dd Proof of concept for poor inhibitor binding and efficient formation of covalent adducts of KRASG12C and ARS compounds By feeds.rsc.org Published On :: Org. Biomol. Chem., 2020, 18,3069-3081DOI: 10.1039/D0OB00071J, PaperMaria G. Khrenova, Anna M. Kulakova, Alexander V. NemukhinComprehensive molecular modeling and kinetic analysis reveal a novel mechanism of the inhibition of the oncogenic mutant of the “undruggable” KRAS protein.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
dd Enantioselective synthesis of chiral α-alkynylated thiazolidones by tandem S-addition/acetalization of alkynyl imines By feeds.rsc.org Published On :: Org. Biomol. Chem., 2020, 18,3117-3124DOI: 10.1039/D0OB00365D, PaperMei-Xin Wang, Juan Liu, Zhen Liu, Yingcheng Wang, Qi-Qiong Yang, Wenyu Shan, Yu-Hua Deng, Zhihui ShaoA SPINOL-CPA catalyzed asymmetric [2 + 3]-annulation of in situ generated alkynyl imines and 1,4-dithiane-2,5-diol has been developed to afford enantiopure α-alkynylated thiazolidones.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
dd Dearomatization of 3-cyanoindoles by (3 + 2) cycloaddition: from batch to flow chemistry By feeds.rsc.org Published On :: Org. Biomol. Chem., 2020, Advance ArticleDOI: 10.1039/D0OB00582G, CommunicationMaxime Manneveau, Saori Tanii, Fanny Gens, Julien Legros, Isabelle Chataigner(3 + 2) Dearomatizing cycloaddition of 3-cyanoindoles occurs in smooth conditions with a non-stabilized azomethine ylide, to yield tricyclic indolines in only 1 min under microflow conditions using 3 equiv of the dipole precursor vs. 6 equiv. in a batch reactor.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
dd Photocatalytic xanthate-based radical addition/cyclization reaction sequence toward 2-biphenyl isocyanides: synthesis of 6-alkylated phenanthridines By feeds.rsc.org Published On :: Org. Biomol. Chem., 2020, Advance ArticleDOI: 10.1039/D0OB00136H, CommunicationPedro López-Mendoza, Luis D. MirandaA photocatalytic xanthate-based radical addition/cyclization reaction cascade toward 2-biphenylisocyanides is described as a practical and modular approach to 6-alkylated phenanthridines.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
dd Visible light induced 3-position-selective addition of arylpropiolic acids with ethers via C(sp3)–H functionalization By feeds.rsc.org Published On :: Org. Biomol. Chem., 2020, 18,3258-3262DOI: 10.1039/D0OB00480D, CommunicationZi-juan Wan, Xiao-feng Yuan, Jun LuoAlthough the 2-position-selective decarboxylative coupling or addition of arylpropiolic acids with cyclic ethers has been intensively investigated, selective functionalization of arylpropiolic acids at the 3-position is still a big challenge.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
dd Base-promoted 1,6-conjugate addition of alkylazaarenes to para-quinone methides By feeds.rsc.org Published On :: Org. Biomol. Chem., 2020, 18,3354-3359DOI: 10.1039/D0OB00419G, PaperAmritha Rayaroth, Rajat Kumar Singh, Kalyanakrishnan A. V., Krishna Hari, Alagiri Kaliyamoorthy1,1,2-Triarylethanes embedded with an azaarene unit were prepared in a single step at ambient temperature via the sodium hexamethyldisilazide mediated 1,6-conjugate addition of unactivated alkylazaarenes on para-quinone methides (p-QMs).The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
dd KI/TBHP-promoted [3 + 2] cycloaddition of pyrrolo[1,2-a]quinoxalines and N-arylsulfonylhydrazones By feeds.rsc.org Published On :: Org. Biomol. Chem., 2020, 18,3360-3366DOI: 10.1039/D0OB00494D, PaperZhen Yang, Jing He, Yueting Wei, Weiwei Li, Ping LiuA series of diverse fused [1,2,4]triazolo[3,4-c]quinoxalines was obtained by an efficient KI/TBHP-promoted [3 + 2] cycloaddition of pyrrolo[1,2-a]quinoxalines and N-arylsulfonylhydrazones.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
dd Chemo- and regioselective click reactions through nickel-catalyzed azide–alkyne cycloaddition By feeds.rsc.org Published On :: Org. Biomol. Chem., 2020, 18,3374-3381DOI: 10.1039/D0OB00579G, PaperWoo Gyum Kim, Seung-yeol Baek, Seo Yeong Jeong, Dongsik Nam, Ji Hwan Jeon, Wonyoung Choe, Mu-Hyun Baik, Sung You HongNickel-catalyzed [3 + 2] cycloaddition reactions of unsymmetrical alkynes and organic azides afford substituted 1,2,3-triazoles with high levels of chemo- and regioselectivity.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
dd Dienaminodioate based multicomponent reactions with post-benzylic oxidative transformations mediated by DDQ By feeds.rsc.org Published On :: Org. Biomol. Chem., 2020, Accepted ManuscriptDOI: 10.1039/D0OB00721H, PaperJaice Ravindran, Velickakathu Yadhukrishnan, Reghuvaran Asha , Ravi Shankar LankalapalliMulticomponent reactions (MCRs) using dienaminodioate with post-benzylic oxidative transformation by DDQ that afforded a diverse array of products is described. An unprecedented rearrangement of 1,2-dihydropyridines (1,2-DHPs), 3CR products, to 2-pyridones...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
dd CISF needs 4,500 addl personnel to man new 'Metro' routes By archive.indianexpress.com Published On :: Fri, 07 Aug 2009 11:37:35 GMT With the Delhi Metro expanding its wings beyond Delhi, the CISF will require additional 4,500 personnel to guard the new operations of the mass rapid transport system. Full Article
dd Gujarati icing on Will-Kat wedding cake! By timesofindia.indiatimes.com Published On :: Mon, 28 Mar 2011 06:29:34 IST The royal wedding cake is set to have a Gujarati connection. It has emerged that Prince William and Kate Middleton have chosen a cake company run by a Gujarati in Leicestershire. Full Article
dd Indian connection to prince William and Kate Middleton's wedding cake By timesofindia.indiatimes.com Published On :: Tue, 05 Apr 2011 11:50:15 IST Had it not been for the encouragement of her Gujarati husband Kishore Patel, Fiona Cairns may have never made the leap from graphic design to luxury baking. Full Article
dd Plea on metro card-address proof linking declined By timesofindia.indiatimes.com Published On :: Sat, 09 May 2020 16:37:36 IST Full Article
dd 'I am a social media addict' By www.rediff.com Published On :: Thu, 05 Dec 2019 09:51:37 +0530 'I am commercial by heart.' Full Article
dd Shraddha does something she has NEVER DONE BEFORE By www.rediff.com Published On :: Tue, 03 Mar 2020 17:02:02 +0530 'I have to pinch myself to believe that 10 years have just gone by.' Full Article
dd [ASAP] Toward Efficient Triple-Junction Polymer Solar Cells through Rational Selection of Middle Cells By dx.doi.org Published On :: Fri, 08 May 2020 04:00:00 GMT ACS Energy LettersDOI: 10.1021/acsenergylett.0c00857 Full Article
dd Biodefense in the age of synthetic biology / Committee on Strategies for Identifying and Addressing Potential Biodenfense Vulnerabilities Posed by Synthetic Biology, Board on Chemical Sciences and Technology, Board on Life Sciences, Division on Earth and By library.mit.edu Published On :: Sun, 28 Apr 2019 07:25:40 EDT Online Resource Full Article
dd The demon in the machine: how hidden webs of information are solving the mystery of life / Paul Davies By library.mit.edu Published On :: Sun, 8 Mar 2020 07:47:17 EDT Dewey Library - QH501.D38 2019 Full Article
dd Interfacing bioelectronics and biomedical sensing Hung Cao, Todd Coleman, Tzung K. Hsiai, Ali Khademhosseini, editors By library.mit.edu Published On :: Sun, 15 Mar 2020 07:45:28 EDT Online Resource Full Article
dd This capitalism theme park will make you shudder By feedproxy.google.com Published On :: 2017-06-30T02:44:25-07:00 KidZania is an unashamed shrine to the sterile, dystopian human-made landscapes, comedian Steve Parry writes. Full Article
dd How to Add a CSS and JavaScript Sticky Menu to Your Site By www.cssdrive.com Published On :: 2018-03-22T22:34:50+00:00 See the two ways to add a sticky horizontal menu to your site, plus 7 beautiful examples of this pattern out in the wild. Full Article
dd [ASAP] Quantitation of DNA Adducts of Aristolochic Acids in Repair-Deficient Cells: A Mechanistic Study of the DNA Repair Mechanism By feedproxy.google.com Published On :: Wed, 04 Mar 2020 05:00:00 GMT Chemical Research in ToxicologyDOI: 10.1021/acs.chemrestox.0c00004 Full Article
dd [ASAP] Interindividual Differences in DNA Adduct Formation and Detoxification of 1,3-Butadiene-Derived Epoxide in Human HapMap Cell Lines By feedproxy.google.com Published On :: Wed, 15 Apr 2020 04:00:00 GMT Chemical Research in ToxicologyDOI: 10.1021/acs.chemrestox.9b00517 Full Article
dd [ASAP] Correction to “Hemoglobin Adducts and Urinary Metabolites of Arylamines and Nitroarenes” By feedproxy.google.com Published On :: Wed, 06 May 2020 04:00:00 GMT Chemical Research in ToxicologyDOI: 10.1021/acs.chemrestox.0c00117 Full Article
dd [ASAP] Clustering a Chemical Inventory for Safety Assessment of Fragrance Ingredients: Identifying Read-Across Analogs to Address Data Gaps By feedproxy.google.com Published On :: Wed, 06 May 2020 04:00:00 GMT Chemical Research in ToxicologyDOI: 10.1021/acs.chemrestox.9b00518 Full Article
dd Diddy and Dre Make Monster Beats By www.wired.com Published On :: Tue, 19 Jan 2010 00:00:00 +0000 Music-industry heavy hitters Dr. Dre, Diddy and Jimmy Iovine, chairman of Interscope-Geffen-A&M, discuss a new line of Beats by Dr. Dre headphones, Diddy Beats. Full Article
dd Freddie Krueger Speaks Out By www.wired.com Published On :: Thu, 26 Aug 2010 00:00:00 +0000 Actor Jackie Earl Haley discusses his role in A Nightmare on Elm Street, the reboot that returned it to its own dark origins. Haley also says playing Rorschach in Watchmen changed his personality. Full Article
dd Southern Grind Granddaddy By www.wired.com Published On :: Fri, 02 Mar 2012 00:00:00 +0000 Bowie style knife with an overall length of 16-7/8". The blade itself is 11" and has a 5-3/4" black micarta handle with the Southern Grind logo laser etched on the micarta. Full Article
dd CES 2013: The Fuji X100S Is Faster Than Your Toddler By www.wired.com Published On :: Fri, 11 Jan 2013 00:00:00 +0000 The "S" stands, appropriately, for speed because this camera is fast. Crazy fast. And while the camera's internals got a boost, the X100S still carries the classic body of the X100. Full Article
dd Kiddie Car Racing for Adults By www.wired.com Published On :: Fri, 19 Apr 2013 21:15:12 +0000 Speed, glory, electrical fires: The new Power Racing Series pits overclocked minimobiles in tiny but heated competitions. Full Article
dd Welcome to Armageddon, USA By www.wired.com Published On :: Fri, 19 Apr 2013 21:16:10 +0000 In Picher, Oklahoma, the mines closed and the people moved away. Then came the sinkholes, looters, and governmental collapse. To survive, you need optimism -- and a gun. Full Article
dd Mr. Know-It-All - Classical Toddler Music By www.wired.com Published On :: Fri, 14 Jun 2013 10:30:00 +0000 You've heard music is good for your kid’s brain, but does it matter what tunes you spin? Mr. Know-It-All weighs in on the age-old debate: Led Zeppelin or The Wiggles? Full Article
dd Angry Nerd - Riddick and Hollywood's Failed Attempts at Using POV Cameras By www.wired.com Published On :: Tue, 14 Jan 2014 11:30:00 +0000 Seeing carnage through a character’s eyes used to mean something. Nowadays, Hollywood is wasting POV shots in sci-fi films like Vin Diesel’s Riddick. Angry Nerd explains why these fancy-schmancy first-person perspectives are failing, and he issues the Tinseltown execs an ultimatum. Full Article
dd RetroGrade - Madden Doesn't Have Anything on this Old-School Football Video Game By www.wired.com Published On :: Mon, 16 Jun 2014 10:30:00 +0000 In 1978 Mattel elevated handheld gaming to the next level with the Football 2. Realistic game sounds, plus the ability to pass the ball? Touchdown! Full Article
dd How to Make a Giant Creature - It’s Back! Watch a Teaser of the Biggest, Baddest Creature Coming to Life for Comic-Con 2014 By www.wired.com Published On :: Wed, 16 Jul 2014 00:00:00 +0000 At San Diego Comic-Con 2013, WIRED debuted a giant robot mech. This year, a new version of the larger-than-life beast will be revealed at the ultimate fan convention. Watch a preview of what’s in store for the colossal creature, created in collaboration with the Stan Winston School, Legacy Effects, Stratasys, and WIRED. From design to tech and prototype to finished product, see how the ultimate cosplay creation came to life. Full Article
dd WIRED's Gadget Challenge - Can a Hand Vacuum Suck Up a Kiddie Pool of Fruity Pebbles? By www.wired.com Published On :: Thu, 20 Nov 2014 14:00:00 +0000 Erik and Justin test out the most stylish gadgets available at this year’s WIRED Store. See what happens when the two get their hands on a Dyson handheld vacuum, the Ballo stool (a sleeker update to the balance ball chair), and a modern, Bluetooth-controlled gramophone. Full Article
dd WIRED Business Conference - The Best Pieces of Fan Art Dedicated to Breakout Wattpad Writer Anna Todd By www.wired.com Published On :: Fri, 15 May 2015 17:20:00 +0000 At the 2015 Wired Business conference, WIRED editor-at-large Jason Tanz interviews breakout fanfic author Anna Todd, who writes novels entirely on her smartphone then uploads them to Wattpad, a wildly popular digital publishing platform and writers community. Full Article
dd Ant-Man Director Says Paul Rudd is Just Right as Tiny Marvel Superhero By www.wired.com Published On :: Wed, 15 Jul 2015 16:55:00 +0000 Ant-Man director Peyton Reed spoke with WIRED about bringing the tiny superhero to the big screen, some easter eggs for Marvel fans and how Paul Rudd preserved the wry humor of the original comic books. Full Article
dd Data Attack - Are You Addicted To Your Phone? By www.wired.com Published On :: Tue, 15 Mar 2016 10:00:00 +0000 On a typical day, the average person checks their phone 85 times. In total, we spend about 5 hours on our phones each day. Here we explore the fine line between normal phone use and device addiction. Full Article
dd Some Fish Swim. Weirder Fish Hop. This Fish Waddles By www.wired.com Published On :: Thu, 24 Mar 2016 10:00:00 +0000 This cave fish climbs waterfalls—that’s right, it actually walks. It moves one fin in front of the other like an awkward lizard. And that movement could teach us a lot about how our fishy ancestors learned to walk. Full Article
dd Absurd Creatures | The Oddly Shaped Peanut Bug Is Sick of Getting Beat Up, Guys By www.wired.com Published On :: Tue, 05 Jul 2016 10:00:00 +0000 In South America, the peanut bug ambles around with a goofy-ass head. And that’s not its only clever defense against the bullies of the rainforest. Full Article
dd Hidden Easter Eggs of Legoland By www.wired.com Published On :: Mon, 25 Jul 2016 10:00:00 +0000 Master Builder Robbie McCarthy show us all the hidden secrets of California's LEGOLAND. Full Article
dd The Numbers Don't Lie: America's Got a Gun Addiction By www.wired.com Published On :: Mon, 26 Sep 2016 23:41:00 +0000 America’s gun addiction is bad. But to understand just how bad it is, you’ve got to see the numbers. Full Article
dd The Middle Class Is in Trouble, and These Numbers Prove It By www.wired.com Published On :: Sun, 06 Nov 2016 11:00:00 +0000 The 45th President of the United States has a big task ahead. Something is happening to the middle class and it's not good. Full Article
dd The Fiddler Crab: One Part Giant Claw, Two Parts Attitude By www.wired.com Published On :: Mon, 09 Jan 2017 12:00:00 +0000 The fiddler crab has one small claw and one big ol' one. Why? All the better to woo the lady crabs and throw down with the dude crabs. Full Article
dd What is a DDoS Hack and How Do You Avoid Them? By www.wired.com Published On :: Fri, 05 May 2017 10:00:00 +0000 DDoS! It stands for distributed denial of service, a kind of attack that turns insecure, internet-connected devices into a sort of zombie army. So here's how you can avoid being part of that zombie army. Full Article
dd Meet The Clever Robot That's Ready to Take On Your Shopping Addiction By www.wired.com Published On :: Fri, 02 Mar 2018 11:00:00 +0000 Robots are historically pretty bad at picking things up. But that's changing thanks to startups like Kindred, which is mixing advanced AI with remote controls to create robots that can pick and sort through objects at dizzying rates. Full Article
dd Thomas Middleditch Let an AI Steal His Face to Make a New Movie By www.wired.com Published On :: Mon, 11 Jun 2018 17:10:00 +0000 Behind the scenes with the actor Thomas Middleditch who teamed up with an artificial intelligence program called Benjamin to create "Zone Out," an entirely AI-made sci-fi film. Full Article
dd WIRED Autocomplete Interviews - Kevin Hart & Tiffany Haddish Answer the Web's Most Searched Questions By www.wired.com Published On :: Thu, 27 Sep 2018 19:00:00 +0000 "Night School" stars Kevin Hart and Tiffany Haddish take the WIRED Autocomplete Interview and answer the internet's most searched questions about themselves. Did Kevin Hart go to Temple University? Is Tiffany Haddish's hair real? Why is Kevin Hart everywhere?? Full Article
dd WIRED25: The Future of Cryptocurrency -- MIT Media Lab's Neha Narula and Reddit's Alexis Ohanian On What's Ahead By www.wired.com Published On :: Tue, 16 Oct 2018 17:11:00 +0000 MIT Media Lab Digital Currency Initiative Director Neha Narula spoke with WIRED’s Brian Barrett as part of WIRED25, WIRED’s 25th anniversary celebration in San Francisco. Full Article