eu

Therapeutic targeting of p300/CBP HAT domain for the treatment of NUT midline carcinoma




eu

Leucine-rich repeat containing 4 act as an autophagy inhibitor that restores sensitivity of glioblastoma to temozolomide




eu

The nuclear oncoprotein Fra-1: a transcription factor knocking on therapeutic applications’ door




eu

Hypertension in rheumatic diseases: prevalence, awareness, treatment, and control rates according to current hypertension guidelines




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The drivers of sustained use of liquified petroleum gas in India




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Single-nucleus transcriptomics of the prefrontal cortex in major depressive disorder implicates oligodendrocyte precursor cells and excitatory neurons




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Nature Neuroscience




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The Syntrophy hypothesis for the origin of eukaryotes revisited




eu

Various Faculty Position (Professor, Associate Professor and Assistant Professor/Lecturer) at School of Materials Science and Engineering , Southeast University (SEU)

About us

Southeast University (SEU), located at Nanjing, is a prestigious higher education institution with its origin traced back to 1902. As one of the national key universities under direct administration of the Ministry of Education of China and jointly established with Jiangsu Province, it is selected in various programs, such National “Project 211” , “Program 985” and “Class A first-rate world universities” sponsored by the Central Government to build world-class universities.

*M…




eu

Various Faculty Position (Professor, Associate Professor and Assistant Professor/Lecturer) at School of Materials Science and Engineering , Southeast University (SEU)

About us

Southeast University (SEU), located at Nanjing, is a prestigious higher education institution with its origin traced back to 1902. As one of the national key universities under direct administration of the Ministry of Education of China and jointly established with Jiangsu Province, it is selected in various programs, such National “Project 211” , “Program 985” and “Class A first-rate world universities” sponsored by the Central Government to build world-class universities.

*M…




eu

Various Faculty Position (Professor, Associate Professor and Assistant Professor/Lecturer) at School of Materials Science and Engineering , Southeast University (SEU)

About us

Southeast University (SEU), located at Nanjing, is a prestigious higher education institution with its origin traced back to 1902. As one of the national key universities under direct administration of the Ministry of Education of China and jointly established with Jiangsu Province, it is selected in various programs, such National “Project 211” , “Program 985” and “Class A first-rate world universities” sponsored by the Central Government to build world-class universities.

*M…




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Rheumatoid arthritis Primer — behind the scenes




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Author Correction: Morphing electronics enable neuromodulation in growing tissue




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The expression of YAP1 is increased in high-grade prostatic adenocarcinoma but is reduced in neuroendocrine prostate cancer




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PARP inhibitors as a new therapeutic option in metastatic prostate cancer: a systematic review




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Simultaneous noninvasive recording of electrocardiogram and skin sympathetic nerve activity (neuECG)




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Daily blue-light exposure shortens lifespan and causes brain neurodegeneration in <i>Drosophila</i>




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High rate of durable remissions post autologous stem cell transplantation for core-binding factor acute myeloid leukaemia in second complete remission




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Phase I trial of maintenance selinexor after allogeneic hematopoietic stem cell transplantation for patients with acute myeloid leukemia and myelodysplastic syndrome




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Donor-derived DNA variability in fingernails of acute myeloid leukemia patients after allogeneic hematopoietic stem cell transplantation detected by direct PCR




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RNAi against therapeutic targets with short interfering ribonucleic neutrals (siRNNs)

siRNNs could enable RNAi knockdown of therapeutic targets in a broader range of cells and tissue types than siRNA.




eu

Extending therapeutic protein half-lives via fusion to affibodies with pH-dependent binding to neonatal Fc receptor

Fusing therapeutic proteins to affibodies with pH-dependent binding to neonatal Fc receptor could improve the proteins' half-lives.




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Epidermal growth factor receptor 1 (EGFR1; ErbB1; HER1); HER2 (EGFR2; ErbB2; neu); HER3 (EGFR3; ErbB3); VEGF

Tumor cell and mouse studies suggest tetravalent antibodies that target four different antigens could help treat cancers resistant to HER-targeted therapies.




eu

Cyclin dependent kinase 7 (CDK7); v-myc myelocytomatosis viral related oncogene neuroblastoma derived (MYCN; NMYC)

In vitro and mouse studies suggest THZ1, a covalent CDK7 inhibitor, could help treat neuroblastoma and other cancers driven by MYCN and other c-MYC (MYC)-family oncoproteins.




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Neutralizing the negatives of RNAi

The siRNN technology that Solstice licensed from UCSD could take RNAi-based therapies to tissues outside the liver and expand their use to a host of new diseases.




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A roadmap for development of neuro-oscillations as translational biomarkers for treatment development in neuropsychopharmacology




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Evaluating the impact of trauma and PTSD on epigenetic prediction of lifespan and neural integrity




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Neuropsychopharmacology




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Nuclear receptor crosstalk — defining the mechanisms for therapeutic innovation




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Combining radiolabelled therapies for neuroendocrine neoplasms




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Recovery after traumatic thoracic- and lumbar spinal cord injury: the neurological level of injury matters




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Reduction of depression-like behavior in rat model induced by ShRNA targeting norepinephrine transporter in locus coeruleus




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Functional neural correlates of psychopathy: a meta-analysis of MRI data




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Mendelian neurodegenerative disease genes involved in autophagy




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Expert opinion—management of chronic myeloid leukemia after resistance to second-generation tyrosine kinase inhibitors




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SHMT inhibition is effective and synergizes with methotrexate in T-cell acute lymphoblastic leukemia




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Leukemia




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Multilevel omics for the discovery of biomarkers and therapeutic targets for stroke




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An update on blood-based biomarkers for non-Alzheimer neurodegenerative disorders




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Parkinson disease and the immune system — associations, mechanisms and therapeutics




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Nature Reviews Neurology




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Breaking the Ice: How France and the UK Could Reshape a Credible European Defense and Renew the Transatlantic Partnership

History is replete with irony, but rarely more poignantly than in the summer of 2016 when, on 23 June, the UK voted to leave the European Union and the next day, 24 June, the EU published its Global Strategy document asserting its ambition of “strategic autonomy.” Whither Franco-British defense cooperation in such chaotic circumstances? This paper attempts to provide the outline of an answer to that question.




eu

European Journal of Clinical Nutrition




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Elevated sorbitol underlies a heritable neuropathy




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Biallelic mutations in <i>SORD</i> cause a common and potentially treatable hereditary neuropathy with implications for diabetes




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Correction: Humanized bone facilitates prostate cancer metastasis and recapitulates therapeutic effects of Zoledronic acid in vivo




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Intronic variant in <i>IQGAP3</i> associated with hereditary neuropathy with proximal lower dominancy, urinary disturbance, and paroxysmal dry cough




eu

Transatlantic Dialogue: The Missing Link in Europe’s Post-Covid-19 Green Deal?

This policy brief emphasizes that the European Green Deal's effectiveness in a post Covid-19 world will require the involvement of strategic partners, especially the US. In the context of a potential US withdrawal from the Paris Agreement and the consequential vacuum, it will be even more important to engage the US in implementing the GD. In light of divergence between the US and the EU during past climate negotiations (e.g. Kyoto, Copenhagen, and Paris), we suggest a gradual approach to US engagement with GD initiatives and objectives.




eu

Transatlantic Dialogue: The Missing Link in Europe’s Post-Covid-19 Green Deal?

This policy brief emphasizes that the European Green Deal's effectiveness in a post Covid-19 world will require the involvement of strategic partners, especially the US. In the context of a potential US withdrawal from the Paris Agreement and the consequential vacuum, it will be even more important to engage the US in implementing the GD. In light of divergence between the US and the EU during past climate negotiations (e.g. Kyoto, Copenhagen, and Paris), we suggest a gradual approach to US engagement with GD initiatives and objectives.




eu

Breaking the Ice: How France and the UK Could Reshape a Credible European Defense and Renew the Transatlantic Partnership

History is replete with irony, but rarely more poignantly than in the summer of 2016 when, on 23 June, the UK voted to leave the European Union and the next day, 24 June, the EU published its Global Strategy document asserting its ambition of “strategic autonomy.” Whither Franco-British defense cooperation in such chaotic circumstances? This paper attempts to provide the outline of an answer to that question.