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Proof of concept for poor inhibitor binding and efficient formation of covalent adducts of KRASG12C and ARS compounds

Org. Biomol. Chem., 2020, 18,3069-3081
DOI: 10.1039/D0OB00071J, Paper
Maria G. Khrenova, Anna M. Kulakova, Alexander V. Nemukhin
Comprehensive molecular modeling and kinetic analysis reveal a novel mechanism of the inhibition of the oncogenic mutant of the “undruggable” KRAS protein.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Enantioselective synthesis of chiral α-alkynylated thiazolidones by tandem S-addition/acetalization of alkynyl imines

Org. Biomol. Chem., 2020, 18,3117-3124
DOI: 10.1039/D0OB00365D, Paper
Mei-Xin Wang, Juan Liu, Zhen Liu, Yingcheng Wang, Qi-Qiong Yang, Wenyu Shan, Yu-Hua Deng, Zhihui Shao
A SPINOL-CPA catalyzed asymmetric [2 + 3]-annulation of in situ generated alkynyl imines and 1,4-dithiane-2,5-diol has been developed to afford enantiopure α-alkynylated thiazolidones.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Dearomatization of 3-cyanoindoles by (3 + 2) cycloaddition: from batch to flow chemistry

Org. Biomol. Chem., 2020, Advance Article
DOI: 10.1039/D0OB00582G, Communication
Maxime Manneveau, Saori Tanii, Fanny Gens, Julien Legros, Isabelle Chataigner
(3 + 2) Dearomatizing cycloaddition of 3-cyanoindoles occurs in smooth conditions with a non-stabilized azomethine ylide, to yield tricyclic indolines in only 1 min under microflow conditions using 3 equiv of the dipole precursor vs. 6 equiv. in a batch reactor.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Photocatalytic xanthate-based radical addition/cyclization reaction sequence toward 2-biphenyl isocyanides: synthesis of 6-alkylated phenanthridines

Org. Biomol. Chem., 2020, Advance Article
DOI: 10.1039/D0OB00136H, Communication
Pedro López-Mendoza, Luis D. Miranda
A photocatalytic xanthate-based radical addition/cyclization reaction cascade toward 2-biphenylisocyanides is described as a practical and modular approach to 6-alkylated phenanthridines.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Visible light induced 3-position-selective addition of arylpropiolic acids with ethers via C(sp3)–H functionalization

Org. Biomol. Chem., 2020, 18,3258-3262
DOI: 10.1039/D0OB00480D, Communication
Zi-juan Wan, Xiao-feng Yuan, Jun Luo
Although the 2-position-selective decarboxylative coupling or addition of arylpropiolic acids with cyclic ethers has been intensively investigated, selective functionalization of arylpropiolic acids at the 3-position is still a big challenge.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Base-promoted 1,6-conjugate addition of alkylazaarenes to para-quinone methides

Org. Biomol. Chem., 2020, 18,3354-3359
DOI: 10.1039/D0OB00419G, Paper
Amritha Rayaroth, Rajat Kumar Singh, Kalyanakrishnan A. V., Krishna Hari, Alagiri Kaliyamoorthy
1,1,2-Triarylethanes embedded with an azaarene unit were prepared in a single step at ambient temperature via the sodium hexamethyldisilazide mediated 1,6-conjugate addition of unactivated alkylazaarenes on para-quinone methides (p-QMs).
The content of this RSS Feed (c) The Royal Society of Chemistry




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KI/TBHP-promoted [3 + 2] cycloaddition of pyrrolo[1,2-a]quinoxalines and N-arylsulfonylhydrazones

Org. Biomol. Chem., 2020, 18,3360-3366
DOI: 10.1039/D0OB00494D, Paper
Zhen Yang, Jing He, Yueting Wei, Weiwei Li, Ping Liu
A series of diverse fused [1,2,4]triazolo[3,4-c]quinoxalines was obtained by an efficient KI/TBHP-promoted [3 + 2] cycloaddition of pyrrolo[1,2-a]quinoxalines and N-arylsulfonylhydrazones.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Chemo- and regioselective click reactions through nickel-catalyzed azide–alkyne cycloaddition

Org. Biomol. Chem., 2020, 18,3374-3381
DOI: 10.1039/D0OB00579G, Paper
Woo Gyum Kim, Seung-yeol Baek, Seo Yeong Jeong, Dongsik Nam, Ji Hwan Jeon, Wonyoung Choe, Mu-Hyun Baik, Sung You Hong
Nickel-catalyzed [3 + 2] cycloaddition reactions of unsymmetrical alkynes and organic azides afford substituted 1,2,3-triazoles with high levels of chemo- and regioselectivity.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Dienaminodioate based multicomponent reactions with post-benzylic oxidative transformations mediated by DDQ

Org. Biomol. Chem., 2020, Accepted Manuscript
DOI: 10.1039/D0OB00721H, Paper
Jaice Ravindran, Velickakathu Yadhukrishnan, Reghuvaran Asha , Ravi Shankar Lankalapalli
Multicomponent reactions (MCRs) using dienaminodioate with post-benzylic oxidative transformation by DDQ that afforded a diverse array of products is described. An unprecedented rearrangement of 1,2-dihydropyridines (1,2-DHPs), 3CR products, to 2-pyridones...
The content of this RSS Feed (c) The Royal Society of Chemistry




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CISF needs 4,500 addl personnel to man new 'Metro' routes

With the Delhi Metro expanding its wings beyond Delhi, the CISF will require additional 4,500 personnel to guard the new operations of the mass rapid transport system.




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Gujarati icing on Will-Kat wedding cake!

The royal wedding cake is set to have a Gujarati connection. It has emerged that Prince William and Kate Middleton have chosen a cake company run by a Gujarati in Leicestershire.




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Indian connection to prince William and Kate Middleton's wedding cake

Had it not been for the encouragement of her Gujarati husband Kishore Patel, Fiona Cairns may have never made the leap from graphic design to luxury baking.




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Plea on metro card-address proof linking declined




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'I am a social media addict'

'I am commercial by heart.'




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Shraddha does something she has NEVER DONE BEFORE

'I have to pinch myself to believe that 10 years have just gone by.'




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[ASAP] Toward Efficient Triple-Junction Polymer Solar Cells through Rational Selection of Middle Cells

ACS Energy Letters
DOI: 10.1021/acsenergylett.0c00857




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Biodefense in the age of synthetic biology / Committee on Strategies for Identifying and Addressing Potential Biodenfense Vulnerabilities Posed by Synthetic Biology, Board on Chemical Sciences and Technology, Board on Life Sciences, Division on Earth and

Online Resource




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The demon in the machine: how hidden webs of information are solving the mystery of life / Paul Davies

Dewey Library - QH501.D38 2019




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Interfacing bioelectronics and biomedical sensing Hung Cao, Todd Coleman, Tzung K. Hsiai, Ali Khademhosseini, editors

Online Resource




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This capitalism theme park will make you shudder

KidZania is an unashamed shrine to the sterile, dystopian human-made landscapes, comedian Steve Parry writes.




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How to Add a CSS and JavaScript Sticky Menu to Your Site

See the two ways to add a sticky horizontal menu to your site, plus 7 beautiful examples of this pattern out in the wild.




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[ASAP] Quantitation of DNA Adducts of Aristolochic Acids in Repair-Deficient Cells: A Mechanistic Study of the DNA Repair Mechanism

Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.0c00004




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[ASAP] Interindividual Differences in DNA Adduct Formation and Detoxification of 1,3-Butadiene-Derived Epoxide in Human HapMap Cell Lines

Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.9b00517




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[ASAP] Correction to “Hemoglobin Adducts and Urinary Metabolites of Arylamines and Nitroarenes”

Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.0c00117




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[ASAP] Clustering a Chemical Inventory for Safety Assessment of Fragrance Ingredients: Identifying Read-Across Analogs to Address Data Gaps

Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.9b00518




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Diddy and Dre Make Monster Beats

Music-industry heavy hitters Dr. Dre, Diddy and Jimmy Iovine, chairman of Interscope-Geffen-A&M, discuss a new line of Beats by Dr. Dre headphones, Diddy Beats.




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Freddie Krueger Speaks Out

Actor Jackie Earl Haley discusses his role in A Nightmare on Elm Street, the reboot that returned it to its own dark origins.  Haley also says playing Rorschach in Watchmen changed his personality.




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Southern Grind Granddaddy

Bowie style knife with an overall length of 16-7/8". The blade itself is 11" and has a 5-3/4" black micarta handle with the Southern Grind logo laser etched on the micarta.




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CES 2013: The Fuji X100S Is Faster Than Your Toddler

The "S" stands, appropriately, for speed because this camera is fast. Crazy fast. And while the camera's internals got a boost, the X100S still carries the classic body of the X100.




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Kiddie Car Racing for Adults

Speed, glory, electrical fires: The new Power Racing Series pits overclocked minimobiles in tiny but heated competitions.




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Welcome to Armageddon, USA

In Picher, Oklahoma, the mines closed and the people moved away. Then came the sinkholes, looters, and governmental collapse. To survive, you need optimism -- and a gun.




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Mr. Know-It-All - Classical Toddler Music

You've heard music is good for your kid’s brain, but does it matter what tunes you spin? Mr. Know-It-All weighs in on the age-old debate: Led Zeppelin or The Wiggles?




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Angry Nerd - Riddick and Hollywood's Failed Attempts at Using POV Cameras

Seeing carnage through a character’s eyes used to mean something. Nowadays, Hollywood is wasting POV shots in sci-fi films like Vin Diesel’s Riddick. Angry Nerd explains why these fancy-schmancy first-person perspectives are failing, and he issues the Tinseltown execs an ultimatum.




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RetroGrade - Madden Doesn't Have Anything on this Old-School Football Video Game

In 1978 Mattel elevated handheld gaming to the next level with the Football 2. Realistic game sounds, plus the ability to pass the ball? Touchdown!




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How to Make a Giant Creature - It’s Back! Watch a Teaser of the Biggest, Baddest Creature Coming to Life for Comic-Con 2014

At San Diego Comic-Con 2013, WIRED debuted a giant robot mech. This year, a new version of the larger-than-life beast will be revealed at the ultimate fan convention. Watch a preview of what’s in store for the colossal creature, created in collaboration with the Stan Winston School, Legacy Effects, Stratasys, and WIRED. From design to tech and prototype to finished product, see how the ultimate cosplay creation came to life.




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WIRED's Gadget Challenge - Can a Hand Vacuum Suck Up a Kiddie Pool of Fruity Pebbles?

Erik and Justin test out the most stylish gadgets available at this year’s WIRED Store. See what happens when the two get their hands on a Dyson handheld vacuum, the Ballo stool (a sleeker update to the balance ball chair), and a modern, Bluetooth-controlled gramophone.




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WIRED Business Conference - The Best Pieces of Fan Art Dedicated to Breakout Wattpad Writer Anna Todd

At the 2015 Wired Business conference, WIRED editor-at-large Jason Tanz interviews breakout fanfic author Anna Todd, who writes novels entirely on her smartphone then uploads them to Wattpad, a wildly popular digital publishing platform and writers community.




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Ant-Man Director Says Paul Rudd is Just Right as Tiny Marvel Superhero

Ant-Man director Peyton Reed spoke with WIRED about bringing the tiny superhero to the big screen, some easter eggs for Marvel fans and how Paul Rudd preserved the wry humor of the original comic books.




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Data Attack - Are You Addicted To Your Phone?

On a typical day, the average person checks their phone 85 times. In total, we spend about 5 hours on our phones each day. Here we explore the fine line between normal phone use and device addiction.




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Some Fish Swim. Weirder Fish Hop. This Fish ​Waddles

This cave fish climbs waterfalls—that’s right, it actually walks. It moves one fin in front of the other like an awkward lizard. And that movement could teach us a lot about how our fishy ancestors learned to walk.




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Absurd Creatures | The Oddly Shaped Peanut Bug Is Sick of Getting Beat Up, Guys

In South America, the peanut bug ambles around with a goofy-ass head. And that’s not its only clever defense against the bullies of the rainforest.




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Hidden Easter Eggs of Legoland

Master Builder Robbie McCarthy show us all the hidden secrets of California's LEGOLAND.




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The Numbers Don't Lie: America's Got a Gun Addiction

America’s gun addiction is bad. But to understand just how bad it is, you’ve got to see the numbers.




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The Middle Class Is in Trouble, and These Numbers Prove It

The 45th President of the United States has a big task ahead. Something is happening to the middle class and it's not good.




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The Fiddler Crab: One Part Giant Claw, Two Parts Attitude

The fiddler crab has one small claw and one big ol' one. Why? All the better to woo the lady crabs and throw down with the dude crabs.




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What is a DDoS Hack and How Do You Avoid Them?

DDoS! It stands for distributed denial of service, a kind of attack that turns insecure, internet-connected devices into a sort of zombie army. So here's how you can avoid being part of that zombie army.




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Meet The Clever Robot That's Ready to Take On Your Shopping Addiction

Robots are historically pretty bad at picking things up. But that's changing thanks to startups like Kindred, which is mixing advanced AI with remote controls to create robots that can pick and sort through objects at dizzying rates.




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Thomas Middleditch Let an AI Steal His Face to Make a New Movie

Behind the scenes with the actor Thomas Middleditch who teamed up with an artificial intelligence program called Benjamin to create "Zone Out," an entirely AI-made sci-fi film.




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WIRED Autocomplete Interviews - Kevin Hart & Tiffany Haddish Answer the Web's Most Searched Questions

"Night School" stars Kevin Hart and Tiffany Haddish take the WIRED Autocomplete Interview and answer the internet's most searched questions about themselves. Did Kevin Hart go to Temple University? Is Tiffany Haddish's hair real? Why is Kevin Hart everywhere??




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WIRED25: The Future of Cryptocurrency -- MIT Media Lab's Neha Narula and Reddit's Alexis Ohanian On What's Ahead

MIT Media Lab Digital Currency Initiative Director Neha Narula spoke with WIRED’s Brian Barrett as part of WIRED25, WIRED’s 25th anniversary celebration in San Francisco.