global

NVIDIA and SoftBank Corp. Accelerate Japan’s Journey to Global AI Powerhouse

NVIDIA today announced a series of collaborations with SoftBank Corp. designed to accelerate Japan’s sovereign AI initiatives and further its global technology leadership while also unlocking billions of dollars in AI revenue opportunities for telecommunications providers worldwide.




global

NVIDIA and Global Consulting Leaders Speed AI Adoption Across Japan’s Industries

Consulting giants including Accenture, Deloitte, EY Strategy and Consulting Co., Ltd. (or EY Japan), FPT,  Kyndryl and Tata Consultancy Services Japan (TCS Japan) are working with NVIDIA to establish innovation centers in Japan to accelerate the nation’s goal of embracing enterprise AI and physical AI across its industrial landscape. The centers will use NVIDIA AI Read Article




global

East-West Center to Launch #galswithLEI Global Webinar Series

East-West Center to Launch #galswithLEI Global Webinar Series East-West Center to Launch #galswithLEI Global Webinar Series
palmaj

News Release

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News Release

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global

The Coming Global Salvation (Revelation 7:9-17)

Check here each week to keep up with the latest from John MacArthur's pulpit at Grace Community Church.




global

Global Warming in Round Numbers— Toward a Zero-Carbon Economy

Global Warming in Round Numbers— Toward a Zero-Carbon Economy Global Warming in Round Numbers— Toward a Zero-Carbon Economy
Anonymous (not verified) Thu, 03/07/2019 - 12:19

East-West Wire

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News, Commentary, and Analysis
East-West Wire

The East-West Wire is a news, commentary, and analysis service provided by the East-West Center in Honolulu. Any part or all of the Wire content may be used by media with attribution to the East-West Center or the person quoted. To receive East-West Center Wire media releases via email, subscribe here.

For links to all East-West Center media programs, fellowships and services, see www.eastwestcenter.org/journalists.

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East-West Wire

Tagline
News, Commentary, and Analysis
East-West Wire

The East-West Wire is a news, commentary, and analysis service provided by the East-West Center in Honolulu. Any part or all of the Wire content may be used by media with attribution to the East-West Center or the person quoted. To receive East-West Center Wire media releases via email, subscribe here.

For links to all East-West Center media programs, fellowships and services, see www.eastwestcenter.org/journalists.

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global

The Global Battle Against Illicit Fishing

The Global Battle Against Illicit Fishing The Global Battle Against Illicit Fishing
venkatp Mon, 10/18/2021 - 15:16

East-West Wire

Tagline
News, Commentary, and Analysis
East-West Wire

The East-West Wire is a news, commentary, and analysis service provided by the East-West Center in Honolulu. Any part or all of the Wire content may be used by media with attribution to the East-West Center or the person quoted. To receive East-West Center Wire media releases via email, subscribe here.

For links to all East-West Center media programs, fellowships and services, see www.eastwestcenter.org/journalists.

Explore

East-West Wire

Tagline
News, Commentary, and Analysis
East-West Wire

The East-West Wire is a news, commentary, and analysis service provided by the East-West Center in Honolulu. Any part or all of the Wire content may be used by media with attribution to the East-West Center or the person quoted. To receive East-West Center Wire media releases via email, subscribe here.

For links to all East-West Center media programs, fellowships and services, see www.eastwestcenter.org/journalists.

Explore




global

Implications of Trump’s election on SA and global trade




global

Earthshot Prize 2024: Celebrating young innovators driving global environmental solutions in Cape Town




global

RECAP: Hong Kong solidifies global ties, strategic role in 9th Belt and Road Summit

The recent summit underscored Hong Kong's position as a "super-connector" and "super value adder," solidifying its status as a premier regional business hub and a vital link to the global market, that could support the eight major steps announced by President Xi Jinping last year to enhance the high-quality development of the Belt and Road Initiative (BRI).





global

Unkept promise: Fossil fuel financing persists despite global pledge for energy transition

The promised global shift from fossil fuels remains unmet as fossil fuel continues to expand in Southeast Asia with the backing of international financiers, environmental groups said.




global

Soweto Fashion Week Showcased Global Talent with Stellar Line-Up of International and Local Designers




global

Philippines joining global road safety meet in Morocco

President Marcos has announced that the Philippines will participate in the 4th Global Ministerial Conference on Road Safety to be held in Morocco in February next year.




global

Global Divestment Day: Shifting Investments to Clean Energy

The divestment movement aims to combat climate change by stripping investments from fossil fuels and redirecting them toward renewable energy.




global

Global Refugee Crisis Deepens by the Day

We are currently seeing the worst refugee crisis since World War II, and developed countries are not doing nearly enough to help those in need.




global

Conflict, violence push global internal displacement to record high levels

GENEVA — Conflicts and violence have pushed the number of internally displaced people around the world to a record-breaking high of 75.9 million, with nearly half living in sub-Saharan Africa, according to a new report by the Internal Displacement Monitoring Center. The report finds conflicts in Sudan, the Democratic Republic of Congo and Palestinian territories accounted for nearly two-thirds of new displacements due to violence, which in total spanned 66 countries in 2023. “Over the past two years, we have seen alarming new levels of people having to flee their homes due to conflict and violence, even in regions where the trend had been improving,” Alexandra Bilak, IDMC director said. In a statement to coincide with the publication of the report Tuesday, she said that the millions of people forced to flee in 2023 were just “the tip of the iceberg.” “Conflict, and the devastation it leaves behind, is keeping millions from rebuilding their lives, often for years on end,” she said. WATCH: Wars in Sudan, Gaza, DRC drive internally displaced to record 76 million The report notes the number of internal displacements, that is the number of times people have been forced to move throughout the year to escape conflict within their country, has increased in the last couple of years. “While we hear a lot about refugees or asylum-seekers who cross the border, the majority of the displaced people actually stay within their country and they are internally displaced,” Christelle Cazabat, head of programs at IDMC, told journalists in Geneva Monday, in advance of the launch of the report. In its 2023 report on forcibly displaced populations, the U.N. refugee agency, UNHCR, reported that 62.5 million people had been internally displaced people at the end of 2022 compared to 36.4 million refugees who had fled conflict, violence and persecution that same year. According to the IDMC, new internal displacements last year were mostly due to the conflict in Ukraine, which started in 2022, as well as to the ongoing conflict in the Democratic Republic of the Congo and the eruption of war in mid-April 2023 in Sudan. The war in Sudan resulted in 6 million internal displacements last year, which was “more than its previous 14 years combined” and the second most ever recorded in one country during a single year after Ukraine’s 16.9 million in 2022, according to the report. “As you know, it is more than a year that this new wave of conflict erupted (in Sudan) and as of the end of last year, the figure was 9.1 million” displaced in total by the conflict, said Vicente Anzellini, IDMCs global and regional analysis manager and lead author of the report. “This figure is the highest that we have ever reported for any country, this 9.1 million internally displaced people.” In the Gaza Strip, IDMC calculated 3.4 million displacements in the last three months of 2023, many of whom had been displaced multiple times during this period. It says this number represented 17% of total conflict displacements worldwide during the year, noting that a total of 1.7 million Palestinians were internally displaced in Gaza by the end of the year. The last quarter of 2023 is the period following the Hamas terrorists’ brutal attack on Israel on Oct. 7, eliciting a military response from Israel on the Palestinian enclave. “There are many other crises that are actually displacing even more people, but we hear a little bit less of them,” said Cazabat, noting that little is heard about the “acute humanitarian crisis in Sudan” though it has the highest number of people “living in internal displacement because of the conflict at the end of last year.” In the past five years, the report finds the number of people living in internal displacement because of conflict and violence has increased by 22.6 million. Sudan topped last year’s list of 66 countries with 9.1 million people displaced internally because of conflict, followed by Syria with more than 7 million, the DRC, Colombia and Yemen. Besides the total of 68.3 million people who were displaced globally by conflict and violence in 2023, the report says 7.7 million were displaced by natural disasters, including floods, storms, earthquakes and wildfires. As in previous years, the report notes that floods and storms caused the most disaster displacement, including in southeastern Africa, where cyclone Freddy triggered 1.4 million movements across six countries and territories. The earthquakes that struck Turkey and Syria triggered 4.7 million displacements, one of the largest disaster displacement events since records began in 2008. Anzellini observed many countries that have experienced conflict displacement also have experienced disaster displacement. “In many situations, they are overlapping. This is the case in Sudan, in South Sudan, but also in Somalia, in the DRC, and other places,” he said. “So, you can imagine fleeing from violence to save your life and then having to escape to higher ground with whatever you can carry as the storm or a flood threatens to wash away your temporary shelter.” He said that no country is immune to disaster displacement. “Last year, we recorded disaster displacements in 148 countries and territories, and these include high-income countries such as Canada and New Zealand, which recorded their highest figures ever. “Climate change is making extreme weather events more frequent and more intense and that can lead to more displacement, but it does not have to,” he said, noting that climate change is one of many factors that contribute to displacement. “There are other economic, social and political factors that governments can address to actually minimize the impacts of displacement even in the face of climate change,” he said, including early warning systems and the evacuation of populations before a natural disaster is forecast to strike.




global

Uncertainty is the winner and incumbents the losers so far in a year of high-stakes global elections

LONDON — Discontented, economically squeezed voters have turned against sitting governments on both right and left during many of the dozens of elections held this year, as global power blocs shift and political certainties crumble. From India to South Africa to Britain, voters dealt blows to long-governing parties. Elections to the European Parliament showed growing support for the continent's far right, while France's centrist president scrambled to fend off a similar surge at home. If there’s a global trend, Eurasia Group president Ian Bremmer said at a summit in Canada in June, it’s that “people are tired of the incumbents.” More than 40 countries have held elections already this year. More uncertainty awaits — nations home to over half the world’s population are going to the polls in 2024. The world is already anxiously turning to November’s presidential election in the U.S., where an acrimonious campaign was dealt a shocking blow by an assassination attempt against Republican nominee and former president, Donald Trump. Unpopular incumbents Aftershocks from the COVID-19 pandemic, conflicts in Africa, Europe and the Middle East, and spiking prices for food and fuel have left dissatisfied voters eager for change. “Voters really, really don’t like inflation,” said Rob Ford, professor of political science at the University of Manchester. “And they punish governments that deliver it, whether they are at fault or not.” Inflation and unemployment are rising in India, the world’s largest democracy, where Prime Minister Narendra Modi’s Hindu nationalist Bharatiya Janata Party unexpectedly lost its parliamentary majority after a decade of dominance. Modi was forced to rely on coalition partners to govern as the opposition doubled its strength in parliament. In South Africa, sky-high rates of unemployment and inequality helped drive a dramatic loss of support for the African National Congress, which had governed ever since the end of the apartheid system of white minority rule in 1994. The party once led by Nelson Mandela lost its parliamentary majority for the first time and was forced to enter a coalition with opposition parties. In Britain, the center-left Labour Party won election in a landslide, ousting the Conservatives after 14 years. As in so many countries, Prime Minister Keir Starmer faces a jaded electorate that wants lower prices and better public services — but is deeply skeptical of politicians’ ability to deliver change. US-China tensions Caught between world powers China and the United States, Taiwan held one of the year's most significant elections. Lai Ching-te, of the Democratic Progressive Party, won a presidential election that was seen as a referendum on the island’s relationship with China, which claims Taiwan as its own. Beijing regards Lai as a separatist and ramped up military pressure with drills in the Taiwan Strait. Lai has promised to strengthen the defenses of the self-governing island, and the U.S. has pledged to help it defend itself, heightening tensions in one of the world’s flashpoints. In Bangladesh, an important partner of the U.S. that has drawn closer to China, Prime Minister Sheikh Hasina won a fourth successive term in an election that opposition parties boycotted. The U.S. and U.K. said the vote was not credible, free or fair. Political dynasties In several countries, family ties helped secure or cement power. Pakistan held messy parliamentary elections – under the eye of the country’s powerful military — that saw well-established political figures vie to become prime minister. The winner, atop a coalition government, was Prime Minister Shehbaz Sharif, younger brother of three-time premier Nawaz Sharif. Opponents say the election was rigged in his favor, with opponent and former prime minister, Imran Khan, imprisoned and blocked from running. The situation remains unstable, with Pakistan’s Supreme Court ruling that Khan’s party was improperly denied some seats. In Indonesia, Southeast Asia’s largest democracy, former Defense Minister Prabowo Subianto was officially declared president more than two months after an election in which he won over 58% of the vote. His two losing rivals alleged fraud and nepotism — Subianto’s vice president-elect is outgoing leader Joko Widodo’s son, and Subianto was the son-in-law of Indonesia’s late dictator, Suharto. The country’s highest court rejected their arguments. Some outcomes were predictable. Russian President Vladimir Putin was reelected to a fifth term in a preordained election that followed his relentless crackdown on dissent. Rwanda's election extended the 30-year rule of President Paul Kagame, an authoritarian leader who ran almost unopposed. Far right's uneven march The far right has gained ground in Europe as the continent experiences economic instability and an influx of migrants from troubled lands. Elections for the parliament of the 27-nation European Union shifted the bloc’s center of gravity, with the far right rocking ruling parties in France and Germany, the EU’s traditional driving forces. The EU election triggered a political earthquake in France. After his centrist, pro-business party took a pasting, President Emmanuel Macron called a risky snap parliamentary election in hope of stemming a far-right surge. The anti-immigration National Rally party won the first round, but alliances and tactical voting by the center and left knocked it down to third place in the second round and left a divided legislature. New faces, daunting challenges A presidential election tested Senegal's reputation as a stable democracy in West Africa, a region rocked by a recent spate of coups. The surprise winner was little-known opposition figure Basirou Diomaye Faye, released from prison before polling day as part of a political amnesty. Faye is Africa’s youngest elected leader, and his rise reflects widespread frustration among Senegal’s youth with the country’s direction. Senegal has made new oil and gas discoveries in recent years, but the population has yet to see any real benefit. Mexico elected Claudia Sheinbaum as the first female president in the country’s 200-year history. A protege of outgoing President Andrés Manuel López Obrador, the 61-year-old former Mexico City mayor vowed to continue in the direction set by the popular leftist leader. She faces a polarized electorate, daunting drug-related violence, an increasingly influential military and tensions over migration with the U.S. Uncertainty is the new normal On July 28, Venezuelan President Nicolás Maduro will seek to extend a decade-plus presidency marked by a complex political, social and economic crisis that has driven millions into poverty or out of the country. Opposition parties have banded together, but the ruling party has tight control over the voting process, and many doubt votes will be counted fairly. South Sudan, the world’s youngest country, is scheduled to hold its long-delayed first elections in December. That would represent a key milestone, but the vote is rife with danger and vulnerable to failure. Looming above all is the choice U.S. voters will make Nov. 5 in a tense and divided country. The July 13 shooting at a Trump rally in Pennsylvania, in which the former president was wounded and a rallygoer was killed, came as Democrats agonize over the fitness of President Joe Biden, who has resisted calls to step aside. The prospect of a second term for Trump, a protectionist wary of international entanglements, is evidence of the world’s shifting power blocs and crumbling political certainties. "The world is in the transition," said Neil Melvin, director of international security at defense think tank the Royal United Services Institute. “There are very broad processes on the way which are reshaping international order," he added. "It’s a kind of anti-globalization. It’s a growing return to the nation state and against multilateralism.”




global

Global index for free and fair elections suffers biggest decline on record in 2023, democracy watchdog says

STOCKHOLM — Lower voter turnout and increasingly contested results globally are threatening the credibility of elections, an intergovernmental watchdog warned on Tuesday, as its sub-index for free and fair elections suffered its biggest decline on record in 2023. In its report, the Stockholm-based International Institute for Democracy and Electoral Assistance (IDEA) said 2023 was the eighth consecutive year with a net decline in overall democratic performance, the longest consecutive fall since records began in 1975. The watchdog bases its Global State of Democracy indexes on more than 100 variables and is using four main categories - representation, rights, rule of law and participation - to categorize performance. The category of democracy related to free and fair elections and parliamentary oversight, a sub-category of representation, suffered its worst year on record in 2023. "This report is a call for action to protect democratic elections," IDEA's Secretary-General Kevin Casas-Zamora said in the report. "The success of democracy depends on many things, but it becomes utterly impossible if elections fail." The think-tank said government intimidation and electoral process irregularities, such as fraudulent voter registration and vote-counting, were increasing. It also said that threats of foreign interference, disinformation and the use of artificial intelligence in campaigns added to challenges. It also said that global voter participation had fallen to 55.5% of eligible voters in 2023 from 65.2% in 2008. Globally, in almost 20% of elections between 2020 and 2024, one of the losing candidates or parties rejected the results. IDEA said that the democratic performance in the U.S., which holds a presidential election this year, had recovered somewhat in the past two years, but the assassination attempt on former President Donald Trump in July highlighted continued risks. "Less than half (47%) of the Americans said the 2020 election was 'free and fair' and the country remains deeply polarized," IDEA said.




global

Nelson Mandela: The Global Icon Goes Home

Mandela's work to end apartheid in South Africa and fight for peace and equality throughout the world has left an indelible imprint on the global community.




global

Ebola: A Global Wake-Up Call

The Ebola outbreak in West Africa is challenging the health systems of some very poor countries, and a proper response requires global cooperation.




global

Global CO2 emissions to hit record high in 2024, report says


The bulk of these emissions are from burning coal, oil and gas. Those emissions would total 37.4 billion tons in 2024, up by 0.8% in 2023, the report said.




global

Africa: African Nations Demand Huge Climate Aid Boost Amid Global Distrust

[RFI] African nations are pushing for a dramatic increase in climate financing at the UN's Cop29 summit that opened in Azerbaijan on Monday - calling for $1.3 trillion (€1.22 trillion) annually to help the continent transition to renewable energy, adapt to climate impacts and address damage from climate-related disasters.




global

Taiwan's Participation in the WHO Annual Assembly Is Vital to Ensuring Global Health Security

Taiwan accepts World Health Organization invitation despite political caveat from China




global

Taiwan Seeks to Join Fight Against Global Warming

The Paris Agreement on climate change, was signed in New York on April 22 by world leaders of 175 countries at the largest, single-day signing ceremony in history. What once seemed unthinkable, is now unstoppable. Every nation has been encouraged to join the chorus of voices combating climate change. So why has Taiwan, who is ready and willing, with vast experience to share, been left on the sidelines?




global

The Impact of Global Megatrends on Poverty in Asia & the Pacific

In the coming decades, the Asia-Pacific region faces a series of challenges that threaten to exacerbate poverty. Among these, climate change, demographic shifts, particularly population ageing and the rise of digital technologies stand out as three interconnected global megatrends. A recent technical paper supporting the Social Outlook for Asia and the Pacific 2024 explores various […]



  • Asia-Pacific
  • Development & Aid
  • Economy & Trade
  • Featured
  • Headlines
  • IPS UN: Inside the Glasshouse
  • Sustainable Development Goals
  • TerraViva United Nations
  • IPS UN Bureau


global

Lead for Learning: Decisive Leadership Urgently Needed To Improve Education Globally

Global education is facing a critical moment amid severe setbacks. Millions of children are out of school, learning levels are falling, and millions are leaving school without the skills they need. New out-of-school figures reveal that global progress in reducing the number of out-of-school children has been just 1 percent since 2015, leaving 251 million […]




global

Brazil Promotes a Freer Global Biofuels Market

Holding this year’s presidency of the Group of 20 (G20) large industrial and emerging economies is allowing Brazil to push forward the dream of creating a global biofuels market without the current trade barriers. Brazil is trying, at least since the beginning of this century, to free up global trade in ethanol, but so far […]




global

Overlapping Crises Hinder Global Social Development and Poverty Reduction

Social development in a global context shows the risk of trending downwards and not recovering if countries do not minimize the long-term impacts of multiple crises and work towards building up their resilience. As much as this will require national political will, it will also need global cooperation for it to be possible. The United […]




global

MEC LEBOGANG MAILE DELIVERS KEYNOTE ADDRESS AT THE BOLT SOUTH AFRICA GLOBAL SAFETY CAMPAIGN LAUNCH

On the 7th of November 2024, the Gauteng MEC for Finance and Economic Development, Lebogang Maile, delivered a keynote address at Bolt South Africa's Global Safety Campaign launch in Johannesburg. The campaign is aimed at improving safety in the e-hailing industry




global

Without Supercharging Adaptation Funding Global Temperatures Could Surge

The Head of Impact Assessment and Adaptation, Henry Neufeldt, UN Environment Programme Copenhagen Climate Centre, has called for increased climate adaptation funding, particularly for developing nations facing significant climate risks. UNEP’s latest report reveals an acute adaptation finance gap, with current international funding for developing countries at USD 30 billion—far below the USD 200 to 400 […]




global

Cryosphere Crisis: Scientists Warn of Devastating Global Impacts Without Urgent Climate Action

Scientists warn of vastly higher impacts on billions of people’s livelihood and cost to the global economy by the accelerating losses in the world’s snow and ice regions, aka the cryosphere. Over 50 leading cryosphere scientists released an annual report on the status of the world’s ice stores on Tuesday (November 12) at the UN […]




global

Countdown Begins in Defining Twelve Days to Historic Global Climate Deal

The 29th session of the Conference of the Parties on climate change has officially kicked off in Baku, Azerbaijan, with the promise of striking yet another historic global climate deal and finance adaptation, gender responsive action and financing, and forgotten issues such as food waste are top on the agenda as every action is as […]




global

Asian Impact Webinar: Global Spillovers from Data-Dependent US Monetary Policy

The Federal Reserve’s monetary policy has become increasingly data-dependent, with inflation and employment figures driving the nascent easing cycle. What does this mean for Asia’s financial markets?




global

Asia-Pacific Trade Facilitation Report 2024: Promoting Sustainability and Resilience of Global Value Chains

This report examines the progress of trade facilitation in Asia and the Pacific, highlights recent trends in paperless trade, and evaluates the impact of trade facilitation initiatives on trade costs and overall trade.




global

Launching a huge dust cloud from the moon could ease global warming

Launching a million tonnes of moon dust around Earth could dim sunlight across our planet by 1.8 per cent. This would reduce the global temperature, but whether it would be worth the resources, and the risks involved in such a strategy, are unclear




global

Global characterization of somatic mutations and DNA methylation changes during vegetative propagation in strawberries [RESEARCH]

Somatic mutations arise and accumulate during tissue culture and vegetative propagation, potentially affecting various traits in horticultural crops, but their characteristics are still unclear. Here, somatic mutations in regenerated woodland strawberry derived from tissue culture of shoot tips under different conditions and 12 cultivated strawberry individuals are analyzed by whole genome sequencing. The mutation frequency of single nucleotide variants is significantly increased with increased hormone levels or prolonged culture time in the range of 3.3 x 10–8–3.0 x 10–6 mutations per site. CG methylation shows a stable reduction (0.71%–8.03%) in regenerated plants, and hypoCG-DMRs are more heritable after sexual reproduction. A high-quality haplotype-resolved genome is assembled for the strawberry cultivar "Beni hoppe." The 12 "Beni hoppe" individuals randomly selected from different locations show 4731–6005 mutations relative to the reference genome, and the mutation frequency varies among the subgenomes. Our study has systematically characterized the genetic and epigenetic variants in regenerated woodland strawberry plants and different individuals of the same strawberry cultivar, providing an accurate assessment of somatic mutations at the genomic scale and nucleotide resolution in plants.




global

Differential Tissue Abundance of Membrane-Bound Drug Metabolizing Enzymes and Transporter Proteins by Global Proteomics [Special Section on New and Emerging Areas and Technologies in Drug Metabolism and Disposition, Part II]

Protein abundance data of drug-metabolizing enzymes and transporters (DMETs) are useful for scaling in vitro and animal data to humans for accurate prediction and interpretation of drug clearance and toxicity. Targeted DMET proteomics that relies on synthetic stable isotope-labeled surrogate peptides as calibrators is routinely used for the quantification of selected proteins; however, the technique is limited to the quantification of a small number of proteins. Although the global proteomics-based total protein approach (TPA) is emerging as a better alternative for large-scale protein quantification, the conventional TPA does not consider differential sequence coverage by identifying unique peptides across proteins. Here, we optimized the TPA approach by correcting protein abundance data by the sequence coverage, which was applied to quantify 54 DMETs for characterization of 1) differential tissue DMET abundance in the human liver, kidney, and intestine, and 2) interindividual variability of DMET proteins in individual intestinal samples (n = 13). Uridine diphosphate-glucuronosyltransferase 2B7 (UGT2B7), microsomal glutathione S-transferases (MGST1, MGST2, and MGST3) carboxylesterase 2 (CES2), and multidrug resistance-associated protein 2 (MRP2) were expressed in all three tissues, whereas, as expected, four cytochrome P450s (CYP3A4, CYP3A5, CYP2C9, and CYP4F2), UGT1A1, UGT2B17, CES1, flavin-containing monooxygenase 5, MRP3, and P-glycoprotein were present in the liver and intestine. The top three DMET proteins in individual tissues were: CES1>CYP2E1>UGT2B7 (liver), CES2>UGT2B17>CYP3A4 (intestine), and MGST1>UGT1A6>MGST2 (kidney). CYP3A4, CYP3A5, UGT2B17, CES2, and MGST2 showed high interindividual variability in the intestine. These data are relevant for enhancing in vitro to in vivo extrapolation of drug absorption and disposition and can be used to enhance the accuracy of physiologically based pharmacokinetic prediction of systemic and tissue concentration of drugs.

SIGNIFICANCE STATEMENT

This study quantified the abundance and compositions of drug-metabolizing enzymes and transporters in pooled human liver, intestine, and kidney microsomes as well as individual intestinal microsomes using an optimized global proteomics approach. The data revealed large intertissue differences in the abundance of these proteins and high intestinal interindividual variability in the levels of cytochrome P450s (e.g., CYP3A4 and CYP3A5), uridine diphosphate-glucuronosyltransferase 2B17, carboxylesterase 2, and microsomal glutathione S-transferase 2. These data are applicable for the prediction of first-pass metabolism and tissue-specific drug clearance.




global

“Je suis desole, ȷe parle francais”: How English Hegemony Undermines Efforts to Shift Power in Global Health

Le texte complet de l’article est aussi disponible en français.




global

Global tech to transform over 3 weeks

THE world’s tech will undergo a transformation over just three weeks with a bonanza of new phones, tablets, smart watches and OLED 4K TVs.




global

The next limited-edition Steam Deck OLED comes in white, and will be available globally this time

The Steam Deck OLED – which is like a Steam Deck but better in almost every way – is getting a new, if potentially more smudge-susceptible Limited Edition. A successor to the translucent version that only went on sale in the US and Canada last year, the Steam Deck OLED: Limited Edition White offers both a snowy look and, for those of us outside North America, the chance to actually buy one. It’ll go on sale November 18th, in all the countries that the Steam Deck currently ships in.

Read more




global

Will mpox become a global pandemic like covid-19?

A new variant of mpox is surging in Central Africa, raising concerns about how quickly it could spread further afield




global

Unveiling Diversity: Nudity Across Borders in Global Cinema

Welcome, film enthusiasts, to a captivating exploration of the diverse world of nudity in global cinema! In an era where cultural nuances shape the way we perceive art, it’s fascinating to dissect how different societies approach the depiction of the human form on the silver screen. Among different diversities like age diversity, political diversity, and […]

The post Unveiling Diversity: Nudity Across Borders in Global Cinema appeared first on Chart Attack.




global

Drowning mangroves in Maldives signal global coastal risk

London, UK (SPX) Nov 13, 2024
Mangrove forests in the Maldives are facing a severe threat as they succumb to rising sea levels and climate changes, according to a new study led by Northumbria University researchers and published in *Scientific Reports*. The study highlights that the Maldives, known for its low-lying islands, experienced significant mangrove dieback since 2020 due to rapid sea-level rise and the effects




global

How the 2024 Election Could Change Access to Health Care in the U.S. and Influence Global Nuclear Policies

The outcome of the 2024 U.S. presidential election could reshape policies from health care at home to nuclear proliferation abroad




global

How the 2024 Election Could Change Access to Education in the U.S. and Influence Global Climate Change Decisions

The outcome of the 2024 U.S. presidential election could set the climate agenda, reshape public education and shift the dynamics of global science collaboration.




global

We Need Scientific Brainstorming about Shared Global Dangers

It is difficult to disentangle Russian and Chinese scientists from international science cooperation. That is a good thing




global

Registration for SAS Global Forum 2015 is now open

Act now for the best deal on SAS Global Forum 2016 registration. You already know that SAS Global Forum will pay for itself in learning opportunities.




global

Last Call for SAS Global Forum Papers

You have just a few more days to submit your paper proposal for the 2017 SAS® Global Forum in Orlando on April 2–5. The call for papers ends and registration begins October 3.




global

Global CO2 emissions to hit record high in 2024: Report

BAKU — Global carbon dioxide emissions, including those from burning fossil fuels, are set to hit a record high this year, pulling the world further off course from averting more destructive climate extremes, scientists said on Wednesday (Nov 13). The Global Carbon Budget report, published during the UN's COP29 climate summit in Azerbaijan, said global CO2 emissions are set to total 41.6 billion metric tons in 2024, up from 40.6 billion tons last year. The bulk of these emissions are from burning coal, oil and gas. Those emissions would total 37.4 billion tons in 2024, up by 0.8 per cent in 2023, the report said. The rest are from land use, a category that includes deforestation and forest fires. The report by more than 80 institutions was led by the University of Exeter in UK. "We don't see a sign of fossil fuel emissions peaking in 2024," said lead author Pierre Friedlingstein, a climate scientist at the University of Exeter. Without immediate and steep emissions cuts worldwide, "we will just go straight into the 1.5C target, we'll just pass it and continue," he said.