Carmel and IU grad Sage Steele will co-host and star athletes like Drew Brees and Venus Williams will announce winners during the online broadcast.

Former South Bend, Indiana, mayor and former Democratic hopeful for president Pete Buttigieg responded to the shooting of Dreasjon Reed.

Former South Bend, Indiana, mayor and former Democratic hopeful for president Pete Buttigieg responded to the shooting of Dreasjon Reed.

Carmel and IU grad Sage Steele will co-host and star athletes like Drew Brees and Venus Williams will announce winners during the online broadcast.

Datatec tells shareholders that the rapidly spreading coronavirus outbreak has reached every region where the group operates.

Local news publishers have struggled to monetize spike in consumer interest.

Please visit Search Engine Land for the full article.

Acidosis is a key driver for many diseases, including cancer, sepsis, and stroke. The spatiotemporal dynamics of dysregulated pH across disease remains elusive and current diagnostic strategies do not provide localization of pH alterations. We sought to explore if PET imaging using hydrophobic cyclic peptides that partition into the cellular membrane at low extracellular pH (denoted as "pHLIC") can permit accurate in vivo visualization of acidosis. Methods: Acid-sensitive cyclic peptide c[E4W5C] pHLIC was conjugated to bifunctional maleimide-NO2A and radiolabeled with copper-64 (t1/2 = 12.7 h). C57BL/6J mice were administered LPS (15 mg/kg) or saline (vehicle) and serially imaged with [⁶⁴Cu]Cu-c[E4W5C] over 24 h. Ex vivo autoradiography was performed on resected brain slices and subsequently stained with cresyl violet to enable high-resolution spatial analysis of tracer accumulation. A non- pH-sensitive cell-penetrating control peptide (c[R4W5C]) was used to confirm specificity of [⁶⁴Cu]Cu-c[E4W5C]. CD11b (macrophage/microglia) and TMEM119 (microglia) immunostaining was performed to correlate extent of neuroinflammation with [⁶⁴Cu]Cu-c[E4W5C] PET signal. Results: [⁶⁴Cu]Cu-c[E4W5C] radiochemical yield and purity was >95% and >99% respectively, with molar activity >0.925 MBq/nmol. Significantly increased [⁶⁴Cu]Cu-c[E4W5C] uptake was observed in LPS-treated mice (vs. vehicle) within peripheral tissues including blood, lungs, liver, and small intestines (P < 0.001-0.05). Additionally, there was significantly increased [⁶⁴Cu]Cu-c[E4W5C] uptake in the brains of LPS-treated animals. Autoradiography confirmed increased uptake in the cerebellum, cortex, hippocampus, striatum, and hypothalamus of LPS-treated mice (vs. vehicle). Immunohistochemical (IHC) analysis revealed microglial/macrophage infiltrate, suggesting activation in brain regions containing increased tracer uptake. [⁶⁴Cu]Cu-c[R4W5C] demonstrated significantly reduced uptake in the brain and periphery of LPS mice compared to the acid-mediated [⁶⁴Cu]Cu-c[E4W5C] tracer. Conclusion: Here, we demonstrate that a pH-sensitive PET tracer specifically detects acidosis in regions associated with sepsis-driven pro-inflammatory responses. This study suggests that [⁶⁴Cu]Cu-pHLIC is a valuable tool to noninvasively assess acidosis associated with both central and peripheral innate immune activation.

23 February 2017

Although most renewable energy policy frameworks treat biomass as carbon-neutral at the point of combustion, biomass emits more carbon per unit of energy than most fossil fuels. 

As the NHS strains under pressure from rising patient activity, an ageing population, and financial constraints, The BMJ hosted a discussion on how clinicians should be helping to manage demand at last week’s Nuffield Trust health policy summit. Taking part are: - Eileen Burns, president of the British Geriatrics Society - Andrew Fernando, GP...

BRIDGETOWN, Barbados, CMC – The Barbados-based the Caribbean Disaster Emergency Management Agency (CDEMA) says its executive director, Ronald Jackson, is leaving the post after seven years “of unwavering and exemplary service to the...

THE EDITOR, Madam: On Wednesday at 8:30 a.m., while watching TVJ, I saw Get Moving home workout series. Very good, TVJ and the Ministry of Health, for bringing this workout programme into our homes. Minister Tufton was a participant; he truly...

From online petitions to organized walkouts, corporate America is facing increasing employee activism over its business involvement with agencies implementing the federal government's immigration policies. This "cubicle activism," seen at companies ranging from Amazon and Google to Bank of America and Wayfair, has garnered mixed success to date, forcing divestiture from private prison contractors but fewer results in other contexts, as this article explores.

India is the world's largest source for immigrant physicians, and for Indian-trained doctors and nurses the allure of working abroad is strong despite an acute domestic shortage of health-care workers. Against this pull, the Indian government has enacted a number of policies to limit and regulate the emigration of health-care professionals, though these have been more ad hoc in nature and not part of a fully realized strategy.

Darmstadt : C.W. Leske, 1850.

Londres : Paris, 1866.

Districts are reconfiguring services, offering hazard pay, and partnering with food banks to keep up with a growing, unprecedented demand for food services during the school shutdown.

Wei-Kuo Chen.

Source: The Annals of Statistics, Volume 47, Number 5, 2734--2756.

Abstract:
We consider the problem of detecting a deformation from a symmetric Gaussian random $p$-tensor $(pgeq3)$ with a rank-one spike sampled from the Rademacher prior. Recently, in Lesieur et al. (Barbier, Krzakala, Macris, Miolane and Zdeborová (2017)), it was proved that there exists a critical threshold $eta_{p}$ so that when the signal-to-noise ratio exceeds $eta_{p}$, one can distinguish the spiked and unspiked tensors and weakly recover the prior via the minimal mean-square-error method. On the other side, Perry, Wein and Bandeira (Perry, Wein and Bandeira (2017)) proved that there exists a $eta_{p}'<eta_{p}$ such that any statistical hypothesis test cannot distinguish these two tensors, in the sense that their total variation distance asymptotically vanishes, when the signa-to-noise ratio is less than $eta_{p}'$. In this work, we show that $eta_{p}$ is indeed the critical threshold that strictly separates the distinguishability and indistinguishability between the two tensors under the total variation distance. Our approach is based on a subtle analysis of the high temperature behavior of the pure $p$-spin model with Ising spin, arising initially from the field of spin glasses. In particular, we identify the signal-to-noise criticality $eta_{p}$ as the critical temperature, distinguishing the high and low temperature behavior, of the Ising pure $p$-spin mean-field spin glass model.

45 Chinese nationals in Nepal demand flights to go home, throw stones  Hindustan TimesView Full coverage on Google News

The COVID-19 pandemic has meant a spike in demand for puppies and an opportunity for scammers who are charging inflated prices for dogs not ready to be adopted out or with missing or bogus papers.

Villagers placed the bodies of three victims of a deadly gas leak from an LG Polymers plant in southern India at the gates of the site on Saturday and demanded the factory be shut down immediately and its top management arrested.

The World Agricultural Supply and Demand Estimates (WASDE) report is prepared monthly and includes forecasts for U.S. and world wheat, rice, and coarse grains (corn, barley, sorghum, and oats), oilseeds (soybeans, rapeseed, palm), and cotton. U.S. coverage is extended to sugar, meat, poultry, eggs, and milk. USDA World Agricultural Outlook Board analysts chair the Interagency Commodity Estimates Committees (ICECs) comprising representatives from several key USDA agencies. The nine ICECs- one for each commodity- compile and interpret information from USDA and other domestic and foreign official sources to produce the report.

The ICECs rely on Foreign Agricultural Service (FAS) attaché reports and analysis of foreign commodity developments, Economic Research Service (ERS) domestic and foreign regional assessments, and National Agricultural Statistics Service (NASS) U.S. crop and livestock estimates. For domestic policy and market information, the Board relies on the Farm Services Agency and the Agricultural Marketing Service. WAOB and FAS use weather analysis and satellite imagery to monitor crop conditions. Additional private and public information sources are considered.

This broad information base is reviewed and analyzed by ICEC members who bring diverse expertise and perspectives to the report. To arrive at consensus forecasts, alternative assessments of domestic and foreign supply and use are vetted at the ICEC meetings. Throughout the growing season and afterwards, estimates are compared with new information on production and utilization, and historical revisions are made as necessary.

The WASDE reports a full balance sheet for each commodity. Separate estimates are made for components of supply (beginning stocks, imports, and production) and demand (domestic use, exports, and ending stocks). Domestic use is subdivided into major categories, for example corn for feed and corn for ethanol. Domestic use may be based on data from other Federal agencies: for example, U.S. wheat ground for flour, soybeans crushed for oil, and cotton mill use come from the Bureau of the Census. The demand side of the balance sheet may include a category for residual or unaccounted disappearance to balance known uses against total supplies.

The WASDE also reports forecast season-average farm prices for most items. Prices tie together both sides of the balance sheet. Market prices aid in rationing available supplies among competing uses. Prices also indicate potential supply responses, for example potential planting decisions for the upcoming year. The process of forecasting price and balance sheet items is complex and involves the interaction of expert judgment, commodity models, and in-depth research by USDA analysts on key domestic and international issues.

While schools are closed to coronavirus, districts are putting together a patchwork of lessons for students to do at home. But districts’ expectations for what students can accomplish at home vary widely, according to parents.

While schools are closed to coronavirus, districts are putting together a patchwork of lessons for students to do at home. But districts’ expectations for what students can accomplish at home vary widely, according to parents.

Cerebral edema (CE) occurs frequently during treatment of diabetic ketoacidosis (DKA) in children. Severe, life-threatening CE occurs rarely, but subclinical CE is common. Whether the rate of infusion of intravenous fluids influences the occurrence or severity of CE is unknown.

This study demonstrates that the rate of fluid infusion in children with DKA does not substantially affect MRI measures of CE. Studies assessing measures other than edema formation are necessary to determine whether fluid infusion rates influence DKA-related brain injury. (Read the full article)

Delayed anaphylaxis, urticaria, and angioedema to mammalian meat products were first described in the adult population in 2009. Patients with this syndrome who consume mammalian meat typically develop symptoms 4 to 6 hours after ingestion.

Specific diagnoses for children who develop urticaria, angioedema, and idiopathic anaphylaxis are few and far between. We have now shown delayed anaphylaxis, urticaria, and angioedema due to mammalian meat products in the pediatric population. (Read the full article)

Patients with hereditary angioedema (HAE) have recurrent episodes of painful swelling. Several new therapies to prevent and treat HAE attacks are approved by the Food and Drug Administration, but their safety and efficacy in children are largely unknown.

Ecallantide appears effective for treatment of HAE attacks in pediatric patients age 10 to 17 years with an acceptable safety profile. It represents a potential treatment option for adolescents with HAE. (Read the full article)

Digital curricula repositories are helping to fill the growing need for more and better multimedia content.

The future choices made by airlines matter a great deal for the oil market, say Liam Denning and Brooke Sutherland.

Siena Salvaggio, who will graduate Saturday with a 4.0 GPA in finance and a minor in economics, has been named Smeal’s spring 2020 finance student marshal.

Seven universities are making major changes to how they train future principals, as part of $48.5 million Wallace Foundation initiative to redesign university-based principal-preparation programs, according to a new report from RAND.

There are so many surprise rankings on this year's p:e table, you're bound to go back into old Sens announcements.

India's fuel demand dipped 45.8% in April from a year earlier, as a nationwide lockdown and travel curbs to combat the spread of novel coronavirus eroded economic activity. Consumption of fuel, a...

Agency: GSS Closing Date: 6/4/2020

There is a high Demand in Australia for all categories of skilled workers, as per a recent report of Deloitte. It says that many jobs are unfilled and also that the employers cannot find workers possessing the required skills. Vacancy rates are…

DOVER, Del. – Governor John Carney on Wednesday issued the following statement on the Senate’s vote to confirm the Governor’s nomination of Claire DeMatteis to serve as the next Commissioner of the Delaware Department of Correction: “Thank you to the members of the Delaware Senate for confirming Claire DeMatteis as Commissioner of the Department of […]

During FY12-17, a cumulative generation capacity of 99,209 MW was added against a target of 88,537 MW, outpacing the growth in demand and resulting in a declining trend of PLFs.

A chemical plant where a gas leak killed 11 and left 1,000 sick in Andhra Pradesh's Visakhapatnam may face investigation on whether its safety protocols were in place and whether it followed all...

As Kia gears up to launch its third model for India, we have discovered a small roadblock for the automaker from Korea. The upcoming sub-compact SUV slated to be called the Sonet may need a new name before it is launched.

In April, the NR consumption forecast for 2020 to 13.016 million tonne which is down 5.1% from the previous year.

Cognizant follows January-December as financial year. Its net profit was at USD 441 million in the March 2019 quarter.

The DoT sent a notice to GAIL soon after the February 14 hearing in the Supreme Court on dues owned by telecom companies such as Bharti Airtel and Vodafone Idea.

There would also be a significant rise in disease-specific health plans as these are only for widespread infections as against normal hospitalisation in order to keep the cost of treatment low.

The President of One America News Network, Charles Herring, has published a blistering letter calling on Vanity Fair to retract claims that Donald Trump’s eldest son secretly bought a stake in the news outlet.
Read Full Article at RT.com

As with the majority of Canadians, Mikayla Demaiter was in love with ice hockey and dreamed of achieving great things in a sport that is almost sacred in her homeland.
Read Full Article at RT.com

Oil demand could rebound enough to exceed supply by the end of this month, Goldman’s head of commodities Jeffrey Currie told Barron’s Market Brief.
Read Full Article at RT.com