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cis 9, trans 11, but not trans 10, cis 12 CLA isomer, impairs intestinal epithelial barrier function in IPEC-J2 cells and mice through activation of GPR120-[Ca2+]i and the MLCK signaling pathway

Food Funct., 2020, 11,3657-3667
DOI: 10.1039/D0FO00376J, Paper
Han Su, Weijie Zhao, Fenglin Zhang, Min Song, Fangfang Liu, Jisong Zheng, Mingfa Ling, Xiaohua Yang, Qiang Yang, Haiwen He, Lin Chen, Xumin Lai, Xiaotong Zhu, Lina Wang, Ping Gao, Gang Shu, Qingyan Jiang, Songbo Wang
In vitro and in vivo studies show that c9, t11-CLA, but not t10, c12-CLA isomer, impairs intestinal epithelial barrier function in IPEC-J2 cells and mice via activation of GPR120-[Ca2+]i and the MLCK pathway.
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Lycium barbarum polysaccharides ameliorate intestinal barrier dysfunction and inflammation through the MLCK-MLC signaling pathway in Caco-2 cells

Food Funct., 2020, 11,3741-3748
DOI: 10.1039/D0FO00030B, Paper
Wei Li, Mingbo Gao, Ting Han
Impairment of the intestinal barrier often occurs in inflammatory bowel diseases, and pro-inflammatory factors play a vital role in the pathogenesis of intestinal diseases.
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Potential neurotoxicity of 5-hydroxymethylfurfural and its oligomers: widespread substances in carbohydrate-containing foods

Food Funct., 2020, Advance Article
DOI: 10.1039/C9FO02526J, Paper
Cheng Wang, Zhenru Liu, Tian Hu, Youjia Li, Rui Liu, Junjie Zhang, Huaizhen He
5-Hydroxymethylfurfural (5-HMF) and its acid-catalyzed oligomers can inhibit nerve cell proliferation and induce neurological deficits at near or below the reported 24 h dietary intake of 5-HMF in humans.
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The development of lentil derived protein–iron complexes and their effects on iron deficiency anemia in vitro

Food Funct., 2020, Advance Article
DOI: 10.1039/D0FO00384K, Paper
Ezgi Evcan, Sukru Gulec
Lentil derived proteins have the capacity to chelate iron minerals and hydrolysed protein–iron complexes have functional properties on iron deficiency anemia in in vitro by influencing mRNA levels of iron regulating genes.
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Kaempferol modulates TCDD- and t-BHQ-induced drug-metabolizing enzymes and luteolin enhances this effect

Food Funct., 2020, 11,3668-3680
DOI: 10.1039/C9FO02951F, Paper
Tomoya Kitakaze, Atsushi Makiyama, Rika Nakai, Yuki Kimura, Hitoshi Ashida
Co-treatment with kaempferol and luteolin inhibits AhR- and Nrf2-induced expression of drug-metabolizing enzymes.
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Comparison of the effects of resveratrol and its derivative pterostilbene on hepatic oxidative stress and mitochondrial dysfunction in piglets challenged with diquat

Food Funct., 2020, Advance Article
DOI: 10.1039/D0FO00732C, Paper
Hao Zhang, Yanan Chen, Yueping Chen, Peilu Jia, Shuli Ji, Jianxiong Xu, Yue Li, Tian Wang
Pterostilbene is more effective than resveratrol in alleviating liver injury, facilitating redox status, and improving mitochondrial function of piglets.
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The cognitive effects of an acute wild blueberry intervention on 7 – 10 year olds using extended memory and executive function task batteries.

Food Funct., 2020, Accepted Manuscript
DOI: 10.1039/C9FO02284H, Paper
Adrian Robert Whyte, Daniel J Lamport, Graham Schafer, Claire M. Williams
Evidence for the health benefits of blueberries is well documented. In particular memory and executive function benefits have both been found for children aged 7 – 10 in the 6...
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Effects of compound K, a metabolite of ginsenosides, on memory and cognitive dysfunction in db/db mice involve the inhibition of ER stress and the NLRP3 inflammasome pathway

Food Funct., 2020, Advance Article
DOI: 10.1039/C9FO02602A, Paper
Chu-Wen Li, Min-Zhen Deng, Zhi-Jie Gao, Yuan-Ye Dang, Guo-Dong Zheng, Xiu-Juan Yang, Ying-Xin Chao, Ye-Feng Cai, Xiao-Li Wu
The metabolite of ginsenosides, compound K improves memory and cognitive dysfunction in diabetes mellitus mice.
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Dietary supplementation of L-arginine and N-carbamylglutamate enhances duodenal barrier and mitochondrial functions and suppresses duodenal inflammation and mitophagy in suckling lambs suffering from intrauterine-growth-restriction

Food Funct., 2020, Advance Article
DOI: 10.1039/D0FO00019A, Paper
Hao Zhang, Yi Ma, Mengzhi Wang, Mabrouk Elsabagh, Juan J. Loor, Hongrong Wang
The work aimed at investigating the effects of N-carbamylglutamate (NCG) or L-arginine (Arg) supplementation on the duodenal mitophagy, inflammation, and barrier function in suckling lambs suffering from intrauterine-growth-retardation (IUGR).
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Influences of dietary starch structure on intestinal morphology, barrier functions, and epithelium apoptosis in weaned pigs

Food Funct., 2020, Advance Article
DOI: 10.1039/C9FO02652E, Paper
Open Access
Xiaoqian Gao, Bing Yu, Jie Yu, Xiangbing Mao, Zhiqing Huang, Yuheng Luo, Junqiu Luo, Ping Zheng, Jun He, Daiwen Chen
The objective of the present study was to evaluate the effects of dietary starch structure on intestinal health of weaned pigs by determining the intestinal morphology, barrier functions, epithelium apoptosis and digestive enzymes.
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Adjunctive vitamin A and D during pulmonary tuberculosis treatment: a randomized controlled trial with a 2×2 factorial design

Food Funct., 2020, Accepted Manuscript
DOI: 10.1039/C9FO02751C, Paper
Jinyu Wang, Ke Xiong, Qiuzhen Wang, Shanliang Zhao, Yufeng Liu, Aiguo Ma
Background and objective: Vitamin A and D have immunoregulatory effects and may improve the response to pulmonary tuberculosis treatment. The interaction of vitamin A and D on pulmonary tuberculosis treatment...
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Health insurance premiums set to rise as firms to follow Irdai mandates

The rise in premiums could be in the range of 5-25 per cent, depending on the features that each insurance company adds on its products




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Be flexible with your financial plan, don't make big commitment

Clearly, these are unusual times. So, things need to be done differently




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10 ways to plan your finances right during the coronavirus crisis

Here's how to protect your finances during these difficult times and work on your short- and long-term financial goals efficiently




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It's a better option to take advance EPF than a loan during tough times

The usual advice is that one should not withdraw from their EPF account because it hurts the retirement corpus




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Quick approval, grace period: Medical insurance process eased amid Covid-19

Use instalments to increase cover; benefit from quick approvals




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7 personal finance tips to guide you through these unprecedented times

Coming out of these unusual times financially fitter and stronger would require discipline, perseverance, conservancy tricks and fortitude. Here are some handy tips for millennials




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Rs 15.75 crore coronavirus health insurance claims lodged till date

The officials said about 790 claims have been lodged claiming about Rs 15.75 crore with several non-life insurers.




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PhonePe launches Super Funds to help users in long-term wealth creation

The Super Fund identifies and invests in top funds across various categories and asset management companies




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Apple Announces Record iPhone 6s and iPhone 6s Plus Sales

Apple has announced it has sold more than 13 million new iPhone 6s and iPhone 6s Plus models, a new record, just three days after launch. iPhone 6s and iPhone 6s Plus will be available in more than 40 additional countries beginning October 9 including Italy, Mexico, Russia, Spain, and Taiwan. The new iPhones will be available in over 130 countries by the end of the year. “Sales for iPhone 6s and iPhone 6s Plus have been phenomenal, blowing past any previous first weekend sales results in Apple’s history,” said Tim Cook, Apple’s CEO. “Customers’ feedback is incredible and they are loving 3D Touch and Live Photos, and we can’t wait to bring iPhone 6s and iPhone 6s Plus to customers in even more countries on October 9.”




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Apple Announces Advancements to ResearchKit

Apple today announced advancements to the open source ResearchKit framework that bring genetic data and a series of medical tests typically conducted in an exam room to iPhone apps. Medical researchers are adopting these new features to design targeted studies for diseases and conditions that affect billions of people and to gather more specific types of data from participants. “The response to ResearchKit has been fantastic. Virtually overnight, many ResearchKit studies became the largest in history and researchers are gaining insights and making discoveries that weren’t possible before,” said Jeff Williams, Apple’s chief operating officer.




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Apple Advances Health Apps with CareKit

Apple today announced CareKit, a new software framework designed to help developers enable people to actively manage their own medical conditions. iPhone apps using CareKit make it easier for individuals to keep track of care plans and monitor symptoms and medication, providing insights that help people better understand their own health. “We believe that giving individuals the tools to understand what is happening with their health is incredibly powerful, and apps designed using CareKit make this a reality by empowering people to take a more active role in their care,” said Jeff Williams, Apple’s chief operating officer.




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Apple Introduces iPhone SE — the Most Powerful Phone with a 4-inch Display

Apple today introduced iPhone SE, the most powerful phone with a 4-inch display, in a compact aluminum design that has been updated with matte-chamfered edges, a color-matched stainless steel Apple logo, and four metallic finishes. iPhone SE offers the same 64-bit A9 chip offered in iPhone 6s and iPhone 6s. “iPhone SE is packed with a stunning 4-inch Retina display, advanced 64-bit A9 chip with M9 motion co-processor, longer battery life, 12-megapixel iSight camera with True Tone flash, Live Photos, 4K video, faster LTE and Wi-Fi, and Touch ID with Apple Pay. Everyone who wants a smaller phone is going to love iPhone SE,” said Philip Schiller, Apple’s senior vice president of Worldwide Marketing.




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Apple Introduces 9.7-inch iPad Pro

Apple today introduced the 9.7-inch iPad Pro, which at just under one pound features a new pro Retina display with greater brightness, wider color gamut, lower reflectivity, Night Shift mode, and new True Tone display technology. The new iPad Pro also has a 64-bit A9X chip that rivals most portable PCs. “iPad Pro is a new generation of iPad that is indispensable and immersive, enabling people to be more productive and more creative. It’s incredibly fast, extremely portable, and completely natural to use with your fingers, Apple Pencil, and Smart Keyboard. And now it comes in two sizes,” said Philip Schiller, Apple’s senior vice president of Worldwide Marketing.





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Trailer: Does Batla House tell the encounter honestly?

The answers will come -- hopefully! -- when the film releases on August 15, feels Syed Firdaus Ashraf.






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The Panchayat review

'Even a hardcore nit-picker will struggle to find faults in this extraordinarily crafted television series that I rate as a must watch, an instant classic,' says Sukanya Verma.




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Rise of street militancy is the real problem: Radha Kumar

Interview with Former interlocutor on Jammu and Kashmir




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India's democracy created dynasties: Kanchan Chandra

Interview with Author,Democratic Dynasties




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Improving quality of governance biggest challenge for India: Mark Tully

Interview with former BBC correspondent




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Cost of pendency of cases could be as high as 1.5% of GDP: Harish Narasappa

Interview with Co-founder, DAKSH & Samvad Partners




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Our reforms aim to improve governance: Vasundhara Raje

Interview with Rajasthan Chief Minister




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Congress will bounce back in Rajasthan in 2018: Sachin Pilot

Interview with Rajasthan Congress president




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Development as a measure of governance

While the best and worst performing states have remained the same a decade apart, sharp changes appear when rankings are adjusted to account for the impact of development




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Google announces company holiday on May 22 to deal with ‘virus burnout’

Google announces company holiday on May 22 to deal with ‘virus burnout’




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Covid-19 lockdown: Delayed academic plans and uncertainty - anxiety grips CBSE class 12 students

Covid-19 lockdown: Delayed academic plans and uncertainty - anxiety grips CBSE class 12 students




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Vizag gas leak: Death toll mounts to 11; AP govt announces Rs 1 crore each to kin of those killed

Vizag gas leak: Death toll mounts to 11; AP govt announces Rs 1 crore each to kin of those killed




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Nobel laureate Bob Dylan announces first album of new music since 2012

Nobel laureate Bob Dylan announces first album of new music since 2012




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Taylor Swift announces 'City of Lover' concert

Taylor Swift announces 'City of Lover' concert




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Taapsee Pannu reveals she's been 'nerdy kid', in note about a school visit experience

Taapsee Pannu reveals she's been 'nerdy kid', in note about a school visit experience




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Vuelta cancels stages in Portugal amid COVID-19 crisis

Vuelta cancels stages in Portugal amid COVID-19 crisis




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European 2021 equestrian championships cancelled

European 2021 equestrian championships cancelled




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2020 World Amateur Golf Team Championships cancelled due to COVID-19 pandemic

2020 World Amateur Golf Team Championships cancelled due to COVID-19 pandemic




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Air France to check passengers' temperatures, require masks - Times of India

Air France to check passengers' temperatures, require masks - Times of India




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Britain to quarantine incoming travellers for 14-days

Britain to quarantine incoming travellers for 14-days




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Lockdown 3.0: Tecno launches doorstep smartphone delivery with over 35,000 retailers - Times of India

Lockdown 3.0: Tecno launches doorstep smartphone delivery with over 35,000 retailers - Times of India




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Cops register FIR against mob for violence in Shahpur

Cops register FIR against mob for violence in Shahpur




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Tirupur sees chance as global brands come calling for masks

Tirupur sees chance as global brands come calling for masks