A comprehensive and standardized system to report lipid structures analyzed by MS is essential for the communication and storage of lipidomics data. Herein, an update on both the LIPID MAPS classification system and shorthand notation of lipid structures is presented for lipid categories Fatty Acyls (FA), Glycerolipids (GL), Glycerophospholipids (GP), Sphingolipids (SP), and Sterols (ST). With its major changes, i.e., annotation of ring double bond equivalents and number of oxygens, the updated shorthand notation facilitates reporting of newly delineated oxygenated lipid species as well. For standardized reporting in lipidomics, the hierarchical architecture of shorthand notation reflects the diverse structural resolution powers provided by mass spectrometric assays. Moreover, shorthand notation is expanded beyond mammalian phyla to lipids from plant and yeast phyla. Finally, annotation of atoms is included for the use of stable isotope-labeled compounds in metabolic labeling experiments or as internal standards. This update on lipid classification, nomenclature, and shorthand annotation for lipid mass spectra is considered a standard for lipid data presentation.

This article has been withdrawn by the authors. We discovered an error after this manuscript was published as a Paper in Press. Specifically, we learned that the structures of glycans presented for the PD-L1 peptide were drawn and labeled incorrectly. We wish to withdraw this article and submit a corrected version for review.

Waiting is the hardest part. In the fall of 2023, HPCwire wrote about the new diverging Xeon processor strategy from Intel. Instead of a on-size-fits all approach; Intel has opted […]

The post Granite Rapids HPC Benchmarks: I’m Thinking Intel Is Back (Updated) appeared first on HPCwire.

I have a free 30 Day Project Calendar that you can use for practicing mindfulness.  There are some instructions and tips at the bottom of the calendar itself and also some more in-depth tips below the image.  If you want to print the calendar, you may prefer this printable PDF version.   Full Instructions Mindfulness […]

The post 30 Days of Mindfulness Printable PDF appeared first on Dr Alice Boyes.

DeVos slammed for remarks on HBCU's, a new Senate measure could overturn Obama-era ESSA rules on accountability, and more.

Where did Texas A&M land in the latest CFP bracket? Here’s the College Football Playoff picture for the Aggies and their path to the championship.

Where did Georgia land in the latest CFP bracket and rankings? Here’s the College Football Playoff picture for the Bulldogs and path to championship.

Miami landed 9th in the latest CFP bracket. Here’s the College Football Playoff picture for the Hurricanes and path to the championship.

Penn State football landed Xth in the second CFP rankings. Here’s the College Football Playoff picture for the Nittany Lions.

LSU women's basketball coach Kim Mulkey provided updates for Shayeann Day-Wilson and Last-Tear Poa on Tuesday after LSU's win vs Charleston Southern.

Large-scale genome-wide association studies (GWASs) have associated intronic variants in PDE4B, encoding cAMP-specific phosphodiesterase-4B (PDE4B), with increased risk for post-traumatic stress disorder (PTSD), as well as schizophrenia and substance use disorders that are often comorbid with it. However, the pathophysiological mechanisms of genetic risk involving PDE4B are poorly understood. To examine the effects of PDE4B variation on phenotypes with translational relevance to psychiatric disorders, we focused on PDE4B missense variant M220T, which is present in the human genome as rare coding variant rs775201287. When expressed in HEK-293 cells, PDE4B1-M220T exhibited an attenuated response to a forskolin-elicited increase in the intracellular cAMP concentration. In behavioral tests, homozygous Pde4b^M220T male mice with a C57BL/6JJcl background exhibited increased reactivity to novel environments, startle hyperreactivity, prepulse inhibition deficits, altered cued fear conditioning, and enhanced spatial memory, accompanied by an increase in cAMP signaling pathway-regulated expression of BDNF in the hippocampus. In response to a traumatic event (10 tone–shock pairings), neuronal activity was decreased in the cortex but enhanced in the amygdala and hippocampus of Pde4b^M220T mice. At 24 h post-trauma, Pde4b^M220T mice exhibited increased startle hyperreactivity and decreased plasma corticosterone levels, similar to phenotypes exhibited by PTSD patients. Trauma-exposed Pde4b^M220T mice also exhibited a slower decay in freezing at 15 and 30 d post-trauma, demonstrating enhanced persistence of traumatic memories, similar to that exhibited by PTSD patients. These findings provide substantive mouse model evidence linking PDE4B variation to PTSD-relevant phenotypes and thus highlight how genetic variation of PDE4B may contribute to PTSD risk.

The October 2020 edition of the FAO publications catalogue is now available, released  to coincide with the digital Frankfurt book fair (14–18 October).

It includes the latest editions of the 

Released to coincide with the 166th Session of the FAO Council (26–30 April 2021), the April 2021 edition of the FAO publications catalogue is now available in English [...]

Released to coincide with the Frankfurt book fair (20-24 October 2021), the October 2021 edition of the FAO publications catalogue is now available. It shares the latest publications produced by FAO across all of its thematic [...]

The Publications branch now offers monthly publications updates in French to ensure you get the most up-to-date FAO’s knowledge products.   

The newsletter highlights the key publications available in French and [...]

The monthly publications updates produced by the Publications branch of the FAO Office of Communications are now available in English, Chinese and French.  

The newsletters highlight key publications available in the respective [...]

Released to coincide with the London Book Fair (5−7 April),  the new edition of the FAO publications catalogue is now available.

It includes the latest edition of the Regional Overviews of Food Security and Nutrition − Statistics [...]

The October 2022 edition of the FAO publications catalogue is out now.

From the latest editions of the State of the World collection to updated technical reports, the catalogue features a [...]

The monthly FAO publications updates produced by the Publications Branch of the FAO Office of Communications are available in English, French and Chinese.

The newsletters highlight key publications available [...]

The monthly FAO publications updates produced by the Publications Branch of the FAO Office of Communications are available in English, French and Chinese.

The newsletters highlight key publications available [...]

Flagship Data Management Solution Introduces‘Item-Centric’ PDM and New BOM Functionality

Leading elevator components supplier implements 550 licenses of the SolidWorks PDM solution

DWGgateway plug-in lets AutoCAD users share designs with virtually anyone

Geographically dispersed workgroups can now access, store, change, and approve

U.K.-based electrical connector manufacturer speeds product development with 3D mechanical design and product data management software

Investment improves coordination and accuracy

Longtime SOLIDWORKS and COSMOS customer reduces costs and time to market

Canadian aluminum die casting company cuts development time in half, reduces errors with 3D CAD and product data management software

Newest version of product data management solution maximizes global design teams' productivity

Fast Deployment Makes it Easy to Focus on Core Business Rather Than Managing Technology

Find out the latest news and updates on the CME Group Metals market, including the continued growth we are seeing with our Precious Metals products.

Get all the latest updates on COMEX Copper options including a new all-time high trading record and the strong growth of RFQs.

When iPhone users accepted new iCloud terms, some were shocked to see all their Notes disappear from the app. Here's how to get them back.

Apple has released new firmware for the AirPods Pro 2 and AirPods 4, another software update for its personal audio devices.

OM Director's Update from Lawrence Tong, International Director

OM Director's Update from Lawrence Tong, International Director

OM Director's Update from Lawrence Tong, International Director

OM Director's Update from Lawrence Tong, International Director

OM Director's Update from Lawrence Tong, International Director

OM Director's Update from Lawrence Tong, International Director

OM Director's Update from Lawrence Tong, International Director.

OM Director's Update from Lawrence Tong, International Director

OM Update from Lawrence Tong, International Director

OM Director's Update from Lawrence Tong, International Director

OM Director's Update by Lawrence Tong, International DIrector

OM Director's Update from Lawrence Tong

OM Director's Update from Lawrence Tong, International director