Background and objectives

Walking while talking is a dual cognitive-motor task that predicts frailty, falls, and cognitive decline in the general elderly population. Adults with CKD have gait abnormalities during usual walking. It is unknown whether they have greater gait abnormalities and cognitive-motor interference during walking while talking.

Design, setting, participants, & measurements

Community-dwelling, nondisabled adults (n=330) ≥65 years of age underwent quantitative gait analysis, including walking while talking. Differences in walking-while-talking performance by CKD status were evaluated, and relative changes between walking-while-talking and walking alone performance were computed to quantify cognitive-motor interference (dual-task cost). Associations were tested using multivariable linear spline regression models, and independent gait domains were derived using factor analysis. CKD was defined as an eGFR<60 ml/min per 1.73 m².

Results

CKD was present in 134 (41%) participants. Participants with CKD had slower gait speed along with various gait cycle abnormalities during walking while talking: among those with CKD, every 10-ml/min per 1.73 m² lower eGFR was associated with 3.3-cm/s (95% confidence interval, 0.4 to 6.1) slower gait speed, 1.8-cm (95% confidence interval, 0.6 to 3.0) shorter step length, 1.1% (95% confidence interval, 0.6 to 1.7) less time in the swing phase, and 1.4% (95% confidence interval, 0.5 to 2.3) greater time in double support after multivariable adjustment. When comparing walking while talking with walking alone, every 10-ml/min per 1.73 m² lower eGFR was associated with 1.8% (95% confidence interval, 0.5 to 3.2) greater decrease in time in the swing phase and 0.9% (95% confidence interval, 0.2 to 1.5) greater increase in time in the stance phase. Factor analysis identified three walking-while-talking domains and three dual-task cost domains: eGFR was associated specifically with the rhythm domain for both walking-while-talking and dual-task cost. Every 10-ml/min per 1.73 m² lower eGFR was associated with a poorer performance of 0.2 SD (95% confidence interval, 0.1 to 0.3) for walking while talking and 0.2 SD (95% confidence interval, 0.03 to 0.3) for dual-task cost.

Conclusions

During walking while talking, CKD is associated with gait abnormalities, possibly due to increased cognitive-motor interference.

The aim of this study was to assess the association of high-sensitivity cardiac troponin (hs-cTnT) and other cardiac, kidney, hyperglycemia, and inflammatory biomarkers with peripheral neuropathy (PN) in a community-based population.We conducted a cross-sectional analysis of 3056 black and white participants in the Atherosclerosis Risk in Communities (ARIC) study who underwent standardized monofilament PN testing and had measures of cardiac function (hs-cTnT, N-terminal pro–B-type natriuretic peptide [NT-proBNP], and growth differentiation factor 15 [GDF15]), kidney function (serum creatinine, cystatin C, β-2 microglobulin, urine albumin-to-creatinine ratio), hyperglycemia (fasting glucose, hemoglobin A_1c [Hb A_1c], fructosamine, glycated albumin, 1,5-anhydroglucitol), and inflammation (C-reactive protein) assessed at visit 6 (2016–2017; age 71–94 years). We used logistic regression to assess the associations of these biomarkers (modeled in diabetes-specific tertiles) with PN in older adults with and without diabetes after adjusting for traditional risk factors.In total, 33.5% of participants had PN (37.3% with diabetes and 31.9% without diabetes). There was an independent association of hs-cTnT with PN regardless of diabetes status (diabetes T3 vs. T1: odds ratio [OR], 2.15 [95% CI, 1.44–3.22]; no diabetes: OR, 2.31 [95%CI, 1.76–3.03]; P = 0.72 for interaction). Among participants without diabetes, there were also significant associations of NT-proBNP (OR, 1.40 [95% CI, 1.08–1.81]) and urine albumin-to-creatinine ratio (OR, 1.55 [95% CI, 1.22–1.97]) with PN. Associations of hyperglycemia biomarkers including Hb A_1c (OR, 1.76 [95% CI, 1.22–2.54]), fructosamine (OR, 1.71 [95% CI, 1.19–2.46]), and glycated albumin (OR, 1.45 [95% CI, 1.03–2.03]) with PN were significant only among participants with diabetes.Overall, hs-cTnT appears to be a global marker of end organ damage, including PN. Laboratory biomarkers may be able to help us identify those individuals with PN.

Burkholderia cepacia (formerly Pseudomonas cepacia) was once thought to be a single bacterial species but has expanded to the Burkholderia cepacia complex (Bcc), comprising 24 closely related opportunistic pathogenic species. These bacteria have a widespread environmental distribution, an extraordinary metabolic versatility, a complex genome with three chromosomes, and a high capacity for rapid mutation and adaptation. Additionally, they present an inherent resistance to antibiotics and antiseptics, as well as the abilities to survive under nutrient-limited conditions and to metabolize the organic matter present in oligotrophic aquatic environments, even using certain antimicrobials as carbon sources. These traits constitute the reason that Bcc bacteria are considered feared contaminants of aqueous pharmaceutical and personal care products and the frequent reason behind nonsterile product recalls. Contamination with Bcc has caused numerous nosocomial outbreaks in health care facilities, presenting a health threat, particularly for patients with cystic fibrosis and chronic granulomatous disease and for immunocompromised individuals. This review addresses the role of Bcc bacteria as a potential public health problem, the mechanisms behind their success as contaminants of pharmaceutical products, particularly in the presence of biocides, the difficulties encountered in their detection, and the preventive measures applied during manufacturing processes to control contamination with these objectionable microorganisms. A summary of Bcc-related outbreaks in different clinical settings, due to contamination of diverse types of pharmaceutical products, is provided.

Obtaining blood and cerebrospinal fluid is generally less invasive than standard tumor biopsy, and are increasingly used to develop surrogate biomarkers. Leptomeningeal disease, a devastating complication of cancer, represents a unique opportunity for using liquid biopsies for diagnosis, treatment, and to elucidate underlying mechanisms of resistance to therapy.

See related article by Smalley et al., p. 2163

In a draft guidance, the FDA urges researchers to take steps to increase enrollment of adults age 65 and older in clinical trials of investigational of cancer drugs. Noting that a drug's risk–benefit profile can vary significantly across age groups, the FDA recommends including older adults in early-phase studies and modifying trial designs and recruitment strategies to make it easier for them to participate.

Liên hệ nhanh: 0909 060 957 để được tư vấn nhanh nhất.Tổng hợp giá cho thuê tại Vinhomes Golden River - hiện nay:- 1 PN (49m2 - 53m2): 16tr - 18,5tr.- 2 PN (68m2 - 74m2): 21tr - 23tr.- 3 PN (98m2 - hơn 100m2): Chỉ từ 27tr.- 4 PN (150m2 - 170m2): 60tr.- Villa Vinhomes Ba Son: Chỉ ...

HC Golden City được giới chuyên gia bất động sản đánh giá cao về vị trí, cũng như chất lượng xây dựng, chất lượng sống cao cấp căn cứ theo các tiêu chuẩn sau:- Dự án HC Golden City được coi là độc nhất vô nhị trên tuyến đường dát vàng Hồng Tiến - tuyến đường Cổ Linh kéo dài kết n...

Nhà trang trí không giống các căn hộ thường gặp, chỉ thích hợp gia chủ ít người, yêu nghệ thuật, thích sự phá cách và " thông thống ". (không gian mở), sàn xi măng. Tầng cao, view dọc sông hướng mặt trời lặn, đã thông không gian phòng ngủ và phòng khách, bếp là bàn đảo và bàn ăn ...

Công ty Cổ phần địa ốc Xuân Lộc Holdings - Chuyên tư vấn đầu tư bất động sản tại thành phố Quy Nhơn:

• Đất nền dự án trung tâm
• Nhà phố
• Căn hộ nghỉ dưỡng mặt biển
• Đất nền dự án ven biển (các dự án như: Nhơn Hội New City, FLC,...)

Thông tin các dự án luôn được cập nhật nhanh chóng, đầy đủ và chính xác với đội ngũ nhân viên tư vấn chuyên nghiệp, nhiệt tình.

Quý khách có nhu cầu tìm hiểu và đầu tư bất động sản tại Quy Nhơn vui lòng liên hệ chúng tôi để được tư vấn tốt nhất và sở hữu những bất động sản chất lượng, giá tốt, phù hợp theo nhu cầu, có khả năng sinh lời cao!

Thông tin liên hệ:

Điện thoại: 0905978389

Email: quipham86@gmail.com

Website: xuanlocland.vn

Địa chỉ: 397A Nguyễn Huệ, Phường Trần Phú, thành phố Quy Nhơn, tỉnh Bình Định

Rất hân hạnh được hợp tác cùng quý khách hàng!

Golden City Tây Ninh là dự án tổ hợp chung cư - thương mại - dịch vụ đầu tiên tại Tây Ninh. Dự án được định hướng trở thành nơi kiến tạo các giá trị sống mới tiện nghi cho cư dân thành phố với tổng vốn đầu tư lên tới trên 2.000 tỷ đồng.

Golden Park là dự án nhà ở xã hội được quy hoạch đồng bộ, hài hòa tại xã Phương Liễu, huyện Quế Võ, tỉnh Bắc Ninh. Dự án gồm các căn hộ được thiết kế hiện đại, thông thoáng với diện tích đa dạng từ 42-96m2.

Khu dân cư Golden Ruby là dự án đất nền nằm tại khu trung tâm của các khu công nghiệp lớn tại Trảng Bom, Đồng Nai.

Cho thuê, nhượng mặt bằng làm văn phòng, cửa hàng giá nhỏ hơn 10 triệu cho 70m2, tòa nhà cao cấp Golden Palace Mễ Trì Tòa nhà nằm ngay tại ngã tư Mễ Trì và Đồng Me. Đây là tòa nhà văn phòng hạng B, mới đi vào sử dụng 5 năm, 4 thang máy (không mất thời gian chờ đợi lâu). Thiết kế ...

Sau khi được mở rộng, Khu đô thị Phú Quý (tên thương mại là Goldenland) tại TP. Hải Dương sẽ có tổng diện tích là 884.085m2.

Liên hệ: 0933.600.261 - Ms Vân. Em tư vấn thật 100%, không mất thời gian của khách hàng.Công ty em quản lý toàn dự án cho thuê tại Quận 4.Nắm giữ nguồn đa dạng và hỗ trợ tìm nhà, deal nhà giá rẻ. Em cam kết sẽ tìm nhà hợp với nhu cầu của khách hàng.Công ty tại block A2 - The Gold...

Bảng giá 1 phòng ngủ giá tốt Ba Son, quận 1 call 0938179199. - 1PN, DT 48m2, tòa Aqua 1, view L81 nội thất cơ bản giá 13 triệu/tháng. - 1PN, DT 50m2, tòa Aqua 1, view đẹp giá 14 triệu/tháng. - 1PN, DT 50m2 full nội thất tòa Aqua, view sông - biệt thự, giá 16 triệu. - 1PN, DT ...

Biệt thự Vinhomes Golden River cho thuê.VIC 10 - giá thuê 170 triệu (Bao phí quản lý và VAT).- Diện tích đất: 225m2. - Diện tích xây dựng: 553,66 m2. - Tiện ích: Phòng giải trí, Quầy Bar.Tầng 4: Phòng tiện ích, phòng giặt, ban công.Tầng 3: Phòng sinh hoạt chung, 2PN Master, 2WC.T...

Selling Goldview Apartment In Van Don Port- Ward 1- District 4 - Address: 346 Van Don Port - Area: 120 sqm, on the seventh floor - Having 3 bedrooms, 2 bathrooms, fully furnished - The Selling Price: Contact Please do not hesitate to contact us via 0907894503 Mr Le for consulting...

Goldlink chuyên cho thuê mua bán nhà Cityland Gò Vấp.* Cho thuê văn phòng tại khu dân cư Cityland Park Hills Gò Vấp. * Nằm ngay trung tâm Gò Vấp, cách sân bay chỉ 5' đi xe, thuận tiện di chuyển đến các quận lân cận. * Vị trí căn góc, tiện kinh doanh, Mặt tiền đường lớn ô tô đậu t...

To make the dream of settling down in a prosperous city come true, young couples, especially ones with limited budgets, need to prepare the right steps to get your home sweet home.

VINHOMES GOLDEN RIVER - SERVICED APARTMENT The apartments are full modern furniture very neat and clean, well decorated Location 2: 2 Ton Duc Thang street, District 1 Special prices only available this month. Has balcony, bathtub, kitchen, TV, bed, fridge, sofa. High-quality wo...

* 1 bedroom apartment (50 - 53m2) - for living or office. Basic furniture: Price from 14 million / month ($ 600). Full luxury furniture from 19tr / month ($ 720).Call: 0931101112 for information - apartment images are clearer.* Apartment 2brs, 2WC, area 67 - 80m2: Basic furniture...

The home has 2 Bedrooms, Full Furniture + Beautiful + New 100%- PRICE: 17 milion Vietnam Dong ($730)+You come to visit and feel, we have a team of enthusiastic, happy welcoming and serving customers. Wish you a happy new day and trust the apartment. Thanks!+ Fully furnished+ New1...

Tổ hợp nghỉ dưỡng Hội An Golden Sea là sản phẩm thứ 2 của Tập đoàn Hòa Bình tại miền Trung. Dự án nằm trên đường Lạc Long Quân, TP. Hội An, tỉnh Quảng Nam với 275m mặt biển cùng 4 mặt đường giao thông kết nối thuận tiện vào trung tâm TP. Hội An.

Clothes that light up by themselves could be a high-tech replacement to high-visibility gear worn by cyclists and construction workers

This image of an enormous ship under construction features in a new book and show that challenge common ideas about beauty - while the real ship may help cut carbon emissions

This film gives us insight into a community that’s already endured plenty even before the zombies arrived.

Adele posted a message to her social media channels this week thanking those on the front lines fighting COVID-19. In the process, the celebrated singer unveiled a thinner frame—and the internet had a lot of thoughts about it, almost all trash.

Enter Bill Maher, noted #MeToo skeptic, with perhaps the most garbage take of them all.

On Friday night, during the interview portion of his HBO show Real Time, the comedian began by placing the bulk of the blame for the high amount of COVID-19 deaths in the U.S. compared to other countries on America’s obesity problem—not, say, the fact that the Trump administration didn’t do a single thing during the month of February to contain the spread of the virus.

Read more at The Daily Beast.

Got a tip? Send it to The Daily Beast here

Venus’s surface is covered in strange wiggling lines that may form when colossal stacks of lava are carved by gentle winds over hundreds of millions of years

The Hayabusa-2 spacecraft bombed the asteroid Ryugu in April. Analysing the crater it left behind suggests Ryugu is a relative youngster at 9 million years old

The interstellar comet Borisov, which flew past Earth in December, is full of carbon monoxide ice that implies its home star is smaller and colder than our sun

One of our favorite consumer drones gets an FPV upgrade

Your weekly selection of awesome robot videos

In response to the ongoing COVID-19 pandemic.

Safety fears derail plan to import reactors.

Chris needs help with Xenoblade. Alice discovers something in deep space. Josh is finally free from the tyranny of Ireland. And Kelley exits a prison...

Wagner Moura and Ana de Armas give strong performances in a mostly effective retelling of the life and tragic death of a celebrated Brazilian diplomat

There’s an old school charm to Sergio, documentarian Greg Barker’s narrative portrait of UN diplomat Sérgio Vieira de Mello, a dramatic retelling of a life he already brought to the screen in a 2009 documentary of the same name. Barker’s knowledge of Sérgio’s life and accomplishments is backgrounded by a clear respect for who he was and so while the film is factually detailed, as one would expect, it’s also rooted in a desire to showcase his humanity, both in and out of work, with Barker deciding to lean into full-tilt romantic tragedy, perhaps also as a way of differentiating his two Sergios.

Related: Love Wedding Repeat review – laboured Netflix romcom farce

Continue reading...

My friend Tom convinced me that Roger Moore’s finest non-Bond moment was this 1974 corker about a maverick mining engineer. He’ll convince you, too

• Read all the other Lockdown watch choices
• Read all the other My favourite film choices
• Read all the What I’m really watching choices
• Read the other classic missed films choices

The pre-eminent film in Sir Roger Moore’s non-Bond oeuvre was released in 1974, between Live and Let Die and The Man With the Golden Gun.

I was born in 1978, so I was far too young to see Gold in its first flush of youth, let alone mine. So was my friend Tom.

Continue reading...

U.S. Chief Justice John Roberts on Friday put a temporary hold on the disclosure to a Democratic-led House of Representatives committee of grand jury material redacted from former Special Counsel Robert Mueller's report on Russian interference in the 2016 election.

The notoriously independent-minded federal judge who once said he was disgusted by the conduct of Michael Flynn could block the administration's bid to drop criminal charges against the former adviser to President Donald Trump, legal experts said.