2 2014 Personal Tax Update – The Year in Review By www.cch.ca Published On :: Mon, 01 Dec 2014 13:57:01 GMT The 2014 T1 season is almost upon us, so it's time for tax return preparers to get updated again on all the current issues that may impact their clients' tax returns. This webinar will get you in position to prepare your clients' 2014 personal tax returns, and will review some of the more commonly experienced issues faced by tax preparers. Join Erin Swint, a tax partner with Squire and Company, for a thorough overview of the key changes from the past year that will impact personal tax return filing including the 2013 Federal Budget, CRA announcements and relevant court cases. Erin will also discuss some other tax matters that are integral to personal taxation as well as administrative issues related to filing returns. Available Sessions for this Seminar:January 20, 2015 12:00 PM - 2:00 PM EST Full Article
2 Chancery papermaking at the University of Iowa Center for the Book, 2013. By library.mit.edu Published On :: Sun, 22 Nov 2015 06:09:42 EST Hayden Library - TS1124.5.C43 2013 Full Article
2 Zouk lambada advanced 2 / By library.mit.edu Published On :: Sun, 31 Jan 2016 06:21:43 EST Hayden Library - GV1796.L36 Z683 2015 Full Article
2 Walk the talk 2014 / By library.mit.edu Published On :: Sun, 7 Feb 2016 06:21:37 EST Hayden Library - HN80.L7 W35 2014 Full Article
2 Ayiti, min chimin libèt: Haiti, le chemin de la liberté = Haiti, el camino de la libertad = Haiti, the way of freedom = Haiti, la via della libertà = Haiti, der Weg zur Freiheit = Haitio, la vojo de la lidereco = Āyitī, tarīq al-hurriyah By library.mit.edu Published On :: Sun, 4 Dec 2016 06:51:38 EST Hayden Library - F1921.A95 2016 Full Article
2 Jacques Stéphen Alexis, mort sans sépulture / By library.mit.edu Published On :: Sun, 4 Dec 2016 06:51:38 EST Hayden Library - PQ3949.A34 Z55 2015 Full Article
2 Eka dôkṭara kī mauta: Ek doctor ki maut = Death of a doctor By library.mit.edu Published On :: Sun, 22 Jan 2017 06:27:36 EST Hayden Library - PN1997.E33 A1 1990 Full Article
2 Neighbors 2 / By library.mit.edu Published On :: Sun, 12 Mar 2017 06:10:05 EDT Hayden Library - PN1997.2.N452 2016 Full Article
2 Café society / By library.mit.edu Published On :: Sun, 9 Apr 2017 06:09:32 EDT Hayden Library - PN1997.2.C337 2016 Full Article
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2 Pokémon.: the complete collection. By library.mit.edu Published On :: Sun, 5 Nov 2017 06:14:50 EST Hayden Library - PN1992.77.P65 A1 2015 Full Article
2 Incredibles 2 / By library.mit.edu Published On :: Sun, 14 Apr 2019 06:39:57 EDT Hayden Library - PN1997.2.I63 2018 Full Article
2 Photovoltaics for professionals : solar electric systems-- marketing, design and installation / Falk Antony, Christian Dürschner, Karl-Heinz Remmers By prospero.murdoch.edu.au Published On :: Antony, Falk Full Article
2 Wind energy in the 21st century : economics, policy, technology, and the changing electricity industry / Robert Y. Redlinger, Per Dannemand Andersen and Poul Erik Morthorst By prospero.murdoch.edu.au Published On :: Redlinger, Robert Y., 1963- Full Article
2 Renewable energy for sustainable development in the Asia Pacific region : Fremantle, Western Australia, 4-8 February 2007 / editors, Philip Jennings ... [et al.] By prospero.murdoch.edu.au Published On :: Full Article
2 Australian bioenergy roadmap : setting the direction for biomass in stationary energy to 2020 and beyond By prospero.murdoch.edu.au Published On :: Full Article
2 Thin-film terrestrial photovoltaic (PV) modules : design qualification and type approval = Modules photovoltaïques (PV) en couches minces pour application terrestre : qualification de la conception et homologation By prospero.murdoch.edu.au Published On :: Full Article
2 Systèmes photovoltaïques (PV) autonomes - vérification de la conception = Photovoltaic (PV) stand-alone systems - design verification By prospero.murdoch.edu.au Published On :: Full Article
2 Grid connected photovoltaic systems - minimum requirements for system documentation, commissioning tests and inspection (IEC 62446:2009 (EQV)) By prospero.murdoch.edu.au Published On :: Full Article
2 Battery charge controllers for photovoltaic systems--performance and functioning = Contrôleurs de charge de batteries pour systèmes photovoltaïques--performance et fonctionnement By prospero.murdoch.edu.au Published On :: Full Article
2 Electrical installations of buildings : part 7-712 : requirements for special installations or locations : solar photovoltaic (PV) power supply systems By prospero.murdoch.edu.au Published On :: Full Article
2 Grid connected photovoltaic systems - minimum requirements for system documentation, commissioning tests and inspection = Systèmes photovoltaïques connectés au réseau électrique - exigences minimales pour la documentation du syst& By prospero.murdoch.edu.au Published On :: Full Article
2 Photovoltaics : system design and practice / Heinrich Häberlin ; translated by Herbert Eppel By prospero.murdoch.edu.au Published On :: Haberlin, Heinrich Full Article
2 2012 ASHRAE handbook : heating, ventilating, and air-conditioning systems and equipment / American Society of Heating, Refrigerating and Air-Conditioning Engineers, Inc By prospero.murdoch.edu.au Published On :: American Society of Heating, Refrigerating and Air-Conditioning Engineers Full Article
2 2013 ASHRAE handbook : fundamentals By prospero.murdoch.edu.au Published On :: American Society of Heating, Refrigerating and Air-Conditioning Engineers Full Article
2 Proceedings of the ASME 14th Fuel Cell Science, Engineering and Technology Conference, 2016 By prospero.murdoch.edu.au Published On :: International Conference on Fuel Cell Science, Engineering and Technology (14th : 2016 : Charlotte, North Carolina), Full Article
2 310 nm UV-LED Attenuates Imiquimod-Induced Psoriasis-like Skin Lesions in C57BL/6 Mice and Inhibits IL-22-Induced STAT3 Expression in HaCaT Cells By feeds.rsc.org Published On :: Photochem. Photobiol. Sci., 2020, Accepted ManuscriptDOI: 10.1039/C9PP00444K, PaperTae-Rin Kwon, Sung-Eun Lee, Jong-Hwan Kim, Yu Na Jang, Su-Young Kim, Seok Kyun Mun, Chan Woong Kim, Jungtae Na, Beom Joon KimUltraviolet light-emitting diodes (UV-LEDs) are a novel light source for phototherapy. This study aimed to evaluate the therapeutic effects of UV-LEDs on psoriasis. Importantly, 310 nm UV-LEDs have not been...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
2 4-(4-Chloro-2-oxo-3(1H-phenanthro[9,10-d]imidazol-2-yl)-2H-chromen-6-yl) benzaldehyde as a fluorescent probe for medical imaging: linear and nonlinear optical properties By feeds.rsc.org Published On :: Photochem. Photobiol. Sci., 2020, 19,473-484DOI: 10.1039/C9PP00478E, PaperPrzemysław KrawczykThis study presents the full theoretical optical and biological characteristics of a new fluorescent probe based on the phenanthroimidazole backbone (PB5).The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
2 Near-IR oxime-based solvatochromic perylene diimide probe as a chemosensor for Pd species and Cu2+ ions in water and live cells By feeds.rsc.org Published On :: Photochem. Photobiol. Sci., 2020, 19,504-514DOI: 10.1039/C9PP00487D, PaperPoonam Sharma, Sandeep Kaur, Satwinderjeet Kaur, Prabhpreet SinghA near-IR colorimetric and fluorescent perylene diimide probe for detection of Pd0 (7.9 × 10−8 M) and Cu2+ (3.4 × 10−7 M) in water and live cells with solvatochromic properties is designed and synthesized.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
2 An antipyrine based fluorescent probe for distinct detection of Al3+ and Zn2+ and its AIEE behaviour By feeds.rsc.org Published On :: Photochem. Photobiol. Sci., 2020, Advance ArticleDOI: 10.1039/C9PP00472F, PaperSamir Maity, Milan Shyamal, Rakesh Maity, Naren Mudi, Paresh Hazra, Prabhat Kr. Giri, Shashanka Shekhar Samanta, Santanu Pyne, Ajay MisraA simple antipyrine based fluorescent probe, 4-(2-hydroxy-3-methoxy-benzylidene)-amino-1,5-dimethyl-2-phenyl-1,2-dihydro-pyrazol-3-one (OVAP), has been successfully synthesized using a one-step condensation method.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
2 The origin of the longer wavelength emission in 2-(4-fluorophenylamino)-5-(2,4-dihydroxybenzeno)-1,3,4-thiadiazole and its analogue 2-phenylamino-5-(2-hydroxybenzono)-1,3,4-thiadiazole By feeds.rsc.org Published On :: Photochem. Photobiol. Sci., 2020, Advance ArticleDOI: 10.1039/C9PP00490D, Paper Ila, Reshmi Dani, Surya Pratap Verma, G. KrishnamoorthyThe longer wavelength emissions of 2-(4-fluorophenylamino)-5-(2,4-dihydroxybenzeno)-1,3,4-thiadiazole (FABT) and 2-phenylamino-5-(2-hydroxybenzono)-1,3,4-thiadiazole (PHBT) are due to ESIPT.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
2 Outstanding Reviewers for Photochemical & Photobiological Sciences in 2019 By feeds.rsc.org Published On :: Photochem. Photobiol. Sci., 2020, Advance ArticleDOI: 10.1039/D0PP90016H, EditorialWe would like to take this opportunity to highlight the Outstanding Reviewers for Photochemical & Photobiological Sciences in 2019, as selected by the editorial team for their significant contribution to the journal.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
2 Environmental effects of stratospheric ozone depletion, UV radiation and interactions with climate change: UNEP Environmental Effects Assessment Panel, update 2019 By feeds.rsc.org Published On :: Photochem. Photobiol. Sci., 2020, Advance ArticleDOI: 10.1039/D0PP90011G, PerspectiveG. H. Bernhard, R. E. Neale, P. W. Barnes, P. J. Neale, R. G. Zepp, S. R. Wilson, A. L. Andrady, A. F. Bais, R. L. McKenzie, P. J. Aucamp, P. J. Young, J. B. Liley, R. M. Lucas, S. Yazar, L. E. Rhodes, S. N. Byrne, L. M. Hollestein, C. M. Olsen, A. R. Young, T. M. Robson, J. F. Bornman, M. A. K. Jansen, S. A. Robinson, C. L. Ballaré, C. E. Williamson, K. C. Rose, A. T. Banaszak, D.-P. Häder, S. Hylander, S.-Å. Wängberg, A. T. Austin, W.-C. Hou, N. D. Paul, S. Madronich, B. Sulzberger, K. R. Solomon, H. Li, T. Schikowski, J. Longstreth, K. K. Pandey, A. M. Heikkilä, C. C. WhiteThis assessment provides an update of the interactive effects of solar ultraviolet (UV) radiation, stratospheric ozone, and climate change on human health, terrestrial and aquatic ecosystems, biochemical cycles, air quality, and material damage.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
2 Deshaun Watson said before the 2017 draft that he talked to the Bears By sports.yahoo.com Published On :: Sat, 09 May 2020 08:48:34 GMT Texans quarterback Deshaun Watson raised plenty of eyebrows on Friday when he tweeted, "The Bears NEVER ONCE talked to me" before the 2017 NFL draft. But that's not what Watson said at the time. Prior to the 2017 draft, Watson said in an interview with Rich Eisen that the Bears had talked to him. "I've [more] Full Article article Sports
2 JAMA: 2005-08-17, Vol. 294, No. 7, Author in the Room Audio Interview By dx.doi.org Published On :: Wed, 21 Sep 2005 20:00:00 +0000 Interview with Fangjun Zhou, PhD, MS and Rafael Harpaz, MD, MPH, authors of Impact of Varicella Vaccination on Health Care Utilization, published in the August 17 issue of JAMA, the Journal of the American Medical Association. Summary Points: 1. Varicella can be severe and at times life threatening, however, since the introduction of varicella vaccine in 1995, varicella hospitalizations have declined significantly, as have outpatient visits. 2. Herd immunity is protecting unvaccinated persons from varicella. Since varicella can be more severe in adults, it is particularly important that patients be screened for evidence of immunity to varicella and anyone susceptible be vaccinated, so that children and adolescents do not remain susceptible at adulthood. The federal government's Advisory Committee on Immunization Practices, or ACIP, provides new recommendations regarding screening patients for evidence of immunity to varicella and vaccinating those at risk of the disease. 3. The diagnosis of varicella has become challenging as rates have declined and since the disease is highly modified among those vaccinated. Laboratory testing will play an increasing role in diagnosis of varicella. 4. Providers should report varicella to the local health department so that public health authorities can act to control outbreaks and can monitor for development of problems in the vaccination program. Thanks to everyone who took part in Author in the Room on September 21. During the call, Dr. Rafael Harpaz mentioned that the CDC has some photo images of more attenuated forms of varicella. You can find these images at www.cdc.gov. Full Article
2 JAMA: 2005-09-28, Vol. 294, No. 12, Author in the Room Audio Interview By dx.doi.org Published On :: Wed, 19 Oct 2005 20:00:00 +0000 Interview with Charles N. Ford, MD, author of Evaluation and Management of Laryngopharyngeal Reflux, published in the September 28 issue of JAMA, the Journal of the American Medical Association. Summary points: 1. Differentiating between gastroesophageal reflux and laryngopharyngeal reflux. 2. Making and confirming laryngopharyngeal reflux diagnosis. 3. Resolution of laryngopharyngeal reflux findings may require aggressive and prolonged treatment. Full Article
2 JAMA: 2005-10-19, Vol. 294, No. 15, Author in the Room Audio Interview By dx.doi.org Published On :: Wed, 16 Nov 2005 20:00:00 +0000 Interview with David R. Flum, MD, MPH, author of Use of Early Mortality Among Medicare Beneficiaries Undergoing Bariatric Surgical Procedures, published in the October 19 issue of JAMA, the Journal of the American Medical Association. Summary Points: 1. Patients 65 years or older have a much higher risk of early death than younger patients after bariatric (obesity) surgery. 2. Already a high risk population, Medicare medically disabled patients have a higher risk of early death after bariatric (obesity) surgery is performed than previously reported. 3. Older patients of more experienced bariatric surgeons had a much lower risk of death than those older patients whose surgeons had less experience performing the surgery. Full Article
2 JAMA: 2005-12-21, Vol. 294, No. 23, Author in the Room Audio Interview By dx.doi.org Published On :: Wed, 18 Jan 2006 20:00:00 +0000 Interview with Sandra Dial, MD, MSc, author of Use of Gastric Acid Suppressive Agents and the Risk of Community Acquired Clostridium difficile Associated Disease, published in the December 21 issue of JAMA, the Journal of the American Medical Association. Summary Points: 1. Acid suppressive therapy use was associated with an increased risk of CDAD, with PPIs appearing to be associated with a higher risk than h2blockers. These agents, particularly PPIs, are being prescribed with increasing frequency to patients, including situations where the benefits may be small. 2. Although the rate is lower than in the hospital, CDAD is occurring in the community and is being diagnosed more frequently. 3. Prior antibiotic exposure appears to be less frequent in patients diagnosed in the community as compared to patients diagnosed in hospital. Full Article
2 JAMA: 2006-01-18, Vol. 295, No. 3, Author in the Room Audio Interview By dx.doi.org Published On :: Wed, 15 Feb 2006 20:00:00 +0000 Interview with Olga Jonasson, MD, author of Watchful Waiting vs Repair of Inguinal Hernia in Minimally Symptomatic Men, published in the January 18 issue of JAMA, the Journal of the American Medical Association. Summary Points: 1. Men, and men only, who have few if any symptoms from their inguinal hemia, can safely delay having it fixed. 2. When symptoms develop, especially if the symptoms worsen suddenly, they should visit a surgeon and request a repair. 3. If the hernia suddenly becomes incarcerated, painful, and signs of a bowel obstruction develop (vomiting, abdominal cramps), an operation should be done immediately. In 2006, even this emergency operation is safe and mortality rates are low. Full Article
2 JAMA: 2006-02-15, Vol. 295, No. 7, Author in the Room Audio Interview By dx.doi.org Published On :: Wed, 15 Mar 2006 20:00:00 +0000 Interview with Anna Taddio, PhD, author of Intravenous Morphine and Topical Tetracaine for Treatment of Pain in Preterm Neonates Undergoing Central Line Placement, published in the February 15 issue of JAMA, the Journal of the American Medical Association. Summary Points: 1. Infants feel pain during central line placement and this pain can be reduced with analgesics. 2. IV Morphine used alone or in combination with Tetracaine Gel is more effective than Tetracaine alone or no treatment. 3. IV Morphine and Tetracaine Gel are associated with expected side effects; IV Morphine causes mild respiratory depression and Tetracaine causes reddening discoloration of the skin. Full Article
2 JAMA: 2006-03-08, Vol. 295, No. 10, Author in the Room Audio Interview By dx.doi.org Published On :: Wed, 19 Apr 2006 20:00:00 +0000 Interview with Thomas Nolan, PhD, and Donald M. Berwick, MD, MPP, author of All-or-None Measurement Raises the Bar on Performance, published in the March 8 issue of JAMA, the Journal of the American Medical Association. Summary Points: 1. All or none measurement more closely reflects the interests and likely desires of patients than other approaches to measurement such as composite or item-by-item. 2. All or none measurement forces a system perspective. 3. All or none measurement offers a more sensitive scale for assessing improvements. Full Article
2 JAMA: 2006-03-08, Vol. 295, No. 10, Author in the Room Audio Interview By dx.doi.org Published On :: Wed, 31 May 2006 20:00:00 +0000 Interview with William Taylor, MD, author of A 71-Year-Old Woman Contemplating a Screening Colonoscopy, published in the March 8 issue of JAMA, the Journal of the American Medical Association. Summary Points: 1. Embedded in experts’ recommendations for colorectal cancer screening are nearly impossible demands on primary care clinicians to discuss the pros and cons of various modalities for screening with each patient and to assess risk even to the detail of learning the pathology of the biopsy of relatives’ colonoscopies (e.g., adenomatous vs. hyperplastic polyps). 2. The complex set of components involved in the decision to screen (or not) for colon cancer includes input from both the doctor (e.g., data about what might happen and how likely the possibilities are) and the patient (e.g., how the patient weighs the relative desirability of the various possible outcomes that result from the possible decisions). 3. The decision to undertake a preventive maneuver involves weighing the risks, cost, and inconvenience of an intervention now for a potential benefit in the future. Full Article
2 JAMA: 2006-03-08, Vol. 295, No. 18, Author in the Room Audio Interview By dx.doi.org Published On :: Wed, 19 Jul 2006 20:00:00 +0000 Interview with Christopher M. Callahan, MD, author of Effectiveness of Collaborative Care for Older Adults With Alzheimer Disease in Primary Care: A Randomized Controlled Trial, published in the May 10 issue of JAMA, the Journal of the American Medical Association. Summary Points: 1. Primary care practices have standard protocols to offer a patient with Alzheimer Disease and their caregivers. 2. The quality of care of many geriatric syndromes, including Alzheimer Disease, can be improved by implementing a collaborative care model. 3. Similarly to many geriatric syndromes, medication may be useful, but it is not enough. Medications are one part of a package of care. Full Article
2 JAMA: 2006-06-21, Vol. 295, No. 23, Author in the Room Audio Interview By dx.doi.org Published On :: Wed, 19 Jul 2006 20:00:00 +0000 Interview with Victor G. Vogel, MD, MHS, author of Effects of Tamoxifen vs Raloxifene on the Risk of Developing Invasive Breast Cancer and Other Disease Outcomes , published in the June 21 issue of JAMA, the Journal of the American Medical Association. Summary Points: 1. Raloxifene is as effective in reducing the risk of invasive breast cancer in postmenopausal women who are at increased risk of the disease. 2. The safety profile of raloxifene is more favorable than tamoxifen with fewer hysterectomies, uterine malignancies, serious thrombotic events, and cataracts. 3. Both physicians and patients are familiar with raloxifene and its use for preventing and treating osteoporosis, and there is a long experience with its use in healthy women. Full Article
2 JAMA: 2006-07-05, Vol. 296, No. 1, Author in the Room Audio Interview By dx.doi.org Published On :: Fri, 22 Sep 2006 18:00:00 +0000 Interview with David Gonzales, PhD, and Stephen Rennard, MD, authors of Helping Patients Stop Smoking: Varenicline vs Bupropion, published in the July 5 issue of JAMA, the Journal of the American Medical Association. Summary Points: 1. There is a new and novel pharmaceutical approach to treating nicotine addiction that helps smokers quit by specifically targeting nicotine receptors. 2. Efficacy for varenicline was three to four times that of placebo and twice that of bupropion at the end of 12 weeks of treatment, but abstinence rates in all groups declined after drug treatment ended. 3. The launch of a new smoking cessation medication will likely drive patient demand for smoking cessation services. Medical practices should be prepared to respond to this demand by having a clear, systematic approach to smoking cessation. Full Article
2 JAMA: 2006-08-02, Vol. 296, No. 5, Author in the Room Audio Interview By dx.doi.org Published On :: Tue, 26 Sep 2006 18:00:00 +0000 Interview with Harriet L. MacMillan, MD, MSc, FRCP(C), author of Approaches to Screening for Intimate Partner Violence in Health Care Settings: A Randomized Trial, published in the August 8 issue of JAMA, the Journal of the American Medical Association. Summary Points: 1. Even though we have long assumed that clinicians should ask patients directly about intimate partner violence, this study shows that self-complete methods for soliciting such information are preferred by women, and may be more efficient. 2. The prevalence rate for intimate partner violence differs by setting and population and varies significantly from approximately 4% to approximately 18%. 3. While this study provides evidence on the best methods to solicit information on intimate partner violence, it doesn't tell us if collecting this information improves outcomes for women exposed to such violence. A randomized controlled trial evaluating the effectiveness of screening women for intimate partner violence in health care settings is currently underway. Full Article
2 JAMA: 2006-09-13, Vol. 296, No. 10, Author in the Room Audio Interview By dx.doi.org Published On :: Wed, 18 Oct 2006 20:00:00 +0000 Interview with David Mark Spiro, MD, MPH, author of Wait-and-See Prescription for the Treatment of Acute Otitis, published in the September 13 issue of JAMA, the Journal of the American Medical Association. Summary Points: 1. Wait-and-See Prescription (WASP) is a viable approach to managing children with acute otitis media. Compared with the standard prescription group, the WASP group filled the antimicrobial prescription much less frequently and had equivalent clinical outcomes. 2. Within the WASP group, fever and ear pain were associated with filling the prescription demonstrating that parents are able to make appropriate care decisions when given clear guidance. 3. In the management of acute otitis media, important points for clinicians are first to make right diagnosis and then to provide sufficient analgesia. Adequate pain control allows parents to better manage their sick child and use antimicrobials judiciously while also reducing the risk of medical adverse effects and antibiotic resistance. Full Article
2 JAMA: 2006-10-18, Vol. 296, No. 15, Author in the Room Audio Interview By dx.doi.org Published On :: Thu, 16 Nov 2006 20:00:00 +0000 Interview with Dariush Mozaffarian, MD, DrPH, author of Fish Intake, Contaminants, and Human Health, published in the October 18 issue of JAMA, the Journal of the American Medical Association. Summary Points: 1. For the general population, the health benefits of fish intake far outweigh the risks. 2. Women of childbearing age, nursing mothers and young children should eat up to two servings of fish per week as the benefits of fish intake still outweigh the risks. 3. Given the magnitude of the benefits, physicians should regularly give dietary advice to patients for cardiovascular disease prevention. Full Article
2 JAMA: 2006-11-15, Vol. 296, No. 19, Author in the Room Audio Interview By dx.doi.org Published On :: Wed, 24 Jan 2007 20:00:00 +0000 Interview with Louise Walter, MD, author of PSA Screening Among Elderly Men With Limited Life Expectancies. Summary Points: 1. Most cancer screening guidelines do not recommend screening elderly persons in poor health who have limited life expectancies because the harms of screening (which occur immediately) outweigh the potential benefits (which occur many years in the future). 2. PSA screening rates among elderly men with limited life expectancies should be much lower than current practice to avoid harming these men with unnecessary tests and procedures. 3. Guidelines should be more explicit about how life expectancy is defined and provide tools to help clinicians identify men with poor prognoses who are most likely to be harmed by PSA screening, considering both age and the presence of severe disease. Full Article
2 JAMA: 2006-12-27, Vol. 296, No. 24, Author in the Room Audio Interview By dx.doi.org Published On :: Wed, 24 Jan 2007 20:00:00 +0000 Interview with Dennis Black, PhD, author of The Effects of Continuing or Stopping Alendronate after Five Years of Treatment: Results from the Fracture Intervention Trial Long-term Extension. Summary Points: 1. The long-term use of alendronate for up to 10 years is safe. 2. Those who discontinued treatment at 5 years lost bone mass compared with those who continued but the bone loss was only moderate. Rates of fracture were similar among those who continued vs those who discontinued except for clinical vertebral fractures which, although relatively uncommon, were higher in those who discontinued treatment. 3. Results suggest that after 5 years of alendronate, many women may discontinue therapy for up to 5 years. However, those at high risk of clinical vertebral fracture may benefit by continuing. Full Article