it Inhibition of Mitochondrial Calcium Overload by SIRT3 Prevents Obesity- or Age-Related Whitening of Brown Adipose Tissue By diabetes.diabetesjournals.org Published On :: 2020-01-20T12:00:26-08:00 The whitening and loss of brown adipose tissue (BAT) during obesity and aging promote metabolic disorders and related diseases. The imbalance of Ca2+ homeostasis accounts for the dysfunction and clearance of mitochondria during BAT whitening. Capsaicin, a dietary factor activating TRPV1, can inhibit obesity induced by high-fat diet (HFD), but whether capsaicin inhibits BAT loss and the underlying mechanism remain unclear. In this study, we determined that the inhibitory effects of capsaicin on HFD-induced obesity and BAT whitening were dependent on the participation of SIRT3, a critical mitochondrial deacetylase. SIRT3 also mediated all of the beneficial effects of capsaicin on alleviating reactive oxygen species generation, elevating mitochondrial activity, and restricting mitochondrial calcium overload induced by HFD. Mechanistically, SIRT3 inhibits mitochondrial calcium uniporter (MCU)-mediated mitochondrial calcium overload by reducing the H3K27ac level on the MCU promoter in an AMPK-dependent manner. In addition, HFD also inhibits AMPK activity to reduce SIRT3 expression, which could be reversed by capsaicin. Capsaicin intervention also inhibited aging-induced BAT whitening through this mechanism. In conclusion, this study emphasizes a critical role of the AMPK/SIRT3 pathway in the maintenance of BAT morphology and function and suggests that intervention in this pathway may be an effective target for preventing obesity- or age-related metabolic diseases. Full Article
it 30 low-key acquisitions who could pay off big By mlb.mlb.com Published On :: Tue, 12 Feb 2019 13:57:13 EDT Fans and analysts spend the entire offseason speculating where the top free agents could go, but sometimes an under-the-radar pickup can end up making a world of difference. As positional competitions begin to heat up at Spring Training camps this month, MLB.com's beat writers were asked to identify one potentially overlooked acquisition for each of the 30 clubs. Here's who they came up with. Full Article
it Astros open camp with bar 'set incredibly high' By mlb.mlb.com Published On :: Wed, 13 Feb 2019 12:14:03 EDT With this many stars and this much talent, you can't help but have visions of playing baseball deep into October. And considering it was only a year ago the Astros were talking about defending their World Series title, their window to win another one remains wide open. Full Article
it Cole wins arbitration case vs. Astros By mlb.mlb.com Published On :: Wed, 13 Feb 2019 14:49:54 EDT All-Star right-hander Gerrit Cole won his arbitration case against the Astros on Wednesday, meaning he will make $13.5 million this season. The team offerred $11.425 million, a difference of $2,075,000. Full Article
it Whitley throws first bullpen session of spring By mlb.mlb.com Published On :: Fri, 15 Feb 2019 18:00:43 EDT All eyes were on right-hander Forrest Whitley, MLB Pipeline's top pitching prospect, when he threw in the bullpen for the first time Friday in Major League camp. Astros manager AJ Hinch, assistant general manager Brandon Taubman and director of player development Pete Putila were all watching intently as Whitley threw 21 pitches -- fastballs, changeups and cutters. Full Article
it JV, Cole, Rodgers face live hitters at camp By mlb.mlb.com Published On :: Sun, 17 Feb 2019 16:58:17 EDT The first live bullpen sessions of the spring typically draw a crowd, and that certainly was the case when Justin Verlander, Gerrit Cole and Brady Rodgers faced hitters for the first time Sunday afternoon on the back fields at Ballpark of the Palm Beaches. Full Article
it Raising HD awareness personal for Smith, wife By mlb.mlb.com Published On :: Mon, 18 Feb 2019 16:25:28 EDT They wrestled with the decision to start a family for five years. It's something most young couples discuss at some point. Timing is important, and considering their busy lives, even more so for Astros pitcher Joe Smith and his wife, TV sports reporter Allie LaForce. The issue facing the couple is far more momentous than most others have to deal with -- one that's a matter of life and death. Full Article
it Hall of Famer Biggio visits camp, shares wisdom By mlb.mlb.com Published On :: Tue, 19 Feb 2019 15:00:37 EDT The first Hall of Famer to join the Astros at Spring Training is Craig Biggio, who was in uniform for morning workouts on Tuesday and will remain with the team throughout the week. Full Article
it UN leader says one billion people with disabilities hard hit by virus By jamaica-gleaner.com Published On :: Wed, 06 May 2020 12:33:18 -0500 UNITED NATIONS (AP) — The United Nation’s leader said Wednesday the world’s one billion people living with disabilities are among the hardest hit by the coronavirus and called for them to have equal access to prevention and... Full Article
it Rare inflammatory condition affects some children with COVID-19 By jamaica-gleaner.com Published On :: Thu, 07 May 2020 17:11:53 -0500 Dozens of United States children have been hospitalised with a serious inflammatory condition possibly linked with the coronavirus and first seen in Europe. New York authorities announced Wednesday that 64 potential cases had been reported to... Full Article
it CSME needed to rescue COVID-hit economies By jamaica-gleaner.com Published On :: Fri, 08 May 2020 00:23:04 -0500 COVID-19-ravaged regional economies, including Jamaica, will need the united strength of the Caribbean Single Market and Economy (CSME) to help revive their micro, small and medium enterprise (MSME) sectors, many of which have been decimated. That... Full Article
it TV network fights closure with court petition By jamaica-gleaner.com Published On :: Fri, 08 May 2020 00:19:25 -0500 MANILA (AP): The Philippines’ largest TV and radio network, which was shutdown this week by a government regulator, asked the Supreme Court on Thursday to allow it to return to the air amid an uproar over its closure. ABS-CBN Corp said in its... Full Article
it Venerable but vulnerable: Centenarians hit hard by virus By jamaica-gleaner.com Published On :: Fri, 08 May 2020 09:42:22 -0500 BOSTON (AP) — Centenarians have always been a rare breed. Now they’re an endangered species. The 100-plus crowd — those most venerable of human beings — is succumbing rapidly and heartbreakingly to the coronavirus... Full Article
it South Africa parliament video call hacked with pornography By jamaica-gleaner.com Published On :: Fri, 08 May 2020 10:43:05 -0500 JOHANNESBURG (AP) — A virtual meeting of South African lawmakers has been disrupted by hackers who flooded the video call with pornographic images. In the incident on Thursday, the hackers also hurled racial and sexual insults at the meeting... Full Article
it No imminent lockdown restrictions in hard-hit UK By jamaica-gleaner.com Published On :: Fri, 08 May 2020 13:03:38 -0500 LONDON — Britain’s minister for the environment, food and rural affairs says Prime Minister Boris Johnson won’t be announcing immediate changes to the country’s coronavirus lockdown when he addresses the nation on Sunday.... Full Article
it Brathwaite for Tallawahs By jamaica-gleaner.com Published On :: Wed, 06 May 2020 00:17:43 -0500 The Jamaica Tallawahs have wasted little time in finding a replacement for the ‘Universe Boss’ Chris Gayle, as they have snapped up the captain of the St Kitts and Nevis Patriots, Carlos Brathwaite. The Gleaner has been reliably informed that... Full Article
it Harriott urges caution with RSPL decision By jamaica-gleaner.com Published On :: Wed, 06 May 2020 23:16:13 -0500 Portmore United captain Rosario Harriott says the Premier League Clubs Association shouldn’t rush to call off this season of the Red Stripe Premier League (RSPL) because of the COVID-19 pandemic. The league was stopped indefinitely in mid-March... Full Article
it MoBay City Run going virtual By jamaica-gleaner.com Published On :: Fri, 08 May 2020 00:14:53 -0500 Western Bureau: THE MOBAY City Run organisers have reconsidered the event’s cancellation. Organising committee chairperson Janet Silvera said on Sunday, the day the event was to have taken place, that the seventh staging of the 5K/10K Walk and Run... Full Article
it Female athletes need more recognition – Clayton By jamaica-gleaner.com Published On :: Fri, 08 May 2020 00:23:08 -0500 National 400m hurdles champion Rushell Clayton is concerned about what she says are inequalities between men and women in track and field. Clayton was speaking at a Women in Sports Conference in Kingston recently and discussed issues of inequality... Full Article
it Windies players lack commitment – Benjamin By jamaica-gleaner.com Published On :: Sat, 09 May 2020 00:13:16 -0500 BRIDGETOWN, Barbados (CMC): Former Windies fast bowler Kenny Benjamin says that cricket in the Caribbean is suffering from players’ lack of loyalty and commitment and that intervention is required to save the sport. The Antiguan called for coaches... Full Article
it Great leap backwards - austerity measures are hitting the vulnerable hardest By feeds.bmj.com Published On :: Wed, 10 Dec 2014 17:19:43 +0000 The UK’s austerity programme has disproportionately affected children and people with disabilities, says David Taylor-Robinson, a senior clinical lecturer in public health at the University of Liverpool. He joins us to discuss why the evidence shows the vulnerable are hit hardest by the cuts to public services, despite the UN conventions on... Full Article
it Operating theatre time, where does it all go? By feeds.bmj.com Published On :: Fri, 19 Dec 2014 15:45:21 +0000 Waiting times in theatre can be a source of friction – but is the delay due to mandatory anaesthetic faff around time (MAFAT), or AWOL surgeons? Elizabeth Travis, and orthopaedic house officer in New Zealand and colleagues, have been trying to create and evidence base to argue the toss, and she joins me now to discuss her study, Operating... Full Article
it Managing multimorbidity in primary care By feeds.bmj.com Published On :: Fri, 23 Jan 2015 11:56:24 +0000 Multimorbidity presents a number of different challenges, for the patients living with the conditions, but also for the health professionals caring for them in systems that often are not designed with these more complex needs in mind. Emma Wallace, general practice lecturer, and Susan Smith, a professor of general practice at the Royal College of... Full Article
it International donations to the Ebola virus outbreak: too little, too late? By feeds.bmj.com Published On :: Wed, 04 Feb 2015 11:19:32 +0000 Karen Grépin, assistant professor of global health policy at New York University, has been examining the pledges made by the international community to help fight the ebola virus outbreak - was it really too little, too late? Read her full analysis: http://www.bmj.com/content/350/bmj.h376 Full Article
it Patient spotlight - Doing it for themselves By feeds.bmj.com Published On :: Tue, 10 Feb 2015 11:45:45 +0000 In our accompanying roundtable discussion,we hear views from a group of patients and clinicians based largely in the UK on the actions required to advance progress towards providing patient centred care. To extend the conversation we talked to members of the BMJ's international patient advisory panel and other patient advocates - and what... Full Article
it Nuffield summit - Bastiaan Bloem on parkinsons.net By feeds.bmj.com Published On :: Thu, 05 Mar 2015 16:22:29 +0000 Bastiaan Bloem, consultant neurologist at Radboud University Nijmegen Medical Centre, Netherlands, discussing his revolutionary approach to patient centred care. Read more from the summit: http://www.bmj.com/content/350/bmj.h1172 Full Article
it Katherine Henderson A and E consultant - lack of ward beds is hitting A and E the hardest By feeds.bmj.com Published On :: Wed, 11 Mar 2015 14:55:57 +0000 Katherine Henderson is the clinical lead of the emergency department at St Thomas's hospital in London. She worries that lack of ward space is having a domino effect throughout A and E and is the cause of increased waiting time for both patients and ambulances. If you would like to contribute to this collection, please email a brief audio... Full Article
it QOF, what is it good for? By feeds.bmj.com Published On :: Mon, 15 Jun 2015 12:58:46 +0000 Martin McShane, medical director of long term conditions at NHS England, questions the validity of the Quality and Outcomes Framework and suggests how it should change in the future. Read the related article: http://www.bmj.com/content/350/bmj.h2540 Full Article
it What it's like to receive cardiac rehabilitation By feeds.bmj.com Published On :: Sat, 26 Sep 2015 14:09:05 +0000 With improved survival and and ageing population, the number of people living with coronary heart disease in the UK has increased to an estimated 2.3 million. There is increasing evidence that cardiac rehabilitation benefits these patients, and as such it has been included in international clinical guidelines. In this podcast, we're joined by... Full Article
it Unexpected findings, with uncertain implications, in research imaging By feeds.bmj.com Published On :: Fri, 13 Nov 2015 16:20:27 +0000 When healthy volunteers are scanned as part of a research project, unexpected findings, with uncertain implications, can be thrown up. Joanna Wardlaw, professor of applied neuroimaging and honorary consultant neuroradiologist at the University of Edinburgh, joins us to discuss how her group deals with these incidental findings, and what... Full Article
it Revisiting the bridge By feeds.bmj.com Published On :: Fri, 13 Nov 2015 16:55:03 +0000 In the podcast, we’ll hear from Kevin Hines the survivor of such an attempt, and Alys Cole-King, a psychiatrist who wants to break down the stigma of suicide. Originally broadcast in 2010 For more on suicide risk assessment and prevention, read our latest clinical review: http://www.bmj.com/content/351/bmj.h4978 Full Article
it Sarah Wollaston - obesity, not a sugary drinks tax, is regressive By feeds.bmj.com Published On :: Wed, 02 Dec 2015 11:28:11 +0000 The UK Parliament's Health Select Committee's recent report on childhood obesity says 1 in 5 children are obese by the time they leave school. The committee calls for legislation to turn the tide by taxing sugary drinks, a pre-watershed ban on junk food advertising, and investment in public health. We joined Sarah Wollaston, conservative MP for... Full Article
it The big (research) book of British teeth By feeds.bmj.com Published On :: Tue, 15 Dec 2015 20:59:35 +0000 Despite what hollywood says, science has proven that British teeth are actually better than American. Richard Watt, head of the Research Department of Epidemiology and Public Health at UCL explains how they came to that conclusion. Read the full research: http://www.bmj.com/cgi/doi/10.1136/bmj.h6543 Full Article
it Cancer screening - does it save lives? By feeds.bmj.com Published On :: Fri, 08 Jan 2016 15:02:28 +0000 The claim that cancer screening saves lives is based on fewer deaths due to the target cancer. Vinay Prasad, assistant professor at Oregon Health and Science University, joins us to argue that reductions in overall mortality should be the benchmark and call for higher standards of evidence for cancer screening. Read the full... Full Article
it What is vaginal seeding - and is it safe? By feeds.bmj.com Published On :: Tue, 23 Feb 2016 16:13:40 +0000 How should health professionals engage with this increasingly popular but unproved practice? Aubrey Cunnington, a consultant paediatrician from Imperial College London joins us to discuss. Read the full editorial: http://www.bmj.com/content/352/bmj.i227 Full Article
it Zika virus - "it really felt like having bad sunburn, all over your body" By feeds.bmj.com Published On :: Fri, 26 Feb 2016 15:07:01 +0000 “Juliet”, a woman living in London, was diagnosed with a mysterious illness in November 2015, Ian Cropley, a consultant in infectious disease from The Royal Free London NHS Foundation Trust, was there to investigate. In this podcast, we find out how Zika, once a little known virus causing a rash and fever, has subsequently become a global health... Full Article
it "It's the workforce, stupid" - is the NHS workforce in crisis? By feeds.bmj.com Published On :: Wed, 09 Mar 2016 10:36:21 +0000 As the junior doctors in England strike, concerns for the workforce are foremost in the minds of those running the NHS. A summary is available here: http://www.bmj.com/content/352/bmj.i1510 In The BMJ roundtable, recorded at the Nuffield Trust Health Policy Summit on Friday 4 March 2016, we asked our participants if they think the NHS is in... Full Article
it "I thought I was the worst person with type I..." - Self management of diabetes By feeds.bmj.com Published On :: Mon, 14 Mar 2016 11:20:56 +0000 Nick Oliver, consultant diabetologist at Imperial Healthcare NHS Trust and Philippa Cooper, who has type I diabetes, join us to explain how structured education works for patients, and give tips on self management. Read the full review: http://www.bmj.com/content/352/bmj.i998 Full Article
it Médecins Sans Frontières's Dunkirk spirit By feeds.bmj.com Published On :: Thu, 31 Mar 2016 13:50:50 +0000 As France has moved in recent weeks to clear camps where migrants stay while trying to cross illegally into Britain, Médecins Sans Frontières has just opened a new one. Sophie Arie talks to Caroline Gollé, medical coordinator at the Médecins Sans Frontières La Linière camp. Read more about the camp: http://www.bmj.com/content/352/bmj.i1696 Full Article
it Caring for patients with delirium at the end of their life By feeds.bmj.com Published On :: Tue, 14 Jun 2016 16:15:33 +0000 Delirium is common in the last weeks or days of life. It can be distressing for patients and those around them. A clinical update explains why successful management involves excluding reversible causes of delirium and balancing drugs that may provoke or maintain delirium while appreciating that most patients want to retain clear cognition at the... Full Article
it Having hip osteoarthritis By feeds.bmj.com Published On :: Fri, 08 Jul 2016 16:25:01 +0000 2.46 million people in England have osteoarthritis of the hip, and many of those go on to eventually have a hip replacement - which is now widely considered one of the most commonly performed and successful operations in the world. Jessamy Bagenal, clinical fellow with The BMJ, talks to Nick Nicholas, an obstetrician who has had OA and one of... Full Article
it Treating hip osteoarthritis By feeds.bmj.com Published On :: Fri, 08 Jul 2016 16:26:00 +0000 2.46 million people in England have osteoarthritis of the hip, and many of those go on to eventually have a hip replacement - which is now widely considered one of the most commonly performed and successful operations in the world. Jessamy Bagenal, clinical fellow with The BMJ, talks to Nick Aresti, a specialist registrar in trauma and... Full Article
it What went wrong with care.data? By feeds.bmj.com Published On :: Fri, 22 Jul 2016 16:20:00 +0000 Failures in implementation of data sharing projects have eroded public trust. In the wake of NHS England’s decision to close down its care.data programme, Tjeerd-Pieter van Staa professor of health e-research at the University of Manchester, examines what lessons must be learnt, and what we can do better next time. Read the full... Full Article
it Not just our ethical credibility as a profession, but our shared humanity By feeds.bmj.com Published On :: Tue, 30 Aug 2016 10:30:57 +0000 "I say to all Australian doctors - young, old, the political and the apolitical - that on this depends not just our ethical credibility as a profession, but our shared humanity. " Following the leaked emails published in The Guardian newspaper, alleging abuse of asylum seekers detained by the Australian government on the Pacific island of Nauru,... Full Article
it Late effects of anticancer chemotherapy: It's hard to trust your body, after it's betrayed you By feeds.bmj.com Published On :: Thu, 08 Sep 2016 13:30:40 +0000 Lily was diagnosed at 14 years old with stage four Hodgkin's lymphoma and received six rounds of chemotherapy and two weeks of radiotherapy. She survived but now lives with the long term effects of that therapy - and joins us to discuss how it has impacted her quality of life. We're also joined by Saif Ahmad and Thankamma Ajithkumar, oncologists... Full Article
it Reprehensible, but the people carrying out atrocities have very low rates of mental disorders By feeds.bmj.com Published On :: Thu, 08 Sep 2016 14:46:46 +0000 Oversimplification and lack of evidence stigmatise people with mental illness and impede prevention efforts, says Simon Wessley, professor of psychiatry at King's College London, in an editorial published on thebmj.com. Read the full editorial: http://www.bmj.com/content/354/bmj.i4869 Full Article
it Evidence for vitamin D supplimentation By feeds.bmj.com Published On :: Fri, 25 Nov 2016 16:15:14 +0000 Despite high quality systematic reviews reporting ineffectiveness, many guideline groups continue to recommend vitamin D supplementation (with or without calcium) for fall or fracture prevention. Recently Public Health England recommended that everyone needs vitamin D equivalent to an average daily intake of 10 μg (400 IU) to protect bone and... Full Article
it Christmas 2016 - ideologies and moralities By feeds.bmj.com Published On :: Fri, 16 Dec 2016 18:10:32 +0000 In an ideal world, policies would be evidence based - but governments are made of humans, who have positions and ideologies and moral bases. In this podcast Anthony Painter, from the RSA will be talking about why universal basic income may work, but who’s proponents cross ideological barriers, and writer and philosopher AC Grayling explains how... Full Article
it Helping patients with medically unexplained symptoms By feeds.bmj.com Published On :: Fri, 17 Feb 2017 16:59:25 +0000 Persistent physical symptoms are common and include those symptoms that last at least three months and are insufficiently explained by a medical condition after adequate examination and investigation. Observational studies in primary care report that women, especially those aged 35-45 years, more commonly present with these symptoms. In this... Full Article
it The inadequacy of the UK's childhood obesity strategy By feeds.bmj.com Published On :: Thu, 02 Mar 2017 17:39:18 +0000 The UK government published its report Childhood Obesity: a Plan for Action, in August 2016. A new analysis article takes them to task for the inadequacy of that response to a growing problem. Neena Modi is a professor of neonatal medicine, at Imperial College London, and president of the Royal College of Paediatrics and Child Health, and joins... Full Article