At 85, Dame Judi Dench has made history as the oldest person ever to star on the cover of Vogue magazine. The veteran actress looked striking on the cover of British Vogue and we couldn't take eyes off her.

Lewis Library - ML3917.U33 K34 2018

Hayden Library - TA418.9.N35 F87 2018

DAMMIT who forgot to pack the spare tire,

DAMN I LOOK GOOD AS HELL! Discount Easter Decorations Put to Good Use

From Notre Dame to the Monon Bell. We rank Indiana's top 50 college football games in 2018.

Reggie Brooks bullish on Notre Dame RB Chris Tyree and the Holtz's Heroes Foundation

Contact between inflammatory cells and endothelial cells (ECs) is a crucial step in vascular inflammation. Recently, we demonstrated that the cell-surface level of endomucin (EMCN), a heavily O-glycosylated single-transmembrane sialomucin, interferes with the interactions between inflammatory cells and ECs. We have also shown that, in response to an inflammatory stimulus, EMCN is cleared from the cell surface by an unknown mechanism. In this study, using adenovirus-mediated overexpression of a tagged EMCN in human umbilical vein ECs, we found that treatment with tumor necrosis factor α (TNF-α) or the strong oxidant pervanadate leads to loss of cell-surface EMCN and increases the levels of the C-terminal fragment of EMCN 3- to 4-fold. Furthermore, treatment with the broad-spectrum matrix metalloproteinase inhibitor batimastat (BB94) or inhibition of ADAM metallopeptidase domain 10 (ADAM10) and ADAM17 with two small-molecule inhibitors, GW280264X and GI254023X, or with siRNA significantly reduced basal and TNFα-induced cell-surface EMCN cleavage. Release of the C-terminal fragment of EMCN by TNF-α treatment was blocked by chemical inhibition of ADAM10 alone or in combination with ADAM17. These results indicate that cell-surface EMCN undergoes constitutive cleavage and that TNF-α treatment dramatically increases this cleavage, which is mediated predominantly by ADAM10 and ADAM17. As endothelial cell-surface EMCN attenuates leukocyte–EC interactions during inflammation, we propose that EMCN is a potential therapeutic target to manage vascular inflammation.

The Catholic Church remembers St. Damien of Molokai on May 10. The Belgian priest sacrificed his life and health to become a spiritual father to the victims of leprosy quarantined on a Hawaiian island.Joseph de Veuser, who later took the name Damien in religious life, was born into a farming family in the Belgian town of Tremlo in 1840. During his youth he felt a calling to become a Catholic missionary, an urge that prompted him to join the Congregation of the Sacred Hearts of Jesus and Mary.Damien's final vows to the congregation involved a dramatic ceremony in which his superiors draped him in the cloth that would be used to cover his coffin after death. The custom was meant to symbolize the young man's solemn commitment, and his identification with Christ's own death. For Damien, the event would become more significant, as he would go on to lay down his life for the lepers of Molokai.His superiors originally intended to send Damien's brother, a member of the same congregation, to Hawaii. But he became sick, and Damien arranged to take his place. Damien arrived in Honolulu in 1864, less than a century after Europeans had begun to establish a presence in Hawaii. He was ordained a priest the same year.During his ninth year of the priesthood, Father Damien responded to his bishop's call for priests to serve on the leper colony of Molokai. A lack of previous exposure to leprosy, which had no treatment at the time, made the Hawaiian natives especially susceptible to the infection. Molokai became a quarantine center for the victims, who became disfigured and debilitated as the disease progressed.The island had become a wasteland in human terms, despite its natural beauty. The leprosy victims of Molokai faced hopeless conditions and extreme deprivation, sometimes lacking not only basic palliative care but even the means of survival.Inwardly, Fr. Damien was terrified by the prospect of contracting leprosy himself. However, he knew that he would have to set aside this fear in order to convey God's love to the lepers in the most authentic way. Other missionaries had kept the lepers at arms' length, but Fr. Damien chose to immerse himself in their common life and leave the outcome to God.The inhabitants of Molokai saw the difference in the new priest's approach, and embraced his efforts to improve their living conditions. A strong man, accustomed to physical labor, he performed the Church's traditional works of mercy – such as feeding the hungry, sheltering the homeless, and giving proper burial to the dead – in the face of suffering that others could hardly even bear to see.Fr. Damien's work helped to raise the lepers up from their physical sufferings, while also making them aware of their worth as beloved children of God. Although he could not take away the constant presence of death in the leper colony, he could change its meaning and inspire hope. The death-sentence of leprosy could, and often did, become a painful yet redemptive path toward eternal life.The priest's devotion to his people, and his activism on their behalf, sometimes alienated him from officials of the Hawaiian kingdom and from his religious superiors in Europe. His mission was not only fateful, but also lonely. He drew strength from Eucharistic adoration and the celebration of the Mass, but longed for another priest to arrive so that he could receive the sacrament of confession regularly.In December of 1884, Fr. Damien discovered that he had lost all feeling in his feet. It was an early, but unmistakable sign that he had contracted leprosy. The priest knew that his time was short. He undertook to finish whatever accomplishments he could, on behalf of his fellow colony residents, before the diseased robbed him of his eyesight, speech and mobility.Fr. Damien suffered humiliations and personal trials during his final years. An American Protestant minister accused him of scandalous behavior, based on the contemporary belief that leprosy was a sexually transmitted disease. He ran into disagreements with his religious superiors, and felt psychologically tormented by the notion that his work had been a failure.In the end, priests of his congregation arrived to administer the last sacraments to the dying priest. During the Spring of 1889, Fr. Damien told his friends that he believed it was God's will for him to spend the upcoming Easter not on Molokai, but in heaven. He died of leprosy during Holy Week, on April 15, 1889.St. Damien of Molokai was beatified in 1995. Pope Benedict XVI canonized him in 2009.

04/13/2020 to 06/12/2020 Daytime intermittent lane closures for milling, patching, paving, and ADA improvements.

Small cardamom exports to Saudi Arabia are likely to increase during the current Ramadan season with the Saudi authorities agreeing to accept the globally accepted Codex Food Standards of the United Nations.

On a similar note, India is trying hard to develop indigenous capacity (Make in India) for machineries and equipment required for, say, new steel capacity augmentation. Otherwise, the large scale of imports of capital goods in the form of machines and equipment for steel plants would have to continue by spending huge foreign exchange and make India import dependent.

Humans are causing irreversible damage to the planet from burning fossil fuels, the biggest ever study of the available science concluded in a report designed to spur the fight against climate change.

For many mining companies, the rallying cry for investigating solar or wind energy options has been that the price of oil and other conventional fuels is too high — and will almost certainly rise over time. Now, though, with oil prices having taken a dramatic nosedive, this argument no longer packs quite the same punch that it once did.

Humans are causing irreversible damage to the planet from burning fossil fuels, the biggest ever study of the available science concluded in a report designed to spur the fight against climate change.

Boko Haram: Brigadier General Idris Dambazzau (ret.), in this interview, reviews war against insurgency, saying expansion of manpower, overhauling of the Defence Ministry and robust intelligence community would make a difference.

The post Our troops are using Shagari era weapons to fight Boko Haram – Dambazzau appeared first on Vanguard News.

Libyan rebels have heavily attacked an airport in the capital Tripoli, killing six civilians and inflicting damage in and around the facility. Several civilians were also injured in the attack on Mitiga International Airport on Saturday, the country’s internationally-recognized government said. The Libyan Interior Ministry said at least 80 rockets were fired in the attack,...

Three young men suspected to be members of a criminal gang called ‘Shila Boys’ have been beaten to death in the Adamawa State capital, Yola. DAILY POST gathered on Sunday morning that the youths were killed by angry passers-by on Saturday night when they tried to snatch belongings of some women coming out of the […]

3 ‘Shilla Boys’ allegedly beaten to death in Adamawa

For him, as long as the Maa community is happy, nothing else matters.

Fishermen in northeast Thailand say they have seen catches in the Mekong River plunge, while some farmers in Vietnam and Cambodia are leaving for jobs in cities as harvests of rice and other crops shrink.The common thread driving these events is erratic water levels in Asia’s third longest waterway.Water flows along the 4,300km (2,700 mile) Mekong shift naturally between monsoon and dry seasons, but non-governmental groups say the 11 hydroelectric dams on China’s portion of the river – five of…

NBA commissioner Adam Silver is cautiously optimistic about finishing out the season in a two-site plan which will likely not include fans -- a condition that may carry into next season. 

Former footballer and AFL coach Grant Thomas has said clubs need to be more diligent when appointing a head coach, saying those who have only been around footy their whole lives are not be prepared for such a job, leading to problems later in life.

Australia’s frontline white ball spinner, Adam Zampa, is poised to leave South Australia in the off-season for a move back home to New South Wales.

Fernando Alonso is relying on tyre strategy to limit the damage to his narrow championship lead at tomorrow's Brazilian Grand Prix

With states and Centre set to meet this week to chalk out jurisdiction over assessees under goods and services tax (GST).

Natural resources provide essential raw materials and other commodities, and are an important source of income and jobs. They also support the provision of ecosystem services necessary to develop human and social capital.

More people than even before now reach a level of educational attainment equivalent to upper secondary education. The available evidence is very conclusive: this level of education can be considered a minimum level to ensure a job and a living wage.

The OECD has published fundamental and guiding principles to facilitate the application of QSAR methods to the risk assessment of chemicals. The main focus is on the critical role of mechanistic consideration in improving various (Q)SAR approaches and possible integrative approaches of combining chemoinformatics and bioinformatics.

Qantas has grounded three Boeing 737 jets after cracks were found in the part of the aircraft connecting the wings with the body. Maintenance engineers want the entire fleet grounded.

He's a Hollywood A-lister, so most people would expect Matt Damon to travel in style everywhere he goes.

1. "The attested copy of the very basis of the seniority list of 594 contractor's workers at BTPS as was published on notice board, the Appendix 'D' of Letter no. BT/DGM(Admn)/2/I-842 dt. 22-05-1998.

2. If there is no basis of preparing the aforesaid seniority list, then why the names of other persons were enlisted in the Appendix 'D' of the aforesaid letter."

2. The CPIO responded on 01-03-2018 & 16-05-2018. The appellant filed the first appeal dated 12-03-2018 which was disposed of by the first appellate authority on 19-04-2018. Thereafter, he filed a second appeal u/Section 19(3) of the RTI Act before the Commission requesting to take appropriate legal action against the CPIO u/Section 20 of the RTI Act, 2005 and also to direct him to provide the sought for information.

British boy bands Five, 911, Damage and A1 topped the charts and played sell-out concerts to thousands of screaming fans at the height of their fame - but the years since are a very different story.

Road users can rapidly find themselves out of pocket if their bike or vehicle is damaged by one, while cyclists can easily be injured if a pothole causes them to come off their bike.

Jessica Ennis-Hill's coach has told Sebastian Coe to immediately start drawing up a list of medals that should be taken from drug cheats and handed to the athletes they robbed.

Jessica Ennis-Hill was an absolute vision as she received a CBE by the Duke of Cambridge at London's Buckingham Palace on Wednesday.

Dame Jessica Ennis-Hill has called for 'standardised' arrangements to be put in place to support female athletes who want to have children.

The legendary actress, 85, also revealed that despite her great success, a career in film was never her intention after she was told she would 'never make a movie'.

As the demands for justice draw embarrassingly close to the PM, the decision to raise the height of the Sardar Sarovar dam is being reviewed. But promises are nothing new, and officials have always known that they can be broken with impunity. Should we expect anything different this time? The India Together editorial.

Over 230,000 people in hundreds of villages to be displaced, tens of thousands of acres submerged, wildlife and forest lands inundated - the Polavaram project will repeat the great tragedy of displacement and environmental damage that has marked so many other projects in the country. R Uma Maheshwari reports.

Randamoozham, the Mohanlal starring period drama is one of the most anticipated upcoming films of the Indian film industry. Recently, it was rumoured that Priyadarshan, the senior filmmaker might take over the Mohanlal project as the director. The rumours started doing

Archives, Room Use Only - HE6935.A33 1935

Archives, Room Use Only - TK5264.F86 1941

Archives, Room Use Only - HE7677.S5 A33 1894

Archives, Room Use Only - TK5262.R46 1924