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Severe cyclone Michaung makes landfall in Andhra Pradesh, wreaks havoc

Heavy rain and high-velocity winds with a maximum sustained speed of 90-100 kmph lash coastal town of Bapatla, villages; three killed in rain-related accidents; power supply affected in many areas; cyclone moving towards north, say officials




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Cyclone Michaung | Death toll rises to seven in Chennai and neighbouring districts; over 61,600 moved to relief camps

Additional workforce is being sourced from neighbouring districts to undertake relief operations in Chennai and three neighbouring districts on war footing




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Panchayats in India earn only one per cent of their revenue through taxes: Data

Most of their revenue comes from the Centre and the States as grants




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Global Chess League: Nihal’s draw stands, SG Pipers’ appeal to reverse result rejected




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Shreyas — the boy who helped his family avoid deportation and is now UK’s youngest ever chess Grandmaster




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Women’s T20 World Cup: How Pakistan can help India to qualify for semifinals even after Australia defeat 

India, on four points after two wins and two losses, hopes that Pakistan defeats New Zealand on Monday (October 14, 2024) to leave the second semi-final place to be decided on net run-rate




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Approach is to treat every game with utmost respect: Gukesh




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Mauritius holds election with cost of living on everyone's minds

Mauritius parliamentary election: Economic promises, alliances, and voter expectations in the Indian Ocean archipelago




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Egyptians exhume the dead as city development takes over cemeteries in Cairo

Since 2020, thousands of graves have been demolished at the UNESCO-listed World Heritage Site




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Daily Quiz: On events surrounding November 11




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Amid threats of violent protests, Brampton Triveni temple cancels life certificate event

“We are deeply saddened that Canadians now feel unsafe coming to Hindu Temples in Canada”




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Setting up of industrial corridor, development of roads in Krishna district soon: Minister




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Requested ₹130 crore from Centre for the development of Vijayawada GGH: Vijayawada MP Chinni

All Anganwadi centres in NTR district will get a building of their own with clean kitchens, says Chinni




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Chief Minister wants to create one entrepreneur in every family in A.P., says MSME Minister

The government plans to set up incubation centres and is formulating a virtual workplace policy with incentives for people who set up workplaces, says Kondapalli Srinivas




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Andhra Pradesh CM Chandrababu Naidu to lead high-level meeting with State officials on streamlining Governance

The CM Chandrababu Naidu’s agenda includes setting priorities for development goals, guiding the administrative machinery on the state government’s objectives, and outlining a strategic framework titled “Ten Principles for Development.”




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A.P. government appoints Inquiry Authority to probe role of revenue officers in alleged land scam in Vizianagaram

Revenue Department Special Chief Secretary directs the Inquiring Authority to submit the inquiry report within a period of six weeks




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Response strategies and biological applications of organic fluorescent thermometry: cell- and mitochondrion-level detection

Anal. Methods, 2024, 16,1968-1984
DOI: 10.1039/D4AY00117F, Minireview
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Shuai Li, Yaoxuan Li, Shiji Zhang, Haixiao Fang, Ze Huang, Duoteng Zhang, Aixiang Ding, Kajsa Uvdal, Zhangjun Hu, Kai Huang, Lin Li
In this review, we primarily summarized four temperature-response strategies. Then, we further analyzed the chemical modifications and biological applications of the probes. Finally, we have provided a prospective on the future development of probes.
The content of this RSS Feed (c) The Royal Society of Chemistry




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One-step electrodeposited hybrid nanofilms in amperometric biosensor development

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00290C, Tutorial Review
Yuliya E. Silina
This review summarizes developments in amperometric biosensors with electrodeposited sensing films. It was shown how the analytical merit of one-step designed biosensors can be controlled by the change of chemical factors within the same engineering platform.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Development of a label-free, sensitive gold nanoparticles-poly (adenine)aptasensing platform for colorimetric determination of aflatoxin B1 in corn

Anal. Methods, 2024, Accepted Manuscript
DOI: 10.1039/D4AY00605D, Paper
Omid Heydari Shayesteh, Katayoun Derakhshandeh, Akram Ranjbar, Reza Mahjub, Abbas Farmany
In this work, a sensitive colorimetric bioassay method based on poly (adenine) aptamer (polyA apt) and gold nanoparticles (AuNPs) was developed to the determination of aflatoxin B1 (AFB1). The polyA...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Resolving phytosterols in microalgae using offline two-dimensional reversed phase liquid chromatography-supercritical fluid chromatography coupled with quadrupole time-of-flight mass spectrometry

Anal. Methods, 2024, 16,2278-2285
DOI: 10.1039/D3AY02261G, Paper
Magali Batteau, Elodie Bouju, Adriana Ramirez-Romero, Sylvie Nuccio, René De Vaumas, Florian Delrue, Karine Faure
Development of an off-line LC-SFc-MS method, separation of sterol isomers in algal unsaponifiable fractions, elution pattern helping in the reduction of structural candidates.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Advancements in the development of fluorescent chemosensors based on CN bond isomerization/modulation mechanistic approaches

Anal. Methods, 2024, 16,2198-2228
DOI: 10.1039/D3AY02321D, Critical Review
Arpna Tamrakar, Manzoor Ahmad Wani, Gargi Mishra, Ankur Srivastava, Rampal Pandey, Mrituanjay D. Pandey
The CN bond isomerization/modulation as a fluorescence signalling mechanism was explored by studying the photophysical properties of conformationally restricted molecules.
The content of this RSS Feed (c) The Royal Society of Chemistry




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An immunochromatographic strip sensor for rapid and sensitive detection of candesartan, olmesartan medoxomil, and irbesartan in herbal beverages

Anal. Methods, 2024, 16,2359-2367
DOI: 10.1039/D4AY00151F, Paper
Dingyu Li, Aihong Wu, Liqiang Liu, Hua Kuang, Chuanlai Xu, Xiaoling Wu
Sartans, as a class of antihypertensive drugs, pose a threat to human health when illegally added to herbal beverages.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Are These the Most Interesting Front-end Developer Tools for 2021?

When I come to the end of any given year, it’s always interesting to look back through the click-through stats for my weekly newsletter Web Tools Weekly to see which tools got the most attention.

This year wasn’t all that different from previous years. I’ve learned that clicks happen for basically one of two reasons:

The post Are These the Most Interesting Front-end Developer Tools for 2021? appeared first on Impressive Webs.



  • Roundups and Resources

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What Makes <I>Andaz Apna Apna</I> Such Fun Even Today

Andaz Apna Apna is practically the most quoted film since Sholay, observes Sukanya Verma, as she celebrates 30 years of this cult classic movie.




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The Woman Who Lost Everything

When the landslide hit, Sruthi's house was washed away, along with its inhabitants.




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Rational design and in vitro testing of new urease inhibitors to prevent urinary catheter blockage

RSC Med. Chem., 2024, 15,3597-3608
DOI: 10.1039/D4MD00378K, Research Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Rachel A. Heylen, Nicola Cusick, Tom White, Emily J. Owen, Bethany L. Patenall, Martin Alm, Peter Thomsen, Maisem Laabei, A. Toby A. Jenkins
In silico identification of urease inhibitors based on thiourea, tested to determine IC50 and tested on a catheterised in vitro bladder model, showing efficacy in reducing catheter blockage.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Development, biological evaluation, and molecular modelling of some benzene-sulfonamide derivatives as protein tyrosine phosphatase-1B inhibitors for managing diabetes mellitus and associated metabolic disorders

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00594E, Research Article
Nagat Ghareb, Khaled M. Darwish, Mohamed S. Nafie, Ranwa Elrayess, Noha M. Abourobe, Shaimaa A. Fattah, Reem M. Hazem, Eman T. Mehanna, Ranza Elrayess
One benzene-sulfonamide derivative exhibited potent protein tyrosine phosphatase-1B inhibition for managing diabetes mellitus and associated metabolic disorders.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Ligand-centred phenotype-driven development of potent kinase inhibitors against oesophageal cancer

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00579A, Research Article
Open Access
Cecilia C. Ayala-Aguilera, Yang Ge, Álvaro Lorente-Macías, Benjamin N. Jones, Catherine Adam, Neil O. Carragher, Asier Unciti-Broceta
A ligand-centred strategy combined with phenotypic screening was used to develop novel antiproliferative inhibitors against oesophageal cancer and identified a lead compound that induces potent anticancer activity and inhibits Aurora kinase A.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Generation and capture of naphthoquinonynes: a new frontier in the development of trypanocidal quinones via aryne chemistry

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00558A, Research Article
Laura P. R. Figueroa, Renato L. de Carvalho, Renata G. Almeida, Esther R. S. Paz, Emilay B. T. Diogo, Maria H. Araujo, Warley S. Borges, Victor F. S. Ramos, Rubem F. S. Menna-Barreto, James M. Wood, John F. Bower, Eufrânio N. da Silva Júnior
This article presents A-ring functionalized quinones via a modern and efficient new strategy involving the generation and capture of benzyne quinones and their evaluation against Trypanosoma cruzi.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Technical, preclinical, and clinical developments of Fc-glycan-specific antibody–drug conjugates

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00637B, Review Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Qiang Yang, Yunpeng Liu
Fc-glycan-specific ADC is a significant advance in site-specific ADCs for cancer therapy. Notably, JSKN003 and IBI343 have demonstrated promising results in phase 1 clinical trials and are advancing into phase 3 studies.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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A practical guide for the assay-dependent characterisation of irreversible inhibitors

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00707G, Review Article
Lavleen K. Mader, Jessica E. Borean, Jeffrey W. Keillor
Kinetic evaluations for assay dependent characterization of irreversible inhibitors.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Water level in Mettur Dam stands at 107.04 feet




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Heavy weed growth at Kasi Viswanathar Temple tank prevents replenishing of underground water table, say Tiruchi residents




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Water level in Mettur dam stands at 106.89 feet




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Ensure time-bound implementation of development schemes, says Thirumavalavan




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Pumping stations to be set up in eight low-lying areas in Tiruchi to prevent inundation




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Udhayanidhi lays foundation stone for infrastructure development projects in Thanjavur district

Buildings at the Government Arts and Science College, Thirukkattupalli, construction of compound wall and an indoor stadium at the Government Rajah Serfoji College, Thanjavur, are among the projects




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High-level committee formed to facilitate clearances for companies that signed MoU, says Minister

Constant monitoring was being done now from the time of signing of MoUs to providing employment in new industrial units, says Industries Minister T.R.B. Rajaa




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Water level in Mettur Dam stands at 106.58 feet




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543: Zach Leatherman on Eleventy, Mastodon, Twitter, and is-land

Zach Leatherman talks with us about what's new with Eleventy, setting up on Mastodon, what's happened with Twitter, and is-land.




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567: Full Stack Dev, Load Bearing Developer, and Being Zod Curious

What do you do if your computer dies? Chris applies to work at Luro, Dave applies at CodePen, Dave's Zod curious, TypeScript, sorting out a 10MB blog post, and how much do you miss jQuery?




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572: Text Sqwunch Property, Figma Developer Mode, Stripe Elements

Show DescriptionDave reports back from the Figma Conference, how to build a better developer to designer bridge, do clients really want to update their website, using Stripe in 2023, permissions and sharing, and are you feeling overwhelmed by CSS in 2023? Listen on Website →Links Config 2023 | Figma’s Annual Conference Figma Visual Studio Code […]




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575: CSS Errors, Proxy and Reverse Proxy, and What’s The Edge?

Bluesky adds first class support for urls as a username, text-wrap pretty update, sqwunching text update, should CSS spit out errors, anchor functionality, what does the edge mean, eSports and bowling, how to test websites on slower CPUs, and what does proxy or reverse proxy mean?




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614: CSS Grid Level 3 aka Masonry with Adam Argyle

Adam Argyle stops by to chat about the conversation that's happening around CSS Grid / Masonry. What do we want? What might Apple's response to Google be? And nitpicking the spec just for fun.




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627: Getting Comfortable with the Struggle and Vibe Driven Development

Chris brings some blog posts to talk about including being comfortable with the struggle of developer life, Cloudflare Workers + monorepos, vibe driven development, and questions about database migrations, and whether we think AI free blogs are going to be a rarity in the future?




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632: Adam Coster on Game Development and Crashlands 2

Adam Coster talks with us about working with his family in game development, how they get started making games, what all is involved with publishing games, deciding to go Steam and Netflix only for Crashlands 2, how web tech is involved in game development, and the fun of testing and doing Q&A for games.




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Flat organisation believers: Can you imagine a world without managers?

What does a manager do that we keep hiring new ones or keep promoting more of them? Which managerial layer is the most important?




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Bengaluru startup develops new tech for battery recycling, begins production

Li-ion battery recycler Metastable Materials launches commercial ops




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Planned meals, personal trainer, and a tea for every reason

Personal fitness diary




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Several Delhi govt. schemes to tackle toxic air yet to take off

AAP govt. yet to implement at least 5 programmes it announced over the past two years to curb air pollution; these include using drones to map bad air sources and making PUC mandatory to buy fuel; our plans have been stopped by Centre: AAP