using Denver’s hot October housing market bucks pre-election tradition By www.denverpost.com Published On :: Fri, 08 Nov 2024 20:55:03 +0000 Despite concerns buyers would delay home purchases until after the election, metro Denver’s housing market sizzled in October. That activity bucks a national trend. A Redfin survey shows that 23% of first-time buyers plan to wait until after the election to purchase, citing economic uncertainty, potential rate cuts, and candidate policy impacts. According to the […] Full Article Business Real Estate Sponsored Content Sponsored: Real Estate Voices Sponsored:
using Kanye West’s Rousing Reflection [Unedited] By www.bet.com Published On :: Mon, 23 Feb 2015 20:00:00 EST He never fails to leave his mark. Full Article BET Honors Kanye West
using QBE Donates To HOME’s Housing Program By bernews.com Published On :: Thu, 07 Nov 2024 15:13:53 +0000 HOME, the registered charity whose purpose is to end homelessness in Bermuda, has welcomed a substantial donation from the QBE Foundation, the charitable arm of international insurance and reinsurance company, QBE. A spokesperson said, “It is the third successive year that QBE has supported HOME, after donations in 2022 and 2023. “The donation will help […] Full Article All Business News #CharityEvents #GoodNews
using Minister On Bermuda’s Housing Shortage By bernews.com Published On :: Fri, 10 Nov 2023 19:55:59 +0000 “Bermuda is now facing what can be considered a housing crisis,” Minister of Economy and Labour Jason Hayward said, adding that “various policies and interventions are needed at distinct levels relying on both public and private sector involvement to garner solutions.” Speaking in the House of Assembly today [Nov 10] the Minister said the ”Government will […] Full Article All News Politics #BermudaPolitics #BermudaRealEstate
using Column: Chris Famous On Housing & OBA By bernews.com Published On :: Mon, 25 Mar 2024 16:35:14 +0000 [Opinion column written by Chris Famous] In 2022 I was asked to join the board of the Bermuda Housing Corporation. There I met persons dedicated to providing affordable housing for almost 800 Bermudian families of various stations in life. For full disclosure, board members are paid $50 per month / Chairman $100 per month. Over […] Full Article All #BermudaPolitics #BermudaRealEstate #ChrisFamousColumns #OpinionColumns
using Women’s Resource Centre On Housing By bernews.com Published On :: Thu, 25 Apr 2024 22:12:22 +0000 The Women’s Resource Centre [WRC] said they ”are encouraged to see the issue of affordable housing being discussed on a national level” and wanted to ”add our voice – the collective voice of women in Bermuda – to the conversation.” A spokesperson said, “The Women’s Resource Centre [WRC] understands the complex issue of housing insecurity and homelessness […] Full Article All News #BermudaRealEstate #CharityEvents
using Minister Updates On BHC Housing Initiatives By bernews.com Published On :: Fri, 31 May 2024 15:08:43 +0000 “The Government through the BHC are making steady progress and we intend to see the completion of all 105 of these housing projects as quickly as possible,” Minister of Public Works David Burch said in the House of Assembly today [May 31] as he provided an update on housing initiatives. The Minister’s full statement follows […] Full Article All #BermudaPolitics #BermudaRealEstate
using Women’s Resource Centre Housing Campaign By bernews.com Published On :: Thu, 29 Aug 2024 17:16:08 +0000 The Women’s Resource Centre [WRC] recently launched a comprehensive Housing Advocacy Campaign to highlight the critical issue of housing insecurity in Bermuda, with a particular focus on the challenges faced by women and single-income families. A spokesperson said, “In alignment with the Universal Declaration of Human Rights, which recognizes housing as a fundamental human right, […] Full Article All News #BermudaRealEstate #CharityEvents
using Video: Minister On Affordable Housing Initiative By bernews.com Published On :: Thu, 12 Sep 2024 23:54:13 +0000 The Ministry of Public Works, in collaboration with the BHC, is partnering with the Leopard’s Club International to transform the vacant three-storey building into affordable housing units, Minister of Public Works Lt/Col David Burch said. Speaking at a press conference today, Minister Burch said, “Good afternoon, everyone. Thank you for joining us here today at […] Full Article All News Videos #BermudaPolitics #BermudaRealEstate
using Minister Burch Updates On Affordable Housing By bernews.com Published On :: Fri, 27 Sep 2024 15:41:39 +0000 Speaking in the House of Assembly today [Sept 27], Minister of Public Works Lt/Col David Burch provided an update on “one of the most pressing challenges we as a country face – the shortage of affordable housing.” The Minister’s full statement follows below: Mr. Speaker, I rise to report on one of the most pressing challenges […] Full Article All News Politics #BermudaPolitics #BermudaRealEstate
using Transformational Living Centre Using Solar Power By bernews.com Published On :: Wed, 03 Aug 2022 00:12:06 +0000 The Transformational Living Centre [TLC] for Families is now utilizing solar power which they said “will provide most of the energy required to power their electrical needs.” A spokesperson said, “Gil Nolan, operations manager of Sunny Side Solar and Nick Hutchings, a volunteer for the non-profit solar company that donated the solar panels to the […] Full Article All Environment News #Electricity #SolarEnergy #TLCCentre
using Man Sentenced To Prison For Causing Death By bernews.com Published On :: Tue, 19 Sep 2023 10:27:13 +0000 Christian Sousa Matias was sentenced to prison time for causing the death of Allen Trott by careless driving. The ruling said, “The Accused appears before this Court for sentence, having been convicted, upon his guilty pleas entered 3 April 2023, to a charge of causing death by careless driving contrary to 37A of the Road […] Full Article Accidents and fires All Court Reports Crime #Collision #FatalAccidents #MagistratesAndSupremeCourt #RoadTrafficFatality
using Curtis Richardson Charged With Causing Death By bernews.com Published On :: Wed, 08 Nov 2023 16:46:18 +0000 [Updated] Former Senator Curtis Richardson was charged with causing the death of Marco Warren by driving without due care and attention. Appearing in Magistrates Court this morning [Nov 8], the 48-year-old was charged with causing the death of Mr Warren in May of this year by driving a vehicle, said to be a taxi, without due care […] Full Article All Court Reports Crime News #CrimeInBermuda #DeathOfMarcoWarren #FatalAccidents
using How to Tell If You're Using a Slow iPhone Charger By www.macrumors.com Published On :: Tue, 12 Nov 2024 15:47:00 PST In iOS 18, Apple has introduced a clever new way to identify if your iPhone charging setup is running at less than optimal speeds. The new feature appears directly in Settings, making it easy to spot when you're not getting the fastest possible charge. The Battery section displays a Slow Charger message when your iPhone detects a "slow" charger in use. You'll also see charging periods with an orange bar. This visual indicator appears in both the 24-hour and 10-day battery usage views. What Makes a Charger "Slow"? Wired chargers providing 7.5W or less power Standard Qi1 wireless chargers (less than 10W) USB ports in cars or hubs Chargers with multiple connected devices sharing power Common Causes of Slow Charging Several situations can slow down your iPhone's charging speed. A counterfeit charger could be the culprit, for example. Even some authentic third-party wireless chargers claim MagSafe compatibility but only deliver standard Qi charging speeds. If you keep accessories like headphones connected during wireless charging, your device automatically limits power to 7.5W to meet safety standards. Running demanding apps, playing graphics-intensive games, or streaming video at high brightness while charging can also reduce charging speeds as your iPhone manages power and heat. Lastly, it's worth bearing in mind that charging in a warm environment may cause your iPhone to temporarily pause charging until the temperature falls. Get Faster Charging Speeds To get the fastest possible charging speeds, you'll want to use a USB-C Power Delivery charger along with the appropriate cable - USB-C for iPhone 15 and later, or USB-C to Lightning for earlier models. Alternatively, you can opt for either Apple's MagSafe Charger or any Qi2-certified wireless charger, both of which provide significantly faster charging than standard Qi chargers.This article, "How to Tell If You're Using a Slow iPhone Charger" first appeared on MacRumors.comDiscuss this article in our forums Full Article Apple Rumors Mac iOS iPhone iPad
using Is Tucker Carlson accusing Republican officeholders of not defending normal American citizens? By www.cpa-connecticut.com Published On :: Wed, 01 Jul 2020 15:58:37 +0000 Republicans are failing for a much more obvious reason, a more fundamental reason. They're failing because they haven't done much that is worth doing. They haven't tried very hard to improve your life. When the crisis came, they fled. They did nothing to defend you. They did nothing to defend the country. Continue reading → Full Article Accountants CPA Hartford Articles Black Lives Matter colorblind meritocracy Donald Trump freedom of speech Governor Nikki Haley http://cpa-connecticut.com/barefootaccountant/is-tucker-carlson-accusing-republican-officeholders-of-not-defending-normal-american-citizens/ Is Tucker Carlson accusing Republican officeholders of not defending normal American citizens? Jeffrey Epstein Jim Crow Middle class families are the core of this country Republican officeholders are not defending normal people from "self-righteous lunatics" Republicans must work as hard as they can to make America fair again Senator Mike Braun Slavery total equality under the law Tucker Carlson Tucker Carlson Tonight June 30 2020 Voters need to demand change from the GOP
using Our government is using Big Tech companies to circumvent the First Amendment and censor free speech on its behalf By www.cpa-connecticut.com Published On :: Mon, 19 Jul 2021 17:20:24 +0000 Google, Facebook and Twitter should be treated as state actors under existing legal doctrines. Using a combination of statutory inducements and regulatory threats, Congress has co-opted Silicon Valley to do through the back door what government cannot directly accomplish under the Constitution. Congress is giving Big Tech immunity and more power in exchange for it censoring whatever Congress wants censored. Continue reading → Full Article Accountants CPA Hartford Articles Accountants CPA Hartford Connecticut LLC barefootaccountant Biden administration Big Tech censorship Constitution Democratic Party Facebook first amendment free speech Jen Psaki Jon Scott July 18 2021 Our government is using Big Tech companies to circumvent the First Amendment and censor free speech on its behalf Vivek Ramaswamy william brighenti Woke Inc.: Inside Corporate America's Social Justice Scam
using FIW using Bonnie Blue Flag Rules By iron-mitten.blogspot.com Published On :: Wed, 30 Oct 2024 12:56:00 +0000 Here are the craziest scribblings of a madman. Having selected BBF for my black powder games, I'm now just trying to down scale it for a skirmish type game. Smaller units but still using multi bases for figures. Units of four seem to work as a base number. Here are the unit sizes in Muskets and Tomahawks that are good to see as a guide. All just early days still just throwing ideas around to see if something sticks.Drilled Vs irregular base.Update: Right! I've bit the bullet and revised my Indians for the game.I decided to go with 60x60mm bases to give a more spread out look. Also these Galloping Major figures are quite large for 28mm so it suits them better.I imagine four bases of Indians to a unit with a base of skirmishers. I just want one rule set for my black powder games and I think BBF is the one, with a few tweaks of course.My latest thinking is make Indians 'green', so they won't stick around long once the casualties start to mount up. A +10 melee modifier makes them dangerous close up so it's worth trying to get them into hand to hand. They are just too wise to stick around when things go bad. An experienced unit of warriors would be quite imposing with their combat bonus, something to be feared.I had thought of giving Rangers the same combat bonus but as they will be veterans, a plus 10 would be too much. I think let's class them as Elites with a +5. Full Article Bonnie Blue Flag
using Zoo must be confusing By satwcomic.com Published On :: Zoo must be confusing View Comic! Full Article
using NFPA and The Center for Campus Fire Safety raise student awareness of fire hazards in on- and off-campus housing during September and October By www.nfpa.org Published On :: 30 Aug2017 19:37:24 GMT September is Campus Fire Safety Month and this year the National Fire Protection Association (NFPA) and The Center for Campus Fire Safety (The Center) are working together to promote their national Campus Fire Safety for Students campaign. The campaign raises awareness about the dangers of fires among college-aged students who live in on- and off-campus college housing. Full Article
using Explaining Oumuamua and Pioneer anomaly using Time relativity By blogs.scienceforums.net Published On :: Sat, 09 May 2020 19:44:18 +0000 I find that in theory the weird Speed Boost of the interstellar object ‘Oumuamua should be 0.217 mm/s above the prediction and that ‘Oumuamua should slow down less than prediction, in proportion of which the difference is 4.28×10-8 near the Sun. For Pioneer anomaly I have computed the gap between real and predicted acceleration and... Full Article SFN Blogs Uncategorized
using Determination of the relative roll, pitch and yaw between arbitrary objects using 3D complex number By blogs.scienceforums.net Published On :: Tue, 06 Dec 2022 19:21:47 +0000 The roll, pitch and yaw of an object relative to another is complex to compute. We use 3D complex number to compute them which makes the computation easier and more intuitive. Roll, pitch and yaw are angles of orientation of an object in space and the conversion of these angles among different reference frames is... Full Article SFN Blogs Uncategorized
using Home not Housing. Engaging with wellbeing outcomes By lx.iriss.org.uk Published On :: Wednesday, August 12, 2015 - 12:14 Home not Housing was one of five Scottish Universities Insight Institute programmes on Wellbeing. A set of ideas workshops explored the concept of ‘home’ from the perspectives of various academic disciplines – housing, planning, social work, healthcare – in order to develop a common vocabulary that will better inform policies relating to house-building, home-working, home-care and general place liveability. This blog records the discussions and findings of the workshops. Full Article
using Five Extremely Long English Words Causing a Civil War Among Linguists By www.cracked.com Published On :: Tue, 12 Nov 2024 08:00:00 -0800 By Jesse Published: November 12th, 2024 Full Article
using Deck Your Halls for Less: 14 Christmas Decor Ideas Using IKEA Finds By ikeahackers.net Published On :: Wed, 30 Oct 2024 10:00:00 +0000 As the year draws to a close, the holiday season is upon us once again. Although we still have two months until Christmas, studies have shown decorating early is actually good for your mood. The vibrant colors and twinkling lights simply trigger the release feel-good dopamine, which in turn, boosts happiness and energy. I must admit, Christmas decor makes me grin like a kid with ice-cream, until I look at the price tag of tinsel and garlands and baubles. Yikes! […] The post Deck Your Halls for Less: 14 Christmas Decor Ideas Using IKEA Finds appeared first on IKEA Hackers. Full Article Christmas Featured Latest on IG
using How Do I Tell Which Program Is Using So Much Memory? By askleo.com Published On :: Thu, 31 Oct 2024 15:00:47 +0000 When Windows tells you it's out of memory, what does it mean and what can you do about it? How Do I Tell Which Program Is Using So Much Memory? from Ask Leo!. Get the Confident Computing weekly newsletter: https://newsletter.askleo.com Full Article Windows Programs memory RAM virtual memory
using These low-cost housing solutions are made from bamboo By inhabitat.com Published On :: Mon, 31 Jul 2023 17:30:00 +0000 The Housing NOW project addresses home insecurity in a variety of affordable, efficient and sustainable ways. Started by Blue Temple, an architecture design studio based in Myanmar, the structures are constructed using bamboo that is locally available and endlessly renewable.[...] Full Article Architecture bamboo architecture sustainable housing housing Myanmar refugees post-format-gallery
using North Korean Hackers Target macOS Using Flutter-Embedded Malware By thehackernews.com Published On :: Tue, 12 Nov 2024 18:30:00 +0530 Threat actors with ties to the Democratic People's Republic of Korea (DPRK aka North Korea) have been found embedding malware within Flutter applications, marking the first time this tactic has been adopted by the adversary to infect Apple macOS devices. Jamf Threat Labs, which made the discovery based on artifacts uploaded to the VirusTotal platform earlier this month, said the Flutter-built Full Article
using THE LAW AND THE FACTS ARE ON OUR SIDE, BUT WE SHOULD BE USING EMOTION, TOO By www.backwoodshome.com Published On :: Tue, 05 Nov 2024 14:00:00 +0000 Historically, both law and facts are on the gun owners’ side of the “gun control” debate, and the Other Side had relied largely on emotion. I respectfully submit that emotion is something our side should play to, as well. I made that point recently at the 2024 Gun Rights Policy Conference in San Diego last […] Full Article Uncategorized
using How to see the invisible: Using the dark matter distribution to test our cosmological model By www.princeton.edu Published On :: Mon, 03 Apr 2023 11:00:00 -0400 A Princeton-led team of astrophysicists has measured a surprising value for the “clumpiness” of the universe’s dark matter. Full Article
using Princeton archaeologists are using cutting-edge digital technologies to help reveal the ancient past By www.princeton.edu Published On :: Tue, 09 Apr 2024 14:13:00 -0400 In the field, digital technology saves immense amounts of time and limits fruitless digging. In the classroom, VR recreations help bring the past to life. Full Article
using Gayle King Calls out Pelosi For Using ‘Egregious’ Language In Referring To Trump Supporters As ‘Henchmen’ By hispolitica.com Published On :: Fri, 25 Sep 2020 19:22:26 +0000 CBS News’s Gayle King criticized House Speaker Nancy Pelosi(D-CA) for calling President Trump’s supporters “henchmen,” reminding her the language she used is “just as egregious” as the insults the president directs towards her. King made the remarks Friday morning on CBS This Morning show when she asked the House Speaker about the upcoming Tuesday’s presidential […] The post Gayle King Calls out Pelosi For Using ‘Egregious’ Language In Referring To Trump Supporters As ‘Henchmen’ appeared first on Hispolitica. Full Article U.S. Congress 2020 2020 Presidential Race cbs news CBS This Morning Gayle King Henchmen Joe Biden nancy pelosi president trump Presidential Debate
using Factoring In PayPal Fees When Sending Money Using the Goods and Services Option By www.tipsandtricks-hq.com Published On :: Wed, 12 May 2021 00:48:45 +0000 With more and more online marketplaces popping up, many individuals prefer to pay for items, whether they be new or second hand using the PayPal Goods and Services option. The PayPal ‘Goods and Services’ option gives buyers further peace of mind with the PayPal guarantee. If the seller does not provide what they have described, […] The post Factoring In PayPal Fees When Sending Money Using the Goods and Services Option appeared first on Tips and Tricks HQ. Full Article General Shop Admin Tips Paypal paypal donation PayPal Tutorials Transfer Money
using "Silver Tsunami:" Using Video for Knowledge Transfer By communicationtransformation.blogspot.com Published On :: Fri, 20 May 2011 22:48:00 +0000 When the Baby Boomers retire they are going to be taking their substantial knowledge with them. The younger generation to whom that knowledge should be transferred likes to consume video. This has some very interesting implications for organizations that want to capture that knowledge, organize it, and make it easy for employees to find it and benefit from it. Here is a link to a webcast on June 1 where Dan Rasmus, a technology strategist and author of Listening to the Future , will discuss the potential for video to serve as an all important medium for knowledge transfer and organizational learning. Topics to be Covered: • Knowledge Acquisition via Video • Video as a Tool for Knowledge Management • Use of Video or Operational Efficiency • Practical Applications of Video for Learning in the Enterprise Click here to register for the webcast Full Article
using Trends in Housing Affordability: Who Can Currently Afford to Buy a Home? By www.nar.realtor Published On :: Tue, 27 Aug 2024 15:26:37 +0000 Who Can Currently Afford to Buy a Home? With mortgage rates recently falling below 6.5%, there has been an improvement in housing affordability. By: Nadia Evangelou Full Article
using HMDA and Housing Demand By www.nar.realtor Published On :: Thu, 05 Sep 2024 20:51:02 +0000 HMDA and Housing Demand Nationwide, the number of home-purchase loan applications has declined from 7.9 million to 6.5 million. By: Anat Nusinovich Mortgages & Home Financing Full Article
using MEF: Focusing on the Muslim Brotherhood, as Revealed in a New Book By cynthiafarahat.com Published On :: Sun, 20 Nov 2022 14:20:00 +0000 Presented by the Middle East Forum on Nov. 18, 2022 Panel discussion with Daniel Pipes, Cynthia Farahat, and Jonathan Schanzer: Full Article 9/11 Al-Azhar University Al-Qaeda CAIR Disinformation Featured Articles IS ISIL ISIS Islamism Muslim Brotherhood
using Reply to Sysel et al.: Comment on the importance of using nitric oxide gas in the synthesis of nitrosylcobalamin and ICH-validated methods to assess purity and stability [Letters to the Editor] By www.jbc.org Published On :: 2020-10-23T00:06:00-07:00 In their comment (1) on our publication (2), the authors make two points: (i) they raise concerns about the possible effect of residual NONOate in our study, and (ii) they promote nitrosylcobalamin (NOCbl) supplied by their own company. Both points lack merit for the following reasons. The authors make the astonishing claim that the spectra of nitric oxide (NO•) and cobalamins overlap. Unlike NO•, cobalamin absorbs in the visible region, permitting unequivocal spectral assignment of NOCbl as reported (3). We demonstrated that whereas NOCbl is highly unstable in solution, it is stabilized by the B12 trafficking protein CblC. So even if present, residual NONOate (which is unstable at neutral pH and is removed during the work-up (3)) could not account for the observed difference.The authors then misrepresent our synthetic method, claiming that anaerobic conditions were used to generate nitrocobalamin (NO2Cbl), which results in the transient formation of NOCbl. We synthesized NO2Cbl aerobically using nitrite as described (4); NOCbl is not an intermediate in this ligand exchange reaction. The aerobic instability of NOCbl has been rigorously described by inorganic chemists (3, 5) and raises obvious questions about its purported biological effects as exemplified by the authors' own 2003 JBC publication, which was later withdrawn.As to promoting NOCbl from their company, the authors refer to a synthetic route from a mixture of NO• gas and aquocobalamin. The authors' method (6) has been described as “dubious” by chemists (5). Whereas DEAE NONOate used in our method is widely known as an NO• donor,... Full Article
using Comment on the importance of using nitric oxide gas in the synthesis of nitrosylcobalamin and ICH-validated methods to assess purity and stability [Letters to the Editor] By www.jbc.org Published On :: 2020-10-23T00:06:00-07:00 After a thorough read of this paper (1), we wish to clarify that the authors' anaerobic method of synthesis for the production of nitrocobalamin results in the transient formation of nitrosylcobalamin, an unstable intermediate upon exposure to air. We concur that the authors' method results in the production of nitrocobalamin based on the UV-visible data as shown. The authors' adapted anaerobic method consists of mixing hydroxocobalamin hydrochloride with diethylamine NONOate diethylammonium salt in aqueous solution. Of concern, the UV spectrum of nitric oxide overlaps that of all cobalamin species under anaerobic conditions, making any assignments of the binding of nitric oxide to hydroxocobalamin suspect (2). Additionally, the use of acetone to precipitate the authors' product causes precipitation of diethylamine NONOate, resulting in an impure product. As a result, its utility for drawing experimental conclusions is faulty.The product from the authors' anaerobic synthetic method has not been assessed for purity, and the synthetic method itself has not been validated using a stability-indicating method as required by the International Conference on Harmonization (ICH) (ICH Q2B, Validation of Analytical Procedures) methodology, which is a hallmark for analytical characterization. Our nitrosylcobalamin synthesis involves reacting nitric oxide gas with hydroxocobalamin acetate as a heterogeneous mixture in a non-electron-donating solvent followed by rotary evaporation. Our nitrosylcobalamin product is stable in air, releases nitric oxide gas in situ (3), and meets ICH stability guidelines (4). Additionally, our nitrosylcobalamin product demonstrates biological activity, which has not been observed for nitrocobalamin (3, 5). Full Article
using Targeted Peptide Measurements in Biology and Medicine: Best Practices for Mass Spectrometry-based Assay Development Using a Fit-for-Purpose Approach By www.mcponline.org Published On :: 2014-03-01 Steven A. CarrMar 1, 2014; 13:907-917Technological Innovation and Resources Full Article
using Highly Selective Enrichment of Phosphorylated Peptides from Peptide Mixtures Using Titanium Dioxide Microcolumns By www.mcponline.org Published On :: 2005-07-01 Martin R. LarsenJul 1, 2005; 4:873-886Technology Full Article
using Multiplexed Protein Quantitation in Saccharomyces cerevisiae Using Amine-reactive Isobaric Tagging Reagents By www.mcponline.org Published On :: 2004-12-01 Philip L. RossDec 1, 2004; 3:1154-1169Research Full Article
using A spectrophotometric assay for lipid peroxides in serum lipoproteins using a commercially available reagent By www.jlr.org Published On :: 1989-04-01 M el-SaadaniApr 1, 1989; 30:627-630Articles Full Article
using Using Math to Support Cancer Research By www.ams.org Published On :: Thu, 29 Dec 2022 2:39:14 -0400 Stacey Finley from University of Southern California discusses how mathematical models support the research of cancer biology. Cancer research is a crucial job, but a difficult one. Tumors growing inside the human body are affected by all kinds of factors. These conditions are difficult (if not impossible) to recreate in the lab, and using real patients as subjects can be painful and invasive. Mathematical models give cancer researchers the ability to run experiments virtually, testing the effects of any number of factors on tumor growth and other processes — all with far less money and time than an experiment on human subjects or in the lab would use. Full Article
using Man heard using racial slur resigns from a Penn State commonwealth campus’ board By www.yahoo.com Published On :: 2024-11-12T14:27:54Z Full Article
using SAS Notes for SAS®9 - 66492: FILENAME FTP(FTP/TLS) fails with "ERROR: The connection was reset by a peer" due to using implicit FTP/TLS By Published On :: Wed, 26 Aug 2020 13:59:34 EST If you connect to a FTP/TLS server that is configured to use implicit FTP/TLS, FILENAME FTP/TLS might fail with the following error: ERRO Full Article BASE+Base+SAS
using Determinants of replication protein A subunit interactions revealed using a phosphomimetic peptide [Molecular Biophysics] By www.jbc.org Published On :: 2020-12-25T00:06:31-08:00 Replication protein A (RPA) is a eukaryotic ssDNA-binding protein and contains three subunits: RPA70, RPA32, and RPA14. Phosphorylation of the N-terminal region of the RPA32 subunit plays an essential role in DNA metabolism in processes such as replication and damage response. Phosphorylated RPA32 (pRPA32) binds to RPA70 and possibly regulates the transient RPA70-Bloom syndrome helicase (BLM) interaction to inhibit DNA resection. However, the structural details and determinants of the phosphorylated RPA32–RPA70 interaction are still unknown. In this study, we provide molecular details of the interaction between RPA70 and a mimic of phosphorylated RPA32 (pmRPA32) using fluorescence polarization and NMR analysis. We show that the N-terminal domain of RPA70 (RPA70N) specifically participates in pmRPA32 binding, whereas the unphosphorylated RPA32 does not bind to RPA70N. Our NMR data revealed that RPA70N binds pmRPA32 using a basic cleft region. We also show that at least 6 negatively charged residues of pmRPA32 are required for RPA70N binding. By introducing alanine mutations into hydrophobic positions of pmRPA32, we found potential points of contact between RPA70N and the N-terminal half of pmRPA32. We used this information to guide docking simulations that suggest the orientation of pmRPA32 in complex with RPA70N. Our study demonstrates detailed features of the domain-domain interaction between RPA70 and RPA32 upon phosphorylation. This result provides insight into how phosphorylation tunes transient bindings between RPA and its partners in DNA resection. Full Article
using Theranostics for Meningioma on the Rise: New EANM/EANO/RANO/SNMMI Guidelines Pave the Way to Improved Patient Outcomes Using Radiolabeled Somatostatin Receptor Ligands By jnm.snmjournals.org Published On :: 2024-10-10T08:33:38-07:00 Full Article
using Improved Localization of Insulinomas Using 68Ga-NODAGA-Exendin-4 PET/CT By jnm.snmjournals.org Published On :: 2024-10-17T09:03:09-07:00 Visual Abstract Full Article
using Comparison Between Brain and Cerebellar Autoradiography Using [18F]Flortaucipir, [18F]MK6240, and [18F]PI2620 in Postmortem Human Brain Tissue By jnm.snmjournals.org Published On :: 2024-10-30T08:04:16-07:00 Visual Abstract Full Article
using Identification of novel serological autoantibodies in Takayasu arteritis patients using HuProt arrays By www.mcponline.org Published On :: 2020-12-17 Xiao-Ting WenDec 17, 2020; 0:RA120.002119v1-mcp.RA120.002119Research Full Article