a c A Credit-fuelled Economic Recovery Stores Up Trouble for Turkey By feedproxy.google.com Published On :: Mon, 17 Feb 2020 13:47:40 +0000 17 February 2020 Fadi Hakura Consulting Fellow, Europe Programme LinkedIn Turkey is repeating the mistakes that led to the 2018 lira crisis and another freefall for the currency may not be far off. 2020-02-17-TurCB.jpg Headquarters of the Central Bank of the Republic of Turkey. Photo: Getty Images. Since the 2018 economic crisis, when the value of the lira plummeted and borrowing costs soared, Turkey’s economy has achieved a miraculous ‘V-shaped’ economic recovery from a recession lasting three quarters to a return back to quarterly growth above 1 per cent in the first three months of 2019.But this quick turnaround has been built on vast amounts of cheap credit used to re-stimulate a consumption and construction boom. This so-called ‘triple C’ economy generated a rapid growth spurt akin to a modestly able professional sprinter injected with steroids.This has made the currency vulnerable. The lira has steadily depreciated by 11 per cent against the US dollar since the beginning of 2019 and crossed the rate of 6 lira versus the US dollar on 7 February. And there are further warning signs on the horizon.Credit bonanzaStatistics reveal that Turkish domestic credit grew by around 13 per cent on average throughout 2019. The credit bonanza is still ongoing. Mortgage-backed home sales jumped by a record high of 600 per cent last December alone and the 2019 budget deficit catapulted by 70 per cent due to higher government spending.Turkey’s central bank fuelled this credit expansion by cutting interest rates aggressively to below inflation and, since the start of this year, purchasing lira-denominated bonds equivalent to around one-third of total acquisitions last year to push yields lower.Equally, it has linked bank lending to reserve requirements – the money that banks have to keep at the central bank – to boost borrowings via state and private banks. Banks with a ‘real’ loan growth (including inflation) of between 5 and 15 per cent enjoy a 2 per cent reserve ratio on most lira deposits, which authorities adjusted from an earlier band of 10-20 per cent that did not consider double-digit inflation.Cumulatively, bond purchases (effectively quantitative easing) and reserve management policies have also contributed to eased credit conditions.Commercial banks have also reduced deposit rates on lira accounts to less than inflation to encourage consumption over saving. Together with low lending rates, the boost to the economy has flowed via mortgages, credit card loans, vehicle leasing transactions and general business borrowings.Accordingly, stimulus is at the forefront of the government’s economic approach, as it was in 2017 and 2018. It does not seem to be implementing structural change to re-orient growth away from consumption towards productivity. In addition, governance is, again, a central issue. President Recep Tayyip Erdogan’s near total monopolization of policymaking means he guides all domestic and external policies. He forced out the previous central bank governor, Murat Cetinkaya, in July 2019 because he did not share the president’s desire for an accelerated pace of interest rate reductions.New challengesDespite the similarities, the expected future financial turbulence will be materially different from its 2018 predecessor in four crucial respects. Firstly, foreign investors will only be marginally involved. Turkey has shut out foreign investors since 2018 from lira-denominated assets by restricting lira swap arrangements. Unsurprisingly, the non-resident holdings of lira bonds has plummeted from 20 per cent in 2018 to less than 10 per cent today.Secondly, the Turkish government has recently introduced indirect domestic capital controls by constraining most commercial transactions to the lira rather than to the US dollar or euro to reduce foreign currency demand in light of short-term external debt obligations of $191 billion.Thirdly, the Turkish state banks are intervening quite regularly to soften Lira volatility, thereby transitioning from a ‘free float’ to a ‘managed float’. So far, they have spent over $37 billion over the last two years in a futile effort to buttress the lira. This level of involvement in currency markets cannot be maintained.Fourthly, the Turkish state is being far more interventionist in the Turkish stock exchange and bond markets to keep asset prices elevated. Government-controlled local funds have participated in the Borsa Istanbul and state banks in sovereign debt to sustain rallies or reverse a bear market. All these measures have one running idea: exclude foreign investors and no crisis will recur. Yet, when the credit boom heads to a downturn sooner or later, Turks will probably escalate lira conversions to US dollars; 51 per cent of all Turkish bank deposits are already dollar-denominated and the figure is still rising.If Turkey’s limited foreign reserves cannot satisfy the domestic dollar demand, the government may have to impose comprehensive capital controls and allow for a double digit depreciation in the value of the lira to from its current level, with significant repercussions on Turkey’s political stability and economic climate.To avoid this scenario, it needs to restore fiscal and monetary prudence, deal the with the foreign debt overhang in the private sector and focus on productivity-improving economic and institutional reforms to gain the confidence of global financial markets and Turks alike. Full Article
a c The Escherichia coli cellulose synthase subunit G (BcsG) is a Zn2+-dependent phosphoethanolamine transferase [Glycobiology and Extracellular Matrices] By feedproxy.google.com Published On :: 2020-05-01T00:06:09-07:00 Bacterial biofilms are cellular communities that produce an adherent matrix. Exopolysaccharides are key structural components of this matrix and are required for the assembly and architecture of biofilms produced by a wide variety of microorganisms. The human bacterial pathogens Escherichia coli and Salmonella enterica produce a biofilm matrix composed primarily of the exopolysaccharide phosphoethanolamine (pEtN) cellulose. Once thought to be composed of only underivatized cellulose, the pEtN modification present in these matrices has been implicated in the overall architecture and integrity of the biofilm. However, an understanding of the mechanism underlying pEtN derivatization of the cellulose exopolysaccharide remains elusive. The bacterial cellulose synthase subunit G (BcsG) is a predicted inner membrane–localized metalloenzyme that has been proposed to catalyze the transfer of the pEtN group from membrane phospholipids to cellulose. Here we present evidence that the C-terminal domain of BcsG from E. coli (EcBcsGΔN) functions as a phosphoethanolamine transferase in vitro with substrate preference for cellulosic materials. Structural characterization of EcBcsGΔN revealed that it belongs to the alkaline phosphatase superfamily, contains a Zn2+ ion at its active center, and is structurally similar to characterized enzymes that confer colistin resistance in Gram-negative bacteria. Informed by our structural studies, we present a functional complementation experiment in E. coli AR3110, indicating that the activity of the BcsG C-terminal domain is essential for integrity of the pellicular biofilm. Furthermore, our results established a similar but distinct active-site architecture and catalytic mechanism shared between BcsG and the colistin resistance enzymes. Full Article
a c It takes two (Las1 HEPN endoribonuclease domains) to cut RNA correctly [RNA] By feedproxy.google.com Published On :: 2020-05-01T00:06:09-07:00 The ribosome biogenesis factor Las1 is an essential endoribonuclease that is well-conserved across eukaryotes and a newly established member of the higher eukaryotes and prokaryotes nucleotide-binding (HEPN) domain-containing nuclease family. HEPN nucleases participate in diverse RNA cleavage pathways and share a short HEPN nuclease motif (RφXXXH) important for RNA cleavage. Most HEPN nucleases participate in stress-activated RNA cleavage pathways; Las1 plays a fundamental role in processing pre-rRNA. Underscoring the significance of Las1 function in the cell, mutations in the human LAS1L (LAS1-like) gene have been associated with neurological dysfunction. Two juxtaposed HEPN nuclease motifs create Las1's composite nuclease active site, but the roles of the individual HEPN motif residues are poorly defined. Here using a combination of in vivo experiments in Saccharomyces cerevisiae and in vitro assays, we show that both HEPN nuclease motifs are required for Las1 nuclease activity and fidelity. Through in-depth sequence analysis and systematic mutagenesis, we determined the consensus HEPN motif in the Las1 subfamily and uncovered its canonical and specialized elements. Using reconstituted Las1 HEPN-HEPN' chimeras, we defined the molecular requirements for RNA cleavage. Intriguingly, both copies of the Las1 HEPN motif were important for nuclease function, revealing that both HEPN motifs participate in coordinating the RNA within the Las1 active site. We also established that conformational flexibility of the two HEPN domains is important for proper nuclease function. The results of our work reveal critical information about how dual HEPN domains come together to drive Las1-mediated RNA cleavage. Full Article
a c Demystifying the media caricatures of Pussy Riot By feedproxy.google.com Published On :: Wed, 05 Feb 2014 12:13:19 +0000 6 February 2014 , Volume 70, Number 1 Masha Gessen, Words will Break Cement: The Passion of Pussy Riot, Granta, £8.70 Sean Guillory, author of seansrussiablog.org Guillory.jpg Maria Alyokhina and Nadazhda Tolokonnikova, two members of Pussy Riot, speak with their lawyer from a glass-walled cage in a court in Moscow. Photo: AFP/Getty Images Full Article
a c Promoting a Culture of Development and Investment: Lessons from the Post-War Era By feedproxy.google.com Published On :: Fri, 17 Oct 2014 10:30:01 +0000 Research Event 5 December 2014 - 1:00pm to 2:00pm Chatham House, London Event participants Giovanni Farese, Assistant Professor of Economic History, European University of RomeChair: Dr Paola Subacchi, Research Director, International Economics, Chatham House This event will discuss the rise of the culture of world development. It will examine the post-war reconstruction and development projects of the 1940s through to the 1960s, including those devised at Chatham House. The speaker will argue that these projects hold valuable lessons that still apply to the current economic environment. The speaker will also discuss the key role played by Eugene R Black (1898-1992), the third president of the International Bank for Reconstruction and Development (the World Bank), who was one of the main architects of post-war reconstruction and development projects and a promoter of a ‘culture of development’. Department/project Global Economy and Finance Programme Effie Theodoridou +44 (0)20 7314 2760 Email Full Article
a c Multivalent feedback regulation of HMG CoA reductase, a control mechanism coordinating isoprenoid synthesis and cell growth By feedproxy.google.com Published On :: 1980-07-01 MS BrownJul 1, 1980; 21:505-517Reviews Full Article
a c A spectrophotometric assay for lipid peroxides in serum lipoproteins using a commercially available reagent By feedproxy.google.com Published On :: 1989-04-01 M el-SaadaniApr 1, 1989; 30:627-630Articles Full Article
a c Fish oils and plasma lipid and lipoprotein metabolism in humans: a critical review By feedproxy.google.com Published On :: 1989-06-01 WS HarrisJun 1, 1989; 30:785-807Reviews Full Article
a c Plasma cholesteryl ester transfer protein By feedproxy.google.com Published On :: 1993-08-01 AR TallAug 1, 1993; 34:1255-1274Reviews Full Article
a c Virtual Roundtable: America’s China Challenge By feedproxy.google.com Published On :: Fri, 03 Apr 2020 14:50:01 +0000 Research Event 17 April 2020 - 2:00pm to 3:00pm Event participants Robert Zoellick, President of the World Bank Group, 2007 - 12Chair: Dr Leslie Vinjamuri, Director, US and the Americas Programme; Dean, Queen Elizabeth II Academy for Leadership in International Affairs, Chatham House This event is part of the Chatham House Global Trade Policy Forum. We would like to take this opportunity to thank founding partner AIG and supporting partners Clifford Chance LLP, Diageo plc, and EY for their generous support of the forum. Department/project US and the Americas Programme, Global Trade Policy Forum US and Americas Programme Email Full Article
a c The UK-Saudi Arabia Relationship: A Closer Look By feedproxy.google.com Published On :: Tue, 04 Sep 2018 00:00:00 +0100 Full Article
a c International Security Institutions: A Closer Look By feedproxy.google.com Published On :: Tue, 13 Nov 2018 00:00:00 +0000 Full Article
a c Leadership in the 21st Century: Jessica Cecil, BBC By feedproxy.google.com Published On :: Thu, 06 Dec 2018 00:00:00 +0000 Full Article
a c Belt and Road: A Chinese World Order? By feedproxy.google.com Published On :: Mon, 10 Dec 2018 00:00:00 +0000 Full Article
a c Undercurrents: Episode 29 - The Future of EU-US Trade, and Why Russia Confronts the West By feedproxy.google.com Published On :: Wed, 20 Mar 2019 00:00:00 +0000 Full Article
a c A Gulf Divided: The Anatomy of a Crisis By feedproxy.google.com Published On :: Thu, 06 Jun 2019 00:00:00 +0100 Full Article
a c Africa’s Economic Outlook in a Challenging External Environment By feedproxy.google.com Published On :: Mon, 10 Jun 2019 00:00:00 +0100 Full Article
a c A Conversation With: Steven T Mnuchin, Secretary, US Treasury By feedproxy.google.com Published On :: Sat, 25 Jan 2020 00:00:00 +0000 Full Article
a c Screening Room: Parts of a Circle - History of the Karabakh Conflict By feedproxy.google.com Published On :: Tue, 18 Feb 2020 00:00:00 +0000 Full Article
a c A comprehensive evaluation of a typical plant telomeric G-quadruplex (G4) DNA reveals the dynamics of G4 formation, rearrangement, and unfolding [Plant Biology] By feedproxy.google.com Published On :: 2020-04-17T00:06:05-07:00 Telomeres are specific nucleoprotein structures that are located at the ends of linear eukaryotic chromosomes and play crucial roles in genomic stability. Telomere DNA consists of simple repeats of a short G-rich sequence: TTAGGG in mammals and TTTAGGG in most plants. In recent years, the mammalian telomeric G-rich repeats have been shown to form G-quadruplex (G4) structures, which are crucial for modulating telomere functions. Surprisingly, even though plant telomeres are essential for plant growth, development, and environmental adaptions, only few reports exist on plant telomeric G4 DNA (pTG4). Here, using bulk and single-molecule assays, including CD spectroscopy, and single-molecule FRET approaches, we comprehensively characterized the structure and dynamics of a typical plant telomeric sequence, d[GGG(TTTAGGG)3]. We found that this sequence can fold into mixed G4s in potassium, including parallel and antiparallel structures. We also directly detected intermediate dynamic transitions, including G-hairpin, parallel G-triplex, and antiparallel G-triplex structures. Moreover, we observed that pTG4 is unfolded by the AtRecQ2 helicase but not by AtRecQ3. The results of our work shed light on our understanding about the existence, topological structures, stability, intermediates, unwinding, and functions of pTG4. Full Article
a c Structural basis of cell-surface signaling by a conserved sigma regulator in Gram-negative bacteria [Molecular Biophysics] By feedproxy.google.com Published On :: 2020-04-24T06:08:45-07:00 Cell-surface signaling (CSS) in Gram-negative bacteria involves highly conserved regulatory pathways that optimize gene expression by transducing extracellular environmental signals to the cytoplasm via inner-membrane sigma regulators. The molecular details of ferric siderophore-mediated activation of the iron import machinery through a sigma regulator are unclear. Here, we present the 1.56 Å resolution structure of the periplasmic complex of the C-terminal CSS domain (CCSSD) of PupR, the sigma regulator in the Pseudomonas capeferrum pseudobactin BN7/8 transport system, and the N-terminal signaling domain (NTSD) of PupB, an outer-membrane TonB-dependent transducer. The structure revealed that the CCSSD consists of two subdomains: a juxta-membrane subdomain, which has a novel all-β-fold, followed by a secretin/TonB, short N-terminal subdomain at the C terminus of the CCSSD, a previously unobserved topological arrangement of this domain. Using affinity pulldown assays, isothermal titration calorimetry, and thermal denaturation CD spectroscopy, we show that both subdomains are required for binding the NTSD with micromolar affinity and that NTSD binding improves CCSSD stability. Our findings prompt us to present a revised model of CSS wherein the CCSSD:NTSD complex forms prior to ferric-siderophore binding. Upon siderophore binding, conformational changes in the CCSSD enable regulated intramembrane proteolysis of the sigma regulator, ultimately resulting in transcriptional regulation. Full Article
a c South Africa Can Easily Afford National Health Insurance By feedproxy.google.com Published On :: Mon, 09 Dec 2019 06:07:40 +0000 9 December 2019 Robert Yates Director, Global Health Programme; Executive Director, Centre for Universal Health @yates_rob Countries with much lower per capita GDP have successfully implemented universal healthcare. 2019-12-06-NMCH.jpg Builders work on an outside yard at the Nelson Mandela Children's Hospital in Johannesburg in 2016. Photo: Getty Images. At the United Nations general assembly in September, all countries, including South Africa, reaffirmed their commitment to achieving universal health coverage by 2030. This is achieved when everybody accesses the health services they need without suffering financial hardship.As governments outlined their universal health coverage plans, it was noticeable that some had made much faster progress than others, with some middle-income countries outperforming wealthier nations. For example, whereas Thailand, Ecuador and Georgia (with national incomes similar to South Africa) are covering their entire populations, in the United States, 30 million people still lack health insurance and expensive health bills are the biggest cause of personal bankruptcy.The key factor in financing universal health coverage is, therefore, not so much the level of financing but rather how the health sector is financed. You cannot cover everyone through private financing (including insurance) because the poor will be left behind. Instead, the state must step in to force wealthy and healthy members of society to subsidise services for the sick and the poor.Switching to a predominantly publicly financed health system is, therefore, a prerequisite for achieving universal health coverage.The National Health Insurance (NHI) Bill, recently presented to parliament, is President Cyril Ramaphosa’s strategy to make this essential transition. In essence, it proposes creating a health-financing system in which people pay contributions (mostly through taxes) according to their ability to pay and then receive health services according to their health needs.Surprisingly, these reforms have been dubbed 'controversial' by some commentators in the South African media, even though this is the standard route to universal health coverage as exhibited by countries across Europe, Asia, Australasia, Canada and much of Latin America.In criticising the NHI other stakeholders (often with a vested interest in preserving the status quo) have said that the government’s universal health coverage strategy is unaffordable because it will require higher levels of public financing for health.Evidence from across the world shows that this is patently false. South Africa already spends more than 8% of its national income on its health sector, which is very high for its income level. Turkey, for example (a good health performer and slightly richer than South Africa), spends 4.3% of its GDP and Thailand (a global universal health coverage leader) spends only 3.7%. Thailand shows what can be accomplished, because it launched its celebrated universal health coverage reforms in 2002 when its GDP per capita was only $1 900 — less than a third of South Africa’s today.In fact, Thailand’s prime minister famously ignored advice from the World Bank that it could not afford publicly financed, universal health coverage in the aftermath of the Asian financial crisis when it extended universal, tax-financed healthcare to the entire population. When these reforms proved a great success, a subsequent president of the World Bank, Dr Jim Kim, congratulated the Thai government for ignoring its previous advice.Similarly the United Kingdom, Japan and Norway all launched successful universal health coverage reforms at times of great economic difficulty at the end of World War II. These should be salutary lessons for those saying that South Africa can’t afford the NHI. If anything, because universal health reforms generate economic growth (with returns 10 times the public investment), now is exactly the time to launch the NHI.So there is enough overall funding in the South African health sector to take a giant step towards universal health coverage. The problem is that the current system is grossly inefficient and inequitable because more than half of these funds are spent through private insurance schemes that cover only 16% of the population — and often don’t cover even this population effectively.Were the bulk of these resources to be channelled through an efficient public financing system, evidence from around the world shows that the health sector would achieve better health outcomes, at lower cost. Health and income inequalities would fall, too.It’s true that in the long term, the government will have to increase public financing through reducing unfair subsidies to private health insurance and increasing taxes. But what the defenders of the current system don’t acknowledge is that, at the same time, private voluntary financing will fall, rapidly. Most families will no longer feel the need to purchase expensive private insurance when they benefit from the public system. It’s this fact that is generating so much opposition to the NHI from the private insurance lobby.This is the situation with the National Health Service in the UK and health systems across Europe, where only a small minority choose to purchase additional private insurance. Among major economies, only the United States continues to exhibit high levels of private, voluntary financing.As a consequence, it now spends an eye-watering 18% of its GDP on health and has some of the worst health indicators in the Organisation for Economic Co-operation and Development, including rising levels of maternal mortality. If South Africa doesn’t socialise health financing this is where its health system will end up — a long way from universal health coverage.What countries celebrating their universal health coverage successes at the UN have shown is that it is cheaper to publicly finance health than leave it to the free market. This is because governments are more efficient and fairer purchasers of health services than individuals and employers. As Dr Gro Harlem Brundtland, the former director general of the World Health Organization, said in New York: 'If there is one lesson the world has learnt, it is that you can only reach UHC [universal health coverage] through public financing.'This is a step South Africa must take — it can’t afford not to.This article was originally published by the Mail & Guardian. Full Article
a c The Hurdles to Developing a COVID-19 Vaccine: Why International Cooperation is Needed By feedproxy.google.com Published On :: Thu, 23 Apr 2020 09:26:36 +0000 23 April 2020 Professor David Salisbury CB Associate Fellow, Global Health Programme LinkedIn Dr Champa Patel Director, Asia-Pacific Programme @patel_champa While the world pins its hopes on vaccines to prevent COVID-19, there are scientific, regulatory and market hurdles to overcome. Furthermore, with geopolitical tensions and nationalistic approaches, there is a high risk that the most vulnerable will not get the life-saving interventions they need. 2020-04-23-Covid-Vaccine.jpg A biologist works on the virus inactivation process in Belo Horizonte, Brazil on 24 March 2020. The Brazilian Ministry of Health convened The Technological Vaccine Center to conduct research on COVID-19 in order to diagnose, test and develop a vaccine. Photo: Getty Images. On 10 January 2020, Chinese scientists released the sequence of the COVID-19 genome on the internet. This provided the starting gun for scientists around the world to start developing vaccines or therapies. With at least 80 different vaccines in development, many governments are pinning their hopes on a quick solution. However, there are many hurdles to overcome. Vaccine developmentFirstly, vaccine development is normally a very long process to ensure vaccines are safe and effective before they are used. Safety is not a given: a recent dengue vaccine caused heightened disease in vaccinated children when they later were exposed to dengue, while Respiratory Syncytial Virus vaccine caused the same problem. Nor is effectiveness a given. Candidate vaccines that use novel techniques where minute fragments of the viruses’ genetic code are either injected directly into humans or incorporated into a vaccine (as is being pursued, or could be pursued for COVID-19) have higher risks of failure simply because they haven’t worked before. For some vaccines, we know what levels of immunity post-vaccination are likely to be protective. This is not the case for coronavirus. Clinical trials will have to be done for efficacy. This is not optional – regulators will need to know extensive testing has taken place before licencing any vaccine. Even if animal tests are done in parallel with early human tests, the remainder of the process is still lengthy. There is also great interest in the use of passive immunization, whereby antibodies to SARS-CoV-2 (collected from people who have recovered from infection or laboratory-created) are given to people who are currently ill. Antivirals may prove to be a quicker route than vaccine development, as the testing requirements would be shorter, manufacturing may be easier and only ill people would need to be treated, as opposed to all at-risk individuals being vaccinated.Vaccine manufacturingDevelopers, especially small biotechs, will have to make partnerships with large vaccine manufacturers in order to bring products to market. One notorious bottleneck in vaccine development is getting from proof-of-principle to commercial development: about 95 per cent of vaccines fail at this step. Another bottleneck is at the end of production. The final stages of vaccine production involve detailed testing to ensure that the vaccine meets the necessary criteria and there are always constraints on access to the technologies necessary to finalize the product. Only large vaccine manufacturers have these capacities. There is a graveyard of failed vaccine candidates that have not managed to pass through this development and manufacturing process.Another consideration is adverse or unintended consequences. Highly specialized scientists may have to defer their work on other new vaccines to work on COVID-19 products and production of existing products may have to be set aside, raising the possibility of shortages of other essential vaccines. Cost is another challenge. Vaccines for industrialized markets can be very lucrative for pharmaceutical companies, but many countries have price caps on vaccines. Important lessons have been learned from the 2009 H1N1 flu pandemic when industrialized countries took all the vaccines first. Supplies were made available to lower-income countries at a lower price but this was much later in the evolution of the pandemic. For the recent Ebola outbreaks, vaccines were made available at low or no cost. Geopolitics may also play a role. Should countries that manufacture a vaccine share it widely with other countries or prioritize their own populations first? It has been reported that President Trump attempted to purchase CureVac, a German company with a candidate vaccine. There are certainly precedents for countries prioritizing their own populations. With H1N1 flu in 2009, the Australian Government required a vaccine company to meet the needs of the Australian population first. Vaccine distributionGlobal leadership and a coordinated and coherent response will be needed to ensure that any vaccine is distributed equitably. There have been recent calls for a G20 on health, but existing global bodies such as the Coalition for Epidemic Preparedness Innovations (CEPI) and GAVI are working on vaccines and worldwide access to them. Any new bodies should seek to boost funding for these entities so they can ensure products reach the most disadvantaged. While countries that cannot afford vaccines may be priced out of markets, access for poor, vulnerable or marginalized peoples, whether in developed or developing countries, is of concern. Developing countries are at particular risk from the impacts of COVID-19. People living in conflict-affected and fragile states – whether they are refugees or asylum seekers, internally displaced or stateless, or in detention facilities – are at especially high risk of devastating impacts. Mature economies will also face challenges. Equitable access to COVID-19 vaccine will be challenging where inequalities and unequal access to essential services have been compromised within some political systems. The need for global leadership There is an urgent need for international coordination on COVID-19 vaccines. While the WHO provides technical support and UNICEF acts as a procurement agency, responding to coronavirus needs clarity of global leadership that arches over national interests and is capable of mobilizing resources at a time when economies are facing painful recessions. We see vaccines as a salvation but remain ill-equipped to accelerate their development.While everyone hopes for rapid availability of safe, effective and affordable vaccines that will be produced in sufficient quantities to meet everyone’s needs, realistically, we face huge hurdles. Full Article
a c South Africa can easily afford the NHI By feedproxy.google.com Published On :: Wed, 15 Jan 2020 12:33:33 +0000 Source Mail & Guardian URL https://mg.co.za/article/2019-12-06-00-south-africa-can-easily-afford-the-nhi/ Release date 06 December 2019 Expert Robert Yates In the news type Op-ed Hide date on homepage Full Article
a c Tariffs on Germany a card Trump seems willing to play, analyst says By feedproxy.google.com Published On :: Tue, 21 Jan 2020 14:34:30 +0000 Source CNBC URL https://www.cnbc.com/video/2019/12/03/tariffs-on-germany-a-card-trump-seems-will... Release date 03 December 2019 Expert Dr Lindsay Newman In the news type Op-ed Hide date on homepage Full Article
a c Will the ICJ Myanmar Ruling Help Bring Accountability for the Rohingya Crisis? By feedproxy.google.com Published On :: Wed, 06 May 2020 17:30:43 +0000 Source The Diplomat URL https://thediplomat.com/2020/03/will-the-icj-myanmar-ruling-help-bring-accountab... Release date 18 March 2020 Expert Dr Champa Patel In the news type Op-ed Hide date on homepage Full Article
a c It takes two (Las1 HEPN endoribonuclease domains) to cut RNA correctly [RNA] By feedproxy.google.com Published On :: 2020-05-01T00:06:09-07:00 The ribosome biogenesis factor Las1 is an essential endoribonuclease that is well-conserved across eukaryotes and a newly established member of the higher eukaryotes and prokaryotes nucleotide-binding (HEPN) domain-containing nuclease family. HEPN nucleases participate in diverse RNA cleavage pathways and share a short HEPN nuclease motif (RφXXXH) important for RNA cleavage. Most HEPN nucleases participate in stress-activated RNA cleavage pathways; Las1 plays a fundamental role in processing pre-rRNA. Underscoring the significance of Las1 function in the cell, mutations in the human LAS1L (LAS1-like) gene have been associated with neurological dysfunction. Two juxtaposed HEPN nuclease motifs create Las1's composite nuclease active site, but the roles of the individual HEPN motif residues are poorly defined. Here using a combination of in vivo experiments in Saccharomyces cerevisiae and in vitro assays, we show that both HEPN nuclease motifs are required for Las1 nuclease activity and fidelity. Through in-depth sequence analysis and systematic mutagenesis, we determined the consensus HEPN motif in the Las1 subfamily and uncovered its canonical and specialized elements. Using reconstituted Las1 HEPN-HEPN' chimeras, we defined the molecular requirements for RNA cleavage. Intriguingly, both copies of the Las1 HEPN motif were important for nuclease function, revealing that both HEPN motifs participate in coordinating the RNA within the Las1 active site. We also established that conformational flexibility of the two HEPN domains is important for proper nuclease function. The results of our work reveal critical information about how dual HEPN domains come together to drive Las1-mediated RNA cleavage. Full Article
a c On a class of singular Sturm–Liouville problems By www.ams.org Published On :: Fri, 10 Apr 2020 08:09 EDT A. A. Vladimirov Trans. Moscow Math. Soc. 80 (2020), 211-219. Abstract, references and article information Full Article
a c On the solvability of a class of nonlinear integral equations in the problem of a spread of an epidemic By www.ams.org Published On :: Fri, 10 Apr 2020 08:09 EDT A. G. Sergeev and Kh. A. Khachatryan Trans. Moscow Math. Soc. 80 (2020), 95-111. Abstract, references and article information Full Article
a c Saiba como ter um sorriso perfeito By saudeprospera.com.br Published On :: Mon, 30 Oct 2017 19:54:02 +0000 Todo mundo quer ter um sorriso bonito. Justamente por isso, a ideia de perder um ou mais dentes deixa qualquer pessoa desesperada. The post Saiba como ter um sorriso perfeito appeared first on Saúde Próspera. Full Article Dicas de Saúde
a c How can a company rely on the COVID-19 exception to shareholder approval requirements? By feedproxy.google.com Published On :: Publication Date: May 4 2020 On May 1, 2020, Nasdaq adopted Rule 5636T, operative through, and including, June 30, 2020, to provide listed companies with a temporary exception from certain shareholder approval requirements. A Company must submit an application to Nasdaq’s Listing Qualifications Department demonstrating that the transaction satisfies the requirements in Rule 5636T and must provide the Notification Form: Listing of Additional Shares (“LAS Form”) required by... Full Article
a c Bridging an Impossible Gap? Japan-South Korea Cooperation in a Changing Asia By feedproxy.google.com Published On :: Fri, 10 Jan 2020 16:35:01 +0000 Research Event 10 February 2020 - 12:00pm to 1:00pm Chatham House | 10 St James's Square | London | SW1Y 4LE Event participants Jennifer Lind, Associate Fellow, US and the Americas Programme and Asia-Pacific Programme, Chatham HouseChair: Tania Branigan, Leader Writer, The Guardian China’s growing power and assertiveness in Asia has led the United States and other liberal partners to move toward an Indo-Pacific strategy. While Japan embraces this, South Korea remains noticeably reticent. Moreover, tensions between the two countries have escalated into crisis with the reinvigoration of historical disputes. This roundtable will explore the root causes of current animosity between Seoul and Tokyo, and the potential ways it can be overcome.This event is co-hosted with Dartmouth College. THIS EVENT IS NOW FULL AND REGISTRATION HAS CLOSED. Department/project Asia-Pacific Programme, Conflict, Peace and Stability, Geopolitics and Governance Lucy Ridout Programme Administrator, Asia-Pacific Programme +44 (0) 207 314 2761 Email Full Article
a c Biosafety Protocol News Issue 8 - Working towards a common goal: Ten years of international cooperation on implementation of the Cartagena Protocol on Biosafety By bch.cbd.int Published On :: Wed, 11 May 2011 00:00:00 GMT Full Article
a c A CBD/Aarhus Convention checklist and summary of tools and resources are now available. By bch.cbd.int Published On :: Fri, 29 Jan 2016 00:00:00 GMT Full Article
a c CBD News: Japan launches the preparation of the Nagoya Biodiversity Summit to be held in Aichi Prefecture, Nagoya city in October 2010. By www.cbd.int Published On :: Tue, 17 Jun 2008 00:00:00 GMT Full Article
a c CBD News: Déclaration de M. Ahmed Djoghlaf, Secrétaire exécutif, à l'occasion de la Conférence de haut niveau sur « L'Union Européenne et l'Outre-Mer : Stratégies face au changement climatique et By www.cbd.int Published On :: Fri, 11 Jul 2008 00:00:00 GMT Full Article
a c CBD News: "Meeting the 2010 biodiversity target: A contribution to poverty alleviation and the benefit of life on Earth", Statement by Dr. Ahmed Djoghlaf, Executive Secretary of the Convention on Biological Diversity at the IUCN World Conservati By www.cbd.int Published On :: Wed, 08 Oct 2008 00:00:00 GMT Full Article
a c CBD News: "Sustainable Development: Which way next", Statement by Executive Secretary, Dr. Ahmed Djoghlaf, on the occasion of the Global Indian Diaspora Conference towards a Dynamic Indian Diaspora, Singapore, 9-11 October 2008. By www.cbd.int Published On :: Thu, 09 Oct 2008 00:00:00 GMT Full Article
a c CBD News: Discours de M. Ahmed Djoghlaf, Secretaire executif de la Convention sur la diversite biologique, à l'occasion de la Journee biodiversite & entreprises de l'European Platform for Biodiversity Research Strategy, Paris, France, le By www.cbd.int Published On :: Tue, 18 Nov 2008 00:00:00 GMT Full Article
a c CBD News: Déclaration de M. Ahmed Djoghlaf, Secretaire executif de la Convention sur la diversite biologique, à la série de conférences: Intégrer la biodiversité dans les stratégies d'entreprise, Montréal, Qu By www.cbd.int Published On :: Thu, 09 Apr 2009 00:00:00 GMT Full Article
a c CBD News: Statement by Ahmed Djoghlaf, Executive Secretary of the Convention on Biological Diversity, on the occasion of the Eighth Session of the United Nations Forum on Forests - Panel Discussion on "Forests in a Changing Environment", 21 Apri By www.cbd.int Published On :: Tue, 21 Apr 2009 00:00:00 GMT Full Article
a c CBD News: Déclaration de M. Ahmed Djoghlaf, secrétaire exécutif de la Convention sur la diversité biologique, sur le thème de l'environnement, la paix et la sécurité mondiale, Alger, Algérie, Juillet, 2009. By www.cbd.int Published On :: Thu, 30 Jul 2009 00:00:00 GMT Full Article
a c CBD News: Biodiversity and Climate Change: A CBD Contribution to the Copenhagen Climate Agreement. By www.cbd.int Published On :: Fri, 11 Sep 2009 00:00:00 GMT Full Article
a c CBD News: Déclaration de M. Ahmed Djoghlaf, Secrétaire exécutif de la Convention sur la diversite biologique, à l'occasion du devoilement du logotype de l'Annee internationale de la biodiversite, 5 Octobre 2009, Nairobi, Kenya. By www.cbd.int Published On :: Mon, 05 Oct 2009 00:00:00 GMT Full Article
a c CBD News: Statement by Mr. Ahmed Djoghlaf, Executive Secretary of the Convention on Biological Diversity, on the occasion of the Aichi-Nagoya COP 10 Promotion Committee Symposium, 11 October 2009, Nagoya, Japan. By www.cbd.int Published On :: Sun, 11 Oct 2009 00:00:00 GMT Full Article
a c CBD News: The Jakarta Charter on Business and Biodiversity. By www.cbd.int Published On :: Mon, 07 Dec 2009 00:00:00 GMT Full Article
a c CBD News: Opening Remarks by the CBD Secretariat at the GRULAC Regional Consultations in Support of the Finalization of the International Regime on Access & Benefit-sharing, 15-16 January 2010, Panama City, Panama. By www.cbd.int Published On :: Fri, 15 Jan 2010 00:00:00 GMT Full Article
a c CBD News: Message from Ahmed Djoghlaf on the occasion of the Aichi-Nagoya Celebration Event of the Opening of the International Year of Biodiversity held on 16 January 2010. By www.cbd.int Published On :: Sat, 16 Jan 2010 00:00:00 GMT Full Article
a c CBD News: Intervention de M. Ahmed djoghlaf, Secrétaire exécutif de la Convention sur la diversité biologique, à l'occasion du Congrès français de la nature, 20 Janvier 2010, Paris, France. By www.cbd.int Published On :: Wed, 20 Jan 2010 00:00:00 GMT Full Article
a c CBD News: Intervention de M. Ahmed Djoghlaf, Secrétaire exécutif de la Convention sur la diversite biologique, à l'occasion de l'événement de haut niveau de l'UNESCO en soutien de l'Année internationale de la By www.cbd.int Published On :: Thu, 21 Jan 2010 00:00:00 GMT Full Article