ic Brexit - Planning for medicine shortages By feeds.bmj.com Published On :: Fri, 13 Sep 2019 18:22:17 +0000 This week we saw the release of the much awaited Yellowhammer documents from the government, documents which outline some of the risks involved with Britain’s sudden departure from the EU. The documents themselves outline that there are risks to the supply of medicines - but do not set out the detail of how those risks have been mitigated, and... Full Article
ic Minimum unit pricing in Scotland By feeds.bmj.com Published On :: Thu, 26 Sep 2019 17:47:38 +0000 On the 1st of May, 2018 Scotland was the first country to try a new way of reducing alcohol consumption in its population. It introduced a minimum unit prices for alcohol. Now new research just published on BMJ.com is looking at the effect of that price increase - and measuring how well it has achieved the goal of reducing drinking in... Full Article
ic How Blockchain could improve clinical trial transparency By feeds.bmj.com Published On :: Sat, 12 Oct 2019 13:06:50 +0000 Blockchain is the digital technology that underpins cryptocurrencies such as bitcoin, and has been proposed as the digital panacea of our times. But Leeza Osipenko, from the London School of Economics, has thought about how it could actually be used in clinical trials, and what else would need to change in our regulatory environment to make that... Full Article
ic Ancestry DNA tests can over or under estimate genetic disease risk By feeds.bmj.com Published On :: Thu, 17 Oct 2019 14:36:18 +0000 Direct-to-consumer genetic tests are sold online and in shops as a way to “find out what your DNA says". They insights into ancestry or disease risks; others claim to provide information on personality, athletic ability, and child talent. However, interpretation of genetic data is complex and context dependent, and DTC genetic tests may produce... Full Article
ic Editors pick of education in 2019 By feeds.bmj.com Published On :: Fri, 03 Jan 2020 14:58:44 +0000 If you’re lucky enough to not be back at work, you might be feeling like you need to quickly refresh your medical knowledge - and this podcast the BMJ’s education editors take you on a whistlestop tour through the BMJ’s education articles of 2019. Tom Nolan (GP in London) is joined by Navjoyt Ladher (GP in London), Anita Jain (GP in India) and... Full Article
ic Michael West - GMC Report On Wellbeing By feeds.bmj.com Published On :: Fri, 10 Jan 2020 15:02:33 +0000 Michael West is professor of organisational psychology, at Lancaster University, and co-author of a new GMC report into the wellbeing of NHS staff. The review he led together with the clinical psychiatrist Denise Coia, focused on primary interventions related to workplace factors and the systems that doctors work in, rather than secondary... Full Article
ic Is it possible to have fair pricing for medicines By feeds.bmj.com Published On :: Fri, 17 Jan 2020 17:50:54 +0000 Is it possible to have a fair price for medicines? Yes, according to a new collection just published on bmj.com. The authors set out to evaluate how we could improve the functioning of the market for medicines, to honestly compensate industry for innovation, whilst allowing the poorest to afford them. Suerie Moon, co-director of global health at... Full Article
ic David Williams - everyday discrimination is an independent predictor of mortality By feeds.bmj.com Published On :: Thu, 13 Feb 2020 12:44:12 +0000 There comes a tipping point in all campaigns when the evidence is overwhelming and the only way to proceed is with action. According to David Williams, it’s time to tackle the disproportionate effects of race on patients in the UK. David Williams, from Harvard University, developed the Everyday Discrimination Scale that, in 1997, launched a new... Full Article
ic Born equal - the launch of The BMJ special issue on race in medicine By feeds.bmj.com Published On :: Fri, 21 Feb 2020 18:18:08 +0000 Last week the BMJ published it’s first special edition into Racism in Medicine. The issues tacked ranged from differential attainment in medical school, to the physiological effects that experiencing everyday discrimination has. The issue was guest edited by Victor Adebowale, the Chief Executive of the social care enterprise Turning Point, and... Full Article
ic Talk Evidence - testing under the microscope and opioid prescription By feeds.bmj.com Published On :: Fri, 20 Mar 2020 20:08:10 +0000 This edition of talk evidence was recorded before the big increase in covid-19 infections in the UK, and then delayed by some self isolation. We'll be back with more evidence on the pandemic very soon. As always Duncan Jarvies is joined by Helen Macdonald (resting GP and editor at The BMJ) and Carl Heneghan (active GP, director of Oxford... Full Article
ic Talk Evidence Covid-19 update - Confused symptoms, fatality rate uncertainty, Iceland's testing By feeds.bmj.com Published On :: Fri, 27 Mar 2020 16:14:17 +0000 For the next few months Talk Evidence is going to focus on the new corona virus pandemic. There is an enormous amount of uncertainty about the disease, what the symptoms are, fatality rate, treatment options, things we shouldn't be doing. We're going to try to get away from the headlines and talk about what we need to know - to hopefully give... Full Article
ic Wellbeing - Some advice on working in PPE By feeds.bmj.com Published On :: Wed, 08 Apr 2020 17:38:56 +0000 Wellbeing might not seem the obvious place to talk about PPE - but lack of appropriate PPE is causing healthcare staff a great deal of stress now. Mary Brindle is a pediatric surgeon and the director of The EQuIS (Efficiency Quality Innovation and Safety) Research platform at Alberta Children’s hospital. In this podcast she reflects on the use... Full Article
ic The public health response to covid - 19 By feeds.bmj.com Published On :: Sun, 12 Apr 2020 19:40:26 +0000 As part of our response to the covid-19 pandemic, we’re going to be running a series of discussions with experts about some of the big issues arising from the virus. In this one, we’re asking about the public health response to an outbreak - what’s necessary, and is it possible to go to far. Joining us are Martin Mckee - professor of european... Full Article
ic Talk Evidence covid-19 update - hydroxy/chloroquinine, prognostic models and facemaskss By feeds.bmj.com Published On :: Mon, 13 Apr 2020 20:39:17 +0000 For the next few months Talk Evidence is going to focus on the new corona virus pandemic. There is an enormous amount of uncertainty about the disease, what the symptoms are, fatality rate, treatment options, things we shouldn't be doing. We're going to try to get away from the headlines and talk about what we need to know - to hopefully give... Full Article
ic Wellbeing - some advice for telehealth in secondary care By feeds.bmj.com Published On :: Thu, 16 Apr 2020 18:30:00 +0000 We’ve published info on Telehealth in primary care - and have been overwhelmed by the response from GPs who are finding it useful. But it’s not only primary care that is dramatically shifting to remote care - routine hospital care is moving online too, so we’ve asked Rowena McCash - GP and out of hours triage trainer joins us to give some tips... Full Article
ic Wellbeing – advice from a military medic to frontline clinicians By feeds.bmj.com Published On :: Wed, 22 Apr 2020 11:53:26 +0000 There is no doubt that anxiety levels that clinicians are feeling during this pandemic are high. One military medic believes the current situation is comparable to his experience when posted during British campaigns in Afghanistan and Iraq. Cormac Doyle offers advice on how to deal with high-stress conditions, both in a work and at home, as... Full Article
ic Talk Evidence - covid ethics, waste and a minimum RCT size By feeds.bmj.com Published On :: Fri, 24 Apr 2020 16:19:18 +0000 For the next few months Talk Evidence is going to focus on the new corona virus pandemic. There is an enormous amount of uncertainty about the disease, what the symptoms are, fatality rate, treatment options, things we shouldn't be doing. We're going to try to get away from the headlines and talk about what we need to know - to hopefully give... Full Article
ic Public Health Vs The Economy By feeds.bmj.com Published On :: Tue, 28 Apr 2020 17:49:55 +0000 Around the world, as the covid pandemic plays out, and some countries are starting to ease their restrictions, this narrative of the economy and public health being opposing weights on a set of scales keeps returning - they need to be balanced. But before this, a healthy population is very much seen as being supportive of the economy. So is a... Full Article
ic Coping with Covid with Monica Schoch-Spana and Jud Brewer By feeds.bmj.com Published On :: Wed, 06 May 2020 23:27:26 +0000 In this week’s episode, we discuss bystander guilt, convergence, brain hacks and “how you can sneeze on someone’s brain from anywhere in the world”. How can GPs cope with the myriad worries around treating patients during the current pandemic, both on the frontline and in general practice? How do we recognise and break unhelpful anxious behaviour... Full Article
ic Glucose-Induced Reactive Oxygen Species Cause Apoptosis of Podocytes and Podocyte Depletion at the Onset of Diabetic Nephropathy By diabetes.diabetesjournals.org Published On :: 2006-01-01 Katalin SusztakJan 1, 2006; 55:225-233Complications Full Article
ic C-Reactive Protein Is an Independent Predictor of Risk for the Development of Diabetes in the West of Scotland Coronary Prevention Study By diabetes.diabetesjournals.org Published On :: 2002-05-01 Dilys J. FreemanMay 1, 2002; 51:1596-1600Complications Full Article
ic The Effect of Thiazolidinediones on Plasma Adiponectin Levels in Normal, Obese, and Type 2 Diabetic Subjects By diabetes.diabetesjournals.org Published On :: 2002-10-01 Joseph G. YuOct 1, 2002; 51:2968-2974Obesity Studies Full Article
ic Morbidity and Mortality in Diabetics In the Framingham Population: Sixteen Year Follow-up Study By diabetes.diabetesjournals.org Published On :: 1974-02-01 Mariano J GarciaFeb 1, 1974; 23:105-111Original Contribution Full Article
ic Moving GLUT4: The Biogenesis and Trafficking of GLUT4 Storage Vesicles By diabetes.diabetesjournals.org Published On :: 1997-11-01 Shane ReaNov 1, 1997; 46:1667-1677Perspectives in Diabetes Full Article
ic High Incidence of Metabolically Active Brown Adipose Tissue in Healthy Adult Humans: Effects of Cold Exposure and Adiposity By diabetes.diabetesjournals.org Published On :: 2009-07-01 Masayuki SaitoJul 1, 2009; 58:1526-1531Metabolism Full Article
ic Endothelial Progenitor Cell Dysfunction: A Novel Concept in the Pathogenesis of Vascular Complications of Type 1 Diabetes By diabetes.diabetesjournals.org Published On :: 2004-01-01 Cindy J.M. LoomansJan 1, 2004; 53:195-199Complications Full Article
ic Are the {beta}-Cell Signaling Molecules Malonyl-CoA and Cystolic Long-Chain Acyl-CoA Implicated in Multiple Tissue Defects of Obesity and NIDDM? By diabetes.diabetesjournals.org Published On :: 1996-03-01 Marc PrentkiMar 1, 1996; 45:273-283Original Article Full Article
ic Inflammatory Cytokines and the Risk to Develop Type 2 Diabetes: Results of the Prospective Population-Based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study By diabetes.diabetesjournals.org Published On :: 2003-03-01 Joachim SprangerMar 1, 2003; 52:812-817Pathophysiology Full Article
ic A Lesson in Metabolic Regulation Inspired by the Glucokinase Glucose Sensor Paradigm By diabetes.diabetesjournals.org Published On :: 1996-02-01 Franz M MatschinskyFeb 1, 1996; 45:223-241Banting Lecture 1995 Full Article
ic Intramyocellular triglyceride content is a determinant of in vivo insulin resistance in humans: a 1H-13C nuclear magnetic resonance spectroscopy assessment in offspring of type 2 diabetic parents By diabetes.diabetesjournals.org Published On :: 1999-08-01 G PerseghinAug 1, 1999; 48:1600-1606Articles Full Article
ic The Effect of Insulin on the Disposal of Intravenous Glucose: Results from Indirect Calorimetry and Hepatic and Femoral Venous Catheterization By diabetes.diabetesjournals.org Published On :: 1981-12-01 R A DeFronzoDec 1, 1981; 30:1000-1007Original Contribution Full Article
ic NCEP-Defined Metabolic Syndrome, Diabetes, and Prevalence of Coronary Heart Disease Among NHANES III Participants Age 50 Years and Older By diabetes.diabetesjournals.org Published On :: 2003-05-01 Charles M. AlexanderMay 1, 2003; 52:1210-1214Complications Full Article
ic Mechanisms of Pancreatic {beta}-Cell Death in Type 1 and Type 2 Diabetes: Many Differences, Few Similarities By diabetes.diabetesjournals.org Published On :: 2005-12-01 Miriam CnopDec 1, 2005; 54:S97-S107Section III: Inflammation and beta-Cell Death Full Article
ic Nonalcoholic Fatty Liver Disease: A Feature of the Metabolic Syndrome By diabetes.diabetesjournals.org Published On :: 2001-08-01 Giulio MarchesiniAug 1, 2001; 50:1844-1850Pathophysiology Full Article
ic Estimation of Insulin Secretion Rates from C-Peptide Levels: Comparison of Individual and Standard Kinetic Parameters for C-Peptide Clearance By diabetes.diabetesjournals.org Published On :: 1992-03-01 Eve Van CauterMar 1, 1992; 41:368-377Original Article Full Article
ic Protein kinase C activation and the development of diabetic complications By diabetes.diabetesjournals.org Published On :: 1998-06-01 D KoyaJun 1, 1998; 47:859-866Articles Full Article
ic Lipotoxicity in the Pathogenesis of Obesity-Dependent NIDDM: Genetic and Clinical Implications By diabetes.diabetesjournals.org Published On :: 1995-08-01 Roger H UngerAug 1, 1995; 44:863-870Perspectives in Diabetes Full Article
ic Diet-Induced Type II Diabetes in C57BL/6J Mice By diabetes.diabetesjournals.org Published On :: 1988-09-01 Richard S SurwitSep 1, 1988; 37:1163-1167Original Article Full Article
ic Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats By diabetes.diabetesjournals.org Published On :: 1999-12-01 G XuDec 1, 1999; 48:2270-2276Articles Full Article
ic Elevated Levels of Acute-Phase Proteins and Plasminogen Activator Inhibitor-1 Predict the Development of Type 2 Diabetes: The Insulin Resistance Atherosclerosis Study By diabetes.diabetesjournals.org Published On :: 2002-04-01 Andreas FestaApr 1, 2002; 51:1131-1137Complications Full Article
ic Hypoglycemia in the Diabetes Control and Complications Trial By diabetes.diabetesjournals.org Published On :: 1997-02-01 The Diabetes Control and Complications Trial Research GroupFeb 1, 1997; 46:271-286Original Article Full Article
ic The Relationship of Glycemic Exposure (HbA1c) to the Risk of Development and Progression of Retinopathy in the Diabetes Control and Complications Trial By diabetes.diabetesjournals.org Published On :: 1995-08-01 The Diabetes Control and Complications Trial Research GroupAug 1, 1995; 44:968-983Original Article Full Article
ic Role of oxidative stress in diabetic complications: a new perspective on an old paradigm By diabetes.diabetesjournals.org Published On :: 1999-01-01 JW BaynesJan 1, 1999; 48:1-9Articles Full Article
ic Preservation of Pancreatic {beta}-Cell Function and Prevention of Type 2 Diabetes by Pharmacological Treatment of Insulin Resistance in High-Risk Hispanic Women By diabetes.diabetesjournals.org Published On :: 2002-09-01 Thomas A. BuchananSep 1, 2002; 51:2796-2803Pathophysiology Full Article
ic Role of Oxidative Stress in Development of Complications in Diabetes By diabetes.diabetesjournals.org Published On :: 1991-04-01 John W BaynesApr 1, 1991; 40:405-412Perspectives in Diabetes Full Article
ic Quantification of the Relationship Between Insulin Sensitivity and {beta}-Cell Function in Human Subjects: Evidence for a Hyperbolic Function By diabetes.diabetesjournals.org Published On :: 1993-11-01 Steven E KahnNov 1, 1993; 42:1663-1672Original Article Full Article
ic PPAR-gamma: adipogenic regulator and thiazolidinedione receptor By diabetes.diabetesjournals.org Published On :: 1998-04-01 BM SpiegelmanApr 1, 1998; 47:507-514Articles Full Article
ic Changes in Gut Microbiota Control Metabolic Endotoxemia-Induced Inflammation in High-Fat Diet-Induced Obesity and Diabetes in Mice By diabetes.diabetesjournals.org Published On :: 2008-06-01 Patrice D. CaniJun 1, 2008; 57:1470-1481Metabolism Full Article
ic The Pathobiology of Diabetic Complications: A Unifying Mechanism By diabetes.diabetesjournals.org Published On :: 2005-06-01 Michael BrownleeJun 1, 2005; 54:1615-1625Banting Lecture 2004 Full Article
ic Metabolic Endotoxemia Initiates Obesity and Insulin Resistance By diabetes.diabetesjournals.org Published On :: 2007-07-01 Patrice D. CaniJul 1, 2007; 56:1761-1772Obesity Studies Full Article