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Deciphering Sex-Specific Genetic Architectures Using Local Bayesian Regressions [Genetics of Complex Traits]

Many complex human traits exhibit differences between sexes. While numerous factors likely contribute to this phenomenon, growing evidence from genome-wide studies suggest a partial explanation: that males and females from the same population possess differing genetic architectures. Despite this, mapping gene-by-sex (GxS) interactions remains a challenge likely because the magnitude of such an interaction is typically and exceedingly small; traditional genome-wide association techniques may be underpowered to detect such events, due partly to the burden of multiple test correction. Here, we developed a local Bayesian regression (LBR) method to estimate sex-specific SNP marker effects after fully accounting for local linkage-disequilibrium (LD) patterns. This enabled us to infer sex-specific effects and GxS interactions either at the single SNP level, or by aggregating the effects of multiple SNPs to make inferences at the level of small LD-based regions. Using simulations in which there was imperfect LD between SNPs and causal variants, we showed that aggregating sex-specific marker effects with LBR provides improved power and resolution to detect GxS interactions over traditional single-SNP-based tests. When using LBR to analyze traits from the UK Biobank, we detected a relatively large GxS interaction impacting bone mineral density within ABO, and replicated many previously detected large-magnitude GxS interactions impacting waist-to-hip ratio. We also discovered many new GxS interactions impacting such traits as height and body mass index (BMI) within regions of the genome where both male- and female-specific effects explain a small proportion of phenotypic variance (R2 < 1 x 10–4), but are enriched in known expression quantitative trait loci.




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Fly eyes are not still: a motion illusion in Drosophila flight supports parallel visual processing [RESEARCH ARTICLE]

Wael Salem, Benjamin Cellini, Mark A. Frye, and Jean-Michel Mongeau

Most animals shift gaze by a ‘fixate and saccade’ strategy, where the fixation phase stabilizes background motion. A logical prerequisite for robust detection and tracking of moving foreground objects, therefore, is to suppress the perception of background motion. In a virtual reality magnetic tether system enabling free yaw movement, Drosophila implemented a fixate and saccade strategy in the presence of a static panorama. When the spatial wavelength of a vertical grating was below the Nyquist wavelength of the compound eyes, flies drifted continuously­ and gaze could not be maintained at a single location. Because the drift occurs from a motionless stimulus—thus any perceived motion stimuli are generated by the fly itself—it is illusory, driven by perceptual aliasing. Notably, the drift speed was significantly faster than under a uniform panorama suggesting perceptual enhancement due to aliasing. Under the same visual conditions in a rigid tether paradigm, wing steering responses to the unresolvable static panorama were not distinguishable from a resolvable static pattern, suggesting visual aliasing is induced by ego motion. We hypothesized that obstructing the control of gaze fixation also disrupts detection and tracking of objects. Using the illusory motion stimulus, we show that magnetically tethered Drosophila track objects robustly in flight even when gaze is not fixated as flies continuously drift. Taken together, our study provides further support for parallel visual motion processing and reveals the critical influence of body motion on visuomotor processing. Motion illusions can reveal important shared principles of information processing across taxa.




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Công ty CP Yeshouse




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Xbox say they “set some wrong expectations” for yesterday's gameplay reveals

After lots and lots of #hype in the form of a livestream digital painting reveal that was the precursor to a proper trailer which was also just a precursor to what we were assured would be a first look at actual gameplay, folks were a bit let down by the not very gameplay-looking new video for […]




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Peekaboo!: Home Air Vent Dragons With Light-Up Eyes

These are the vent dragons made and sold by artist David Lee Pancake. The dragons are available in a variety of dragony colors, cost $200 apiece, and are made to be hung on the wall, NOT cover an actual air vent. "But--" Hey, if you want to be hot all summer because the A/C isn't blowing in the living room, that's up to you.

Vent Dragons comes with a little remote control to light up the eyes of the two little monsters and surprise your guests and friends. The lights are powered by 3 AA batteries and should burn for 150 hours before you need to replace them. To replace the batteries unscrew the grate and lift off, the batteries are in a small pack inside. The lighted eyes have 8 different settings from fast blinking to continually glowing and there is a timer to turn them off in 6 hours. Enjoy! Size: 12x7 inches. Do NOT install in an actual heating/AC vent.
Gosh, just think how much you could save on home heating and cooling costs if you had ACTUAL fire and ice breathing dragons living in your air vents. I mean granted they'd have to be trained, but I have seen all those movies. Keep going for a few more shots of some of the different colors.



  • a/c
  • aircon! i need aircon! (that was supposed to be ed from 90 day fiance: before the 90 days)
  • baby dragons
  • dang i wish i had $200 to spend on vent dragons
  • dragons
  • heating and cooling
  • light effects
  • sure why not
  • that's cool i'm into that

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The Weeknd eyes The Simpsons cameo after American Dad debut

The Simpsons officials have yet to respond to The Weeknd's public proposal.




yes

Demi Lovato eyes duet with Tori Kelly

The new music is expected to feature on Demi's upcoming album, the follow-up to 2017's Tell Me You Love Me, and her first under the guidance of Braun.




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Murder probe launched in Hayes after man, 37, dies in &apos;vicious assault&apos;

Detectives have launched a murder investigation after a 37-year-old man died following a "vicious assault" in west London.




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‘In lockdown, spring is unfolding before my eyes’

With no alternative but to explore the nature on their doorstep, three writers describe the joy of enforced slow travel

It is a place I’d discovered before the virus: a left-hand bend in a narrow stream, a couple of steps off the footpath. There is nothing remarkable there, or not at first glance. There are breeze blocks in the stream bed and plastic bags deeply embedded in the roots of an alder tree. With a few variations, it could be anywhere in Britain: the neglected corner of a city park, the back of a private garden, behind a national park cafe. It’s just one of those spots that no one ever thinks to stop at and, if not for Covid-19, I would not have begun visiting daily, pausing for a few breaths before continuing. I saw the first snowdrops appear there, followed by primroses; then they were swamped by wild garlic and wood anemone. One morning a weasel shot out of a hole under a root and sprinted up the opposite bank. It was the first of several surprises.

Continue reading...




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YES Bank in talks with Microsoft for stake sale; stock climbs 9%

A Reuters report quoting Mint suggested that Yes Bank is in talks with Microsoft and two other tech firms for a possible stake sale.




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Narendra Modi has his eyes set on boosting business: Joao Cravinho, EU Ambassador

Ambassador Joao Cravinho, head of the EU delegation, led Ambassadors of various European countries to a quiet lunch with Modi at the capital last year.




yes

Miriam Margolyes shocks fans after admitting she &apos;had difficulty not wanting Boris Johnson to die&apos; during coronavirus battle

Actor is famous for making her opinions known during interviews




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Trump says in his mother's eyes, he could do no wrong...


Trump says in his mother's eyes, he could do no wrong...


(First column, 5th story, link)

Related stories:
'She Loved Me'...





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David Moyes predicts tight turnaround for West Ham squad when football season resumes

West Ham manager David Moyes says he does not expect to have any more than three weeks to work with his players before the season resumes.




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Former Manchester United boss David Moyes reveals the three big signings he missed out on at Old Trafford

Former Manchester United boss David Moyes has revealed the three big name transfer targets he missed out on while in charge at Old Trafford.




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West Ham boss David Moyes turns delivery boy for his village: &apos;One lady gave me £20 and said: Keep the change, son!&apos;

INTERVIEW




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West Ham problem position: Four players who could solve full-back issues for David Moyes

Before the suspension of the 2019-20 Premier League campaign, West Ham were embroiled in a fierce fight to retain their top-flight status.




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West Ham won&apos;t sell Declan Rice for less than £70m with midfielder key to David Moyes rebuild

David Moyes remains set on overhauling the West Ham squad this summer, but sees Declan Rice as a vital part of his plans going forward.




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Former Liverpool defender Dominic Matteo reveals how eyesight concerns led to brain tumour diagnosis

Dominic Matteo has opened up on the frightening moment that he was hit with a shock brain tumour diagnosis after seeking out an eye test.




yes

Chelsea want Declan Rice? Then I want Billy Gilmour, says West Ham manager David Moyes

David Moyes says Billy Gilmour is the one Scottish player he would sign for West Ham over any other.




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Coronavirus update: What are the main symptoms to look out for in your eyes?



CORONAVIRUS can linger in the eyes for weeks and cause a host of problems especially for those who wear contact lenses. How can you protect your eyes during this difficult time and what are the symptoms to spot?




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Yes Yes Yes wins The Everest, Mer De Glace takes the Caulfield Cup, but focus remains on racing's slaughter scandal

Chris Waller continues his big race domination, taking out The Everest at Randwick with Yes Yes Yes, on a day marked by protests and calls for change after an investigation revealed widespread slaughter and abuse of former racehorses in Australian abattoirs.




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Ayesha, Steph Curry Enjoy Quarantine Date Night



Reese Witherspoon and Kerry Washington sent hugs.




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Having trouble with the IRS site? Try all caps — yes, really

Are you getting 'Payment Status Not Available' when tracking down your coronavirus stimulus check? Try entering your address in all caps.




yes

We need Ghebreyesus to lead WHO through this crisis

We blame the captain when we find our modest paddle-steamer unable to weather a hurricane. But this UN agency's failings are by design.




yes

We need Ghebreyesus to lead WHO through this crisis

We blame the captain when we find our modest paddle-steamer unable to weather a hurricane. But this UN agency's failings are by design.




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Milo Gore's 'Green Eyes' Is A Fantastic Piece Of Pop-Edged Indie

New album 'How Do You Cope While Grieving For The Living?' is out on August 20th...

Milo Gore will release new album 'How Do You Cope While Grieving For The Living?' this summer.

The five-piece met while studying at Falmouth University in Cornwall, a quartet brought together by mutual interests and a shared sense of humour.

Each of those elements come to the fore on new single 'Green Eyes', a fizzing piece of pop-edged indie that lights the path for their new album.

'How Do You Cope While Grieving For The Living?' is out on August 20th, and this new single bursts out of the traps with relentless energy.

The video is online now, with Milo Gore commenting:

“The ‘Green Eyes’ music video is about the rise and fall of Milo’s past relationship. The video depicts the story of how he and his girlfriend first met, and consequently, how they drifted apart. The two should have never ended up together - they both had issues with their mental health, issues that were clearly going unchecked. Perhaps that’s what initially brought them together? However, it was sadly the thing that also tore them apart.”

“A video about self-discovery, that eventually ends with a smile, as Robi, the actor who plays Milo, ends up in the same place he had initially met his ex-girlfriend. The song, and the video, are both about learning to be content on your own again. Hindsight is a beautiful thing...” 

Tune in now.

Join us on the ad-free creative social network Vero, as we get under the skin of global cultural happenings. Follow Clash Magazine as we skip merrily between clubs, concerts, interviews and photo shoots. Get backstage sneak peeks, exclusive content and access to Clash Live events and a true view into our world as the fun and games unfold.

 




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We need Ghebreyesus to lead WHO through this crisis

We blame the captain when we find our modest paddle-steamer unable to weather a hurricane. But this UN agency's failings are by design.




yes

Eyes on world

NIGHT-LIFE in Cairns is set to reach new heights in 2017, with local nightclub Gilligan’s hoping to bring more international artists to its venue this year.




yes

Is all this screen time damaging my eyes? (Yes. But here’s what to do)


Avoiding screens before bed and taking breaks to stare out the window will help mitigate the damage.





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Candice discovered she was losing her eyesight — so she took up cycling

The 20-year-old was a softballer on an elite path, but was told her eyesight was failing because of a genetic condition — so she turned to the Tandem Project.




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You can play video games with your cat — yes, your cat! Here's how

'Mew and Me' is a game designed for cats. Well, cats and humans. The surprising lessons the game's creator learned from cats.




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Secretary Napolitano and Attorney General Holder Form Joint Task Force to Assist Mexico’s Investigation into Yesterday’s Shooting of Two ICE Agents in Mexico

Secretary of Homeland Security Janet Napolitano and Attorney General Eric Holder today met to discuss the shooting by unknown assailants of two U.S. Immigration and Customs Enforcement (ICE) special agents in the line of duty yesterday while driving in Mexico.



  • OPA Press Releases

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LIFE In COVID-19 Battle, LH On Watch, CARA Keeps KALM, All Eyes On MYOV

Today's Daily Dose brings you news about aTyr Pharma joining the COVID-19 battle; Cara's pivotal KALM-2 trial; LabCorp's at-home collection kit for COVID-19 testing securing Emergency Use Authorization from the FDA, and Myovant's much-awaited clinical trial catalyst.




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Moderna eyes 'early summer' start for phase 3 COVID-19 vaccine trial

Moderna is finalizing the protocol for a phase 3 trial of its COVID-19 vaccine with a view to starting the study early in the summer. The establishment of the timeline, which follows FDA clearance to run a phase 2 trial, puts Moderna on track to win approval for its mRNA vaccine mRNA-1273 next year.





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Extinction watch: Amber eyes, dwindling fast

As of December 2017, fewer than 50 individuals are thought to be remaining in three subpopulations that are scattered over 140,000 square km in Iran’s central plateau. The cats have been nearly wiped out by excessive hunting, habitat degradation and scarcity of prey species.




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Valencia eyes circuit changes to boost overtaking

Changes to the layout of Valencia's street circuit could be made prior to F1's return next year




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Massa eyes big points haul

Felipe Massa hopes that Ferrari's run of bad luck will come to an end at the German Grand Prix after he qualified third on the grid behind team-mate Fernando Alonso




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Schumacher's son Mick eyes F1 career

Michael Schumacher's 15-year-old son Mick wants to follow in his father's famous footsteps and be a Formula One world champion after being crowned World Karting Vice-Champion




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Yesterday, the Northern Lights went out: The Arctic and the future of global energy


This week, Royal Dutch Shell announced that it would postpone oil drilling in the Chukchi Sea and the broader American Arctic indefinitely. The decision came in the wake of disappointing output from its Burger field, the high costs associated with the project (already nearing $7 billion), the “challenging and unpredictable federal regulatory environment in offshore Alaska,” and a growing public relations problem with environmental groups opposed to Arctic drilling.

This decision is a momentous one—both for the future of the U.S. energy policy and the ability of the international oil industry to balance global oil supply and demand. The announcement came only days after Hillary Clinton spoke out against the Keystone Pipeline, not only because it would lead to the consumption of more fossil fuels but also because much of the oil might be exported. With broader opposition to lifting the ban on crude oil exports gaining momentum in the White House, it is clear that at least part of the nation’s political leadership is moving in a nationalistic direction. This means that the United States—with its vast resources—is unwilling to help meet the burgeoning energy needs of the world’s population: especially the 1.2 billion people who have no access to commercial energy.

Shell’s decision highlights four significant and diverse areas of concern for the future of energy globally and energy policy here in the United States.

Mapping supply and demand

Shell and much of the rest of the international petroleum industry had viewed the Chukchi Sea as one of the last great oil frontiers. The Chukchi and adjoining Beaufort Seas are vital for meeting the estimated 12 to 15 million barrels per day (mmbd) of additional oil demand projected by almost all oil forecasts (both inside and outside the industry) needed between 2035 and 2040. 

Without the U.S. Arctic, the other areas projected to make major contributions by this time are Iraq, Iran, Saudi Arabia, shale oil around the world (including North America), the Orinoco region of Venezuela, and the pre-salt offshore Brazil. Needless to say, given the political turmoil in Iraq, Iran, Venezuela, and Brazil—as well as concerns about the long term stability of Saudi Arabia—one has to wonder: Where will the world discover additional, reliable crude oil supplies without a major contribution from the Arctic?

Many in the environmental community argue that we will not need fossil fuels in the future, predicting a turn to renewables, enhanced energy efficiency, large scale battery storage, and electric vehicles. Unfortunately, this has no basis in fact. Clearly renewables will grow exponentially as their prices fall, new technologies will increase energy efficiency, large scale battery storage will commence, and many electric vehicles will hit the road. But there are currently more than 260 million gas and diesel vehicles running on U.S. roads alone, with less than 1 percent of these running on electricity. With transportation fuel demand mushrooming globally, it’s unlikely that oil consumption in the transportation sector will die or even decline significantly. 

Fossil fuels for development

Drilling in the Arctic poses unique environmental risks which must be managed through state-of–the-art technology and accompanied by the most stringent regulatory enforcement. A recent National Petroleum Council examination of all possible challenges involved in Arctic offshore drilling found that drilling can be done safely. Yet despite these findings, most major national environmental groups have opposed any drilling in the Arctic and have even asserted that Shell’s decision is a vindication of their position. But these groups don’t seem concerned or even thoughtful about the long-term implications of the U.S. energy industry’s abandonment of the Arctic.

With the world’s population forecast to rise by 1.6 billion people by 2035, do we really think global oil demand won’t continue to rise? While I recognize that we must do everything to limit the growing use of fossil fuels to attack climate change, do we really have no moral obligation to help countries emerge from poverty, which will almost certainly involve continued use of fossil fuels? 

During his recent visit to America, Pope Francis called for the world to make a renewed commitment to help the “poorest of the poor,” and the United Nations has also put forward new sustainable development goals that include an expansion of energy access to those who are either unserved or underserved. Focusing our policies exclusively on shutting down U.S. fossil fuel development, as some environmental groups advocate, takes away resources that can be used to improve global health, education, clean water, and women’s empowerment—all of which are all directly related to energy access. In looking at girl’s education, for example, increasing energy availability allows water to be pumped up from the river, obviating the need for arduous, tedious work for the women and girls that would otherwise have to carry this water by hand to their communities, limiting time for education. The availability of energy allows vaccines to be safely stored, crops to be refrigerated, and children to have the electricity available to study at night. 

All of these benefits—and many others—cannot happen without improving electricity access, which still involves fossil fuel. The United States can and should play a role in this effort.

Jostling for Arctic access

Shell is not the only company to experience setbacks in the Arctic. Italy’s ENI SpA and Norway’s Statoil ASA just yesterday had another regulatory setback due to delays in obtaining permission from Norway to commence production. In June, a consortium including Exxon and BP PLC suspended its Canadian Arctic exploration, noting insufficient time to begin test drilling before the expiration of its lease in 2020. In addition, Exxon had to curtail its plans to drill in the Russian Arctic after the United States imposed sanctions on Moscow and its energy industry following the annexation of Crimea. 

Russia, though, remains active in the Arctic, and it can be assumed that once sanctions are lifted, many oil companies will try to gain a toehold. China, Korea, India, and Singapore, among other countries, have expressed interest in gaining access to the region’s mineral, energy, and/or marine resources. In several cases, they are building ice-worthy vessels to give them the capability to do so. The Bering Strait is emerging as a significant new maritime route in desperate need of enhanced regulation.

In a report last year, my colleagues and I looked at key recommendations for offshore oil and gas governance as the United States assumed chairmanship of the Arctic Council. Beyond highlighting the resource potential of the region, our work looked at increasing needs for safety and security as a result of increasing transportation across the Arctic. Even as the United States stands to be less involved in Arctic energy development, it is our duty as chair of the Arctic Council to lead in region. 

Alaska is a state, not a park

The promise of the Arctic has inspired adventurers, explorers, geographers, scientists, and entrepreneurs for generations and will continue to do so in the future. The United States should be actively involved in helping to ensure that Arctic resources are developed and used prudently—rather than sit on the sidelines with myopic dreams of leaving the region a pristine wilderness. Arctic inhabitants—both natives and others—of course want to keep the Arctic safe, but they do not want to make it a museum. 

Development of the region’s resources accounts for nearly 95 percent of Alaska’s revenues. If we deny its development, are we prepared to make a line item in the federal budget to pay for Alaska to remain a park? 

      
 
 




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China and Africa’s debt: Yes to relief, no to blanket forgiveness

As COVID-19 exacerbates the pressure on vulnerable public health systems in Africa, the economic outlook of African countries is also becoming increasingly unstable. Just this month, the International Monetary Fund (IMF) projected that the region’s economic growth will shrink by an unprecedented 1.6 percent in 2020 amid tighter financial conditions, a sharp decline in key…

       




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Building a more data-literate city: A Q&A with HyeSook Chung


DC KIDS COUNT, housed at the nonprofit DC Action for Children, is the DC chapter of a nationwide network of local-level organizations aiming to provide a community-by-community picture of the conditions of children. The 26 year-old project is funded by the Annie E. Casey Foundation and its aim is to provide high-quality data and trend analysis as well as help local governments monitor budget and legislative decisions based on evidence of what works for children and families. As we pointed out in our recent papers and a blog, developing reliable and comprehensive data is a critical step to building effective community partnerships and producing outcomes that improve economic mobility and health in a neighborhood.

We discussed these issues with HyeSook Chung, Executive Director of DC Action for Children.

Q. Please summarize the history of the DC Kids Count project. What motivated it, and how it has evolved over the last years?

A. As part of the nationwide Kids Count network, each chapter tracks a number of indicators on child and family well-being through an online database called Kids Count Data Center. Each chapter also releases a yearly data book which summarizes the state of child well-being within their state or locality. When DC Action for Children became the host of DC Kids Count in 2012, I wanted to rethink the way we presented our data to move beyond the traditional print format into the exciting realm of visualizing data. This led to the beginning of our partnership with DataKind, a group of dedicated pro-bono data scientists who worked with us to create an interactive, web-based data tool that maps out indicators of child well-being across DC’s 39 neighborhood clusters.

We know that the neighborhood children grow up in, and the resources they have access to, plays a huge role in shaping children’s future opportunities. The maps we created with our Data Tool 2.0  reveal sharp disparities in DC neighborhoods: some DC neighborhoods are wealthy and have many assets, while others are characterized by high levels of poverty. The many challenges that come with high poverty neighborhoods include: poorer performing schools, more crime, and less access to libraries, parks, and healthy foods.  

Q. What type of indicators do you gather? How many years does the data cover? What level of granularity does the data have?

A. We track a variety of indicators of child well-being, including demographics, economic well-being, health and safety. The data is housed online in two places: The KIDS COUNT Data Center and our Data Tool 2.0. The Data Tool 2.0 maps the most recent available data at the neighborhood cluster, while the Data Center allows for a wider range of geographies (citywide and ward level) and different timeframes.  Many of the indicators have data from 1990 to the present.

Q. How do you measure the data tool’s impact on policy and legislation?

A. We have made it a priority to conduct internal evaluations to assess the utilization of the online tool, but we also believe that measuring the tool’s impact must go beyond traditional web analytics. We regularly use the Data Tool 2.0 in our work with city officials and direct service providers to offer an overview of the social context in the city’s different neighborhoods.     

In a city where the allocation of resources is often guided by personal relationships and old-school politics, it is important to show clearly whether budget decisions are aligned with the needs of our children. We believe that our Data Tool 2.0 project can bring much needed transparency to the allocation of the DC government budget and help achieve agreement.

Q. The DC Kids Count project is helping build data capacity across organizations, with the aim of creating a more “data-literate” city. Could you tell us about some of these initiatives? 

A. Businesses like Amazon and Netflix increasingly focus on finding “actionable” insights from their data. For them, “big data” analytics can help answer tough business questions. With the right platforms for analytics, they can increase efficiency or even improve operations and sales.

In a similar manner, we at DC Action for Children believe that big data opens up the opportunity for us to improve and reshape our strategy and decision making process to better align services with the needs of DC children in the same way Amazon or Netflix does with their customers.

For instance, we are offering the Child and Family Services Agency technical and data analysis support for their Healthy Families Thriving Communities Collaboratives, which are a citywide network of community-based organizations designed to embed family supports in their communities. Their mission is to strengthen and stabilize families and to prevent child abuse and neglect by offering services in the form of case management and support. We use KIDS COUNT data at the ward and neighborhood levels to highlight needs in the community and inform their planning. This encourages the Collaboratives’ staff to look at data differently—integrating it as a vital part of their program planning and strategy.

Q. What are some of the obstacles and challenges you face in integrating the data, and updating it?

A. Historically, our data analysis looked at more traditional indicators, such as program enrollment and the number of child welfare cases. But now we think we can use our access to big data to pull out patterns within our datasets and help guide the decisions of the city administrators. For example, if we are trying to prevent future child abuse cases, we can look at patterns analyzing family and child data in specific neighborhoods. We can use the type of predictive analysis practiced in the for-profit business to help us serve DC children more efficiently and effectively.

One of the most significant obstacles we face is ensuring that the indicators are up-to-date. This can be an issue with government agencies since some of them are slow in their release of new data.  Moreover, there is also no standard format across local agencies for how data is collected and released. Furthermore, data is often aggregated at different geographical units, like zip codes or census tracts. To get the data ready to upload to our Data Tool, we must recalculate the data into neighborhood clusters.  

Q. What policy changes would help produce better data-sharing ecosystems? 

A. DC has in many ways demonstrated leadership in data sharing. The Office of the Chief Technology Officer works to make a large variety of datasets publicly available. We have also seen large investments over the years to create new data systems that track progress and service delivery for different agencies. But our city can do more to promote a data-sharing ecosystem. So can other cities.

While multiple agencies are adopting innovative data systems, the systems are often siloed and do not speak to each other. Moreover, since data is tracked differently across agencies, based on needs and requirements for reporting, it is difficult for agencies to share data both publicly and internally. It is also often difficult to get access to de-identified disaggregated data for richer analysis. We are glad that many agencies recognize the value of robust data collection, but more data transparency policies would give us a better understanding of the challenges that lie behind improving the wellbeing of children in the city.

Q. What are the next steps for the DC Kids Count project, and how do you expect it to grow over the next few years?

A. We just finished wrapping up some of the final work on our DataTool 2.0. In terms of next steps, we are working on a handbook that explains how we created our Data Tool so that other Kids Count chapters and organizations can replicate and adapt our tool.

We would also like to add local budget data to the asset maps to see if public investments align with the neighborhoods that need it the most. This would give us a more nuanced understanding of the geography of DC budget investments, including inequities in investments by geography and demographics.

Big data analytics has changed the way we focus our priorities and engage in business practices. I’m committed to this movement. I think that, through big data, we can also revolutionize the way we do policy.

***

In conclusion, DC Kids Count, housed at the nonprofit DC Action for Children, belongs to a larger, nationwide group of organizations helping to better coordinate regional development through data-driven decision making. By centralizing different government databases, and providing real-time, community level data, DC Kids Count can help local government entities allocate their resources more efficiently and creatively and help foster place-conscious strategies. The process behind compiling the data also illustrates many of the challenges—data sharing, interoperability of data systems, access to real-time data involved in building “data- sharing ecosystems.”

Authors

     
 
 




yes

China and Africa’s debt: Yes to relief, no to blanket forgiveness

As COVID-19 exacerbates the pressure on vulnerable public health systems in Africa, the economic outlook of African countries is also becoming increasingly unstable. Just this month, the International Monetary Fund (IMF) projected that the region’s economic growth will shrink by an unprecedented 1.6 percent in 2020 amid tighter financial conditions, a sharp decline in key…

       




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"Should we live together first?" Yes, say Democrats. No, say Republicans (even young ones)


There is a marriage gap in America. This is not just a gap in choices and actions, but in norms and attitudes. Each generation is more liberal, on average, when it comes to issues like premarital relationships, same-sex marriage, and divorce. But generational averages can obscure other divides, including ideology—which in many cases is a more powerful factor.

Take opinions on the most important prerequisites for marriage, as explored in the American Family Survey conducted earlier this year by Deseret News and the Center for the Study of Elections and Democracy (disclosure: I am an adviser to the pollsters). There is widespread agreement that it is best to have a stable job and to have completed college before tying the knot. But there is less agreement in the 3,000-person survey on other questions, including premarital cohabitation.

Living in sin, or preparing for commitment?

In response to the question of whether it is “important to live with your future spouse before getting married,” a clear gap emerges between those who identify as Democrats and those who identify as Republicans. This gap trumps the generational one, with younger Republicans (under 40) more conservative than Democrats over the age of 40:

The importance of family stability for a child’s wellbeing and prospects is well-documented, not least in Isabel Sawhill’s book, Generation Unbound. The question is not whether stability matters, but how best to promote it. To the extent that biological parents stay together and provide a stable environment, it doesn’t much matter if they are married. For children living with both biological parents, there is no difference in outcomes between those being raised by a married couple compared to a cohabiting couple, according to research by Wendy Manning at Bowling Green State University.

But people who marry are much more likely to stay together:

Marriage, at least in America, does seem to act as an important commitment device, a “co-parenting” contract for the modern world, as I’ve argued in an essay for The Atlantic, “How to Save Marriage in America.”

The varied meaning of “cohabitation”

Cohabitation can signal radically different situations. A couple who plan to live together for a couple of years, then marry, and then plan the timing of having children are very different from a couple who start living together, accidentally get pregnant, and then, perhaps somewhat reluctantly, get married.

There is some evidence that cohabitation is in fact becoming a more common bridge to marriage and commitment. First-time premarital cohabiting relationships are also lasting longer on average and increasingly turn into marriage: around seven in ten cohabiting couples are still together after three years, of whom four have married.

In the end what matters is planning, stability, and commitment. If cohabitation is a planned prelude to what some scholars have labeled “decisive marriages,” it seems likely to prove a helpful shift in social norms, by allowing couples to test life under the same roof before making a longer-term commitment. Sawhill’s distinction between “drifters” and “planners” in terms of pregnancy may also be useful when it comes to thinking about cohabitation, too.

Authors

Image Source: © Brendan McDermid / Reuters
     
 
 




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Saban Forum 2015—Israel and the United States: Yesterday, today, and tomorrow


Event Information

December 4-6, 2015

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Live Webcast



On December 4 to 6, the Center for Middle East Policy at Brookings hosted its 12th annual Saban Forum, titled “Israel and the United States: Yesterday, today, and tomorrow.” The 2015 Saban Forum included webcasts featuring remarks by Israel’s Minister of Defense Moshe Ya’alon, Chairman of the Yesh Atid Party Yair Lapid, National Security Adviser to President George W. Bush Stephen Hadley, Secretary of State John Kerry, Israeli Prime Minister Benjamin Netanyahu (via video), and former Secretary of State Hillary Rodham Clinton. The forum’s webcast sessions focused on the future for Israelis and Palestinians, Iran’s role in the Middle East, spillover from the war in Syria, and the global threat posed by the Islamic State and other violent jihadi groups.

Over the past twelve years, the Saban Forum has become the premier platform for frank dialogue between American and Israeli leaders from government, civil society, business, and the media. As a result, the Saban Forum is a seminal event, generating new ideas and helping shape the future of the U.S.-Israel relationship.

Join the conversation on Twitter using #Saban15

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Government spending: yes, it really can cut the U.S. deficit


Hypocrisy is not scarce in the world of politics. But the current House and Senate budget resolutions set new lows. Each proposes to cut about $5 trillion from government spending over the next decade in pursuit of a balanced budget. Whatever one may think of putting the goal of reducing spending when the ratio of the debt-to-GDP is projected to be stable above investing in the nation’s future, you would think that deficit-reduction hawks wouldn’t cut spending that has been proven to lower the deficit.

Yes, there are expenditures that actually lower the deficit, typically by many dollars for each dollar spent. In this category are outlays on ‘program integrity’ to find and punish fraud, tax evasion, and plain old bureaucratic mistakes. You might suppose that those outlays would be spared. Guess again. Consider the following:

Medicare. Roughly 10% of Medicare’s $600 billion budget goes for what officials delicately call ‘improper payments, according to the 2014 financial report of the Department of Health and Human Services. Some are improper merely because providers ‘up-code’ legitimate services to boost their incomes. Some payments go for services that serve no valid purpose. And some go for phantom services that were never provided. Whatever the cause, approximately $60 billion of improper payments is not ‘chump change.’

Medicare tries to root out these improper payments, but it lacks sufficient staff to do the job. What it does spend on ‘program integrity’ yields an estimated $14.40? for each dollar spent, about $10 billion a year in total. That number counts only directly measurable savings, such as recoveries and claim denials. A full reckoning of savings would add in the hard-to-measure ‘policeman on the beat’ effect that discourages violations by would-be cheats.

Fat targets remain. A recent report from the Institute of Medicine presented findings that veritably scream ‘fraud.’ Per person spending on durable medical equipment and home health care is ten times higher in Miami-Dade County, Florida than the national average. Such equipment and home health accounts for nearly three-quarters of the geographical variation in per person Medicare spending. Yet, only 4% of current recoveries of improper payments come from audits of these two items and little from the highest spending locations.

Why doesn’t Medicare spend more and go after the remaining overpayments, you may wonder? The simple answer is that Congress gives Medicare too little money for administration. Direct overhead expenses of Medicare amount to only about 1.5% of program outlays—6% if one includes the internal administrative costs of private health plans that serve Medicare enrollees. Medicare doesn’t need to spend as much on administration as the average of 19% spent by private insurers, because for example, Medicare need not pay dividends to private shareholders or advertise.

But spending more on Medicare administration would both pay for itself—$2 for each added dollar spent, according to the conservative estimate in the President’s most recent budget—and improve the quality of care. With more staff, Medicare could stop more improper payments and reduce the use of approved therapies in unapproved ways that do no good and may cause harm.

Taxes. Compare two numbers: $540 billion and $468 billion. The first number is the amount of taxes owed but not paid. The second number is the projected federal budget deficit for 2015, according to the Congressional Budget Office.

Collecting all taxes legally owed but not paid is an impossibility. It just isn’t worth going after every violation. But current enforcement falls far short of practical limits. Expenditures on enforcement directly yields $4 to $6 for each dollar spent on enforcement. Indirect savings are many times larger—the cop-on-the-beat effect again. So, in an era of ostentatious concern about budget deficits, you would expect fiscal fretting in Congress to lead to increased efforts to collect what the law says people owe in taxes.

Wrong again. Between 2010 and 2014, the IRS budget was cut in real terms by 20%. At the same time, the agency had to shoulder new tasks under health reform, as well as process an avalanche of applications for tax exemptions unleashed by the 2010 Supreme Court decision in the Citizens United case. With less money to spend and more to do, enforcement staff dropped by 15% and inflation adjusted collections dropped 13%.

One should acknowledge that enforcement will not do away with most avoidance and evasion. Needlessly complex tax laws are the root cause of most tax underpayment. Tax reform would do even more than improved administration to increase the ratio of taxes paid to taxes due. But until that glorious day when Congress finds the wit and will to make the tax system simpler and fairer, it would behoove a nation trying to make ends meet to spend $2 billion to $3 billion more each year to directly collect $10 billion to 15 billion a year more of legally owed taxes and, almost certainly, raise far more than that by frightening borderline scoff-laws.

Disability Insurance. Thirteen million people with disabling conditions who are judged incapable of engaging in substantial gainful activity received $161 billion in disability insurance in 2013. If the disabling conditions improve enough so that beneficiaries can return to work, benefits are supposed to be stopped. Such improvement is rare. But when administrators believe that there is some chance, the law requires them to check. They may ask beneficiaries to fill out a questionnaire or, in some cases, undergo a new medical exam at government expense. Each dollar spent in these ways generated an estimated $16 in savings in 2013.

Still, the Social Security Administration is so understaffed that SSA has a backlog of 1.3 million disability reviews. Current estimates indicate that spending a little over $1 billion a year more on such reviews over the next decade would save $43 billion. Rather than giving Social Security the staff and spending authority to work down this backlog and realize those savings, Congress has been cutting the agency’s administrative budget and sequestration threatens further cuts.

Claiming that better administration will balance the budget would be wrong. But it would help. And it would stop some people from shirking their legal responsibilities and lighten the burdens of those who shoulder theirs. The failure of Congress to provide enough staff to run programs costing hundreds of billions of dollars a year as efficiently and honestly as possible is about as good a definition of criminal negligence as one can find.

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Wretched Excess: Private yachts are so yesterday, now it's private floating islands.

But, we ask, are they green and sustainable?