ics Human Genetics and Genomics: A Practical Guide By www.wiley.com Published On :: 2020-04-13T04:00:00Z Finally meeting the need for a laboratory manual on human genetics, this practical guide is the perfect companion title to all major standard textbooks on the subject. The authors all have a high-level research background and are actively involved in teaching and counseling.Based on a standard curriculum in human genetics, each chapter equals one practical unit of the course and topics range from basics in human inheritance to genetics in major disease Read More... Full Article
ics A high-throughput and untargeted lipidomics approach reveals new mechanistic insight and the effects of salvianolic acid B on the metabolic profiles in coronary heart disease rats using ultra-performance liquid chromatography with mass spectrometry By feeds.rsc.org Published On :: RSC Adv., 2020, 10,17101-17113DOI: 10.1039/D0RA00049C, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Ying-peng Li, Cong-ying Wang, Hong-tao Shang, Rui-rui Hu, Hui Fu, Xue-feng XiaoHigh-throughput lipidomics provides the possibility for the development of new therapeutic drugs.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ics In vivo and in vitro evaluation of dihydroartemisinin prodrug nanocomplexes as a nano-drug delivery system: characterization, pharmacokinetics and pharmacodynamics By feeds.rsc.org Published On :: RSC Adv., 2020, 10,17270-17279DOI: 10.1039/D0RA02150D, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Guolian Ren, Pei Chen, Jiaqi Tang, Wenju Guo, Rongrong Wang, Ning Li, Yujie Li, Guoshun Zhang, Ruili Wang, Shuqiu ZhangTo develop new, more effective and lower toxicity antitumor dihydroartemisinin (DHA) nanocomplexes, a DHA prodrug synthesized in this study was used to prepare DHA prodrug self-assembled nanocomplexes (DHANPs) by molecular self-assembly technology.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ics Molecular dynamics study of the frictional properties of multilayer MoS2 By feeds.rsc.org Published On :: RSC Adv., 2020, 10,17418-17426DOI: 10.1039/D0RA00995D, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Chengzhi Hu, Changli Yi, Minli Bai, Jizu Lv, Dawei TangDeformation of MoS2 layers directly leads to decrease in potential and ultimately leads to decrease in friction coefficient.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ics About HTML semantics and front-end architecture By nicolasgallagher.com Published On :: Wed, 14 Mar 2012 17:00:00 -0700 A collection of thoughts, experiences, ideas that I like, and ideas that I have been experimenting with over the last year. It covers HTML semantics, components and approaches to front-end architecture, class naming patterns, and HTTP compression. About semantics Semantics is the study of the relationships between signs and symbols and what they represent. In linguistics, this is primarily the study of the meaning of signs (such as words, phrases, or sounds) in language. In the context of front-end web development, semantics are largely concerned with the agreed meaning of HTML elements, attributes, and attribute values (including extensions like Microdata). These agreed semantics, which are usually formalised in specifications, can be used to help programmes (and subsequently humans) better understand aspects of the information on a website. However, even after formalisation, the semantics of elements, attributes, and attribute values are subject to adaptation and co-option by developers. This can lead to subsequent modifications of the formally agreed semantics (and is an HTML design principle). Distinguishing between different types of HTML semantics The principle of writing “semantic HTML” is one of the foundations of modern, professional front-end development. Most semantics are related to aspects of the nature of the existing or expected content (e.g. h1 element, lang attribute, email value of the type attribute, Microdata). However, not all semantics need to be content-derived. Class names cannot be “unsemantic”. Whatever names are being used: they have meaning, they have purpose. Class name semantics can be different to those of HTML elements. We can leverage the agreed “global” semantics of HTML elements, certain HTML attributes, Microdata, etc., without confusing their purpose with those of the “local” website/application-specific semantics that are usually contained in the values of attributes like the class attribute. Despite the HTML5 specification section on classes repeating the assumed “best practice” that… …authors are encouraged to use [class attribute] values that describe the nature of the content, rather than values that describe the desired presentation of the content. …there is no inherent reason to do this. In fact, it’s often a hindrance when working on large websites or applications. Content-layer semantics are already served by HTML elements and other attributes. Class names impart little or no useful semantic information to machines or human visitors unless it is part of a small set of agreed upon (and machine readable) names – Microformats. The primary purpose of a class name is to be a hook for CSS and JavaScript. If you don’t need to add presentation and behaviour to your web documents, then you probably don’t need classes in your HTML. Class names should communicate useful information to developers. It’s helpful to understand what a specific class name is going to do when you read a DOM snippet, especially in multi-developer teams where front-enders won’t be the only people working with HTML components. Take this very simple example: <div class="news"> <h2>News</h2> [news content] </div> The class name news doesn’t tell you anything that is not already obvious from the content. It gives you no information about the architectural structure of the component, and it cannot be used with content that isn’t “news”. Tying your class name semantics tightly to the nature of the content has already reduced the ability of your architecture to scale or be easily put to use by other developers. Content-independent class names An alternative is to derive class name semantics from repeating structural and functional patterns in a design. The most reusable components are those with class names that are independent of the content. We shouldn’t be afraid of making the connections between layers clear and explicit rather than having class names rigidly reflect specific content. Doing this doesn’t make classes “unsemantic”, it just means that their semantics are not derived from the content. We shouldn’t be afraid to include additional HTML elements if they help create more robust, flexible, and reusable components. Doing so does not make the HTML “unsemantic”, it just means that you use elements beyond the bare minimum needed to markup the content. Front-end architecture The aim of a component/template/object-oriented architecture is to be able to develop a limited number of reusable components that can contain a range of different content types. The important thing for class name semantics in non-trivial applications is that they be driven by pragmatism and best serve their primary purpose – providing meaningful, flexible, and reusable presentational/behavioural hooks for developers to use. Reusable and combinable components Scalable HTML/CSS must, by and large, rely on classes within the HTML to allow for the creation of reusable components. A flexible and reusable component is one which neither relies on existing within a certain part of the DOM tree, nor requires the use of specific element types. It should be able to adapt to different containers and be easily themed. If necessary, extra HTML elements (beyond those needed just to markup the content) and can be used to make the component more robust. A good example is what Nicole Sullivan calls the media object. Components that can be easily combined benefit from the avoidance of type selectors in favour of classes. The following example prevents the easy combination of the btn component with the uilist component. The problems are that the specificity of .btn is less than that of .uilist a (which will override any shared properties), and the uilist component requires anchors as child nodes. .btn { /* styles */ } .uilist { /* styles */ } .uilist a { /* styles */ } <nav class="uilist"> <a href="#">Home</a> <a href="#">About</a> <a class="btn" href="#">Login</a> </nav> An approach that improves the ease with which you can combine other components with uilist is to use classes to style the child DOM elements. Although this helps to reduce the specificity of the rule, the main benefit is that it gives you the option to apply the structural styles to any type of child node. .btn { /* styles */ } .uilist { /* styles */ } .uilist-item { /* styles */ } <nav class="uilist"> <a class="uilist-item" href="#">Home</a> <a class="uilist-item" href="#">About</a> <span class="uilist-item"> <a class="btn" href="#">Login</a> </span> </nav> JavaScript-specific classes Using some form of JavaScript-specific classes can help to reduce the risk that thematic or structural changes to components will break any JavaScript that is also applied. An approach that I’ve found helpful is to use certain classes only for JavaScript hooks – js-* – and not to hang any presentation off them. <a href="/login" class="btn btn-primary js-login"></a> This way, you can reduce the chance that changing the structure or theme of components will inadvertently affect any required JavaScript behaviour and complex functionality. Component modifiers Components often have variants with slightly different presentations from the base component, e.g., a different coloured background or border. There are two mains patterns used to create these component variants. I’m going to call them the “single-class” and “multi-class” patterns. The “single-class” pattern .btn, .btn-primary { /* button template styles */ } .btn-primary { /* styles specific to save button */ } <button class="btn">Default</button> <button class="btn-primary">Login</button> The “multi-class” pattern .btn { /* button template styles */ } .btn-primary { /* styles specific to primary button */ } <button class="btn">Default</button> <button class="btn btn-primary">Login</button> If you use a pre-processor, you might use Sass’s @extend functionality to reduce some of the maintenance work involved in using the “single-class” pattern. However, even with the help of a pre-processor, my preference is to use the “multi-class” pattern and add modifier classes in the HTML. I’ve found it to be a more scalable pattern. For example, take the base btn component and add a further 5 types of button and 3 additional sizes. Using a “multi-class” pattern you end up with 9 classes that can be mixed-and-matched. Using a “single-class” pattern you end up with 24 classes. It is also easier to make contextual tweaks to a component, if absolutely necessary. You might want to make small adjustments to any btn that appears within another component. /* "multi-class" adjustment */ .thing .btn { /* adjustments */ } /* "single-class" adjustment */ .thing .btn, .thing .btn-primary, .thing .btn-danger, .thing .btn-etc { /* adjustments */ } A “multi-class” pattern means you only need a single intra-component selector to target any type of btn-styled element within the component. A “single-class” pattern would mean that you may have to account for any possible button type, and adjust the selector whenever a new button variant is created. Structured class names When creating components – and “themes” that build upon them – some classes are used as component boundaries, some are used as component modifiers, and others are used to associate a collection of DOM nodes into a larger abstract presentational component. It’s hard to deduce the relationship between btn (component), btn-primary (modifier), btn-group (component), and btn-group-item (component sub-object) because the names don’t clearly surface the purpose of the class. There is no consistent pattern. In early 2011, I started experimenting with naming patterns that help me to more quickly understand the presentational relationship between nodes in a DOM snippet, rather than trying to piece together the site’s architecture by switching back-and-forth between HTML, CSS, and JS files. The notation in the gist is primarily influenced by the BEM system‘s approach to naming, but adapted into a form that I found easier to scan. Since I first wrote this post, several other teams and frameworks have adopted this approach. MontageJS modified the notation into a different style, which I prefer and currently use in the SUIT framework: /* Utility */ .u-utilityName {} /* Component */ .ComponentName {} /* Component modifier */ .ComponentName--modifierName {} /* Component descendant */ .ComponentName-descendant {} /* Component descendant modifier */ .ComponentName-descendant--modifierName {} /* Component state (scoped to component) */ .ComponentName.is-stateOfComponent {} This is merely a naming pattern that I’m finding helpful at the moment. It could take any form. But the benefit lies in removing the ambiguity of class names that rely only on (single) hyphens, or underscores, or camel case. A note on raw file size and HTTP compression Related to any discussion about modular/scalable CSS is a concern about file size and “bloat”. Nicole Sullivan’s talks often mention the file size savings (as well as maintenance improvements) that companies like Facebook experienced when adopting this kind of approach. Further to that, I thought I’d share my anecdotes about the effects of HTTP compression on pre-processor output and the extensive use of HTML classes. When Twitter Bootstrap first came out, I rewrote the compiled CSS to better reflect how I would author it by hand and to compare the file sizes. After minifying both files, the hand-crafted CSS was about 10% smaller than the pre-processor output. But when both files were also gzipped, the pre-processor output was about 5% smaller than the hand-crafted CSS. This highlights how important it is to compare the size of files after HTTP compression, because minified file sizes do not tell the whole story. It suggests that experienced CSS developers using pre-processors don’t need to be overly concerned about a certain degree of repetition in the compiled CSS because it can lend itself well to smaller file sizes after HTTP compression. The benefits of more maintainable “CSS” code via pre-processors should trump concerns about the aesthetics or size of the raw and minified output CSS. In another experiment, I removed every class attribute from a 60KB HTML file pulled from a live site (already made up of many reusable components). Doing this reduced the file size to 25KB. When the original and stripped files were gzipped, their sizes were 7.6KB and 6KB respectively – a difference of 1.6KB. The actual file size consequences of liberal class use are rarely going to be worth stressing over. How I learned to stop worrying… The experience of many skilled developers, over many years, has led to a shift in how large-scale website and applications are developed. Despite this, for individuals weaned on an ideology where “semantic HTML” means using content-derived class names (and even then, only as a last resort), it usually requires you to work on a large application before you can become acutely aware of the impractical nature of that approach. You have to be prepared to disgard old ideas, look at alternatives, and even revisit ways that you may have previously dismissed. Once you start writing non-trivial websites and applications that you and others must not only maintain but actively iterate upon, you quickly realise that despite your best efforts, your code starts to get harder and harder to maintain. It’s well worth taking the time to explore the work of some people who have proposed their own approaches to tackling these problems: Nicole’s blog and Object Oriented CSS project, Jonathan Snook’s Scalable Modular Architecture CSS, and the Block Element Modifier method that Yandex have developed. When you choose to author HTML and CSS in a way that seeks to reduce the amount of time you spend writing and editing CSS, it involves accepting that you must instead spend more time changing HTML classes on elements if you want to change their styles. This turns out to be fairly practical, both for front-end and back-end developers – anyone can rearrange pre-built “lego blocks”; it turns out that no one can perform CSS-alchemy. Full Article
ics The subjective well-being module of the American Time Use Survey [electronic resource] : assessment for its continuation / Panel on Measuring Subjective Well-Being in a Policy-Relevant Framework, Committee on National Statistics, Division of Behavioral an By prospero.murdoch.edu.au Published On :: Full Article
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ics ITC’s (GST/HST) – Beyond the Basics By www.cch.ca Published On :: Fri, 05 Dec 2014 10:29:41 GMT One of the objectives of a value-added tax system is to simplify the administration of taxes, and this is accomplished by taxing almost everything and everyone, but allowing input tax credits (ITCs) for those who are not considered to be the final consumer of supplies. While many accounting and finance professionals understand the basic rules for claiming ITCs for GST/HST paid on property and services acquired in relation to an organization’s commercial activities, few have the time to explore some of the more complex issues associated with ITCs. Available Sessions for this Seminar:ipwebinar.aspx?tab=1&smid=1711, March 04, 2015 Full Article
ics Cantax FormMaster Basics Webinar 2014 By www.cch.ca Published On :: Wed, 08 Oct 2014 15:02:43 GMT This Webinar will focus on how to prepare and submit your T-Slips using the new interface with FormMaster. Plus how to navigate around in the program when searching for extraneous forms. Available Sessions for this Seminar:ipwebinar.aspx?tab=1&smid=1699, January 14, 2015ipwebinar.aspx?tab=1&smid=1699, January 21, 2015 Full Article
ics Plant systematics : an integrated approach / Gurcharan Singh By prospero.murdoch.edu.au Published On :: Singh, Gurcharan, 1945- author Full Article
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ics Human Genetics and Genomics: A Practical Guide By www.wiley.com Published On :: 2020-04-13T04:00:00Z Finally meeting the need for a laboratory manual on human genetics, this practical guide is the perfect companion title to all major standard textbooks on the subject. The authors all have a high-level research background and are actively involved in teaching and counseling.Based on a standard curriculum in human genetics, each chapter equals one practical unit of the course and topics range from basics in human inheritance to genetics in major disease Read More... Full Article
ics Temporary Anchorage Devices in Clinical Orthodontics By www.wiley.com Published On :: 2020-04-21T04:00:00Z Provides the latest information on all aspects of using temporary anchorage devices in clinical orthodontics, from diagnosis and treatment planning to appliances and applications Written by some of the world’s leading experts in orthodontics, Temporary Anchorage Devices in Clinical Orthodontics is a comprehensive, up-to-date reference that covers all aspects of temporary anchorage device (TAD) use in contemporary orthodontics. Taking a real-world Read More... Full Article
ics Removable Prosthodontics at a Glance By www.wiley.com Published On :: 2020-04-21T04:00:00Z Removable Prosthodontics at a Glance provides a comprehensive and accessible guide to the practical elements of complete and partial denture provision. It serves as the perfect illustrated guide for learners, and a handy revision guide for subsequent undergraduate and postgraduate studies.Following the familiar, easy to use at a Glance format, each topic is presented as a double page spread with text accompanied by clear colour diagrams and clinical Read More... Full Article
ics Enhanced piezoelectric properties of (1 − x)BiFe0.98(Zn0.5Hf0.5)0.02O3-xBaTiO3 ceramics near the morphotropic phase boundary By feeds.rsc.org Published On :: Dalton Trans., 2020, 49,5573-5580DOI: 10.1039/C9DT04664J, PaperYunjing Shi, Hairui Bai, Fei Yan, Rui Hu, Kaikai Chen, Bo Shen, Jiwei ZhaiThe component with the R–T phase coexistence near MPB affords an optimal piezoelectric coefficient (d33) of 130 pC N−1.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
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