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Disruption of lipid metabolism to induce ferroptosis using multifunctional fibrate-Pt(IV) prodrugs for cancer treatment

Inorg. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QI00386A, Research Article
Peng Sun, Jia-Qian Wang, Qiang Xie, Xuan-Lin Ren, Xin Qiao, Jing-Yuan Xu
Two multifunctional fibrate-Pt(IV) prodrugs, 1 and 3, bearing lipid-modulating agents, exhibited impressive anticancer activity by triggering ferroptosis and apoptosis.
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Insights into the modulation mechanisms of multiple active sites in a conjugated small molecule towards organic cathode capacity from first-principles

Inorg. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QI00547C, Research Article
Zhaopeng Sun, Hao Tian, Meng Zhang, Yi Zhang, Zhiping Li, Weiwei Huang
The modulation mechanisms of Na+ within the redox-active sites of the two-dimensional conjugated organic small-molecule 3BQ, and their impact on the initial capacity of a 3BQ cathode for Na-ion batteries, were investigated using first-principles calculations.
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Trifluoroacetic acid molecules confined into/onto metal–organic frameworks using H2btzip for efficiently improving proton conductivity using a synergistic effect

Inorg. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QI00605D, Research Article
Xiaoxue Ma, Xin Li, Xueke Han, Lu Zhang, Ronghua Liu, Hongguo Hao, Hui Yan, Xin Zhao, Xiangjin Kong, Huawei Zhou, Xia Li, Hongjie Zhu, Suna Wang, Yunwu Li, Dichang Zhong, Fangna Dai
Two outstanding proton conducting materials have been obtained by loading TFA molecules onto/into the surface or pores of MOFs. After post-treatment, their proton conductivity values are greatly increased under the same conditions.
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Crude oil futures dip amid easing Middle East tensions

Brent and WTI oil futures saw declines of over 3%, with MCX crude oil futures also experiencing significant drops.




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Kandla Customs Commissioner orders release of ship detained in organic rice export irregularities

Tells Kandla traffic manager to allow another ship to set sail after getting release order from Gujarat HC




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Natural gas: Futures in bear grip

Traders can consider going short 




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Crude oil futures slip as industry data shows increase in US inventory 

US crude oil inventories rose by 1.64 million barrels for the week ended October 18. Market estimates had earlier pegged increase at 0.7 million barrels




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Crude oil futures dip after Israeli attack avoids Iranian oil facilities 

November natural gas futures were trading at ₹254.50 on MCX during the initial hour of trading on Monday against the previous close of ₹258.20, down by 1.43 per cent




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Reviewing TRIPS, an opportunity for evidence-based policies

Colombia calls for review of TRIPS Agreement implementation, highlighting need for evidence-based IP law and policy




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Why maternal nutrition is blue-chip investment

Guaranteed maternal nutrition can break the cycle of malnutrition passed from one generation to the next




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India’s H1 agriculture exports a tad lower at $12.13 billion on dip in cereal shipments

As per APEDA, the fall in non-basmati rice exports pulled down the overall cereal shipments by 8.35 per cent to $5.22 billion during April-September period from corresponding last year’s $5.69 billion




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India’s journey towards biofuel leadership

With continued government support, private sector investment, and public participation, India can become a global biofuel leader




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25% dip in urad output to drag down pulses production despite rise in area

Trade sees no impact on prices in near term due to imports




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Western Carriers seeks to haul more post IPO

Western Carriers targets more sectors, geographies for its value-added services




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Skye Air intensifies quick-commerce partnerships, targets expansion to six cities within two years

The firm focuses on delivering consignments within 10 minutes for quick-commerce clients and within four hours for e-commerce clients




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Shiprocket reports 21% operating revenue growth in FY24

The company also announced that it achieved profitability in the first two quarters of FY 2024, ending September, positioning it well ahead of its goal to reach full profitability by FY 2025




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Escorts Kubota to divest railway equipment business to Sona Comstar for ₹1,600 crore

The transaction, structured as a slump sale, is expected to close by September 30, 2025. 




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InterGlobe Aviation likely to slip into red on higher costs, weak rupee

Emkay Global Research estimates InterGlobe Aviation’s second quarter loss at ₹780 crore largely driven by foreign exchange loss




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InterGlobe Aviation slips into red

Posts ₹986 crore loss in Q2 on higher costs




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New terminal operating system and bunching of ships disrupt truck movements at Kattupalli and Ennore container terminals

While the issue with the of TOS has been addressedsorted out, the trailers are still facing delays in the scanning centre




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Great Eastern Shipping to sell 19-year-old product tanker 

Following the sale, G E Shipping’s fleet will consist of 41 vessels with a total deadweight tonnage of 3.31 million, including 28 tankers and 13 dry bulk carriers.




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Kandla Port plans new container terminal and multipurpose berth with ₹27,000 crore investment

Positioned strategically between Tuna Tekra and the entry point of Kandla, the proposed site could help vessels avoid an 11-kilometer trek through the creek, providing cost advantages




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India gears up to expand carbon-efficient coastal shipping services

Coastal Shipping Bill moots identifying newer routes for movement of additional cargo




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Pipavav Port’s Q2 net profit declines 18%

The company logged consolidated net profits of ₹92.3 crore in the year-ago period




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Wipro inks $700-million takeover deal with Metro AG




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Mutuality principle: Bowring Institute gets AAR reprieve on GST

But says waiver willend once Finance Act amendment is notified




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IPO: Sresta Natural Bioproducts files draft papers with SEBI

The IPO comprises a fresh issue of equity shares aggregating up to ₹50 crore and an offer sale of up to 70.3 lakh equity shares




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Cyclic peptides targeting the SARS-CoV-2 programmed ribosomal frameshifting RNA from a multiplexed phage display library

Chem. Sci., 2024, Advance Article
DOI: 10.1039/D4SC04026K, Edge Article
Open Access
Jacob A. Iannuzzelli, Rachel Bonn, Andrew S. Hong, Abhijith Saseendran Anitha, Jermaine L. Jenkins, Joseph E. Wedekind, Rudi Fasan
Cyclopeptide agents targeted against the −1 programmed ribosomal frameshifting stimulatory sequence RNA pseudoknot of SARS-CoV-2 were discovered by screening a multiplexed phage display library of genetically encoded peptide macrocycles.
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Analysis of the cryptic biosynthetic gene cluster encoding the RiPP curacozole reveals a phenylalanine-specific peptide hydroxylase

Chem. Sci., 2024, Advance Article
DOI: 10.1039/D4SC02262A, Edge Article
Open Access
Samantha Hollands, Julia Tasch, David J. Simon, Dimah Wassouf, Isobel Barber, Arne Gessner, Andreas Bechthold, David L. Zechel
The noncanonical biosynthesis of curacozole by Streptomyces curacoi is shown to be dependent on the bldA-encoded Leu-tRNAUUA. The minimal biosynthetic gene cluster is defined, and the functions of key biosynthetic enzymes are established in vitro.
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Dynamic satellite–parent liposome networks for quantitative microreactions

Chem. Sci., 2024, Advance Article
DOI: 10.1039/D4SC04925J, Edge Article
Open Access
Jia-Qi Tian, Nan-Nan Deng
A dynamic satellite–parent liposome network was developed to explore molecular transfer and quantitative microreactions through environmental stimuli, offering a platform to mimic multicellular systems in vitro.
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Bridge Editing of Spin-Flip Emitters gives Insight into Excited State Energies and Dynamics

Chem. Sci., 2024, Accepted Manuscript
DOI: 10.1039/D4SC05860G, Edge Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Florian Reichenauer, Robert Naumann, Christoph Förster, Winald Robert Robert Kitzmann, Antti-Pekka M. Reponen, Sascha Feldmann, Katja Heinze
Six-coordinate chromium(III) complexes with high spin-flip (SF) photoluminescence quantum yields and lifetimes (molecular rubies) have attracted huge interest in the past years due to their applicability in sensing, photocatalysis or...
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Diphosphaenones: Beyond the Phosphorus Analogue of Enones

Chem. Sci., 2024, Accepted Manuscript
DOI: 10.1039/D4SC06462C, Edge Article
Open Access
Jieli Lin, Shihua Liu, Shunlin Zheng, Hansjörg Grützmacher, Cheng-Yong Su, Zhongshu Li
Phosphaenones, like their carbon analogue enones (C=C–C=O), are promising building blocks for synthetic chemistry and materials science. However, in contrast to the α- and β-phosphaenones, structurally and spectroscopically well-defined diphosphaenones...
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Bipolar electrochemiluminescence at the water/organic interface

Chem. Sci., 2024, Advance Article
DOI: 10.1039/D4SC06103A, Edge Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Yuheng Fu, Bingbing Xie, Miaoxia Liu, Shaojuan Hou, Qunyan Zhu, Alexander Kuhn, Lin Zhang, Wensheng Yang, Neso Sojic
A novel bipolar electrochemistry approach for wireless dual-color ECL emission at the water/organic interface is developed. This system overcomes spatial limitations of conventional methods, enabling imaging of complex multiphase environments.
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Mechanism of action and evaluation of ratiometric probes for uric acid using lanthanide complexes with tetraazatriphenylene sensitisers

Chem. Sci., 2024, Advance Article
DOI: 10.1039/D4SC05743K, Edge Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Xinyi Wen, Huishan Li, Zhijie Ju, Renren Deng, David Parker
Six Eu(III) and Tb(III) complexes are evaluated for the rapid ratiometric analysis of urate in diluted serum, together with mechanistic studies probing the intermediate exciplex and the excited state dynamics by transient absorption spectroscopy.
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Triple-Function Porphyrin in Glycopolymeric Photosensitizer: From PhotoATRP to Targeted PDT

Chem. Sci., 2024, Accepted Manuscript
DOI: 10.1039/D4SC06466F, Edge Article
Open Access
Jiahui Lin, Zhiyuan Ma, Weiwei Zuo, Meifang Zhu
Porphyrin derivatives serve as photocatalysts in reversible-deactivation radical polymerization and as photosensitizers in photodynamic therapy (PDT). Herein, a triple function porphyrin, ZnTPPC6Br, was synthesized as photocatalyst and initiator for photoATRP....
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The pain and power of multiples

With as many as 14 Bollywood franchise films seeing the light of the day in 2016, we decode the phenomenon




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PM Modi participates in 200th year celebrations of Shree Swaminarayan Mandir in Gujarat




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Knives Cooks Love: Selection. Care. Techniques. Recipes. Reviewed by the Tampa Tribune

Knives Cooks Love Review

As Emeril Lagasse writes in the book's foreword, knives are the most highly valued cooking tool in a chef's possession, and yet they are often the least discussed in the kitchen. This book, produced by Sur La Table, pulls the cloak back on that tool to provide a wonderfully coherent, easy-to-follow guide to selecting knives, maintaining them and, as you might guess, using them properly. Even better, they pair those instructions along with recipes that you can make immediately after learning each new cut, chop or slice.

Knives Cooks Love: Selection. Care. Techniques. Recipes. focuses on this most versatile tool in the kitchen and provides tantalizing recipes allowing you to practice and perfect techniques. Consider this Knives 101—lessons on everything you need to know to make your experiences behind the blade more straightforward, efficient, and enjoyable.




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A paper-in-polymer-pond (PiPP) hybrid microfluidic microplate for multiplexed ultrasensitive detection of cancer biomarkers

Lab Chip, 2024, 24,4962-4973
DOI: 10.1039/D4LC00485J, Paper
Sanjay S. Timilsina, XiuJun Li
A reusable and cost-effective paper-in-polymer-pond (PiPP) hybrid microfluidic microplate with unique features for ultrasensitive and high-throughput multiplexed detection of disease biomarkers within an hour without using specialized instruments.
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Dynamic sampling from ex vivo adipose tissue using droplet-based microfluidics supports separate mechanisms for glycerol and fatty acid secretion

Lab Chip, 2024, 24,5020-5031
DOI: 10.1039/D4LC00664J, Paper
Md Moniruzzaman, Andresa B. Bezerra, Md Mohibullah, Robert L. Judd, James G. Granneman, Christopher J. Easley
Droplet-based microfluidic sampling of adipose tissue reveals unique information on lipolytic dynamics.
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Exploring cancer-associated fibroblast-induced resistance to tyrosine kinase inhibitors in hepatoma cells using a liver-on-a-chip model

Lab Chip, 2024, 24,5043-5054
DOI: 10.1039/D4LC00624K, Paper
Madhu Shree Poddar, Yu-De Chu, Gaurav Pendharkar, Cheng-Hsien Liu, Chau-Ting Yeh
3D liver-on-a-chip reveals AHSG and CLEC3B to mediate cancer-associated fibroblast-induced resistance to TKIs in hepatoma cells.
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Rapid low-cost assembly of modular microvessel-on-a-chip with benchtop xurography

Lab Chip, 2024, 24,5065-5076
DOI: 10.1039/D4LC00565A, Paper
Open Access
Shashwat S. Agarwal, Marcos Cortes-Medina, Jacob C. Holter, Alex Avendano, Joseph W. Tinapple, Joseph M. Barlage, Miles M. Menyhert, Lotanna M. Onua, Jonathan W. Song
Our study is a novel implementation of xurography for multi-layer microfluidic device fabrication. We demonstrate the versatility of this approach by presenting several modular 3D vessel-matrix arrangements.
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Self-actuated microfluidic chiplet for two-stage multiplex nucleic acid amplification assay

Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00752B, Paper
Open Access
Felix Ansah, Marziyeh Hajialyani, Fatemeh Ahmadi, Yuming Gu, Ergün Alperay Tarım, Michael G. Mauk, Gordon A. Awandare, Haim H. Bau
Self-actuated chiplet for Penn-RAMP assay.
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Correction: Deciphering hepatoma cell resistance to tyrosine kinase inhibitors: insights from a Liver-on-a-Chip model unveiling tumor endothelial cell mechanisms

Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC90093F, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Madhu Shree Poddar, Yu-De Chu, Chau-Ting Yeh, Cheng-Hsien Liu
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A gravity-driven tissue chip to study the efficacy and toxicity of cancer therapeutics

Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00404C, Paper
Open Access
Pouria Rafsanjani Nejad, Astha Lamichhane, Prasiddha Guragain, Gary Luker, Hossein Tavana
A 96-well plate format, fully-automated multi-organ tissue chip array with gravity-driven flow for cancer research.
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Real-time impedance-activated dielectrophoretic actuation for reconfigurable manipulation of single flowing particles

Lab Chip, 2024, 24,5145-5154
DOI: 10.1039/D4LC00622D, Paper
Alexis Lefevre, Cristian Brandi, Adele De Ninno, Filippo Ruggiero, Enrico Verona, Michaël Gauthier, Paolo Bisegna, Aude Bolopion, Federica Caselli
We present an original all-electrical platform that combines MIC-sensing and DEP-actuation for precise and selective trajectory control of single flowing particles.
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Impact of microchannel width on axons for brain-on-chip applications

Lab Chip, 2024, 24,5155-5166
DOI: 10.1039/D4LC00440J, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Katarina Vulić, Giulia Amos, Tobias Ruff, Revan Kasm, Stephan J. Ihle, Joël Küchler, János Vörös, Sean Weaver
Axon growth is influenced by the width and number of microchannels, with growth cone adaptability reaching its limit for constraints smaller than 350 nm. Tradeoffs between axon growth and control need to be made for neurofluidic devices.
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Observing root growth and signalling responses to stress gradients and pathogens using the bi-directional dual-flow RootChip

Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00659C, Paper
Open Access
Claudia Allan, Yiling Sun, Stephen C. Whisson, Michael Porter, Petra C. Boevink, Volker Nock, Claudia-Nicole Meisrimler
Using a bi-directional dual-flow RootChip with integrated force sensing micropillars, root growth and signalling responses to stress gradients and pathogens were studied in Arabidopsis thaliana, Nicotiana benthamiana and Solanum lycopersicum.
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An imaging scheme to study the flow dynamics of co-flow regimes in microfluidics: implications for nanoprecipitation

Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00652F, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Wali Inam, Anton Vladyka, Joanna W. Pylvänäinen, Junel Solis, Dado Tokic, Pasi Kankaanpää, Hongbo Zhang
Herein, by presenting a novel imaging-based scheme for analyzing fluid interactions in co-flow regimes, we identify oscillatory and chaotic flow behaviors to optimize nanoprecipitation through controlled fluid manipulation.
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SERS-based pump-free microfluidic chip sensor for highly sensitive competitive immunoassay of cortisol in human sweat

Lab Chip, 2024, Accepted Manuscript
DOI: 10.1039/D4LC00858H, Paper
Siyue Xiong, Chushu Zhu, Chengxuan Wang, Peitao Dong, Xuezhong Wu
Cortisol, known as the "stress hormone," is secreted by the adrenal cortex. Measuring cortisol levels in body fluids is essential for evaluating stress levels, adrenal function, hormone imbalances, and psychological...
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