically significantly, albeit weakly and incompletely, reduced inhibition by 3α5βP and ACN.

Glioblastoma (GBM) is a disease of the whole brain, with infiltrative tumor cells protected by an intact blood-brain barrier (BBB). GBM has a poor prognosis despite aggressive treatment, in part due to the lack of adequate drug permeability at the BBB. Standard of care GBM therapies include radiation and cytotoxic chemotherapy that lead to DNA damage. Subsequent activation of DNA damage response (DDR) pathways can induce resistance. Various DDR inhibitors, targeting the key regulators of these pathways such as ataxia telangiectasia mutated and Rad3-related (ATR), are being explored as radio- and chemosensitizers. Elimusertib, a novel ATR kinase inhibitor, can prevent repair of damaged DNA, increasing efficacy of DNA-damaging cytotoxic therapies. Robust synergy was observed in vitro when elimusertib was combined with the DNA-damaging agent temozolomide; however, we did not observe improvement with this combination in in vivo efficacy studies in GBM orthotopic tumor-bearing mice. This in vitro–in vivo disconnect was explored to understand factors influencing central nervous system (CNS) distribution of elimusertib and reasons for lack of efficacy. We observed that elimusertib is rapidly cleared from systemic circulation in mice and would not maintain adequate exposure in the CNS for efficacious combination therapy with temozolomide. CNS distribution of elimusertib is partially limited by P-glycoprotein efflux at the BBB, and high binding to CNS tissues leads to low levels of pharmacologically active (unbound) drug in the brain. Acknowledging the potential for interspecies differences in pharmacokinetics, these data suggest that clinical translation of elimusertib in combination with temozolomide for treatment of GBM may be limited.

The development of transforming growth factor βreceptor inhibitors (TGFβRi) as new medicines has been affected by cardiac valvulopathy and arteriopathy toxicity findings in nonclinical toxicology studies. PF-06952229 (MDV6058) selected using rational drug design is a potent and selective TGFβRI inhibitor with a relatively clean off-target selectivity profile and good pharmacokinetic properties across species. PF-06952229 inhibited clinically translatable phospho-SMAD2 biomarker (≥60%) in human and cynomolgus monkey peripheral blood mononuclear cells, as well as in mouse and rat splenocytes. Using an optimized, intermittent dosing schedule (7-day on/7-day off/cycle; 5 cycles), PF-06952229 demonstrated efficacy in a 63-day syngeneic MC38 colon carcinoma mouse model. In the pivotal repeat-dose toxicity studies (rat and cynomolgus monkey), PF-06952229 on an intermittent dosing schedule (5-day on/5-day off cycle; 5 cycles, 28 doses) showed no cardiac-related adverse findings. However, new toxicity findings related to PF-06952229 included reversible hepatocellular (hepatocyte necrosis with corresponding clinically monitorable transaminase increases) and lung (hemorrhage with mixed cell inflammation) findings at ≥ targeted projected clinical efficacious exposures. Furthermore, partially reversible cartilage hypertrophy (trachea and femur in rat; femur in monkey) and partially to fully reversible, clinically monitorable decreases in serum phosphorus and urinary phosphate at ≥ projected clinically efficacious exposures were observed. Given the integral role of TGFβ in endochondral bone formation, cartilage findings in toxicity studies have been observed with other TGFβRi classes of compounds. The favorable cumulative profile of PF-06952229 in biochemical, pharmacodynamic, pharmacokinetic, and nonclinical studies allowed for its evaluation in cancer patients using the intermittent dosing schedule (7-day on/7-day off) and careful protocol-defined monitoring.

Previous studies demonstrated that sigma receptor (R) antagonists alone fail to alter cocaine self-administration despite blocking various other effects of cocaine. However, R antagonists when combined with dopamine transporter (DAT) inhibitors substantially decrease cocaine self-administration. To better understand the effects of this combination, the present study examined the effects of R antagonist and DAT inhibitor combinations in male rats discriminating cocaine (10 mg/kg, i.p.) from saline injections. The DAT inhibitors alone [(–)-2-β-carbomethoxy-3-β-(4-fluorophenyl)tropane 1,5-naphthalenedisulfonate monohydrate (WIN 35,428) and methylphenidate] at low (0.1-mg/kg) doses that were minimally active failed to shift the dose-effect function for discriminative-stimulus effects of cocaine to the left more than 2-fold. At 0.32 mg/kg the DAT inhibitors alone shifted the cocaine dose-effect function leftward 24- or 6.6-fold, respectively. The R antagonists (BD1008, BD1047, and BD1063) failed to fully substitute for cocaine, although BD1008 and BD1047 substituted partially. At 10 mg/kg, BD1008, BD1047, or BD1063 alone shifted the cocaine dose-effect function leftward less than 6.0-fold. In combination with 0.1 mg/kg WIN 35,428, the 10 mg/kg doses of R antagonists shifted the cocaine dose-effect function from 12.3- to 36.7-fold leftward, and with 0.32 mg/kg WIN 35,428 from 14.3- to 440-fold leftward. In combination with 0.1 mg/kg methylphenidate, those R antagonist doses shifted the cocaine dose-effect function from 5.5- to 55.0-fold leftward, and with 0.32 mg/kg methylphenidate from 10.5- to 48.1-fold leftward. The present results suggest that dual DAT/R inhibition produces agonist-like subjective effects that may promote decreases in self-administration obtained in previous studies.

Oxidative stress, fibrosis, and inflammasome activation from advanced glycation end product (AGE)–receptor of advanced glycation end product (RAGE) interaction contribute to diabetic cardiomyopathy (DCM) formation and progression. Our study revealed the impact of β-caryophyllene (BCP) on activating cannabinoid type 2 receptors (CB2Rs) against diabetic complication, mainly cardiomyopathy and investigated the underlying cell signaling pathways in mice. The murine model of DCM was developed by feeding a high-fat diet with streptozotocin injections. After the development of diabetes, the animals received a 12-week oral BCP treatment at a dose of 50 mg/kg/body weight. BCP treatment showed significant improvement in glucose tolerance and insulin resistance and enhanced serum insulin levels in diabetic animals. BCP treatment effectively reversed the heart remodeling and restored the phosphorylated troponin I and sarcoplasmic/endoplasmic reticulum Ca2+ ATPase 2a expression. Ultrastructural examination showed reduced myocardial cell injury in DCM mice treated with BCP. The preserved myocytes were found to be associated with reduced expression of AGE/RAGE in DCM mice hearts. BCP treatment mitigated oxidative stress by inhibiting expression of NADPH oxidase 4 and activating phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/nuclear factor erythroid 2–related factor 2 (Nrf2) signaling. Also, BCP suppressed cardiac fibrosis and endothelial-to-mesenchymal transition in DCM mice by inhibiting transforming growth factor β (TGF-β)/suppressor of mothers against decapentaplegic (Smad) signaling. Further, BCP treatment suppressed nucleotide-binding domain, leucine-rich–containing family, pyrin domain–containing-3 (NLRP3) inflammasome activation in DCM mice and alleviated cellular injury to the pancreatic tissues evidenced by significant elevation of the number of insulin-positive cells. To demonstrate a CB2R-dependent mechanism of BCP, another group of DCM mice were pretreated with AM630, a CB2R antagonist. AM630 was observed to abrogate the beneficial effects of BCP in DCM mice. Taken together, BCP demonstrated the potential to protect the myocardium and pancreas of DCM mice mediating CB2R-dependent mechanisms.

Chris gets trolled by the bear cave. Jason sets optics to stun. Josh is hiding in a rest stop bathroom. Kelley stretches harder than she did for The Witch and the Hundred Knight. Also, find out how to increase your poop by 10 and express your opinions about Dragon Quest Soundtracks.

The post RPG Cast – Episode 664: “We Need to Talk About Gambit” appeared first on RPGamer.