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Protein-bound AGEs derived from methylglyoxal induce pro-inflammatory response and barrier integrity damage in epithelial cells by disrupting the retinol metabolism

Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO00364K, Paper
Gang Yu, Jianxin He, Zhongshan Gao, Linglin Fu, Qiaozhi Zhang
Protein-bound advanced glycation end-products (AGEs) induce pro-inflammatory response and barrier integrity damage in epithelial cells by disrupting the retinol metabolism.
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Lactobacillus plantarum 69-2 combined with α-lactalbumin hydrolysate alleviates DSS-induced ulcerative colitis through the TLR4/NF-κB inflammatory pathway and the gut microbiota in mice

Food Funct., 2024, 15,10987-11004
DOI: 10.1039/D4FO02975E, Paper
Yue Ma, Chuanbing Hu, Jing Zhang, Cong Xu, Lizhi Ma, Yunhe Chang, Muhammad Altaf Hussain, Jiage Ma, Juncai Hou, Zhanmei Jiang
Ulcerative colitis (UC), an inflammatory bowel disease, seriously affects people's quality of life.
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Dietary supplementation of pterostilbene, a major component in small berries, prevents alcohol-induced liver injury associated with lipid accumulation and inflammation

Food Funct., 2024, 15,11206-11219
DOI: 10.1039/D4FO03898C, Paper
Jia-Yi Dou, Sai-Hu Liu, Jia Guo, Chen-Yu Wang, Xu Dai, Li-Hua Lian, Zhen-Yu Cui, Ji-Xing Nan, Yan-Ling Wu
Pterostilbene (PTE), a natural stilbene found in small berries, exhibits multiple pharmacological activities, particularly antioxidant and anti-inflammatory activities.
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Exosome-like nanoparticles from Arbutus unedo L. mitigate LPS-induced inflammation via JAK-STAT inactivation

Food Funct., 2024, 15,11280-11290
DOI: 10.1039/D4FO03646H, Paper
Cristian Martínez Fajardo, Lucía Morote, Elena Moreno-Giménez, Susana López-López, Ángela Rubio-Moraga, María José M. Díaz-Guerra, Gianfranco Diretto, Alberto J. López Jiménez, Oussama Ahrazem, Lourdes Gómez-Gómez
Exosomes have garnered attention as a potential cell-free therapy for inflammatory diseases due to their immunomodulatory and anti-inflammatory properties.
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Mechanistic insights into EGCG's preventive effects on obesity-induced precocious puberty through multi-omics analyses

Food Funct., 2024, 15,11169-11185
DOI: 10.1039/D4FO03844D, Paper
Qiuyun Gu, Qiujv Du, Lina Xia, Xiaoting Lu, Xiaoqing Wan, Ying Shao, Jieyi He, Peiying Wu
Epigallocatechin gallate (EGCG) has demonstrated potential effects on obesity-induced precocious puberty, but the underlying mechanisms remain unclear.
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Ellagic acid ameliorates alcohol-induced cognitive and social dysfunction through the gut microbiota-mediated CCL21-CCR7 axis

Food Funct., 2024, 15,11186-11205
DOI: 10.1039/D4FO03985H, Paper
Hongbo Zhang, Min Luo, Yinuo Li, Lu Liu, Ji Bian, Lan Gong, Caian He, Lin Han, Min Wang
EA enhanced the abundance of beneficial bacteria as well as their derived metabolites, thereby inhibiting chronic alcohol-induced neuroinflammation via regulation of the gut microbiota-mediated CCL21-CCR7 axis, ultimately ameliorating AICSD.
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The co-fermentation of whole-grain black barley and quinoa improves murine cognitive impairment induced by a high-fat diet via altering gut microbial ecology and suppressing neuroinflammation

Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO02704C, Paper
Fenfen Wei, Huibin Jiang, Chuang Zhu, Lingyue Zhong, Zihan Lin, Yan Wu, Lihua Song
A high-fat diet (HFD) is associated with various adverse health outcomes, including cognitive impairment and an elevated risk of neurodegenerative conditions.
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Ergothioneine improves cognitive function by ameliorating mitochondrial damage and decreasing neuroinflammation in a D-galactose-induced aging model

Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO02321H, Paper
Fangyang Chen, Botao Wang, Xin Sun, Yage Wang, Ruiyan Wang, Kaikai Li
EGT intervention significantly improved D-galactose induced oxidative stress, neuroinflammation, and mitochondrial function, resulting in the alleviation of memory injury.
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Editorial. India needs a stable population, not more children

Southern States’ concerns need to be addressed by the Finance panel




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Editorial. India needs to focus on being a global AI power

The country’s vast pool of skilled professionals in engineering, data science and software development puts it in a position to become a global AI hub




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Which States are leading the race towards renewables in India?

India with 300 days of sunshine each year, possesses vast solar energy potential. The National Institute of Energy estimated the country’s solar potential at 748 GW, assuming solar PV modules cover 3% of the geographical surface. Solar energy is expected to be the main driver pushing India closer to its renewable energy targets. Diving deep into the state-wise push towards solar energy. Rajasthan, Gujarat, Tamil Nadu and Karnataka are the leading States in India, both in terms of installed capacities and power generation, in the solar segment. Also, with respect to solar energy projects, Rajasthan and Gujarat lead in terms of the capacities added since FY22 and projects in pipeline




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Trump 2.0: A new era for India-US relations?

Modi and Trump have the potential to redefine bilateral ties based on mutual economic growth, security, and strategic interests in an increasingly complex global landscape




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Copper’s role in India’s solar, wind energy plans

For every tonne of copper used in renewable energy systems, carbon emissions are reduced by 100 to 7,500 tonnes over the system’s lifecycle




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What Indian trade can expect from Trump 2.0

India could well face higher tariffs on exports like textiles, chemicals, pharma and auto/engineering products




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India on road to achieving 500 GW of RE

Renewable energy is a sector where there is strong alignment and co-operation between the Centre and the States. Public sector units and the private sector must now deliver




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Indian Police Force Review

Rohit Shetty's strengths have been action and humour; the former he delivers in spades, but the latter is totally lacking in Indian Police Force, observes Deepa Gahlot.




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All India Rank Review

All India Rank achieves a fine balance of authenticity and sensitivity in the fine portrayals of its young actors and old.




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The Indrani Mukerjea Story Review

If Indrani Mukerjea wanted to whitewash her image, this docu series was not the right platform, asserts Deepa Gahlot.




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The Great Indian Kapil Show Review

Stand-up comedian Kapil Sharma is back with his show and while the set is bigger and the look is grander, the gags are still the same, feels Namrata Thakker.




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Malayalee From India Review

Malayalee From India is trapped within its self-serving corniness and refuses to break free in the process, observes Arjun Menon.




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Indian 2 Review

The saving grace of Shankar's expanded universe is the masterful precision with which Kamal Haasan drops himself into a messy setup, only slightly to elevate the pulpy tendencies of Shankar's vision, observes Arjun Menon.




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Brinda Review

Brinda examines some alarming aspects of religious fanaticism through the narrative engine of a well-oiled serial killer mystery, observes Arjun Menon.





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Punjab CM seeks incentives for industry on par with hill states




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Stop the free fall: On India-Canada ties

India and Canada must not allow ties to deteriorate further 




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A mixed report card for the India-Middle East-Europe Corridor

Implementation on the northern part of the corridor, which is mostly in West Asia, is going to move slowly until the conflict subsides, while progress is faster on the eastern leg connecting the UAE and Indian ports




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Mercedes-Benz India introduces sportscar AMG C 63 S E at ₹1.95 crore

The Mercedes-AMG C 63 S E Performance’s hybrid powertrain merges a 2.0-litre AMG turbo engine with an Electric Drive Unit (EDU)




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SDG goals at risk in nations such as India due to declining health spending: Data

Pre-pandemic gains are eroding. In India, the share of health in the budget dropped below the 2% mark after the pandemic




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India, Bangladesh consider making some land ports operational 24/7

In a meeting on land port infrastructure, the two countries discussed ways to facilitate the movement of Bangladeshi trucks carrying export cargo to Nepal, Bhutan through India




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Progress in trade between India and Russia: Jaishankar

Since the war in Ukraine and Russia ouster from the international SWIFT payment system, payments have emerged as a major bottleneck between India and Russia




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Nilakanta Sastri’s take on Dravidian-Aryan divide and the claims on the Indus Valley Civilisation

In his lectures at Patna University in 1964, Sastri quotes J. Burrow, Professor of Oxford University, who had suggested that “Vedic speech was influenced not by the Dravidian languages of history as we know them, but by an earlier form, a sort of proto-Dravidian, which has long preceded them as well as Aryan advent into India”




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Global carbon dioxide emissions set to rise 0.8% over 2023, India’s contribution to go up 4.6%

In 2023, the largest absolute contributions to global fossil CO2 (carbon dioxide) emissions were from China (31%), followed by the United States with 13% and India taking up 8%




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Colour Blind Casting or Cultural Appropriation?

'Acting, by definition, is a portrayal of a character other than oneself.''If every role is to be played only by someone answering to that precise description, most professional actors -- of all ethnicities and genders -- would be out of a job,' observes Indira Kannan.




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Salute the Power & Glory of Indian Cinema!

It is the most potent symbol of India's soft power -- more perhaps than the IT industry and our managerial skill, notes Vanita Kohli-Khandekar




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Is Jaideep Ahlawat India's Finest Actor?

If Irrfan could have been our finest professor of empirical philosophy, and Nawaz is our foremost poet of that space halfway between the gutter and the stars, then Jaideep Ahlawat has to be our greatest artist-scientist, asserts Sreehari Nair.




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Is He India's Finest Director Of Romcoms?

Girish AD doesn't make romantic comedies so much as he elevates the genre, observes Sreehari Nair.





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The Declaration of Independence

Hear the words that were catalyst to the Revolution, read by Bill Barker, Colonial Williamsburg's Thomas Jefferson.




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Backstory Radio Presents: The American Indian Story

In October 2010, the hosts of Backstory visited Colonial Williamsburg's Kimball Theatre to perform a live show.




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Leading Indian woman scientist is International Brain Research Organisation’s president-elect

The first scientist from a developing country to be appointed to the top position of IBRO, Shubha Tole is currently the dean of graduate studies at Tata Institute of Fundamental Research, Mumbai




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Nobel Prize for microRNA find underscores RNA’s primacy in biology

When Victor Ambros and Gary Ruvkun won the Nobel Prize last week, 581 clinical trials involving miRNA had been registered in the U.S. alone




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Sci-Five | The Hindu Science Quiz: On Ada Lovelace

This week’s Sci-five quiz is on Ada Lovelace.




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What do the Atlantic Ocean hurricane forecasts foretell for India?

Climate models forecast cyclones indirectly, based on metrics that indicate cyclonic activity and its potential intensity




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Tea drinking across India




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New genus of jumping spiders ‘Tenkana’ discovered in south India

Unlike related species that live in forests, Tenkana spiders prefer drier areas and ground habitats and have been found in Tamil Nadu, Puducherry, Karnataka, Telangana and Andhra Pradesh 




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Researchers meld AI and genomics to find thousands of new viruses

It’s important to anticipate RNA viruses and how they could evolve because they mutate rapidly and adapt quickly to new conditions




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Science and technology key to raising India’s profile in the world, says CSIR chief

Over 70,000 undergraduate, postgraduate and M.Phil students given degrees in absentia and 520 Ph.D candidates, including 90 gold medal-winners, receive their degrees in person




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Sci-Five | The Hindu Science Quiz: On Drones

This week’s Sci-Five quiz is on drones.




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India’s first analog space mission to simulate extra-terrestrial conditions on Mars and Moon kicks off 




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Study finds long-term dynamics of transplanted stem cells