cia Chatham House Primer: Democratic Socialism By feedproxy.google.com Published On :: Thu, 13 Feb 2020 00:00:00 +0000 Full Article
cia Identification of an Unconventional Subpeptidome Bound to the Behcet's Disease-associated HLA-B*51:01 that is Regulated by Endoplasmic Reticulum Aminopeptidase 1 (ERAP1) [Research] By feedproxy.google.com Published On :: 2020-05-01T00:05:26-07:00 Human leukocyte antigen (HLA) B*51:01 and endoplasmic reticulum aminopeptidase 1 (ERAP1) are strongly genetically associated with Behcet's disease (BD). Previous studies have defined two subgroups of HLA-B*51 peptidome containing proline (Pro) or alanine (Ala) at position 2 (P2). Little is known about the unconventional non-Pro/Ala2 HLA-B*51-bound peptides. We aimed to study the features of this novel subpeptidome, and investigate its regulation by ERAP1. CRISPR-Cas9 was used to generate an HLA-ABC-triple knockout HeLa cell line (HeLa.ABC-KO), which was subsequently transduced to express HLA-B*51:01 (HeLa.ABC-KO.B51). ERAP1 was silenced using lentiviral shRNA. Peptides bound to HLA-B*51:01 were eluted and analyzed by mass spectrometry. The characteristics of non-Pro/Ala2, Pro2, and Ala2 peptides and their alteration by ERAP1 silencing were investigated. Effects of ERAP1 silencing on cell surface expression of HLA-B*51:01 were studied using flow cytometry. More than 20% of peptides eluted from HLA-B*51:01 lacked Pro or Ala at P2. This unconventional group of HLA-B*51:01-bound peptides was relatively enriched for 8-mers (with relatively fewer 9-mers) compared with the Pro2 and Ala2 subpeptidomes and had similar N-terminal and C-terminal residue usages to Ala2 peptides (with the exception of the less abundant leucine at position ). Knockdown of ERAP1 increased the percentage of non-Pro/Ala2 from 20% to ~40%, increased the percentage of longer (10-mer and 11-mer) peptides eluted from HLA-B*51:01 complexes, and abrogated the predominance of leucine at P1. Interestingly knockdown of ERAP1 altered the length and N-terminal residue usage of non-Ala2&Pro2 and Ala2 but not the Pro2 peptides. Finally, ERAP1 silencing regulated the expression levels of cell surface HLA-B*51 in a cell-type-dependent manner. In conclusion, we have used a novel methodology to identify an unconventional but surprisingly abundant non-Pro/Ala2 HLA-B*51:01 subpeptidome. It is increased by knockdown of ERAP1, a gene affecting the risk of developing BD. This has implications for theories of disease pathogenesis. Full Article
cia Decreased Immunoglobulin G Core Fucosylation, A Player in Antibody-dependent Cell-mediated Cytotoxicity, is Associated with Autoimmune Thyroid Diseases [Research] By feedproxy.google.com Published On :: 2020-05-01T00:05:26-07:00 Autoimmune thyroid diseases (AITD) are the most common group of autoimmune diseases, associated with lymphocyte infiltration and the production of thyroid autoantibodies, like thyroid peroxidase antibodies (TPOAb), in the thyroid gland. Immunoglobulins and cell-surface receptors are glycoproteins with distinctive glycosylation patterns that play a structural role in maintaining and modulating their functions. We investigated associations of total circulating IgG and peripheral blood mononuclear cells glycosylation with AITD and the influence of genetic background in a case-control study with several independent cohorts and over 3,000 individuals in total. The study revealed an inverse association of IgG core fucosylation with TPOAb and AITD, as well as decreased peripheral blood mononuclear cells antennary α1,2 fucosylation in AITD, but no shared genetic variance between AITD and glycosylation. These data suggest that the decreased level of IgG core fucosylation is a risk factor for AITD that promotes antibody-dependent cell-mediated cytotoxicity previously associated with TPOAb levels. Full Article
cia Chile’s Social Unrest: Why It’s Time to Get Serious about a ‘Just’ Transition By feedproxy.google.com Published On :: Mon, 04 Nov 2019 15:40:38 +0000 4 November 2019 Patrick Schröder Senior Research Fellow, Energy, Environment and Resources Programme @patricks_CH Google Scholar President Sebastián Piñera’s decision to cancel the COP25 climate negotiations, which Chile was due to host in early December, shows the importance of ensuring the transition to a sustainable world is just. 2019-11-04-Chile-Protests.jpg Demonstrators march in Santiago, Chile during street protests which erupted over a now suspended hike in metro ticket prices. Photo: Getty Images. One year ago, during the last annual Conference of Parties (COP) held in Katowice, the Polish government launched a Solidarity and Just Transition Declaration, signed by 56 governments including the UK, making the case for why the green transition must be just.Three years earlier in 2015, the landmark Paris Agreement also included provisions for a just transition where it stated that the decarbonization process should be ‘Taking into account the imperatives of a just transition of the workforce and the creation of decent work and quality jobs in accordance with nationally defined development priorities’. In practice, however, the concept of a just transition has not yet been implemented and has not been sufficiently considered by governments or corporations around the world.The social unrest that has erupted in Chile’s capital Santiago over the past month, which has forced the Chilean government to ask to move this year’s COP to Madrid, is a case in point. This discontent clearly shows that climate action cannot be separated from social justice concerns. There has not been a real commitment by governments to ensure a just transition based on social dialogue from the local to the national level. This was seen in France with the gilets jaunes protests in November 2018 – one month after President Emmanuel Macron ended the so-called ‘fortune tax’ and instead introduced taxes on diesel fuel as part of an effort to transition to green energy – and the current situation in Chile has some striking parallels. Sustainability transitions are a complex web of political choices and investment decisions which affect countries and societies in many different ways. Questions of social justice are everywhere, but in most cases, poorly understood by decision-makers. For example, although poverty has been reduced significantly over the last decade, Chile has one of the worst rates of inequality in Latin America and the highest Gini index in the OECD. The decisions taken in 2017 to power Metro de Santiago with solar photovoltaics and wind energy are commendable from a climate perspective, however, it led to students and young people protesting against rises in subway fares in October 2019.They were joined by Chileans who are frustrated with rising living costs and by workers and trade unions struggling with low wages. As reported by the Chilean Human Rights Commission (INDH), so far more than 4,200 people have been arrested and more than 1,300 injured and hospitalized.Climate negotiations beyond technicalitiesThis time there is also another important dimension to the protests: social unrest as a reaction to worsening inequality has the potential to derail multilateral cooperation on climate change and other global issues. Since tackling climate change is a race against the clock, the world faces the challenge of addressing both urgency and equity. The world cannot afford delays and needs to move fast but decision-makers need to take time for deliberation and civic participation to avoid rapid and ill-conceived transitions which eventually meet public resistance.Many technical experts and negotiators, who often unintentionally divorce climate policy and technical discussions about emission reductions from social justice concerns, have been caught by surprise by the cancellation of the negotiations. For this year’s COP, one important focus of the official negotiations are the so-called 'Article 6 Rules' – the accounting mechanisms and modalities for a new form of international interaction on carbon markets and off-setting to ensure carbon markets can support countries in enhancing the ambitions of their stated climate action, known as Nationally Determined Contributions (NDCs). What is becoming much more obvious now is that just transitions are at least equally important for achieving NDCs and other long-term mitigation strategies.In order to meet the 1.5 degree target, stated by the Intergovernmental Panel on Climate Change (IPCC), the world will have to invest an average of around $3 trillion a year over the next three decades in transforming its energy supply systems. But how can we ensure that these investments benefit low-income communities? Will they further increase everyday living costs? The climate finance related discussions focussing on commercially-oriented investments for low-carbon energy systems in most cases only consider the aspect of affordability, but not the other important principles of alternative ‘just’ energy finance, such as good governance, due process, intra-generational equity, spatial equity and financial resilience. Investments to support just transitions need to ensure investments, not only for large energy infrastructure, but also in the jobs, skills and work vital to both adaptation and mitigation.Just transitions for a circular economy The just transition concept is also the entry point to broader discussions about inclusive economic transformations, questioning the dominant paradigm of consumerism and ending the wasteful use of critical resources. The current linear economic model of take-make-throw away – in Chile epitomized by the linear extractive model of the mining sector that has contributed to widening inequality – the linear extractive model is not only destructive on the natural environment but also destructive for social cohesion.In Chile, the commodity boom in copper production – the country accounts for about 30 per cent of the world’s output – and more recently lithium – which is used in batteries for mobile phones, laptops and electric cars – have generated enormous prosperity in Chile. But the wealth has been unequally distributed and has not been used to lay the foundation for raising the overall level of incomes.A socially embedded and inclusive circular economy can, therefore, be a way forward from the current situation the Latin American country finds itself in. The circular economy was intended to feature prominently during the 25th COP and Chile’s policies – from the Ministry of Environment and Chile's Production Development Corporation (CORFO) – have played an important role in supporting the development of a circular economy, launching in 2018, the first public circular economy programme in Latin America. The government’s support for start-up companies and entrepreneurs to develop inclusive circular economy business models is the right approach to addressing the issues of waste, employment, services for low-income communities and local economic development. These are solutions that need to be scaled up having the potential to reduce Chile’s economic reliance on the dominant extractive model.As a global community, it is necessary to address the environmental and social objectives equally as not addressing social objectives will become an obstacle in achieving climate mitigation and solving other environmental issues. The Chilean protests are a wake-up call and present an opportunity for the global climate change community – which includes governments – to ensure just transitions are implemented in practice. Full Article
cia Schnyder corneal dystrophy-associated UBIAD1 is defective in MK-4 synthesis and resists autophagy-mediated degradation [Research Articles] By feedproxy.google.com Published On :: 2020-05-01T00:05:27-07:00 The autosomal dominant disorder Schnyder corneal dystrophy (SCD) is caused by mutations in UbiA prenyltransferase domain-containing protein-1 (UBIAD1), which uses geranylgeranyl pyrophosphate (GGpp) to synthesize the vitamin K2 subtype menaquinone-4 (MK-4). SCD is characterized by opacification of the cornea, owing to aberrant build-up of cholesterol in the tissue. We previously discovered that sterols stimulate association of UBIAD1 with ER-localized HMG-CoA reductase, which catalyzes a rate-limiting step in the synthesis of cholesterol and nonsterol isoprenoids, including GGpp. Binding to UBIAD1 inhibits sterol-accelerated ER-associated degradation (ERAD) of reductase and permits continued synthesis of GGpp in cholesterol-replete cells. GGpp disrupts UBIAD1-reductase binding and thereby allows for maximal ERAD of reductase as well as ER-to-Golgi translocation of UBIAD1. SCD-associated UBIAD1 is refractory to GGpp-mediated dissociation from reductase and remains sequestered in the ER to inhibit ERAD. Here, we report development of a biochemical assay for UBIAD1-mediated synthesis of MK-4 in isolated membranes and intact cells. Using this assay, we compared enzymatic activity of WT UBIAD1 with that of SCD-associated variants. Our studies revealed that SCD-associated UBIAD1 exhibited reduced MK-4 synthetic activity, which may result from its reduced affinity for GGpp. Sequestration in the ER protects SCD-associated UBIAD1 from autophagy and allows intracellular accumulation of the mutant protein, which amplifies the inhibitory effect on reductase ERAD. These findings have important implications not only for the understanding of SCD etiology but also for the efficacy of cholesterol-lowering statin therapy, which becomes limited, in part, because of UBIAD1-mediated inhibition of reductase ERAD. Full Article
cia Assad’s extortion fails to ease Syria’s financial crisis By feedproxy.google.com Published On :: Mon, 24 Feb 2020 14:55:32 +0000 Source Arab News URL https://www.arabnews.com/node/1625786 Release date 10 February 2020 Expert Haid Haid In the news type Op-ed Hide date on homepage Full Article
cia China already leads 4 of the 15 U.N. specialized agencies — and is aiming for a 5th By feedproxy.google.com Published On :: Thu, 05 Mar 2020 10:58:21 +0000 Source The Washington Post URL https://www.washingtonpost.com/politics/2020/03/03/china-already-leads-4-15-un-s... Release date 03 March 2020 Expert Courtney J. Fung In the news type Op-ed Hide date on homepage Full Article
cia What is best practice to choose social profile username? By forums.digitalpoint.com Published On :: Fri, 08 May 2020 23:38:07 +0000 Full Article
cia What's Your Favorite Social Media Platform? By forums.digitalpoint.com Published On :: Sat, 09 May 2020 10:55:55 +0000 Full Article
cia Summary Outcomes of the Fifth Meeting of the BCH Informal Advisory Committee (BCH IAC). The BCH IAC provides guidance regarding the technical issues associated with the ongoing development of the BCH. By www.cbd.int Published On :: Thu, 18 Feb 2010 00:00:00 GMT Full Article
cia Facial recognition on the rise: can current laws protect the public? By www.techworld.com Published On :: Thu, 29 Aug 2019 14:00:00 GMT The ICO is investigating reports that a property developer has quietly installed a facial recognition system in London's King's Cross. We spoke to experts from the legal and technology sectors to find some clarity about the rules Full Article
cia CBD Communiqé: Training Workshop for Government Officials in the Use of the Biosafety Clearing-House Successfully Concluded. By www.cbd.int Published On :: Sun, 11 May 2008 00:00:00 GMT Full Article
cia CBD News: Statement by the Executive Secretary, Ahmed Djoghlaf, at the Annual Ministerial Review of the High-level Segment of the 2008 Substantive Session of the Economic and Social Council, United Nations, New York, 1 July 2008 By www.cbd.int Published On :: Tue, 01 Jul 2008 00:00:00 GMT Full Article
cia CBD News: The province of Santa Elena, Ecuador, proclaims "A Provincial Day for Protected Areas" By www.cbd.int Published On :: Fri, 26 Sep 2008 00:00:00 GMT Montreal, 26 September 2008 - The province of Santa Elena, the newest province in Ecuador, emerged as the first jurisdiction in the world to proclaim a provincial day for protected areas, the Prefecta of the province, Ms. Ana Triviño Cisneros, has announced. To be celebrated annually on 23 September, the Day celebrates the designation of a new marine protected area off Ecuador's coast aimed at conserving about 47,000 hectares of some of the world's most spectacular biodiversity. Full Article
cia CBD News: Joint press-release by GEF and CBD on the approval by the GEF Council of a special initiative designed to build global awareness and catalyze decisive action during the upcoming 2010 International Year of Biodiversity (IYB). By www.thegef.org Published On :: Wed, 24 Jun 2009 00:00:00 GMT Full Article
cia CBD Communiqué: G-77 Ministers Pay Special Tribute to CBD Secretariat's Leading Role in South-South Cooperation. By www.cbd.int Published On :: Fri, 25 Sep 2009 00:00:00 GMT Full Article
cia CBD News: Statement by dr. Ahmed Djoghlaf, Executive Secretary, at the Special East Partnership Council Meeting: East Asian Seas Congress 2009, Manila, Philippines, 25 November 2009. By www.cbd.int Published On :: Wed, 25 Nov 2009 00:00:00 GMT Full Article
cia CBD News: The Natural History Museum (United Kingdom) launches its official International Year of Biodiversity website: www.biodiversityislife.net By www.biodiversityislife.net Published On :: Mon, 30 Nov 2009 00:00:00 GMT http://www.biodiversityislife.net/ Full Article
cia CBD News: Statement by Mr Ahmed Djoghlaf, Executive Secretary of the Convention on Biological Diversity, on the occasion of the Official Launch of the International Year of Biodiversity, 11 January 2010, Berlin, Germany. By www.bmu.de Published On :: Mon, 11 Jan 2010 00:00:00 GMT Full Article
cia CBD Press Release: German Chancellor Angela Merkel and UN Secretary-General Ban Ki-moon officially launch the International Year of Biodiversity. By www.cbd.int Published On :: Tue, 12 Jan 2010 00:00:00 GMT Full Article
cia CBD News: Statement by Mr Ahmed Djoghlaf, Executive Secretary of the Convention on Biological Diversity, on the occasion of the 'Green Economy' Roundtable at the Eleventh Special Session of the United Nations Environment Programme Governing Counci By www.cbd.int Published On :: Thu, 25 Feb 2010 00:00:00 GMT Full Article
cia CBD Press Release: The Government of Finland Announces International Support for Sustaining Biodiversity in Association with the Life Web Initiative. By www.cbd.int Published On :: Tue, 16 Mar 2010 00:00:00 GMT Full Article
cia CBD Announcement: On behalf of the European Commission and in collaboration with EU Member States, STELLA Consulting is organising annual information sessions on preparing LIFE+ project proposals and managing LIFE+ projects. LIFE+ is the Financial Instrum By www.cbd.int Published On :: Fri, 09 Apr 2010 00:00:00 GMT Full Article
cia CBD News: Message by Mr. Ahmed Djoghlaf, Executive Secretary of the Convention on Biological Diversity, on the occasion of the First International Conference of ATUTAX, the Association Tunisienne de Taxonomie, Cité des Sciences de Tunis, 23-25 April By www.cbd.int Published On :: Fri, 23 Apr 2010 00:00:00 GMT Full Article
cia CBD News: Statement by the Executive Secretary, Mr. Ahmed Djoghlaf, at the occasion of the Official Launch of the Third Edition of Global Biodiversity Outlook, 10 May 2010, UNEP, Nairobi. By www.cbd.int Published On :: Mon, 10 May 2010 00:00:00 GMT Full Article
cia CBD Press Release: Government of Finland Announces International Support for Sustaining Biodiversity in Association with the LifeWeb Initiative. By www.cbd.int Published On :: Tue, 25 May 2010 00:00:00 GMT Full Article
cia CBD Communiqué: Establishment of Canadian "Friends of the CBD" Association to Support Canada's Efforts in Protecting Biodiversity. By www.cbd.int Published On :: Wed, 30 Jun 2010 00:00:00 GMT Full Article
cia CBD Press Release: Georgian Bank Supports Biodiversity in the South Caucasus in Association with the Lifeweb Initiative. By www.cbd.int Published On :: Mon, 27 Sep 2010 00:00:00 GMT Full Article
cia CBD Communiqué: Building bridges for Biodiversity: Governor of Ishikawa Prefecture pays official visit to the Secretariat of the Convention on Biological Diversity. By www.cbd.int Published On :: Wed, 29 Sep 2010 00:00:00 GMT Full Article
cia CBD News: Statement by Mr. Ahmed Djoghlaf, CBD Executive Secretary, on the occasion of the Pre-COP10-MOP5 Citizen Forum - Social Sustainability and Biological Safety Policy Reactions & Public Participation, Nagoya, Japan, 9 October 2010. By www.cbd.int Published On :: Sat, 09 Oct 2010 00:00:00 GMT Full Article
cia CBD Press Release: German Chancellor Angela Merkel Awarded Special Biodiversity Prize. By www.cbd.int Published On :: Fri, 29 Oct 2010 00:00:00 GMT Full Article
cia CBD News: Message by Mr Ahmed Djoghlaf, CBD Executive Secretary, on the occasion of the Seminar "Bananas and Bamboo": Biodiversity Management of at Risk Commercially Valuable Crops through Community-Technology Integration, 29-30 November 2010, K By www.cbd.int Published On :: Mon, 29 Nov 2010 00:00:00 GMT Full Article
cia CBD Notification: Report of the Second Committee of the United Nations General Assembly. Sustainable development: report of the Governing Council of the United Nations Environment Programme on its eleventh special session. By www.cbd.int Published On :: Wed, 22 Dec 2010 00:00:00 GMT Full Article
cia CBD Announcement: On behalf of the European Commission and in collaboration with EU Member States, STELLA Consulting is organising annual information sessions on preparing LIFE+ project proposals and managing LIFE+ projects. LIFE+ is the Financial Instrum By www.cbd.int Published On :: Tue, 11 Jan 2011 00:00:00 GMT Full Article
cia CBD News: 15e École d'été en évaluation environnementale Évaluation de la durabilité du développement urbain et industriel: outils d'analyse de l'empreinte écologique et des impacts sociaux et sanitaires By www.cbd.int Published On :: Tue, 01 Feb 2011 00:00:00 GMT Full Article
cia CBD Communiqué: Joint GEF and CBD Exploration for Financial Solutions to Global Biodiversity Challenges in Eastern Europe. By www.cbd.int Published On :: Mon, 28 Mar 2011 00:00:00 GMT Full Article
cia CBD Press Release: Policy makers and senior officials briefed on the coherent implementation of the International Treaty on Plant Genetic Resources for Food and Agriculture and the Nagoya Protocol By www.cbd.int Published On :: Thu, 30 Jun 2011 00:00:00 GMT Full Article
cia CBD News: The Society for Ecological Restoration has conferred its 2011 Special Recognition Award to the Parties to the Convention on Biological Diversity (CBD) at the Gala Awards Banquet on 23 August 2011 in Mérida, Yucatán, Mexico, on the marg By www.cbd.int Published On :: Wed, 24 Aug 2011 00:00:00 GMT Full Article
cia CBD Communiqué: United Nations University launches Master of Science programme in nvironmental Governance with specialization in Biodiversity By www.cbd.int Published On :: Tue, 11 Oct 2011 00:00:00 GMT Full Article
cia CBD Communiqué: Japan Airlines introduces United Nations Decade on Biodiversity logo on special "Eco Jet" By www.cbd.int Published On :: Wed, 12 Oct 2011 00:00:00 GMT Full Article
cia CBD Communiqué: World Association of Zoos and Aquariums mobilized for the United Nations Decade on Biodiversity By www.cbd.int Published On :: Fri, 14 Oct 2011 00:00:00 GMT Full Article
cia CBD News: Remarks by Mr. Braulio Ferreira de Souza Dias, CBD Executive Secretary at the Special evening event with the participation of school and college students, on the occasion of the International Day for Biological Diversity, 22 May 2012, Marina Bea By www.cbd.int Published On :: Tue, 22 May 2012 00:00:00 GMT Full Article
cia CBD News: Statement by Mr. Braulio Ferreira de Souza Dias, CBD Executive Secretary, on the occasion of Special Event Celebrating the Twentieth Anniversary of the 1992 Earth Summit, 15 June 2012, Rio de Janeiro, Brazil By www.cbd.int Published On :: Fri, 15 Jun 2012 00:00:00 GMT Full Article
cia CBD News: Rio de Janeiro 22 June 2012. The nations of the world have recognized the crucial role of biodiversity in ensuring sustainable development in the outcome document of the Rio + 20 conference and called for greater efforts to implement the Convent By www.cbd.int Published On :: Fri, 22 Jun 2012 00:00:00 GMT Full Article
cia CBD News: The Ministry of Environment and Forests, Government of India, and the National Biodiversity Authority are hosting an International Biodiversity Film Festival and Forum in Hyderabad as part of COP-11 in association with CMS Environment. The festi By www.cbd.int Published On :: Sat, 06 Oct 2012 00:00:00 GMT Full Article
cia CBD Press Release: At United Nations Biodiversity Conference, countries agree to double resources for biodiversity protection by 2015 - Special attention for biodiversity-rich marine areas among other key outcomes. By www.cbd.int Published On :: Sat, 20 Oct 2012 00:00:00 GMT Full Article
cia CBD News: Biodiversity at the centre of sustainable development: CBD Executive Secretary Braulio Ferreira de Souza Dias briefs UN Secretary-General, senior UN officials. By www.cbd.int Published On :: Thu, 07 Feb 2013 00:00:00 GMT Full Article
cia CBD News: Braulio F. de Souza Dias participates in event "Biodiversity and Business: Perspectives from the Region" and pays a visit to Uruguayan state officials. By www.mvotma.gub.uy Published On :: Thu, 25 Jul 2013 00:00:00 GMT Full Article
cia CBD News: Articles are presently being sought from members of civil society (including NGOs, social movements, indigenous organizations and representatives, local communities) for the eighth issue of the CBD newsletter for civil society, [square brackets] By www.cbd.int Published On :: Mon, 05 Aug 2013 00:00:00 GMT Full Article
cia CBD News: The World Public Health Nutrition Association (WPHNA) has been declared a Biodiversity Champion by the Executive Secretary of the Convention on Biological Diversity (CBD) in recognition of its important contribution to the implementation of th By www.cbd.int Published On :: Fri, 29 Nov 2013 00:00:00 GMT Full Article