The active ingredient in an anti-ageing lotion launched this week won its developers a Nobel Prize but unsurprisingly Bioeffect EGF Serum doesn’t come cheap.

The new generation of Crème Fraîche de Beauté is a range of deliciously light and moisturising skin savers tipped as the next big thing.

One quarter of women surveyed confessed to having at least one beauty secret, while 23 per cent confided that nobody (even their friends) really knows the extent of their beautifying.

Binky says that the New Year is a great opportunity to revamp your skincare routine and improve your complexion. Here she shares her favourite products that will see you through detox January.

Manchester United have told striker Radamel Falcao that his time at Old Trafford is over. Sportsmail can reveal that United manager Louis van Gaal has informed Falcao of the club's decision.

SIMON JONES: Chelsea and Monaco are expected to continue talks this week over the possible transfer of Radamel Falcao. Monaco want to recoup around £25m from the Colombian's sale

The Copa America in Chile, which kicks-off on Thursday night, will serve as the perfect shop window for players keen on a move this summer. Here's 10 of them

Follow Sportsmail's live coverage of the 0-0 draw between Colombia and Peru as both sides managed to book a place in the Copa America quarter-finals.

RIK SHARMA: Colombia reached the Copa America quarter finals despite a painful goalless draw with Peru thanks to Brazil's victory over Venezuela.

OLIVER HOLT AT STAMFORD BRIDGE: The internet was awash with advice and mock sympathy for Jose Mourinho on Saturday night after their second defeat of the season.

The former Chelsea and Manchester United flop started for the principality side and equalised from close range after Emenike had given the Turkish outfit the lead in the third round qualifying tie.

Teen prodigy Kylian Mbappe showed why he has caught Arsene Wenger's eye with a well-taken goal as Monaco overcame determined Montpellier to stay three points clear in Ligue 1.

Juventus secured their place in the Champions League final as a 2-1 second-leg win secured a 4-1 aggregate success. Here's how the players rated in the second-leg of the semi-final clash.

No trophies are handed out in December but one of football's biggest personal accolades is about to go on the line in Paris. Here Sportsmail gives you a lowdown to the 2017 Ballon d'Or.

Falcao spared Monaco's blushes with a 91st-minute equaliser to deny Nice a shock win on Tuesday night. Monaco's only Ligue 1 defeat on home soil this season came at the hands of PSG, but they trailed.

Sportsmail provide you with everything you need to know for the World Cup 2018 clash between Colombia vs Japan including how to watch, kick-off time, squads, stats and latest odds.

Colombia went through courtesy of a Yerry Mina header that saw them pick up three points and top Group H. It was a moment of rare quality in a match lacking in clear-cut chances.

Sportsmail provide you with everything you need to know for the World Cup 2018 clash Senegal vs Colombia including how to watch, kick-off time, squads, stats and latest odds.

Join Sportsmail's ANTHONY HAY with all the live action from the 7pm (BST) kick-off, with our reporters providing all the updates from Moscow.

Radamel Falcao rescued struggling Monaco with two second-half goals in a 2-2 draw at Rennes in the French league on Wednesday.

PETE JENSON IN SPAIN: Great managers build winning teams, then dismantle them and rebuild again, and again. This season we might find out if Diego Simeone is in that category.

She wowed audiences with a breathtaking Super Bowl halftime performance that included pole-dancing and political statements on Sunday evening.

An estimated 17.2 million Americans will not make it into work hours after Kansas City Chiefs beat San Franscisco 49ers 30-21 in Super Bowl LIV in Miami.

Kanye West along with fellow rap music makers Lil Wayne and 2 Chainz decided to celebrate Super Bowl LIV in style at LIV nightclub located at Fountainebleau in Miami on Sunday evening.

Kobe Bryant and his daughter Gianna tragically died in a helicopter one week ago along seven other passengers. Ciara and husband Russell Wilson honored the NBA legend at the Super Bowl.

And it was announced on Monday that Shakira, 43, will embark on a world tour come 2021.Ticketmaster revealed the news on their site,with an option to let fans pre-register for tickets.

She didn't just perform at this year's Super Bowl, but appeared in one of the coveted advert slots too.  And new behind the scenes snap from the Michael Bay-helmed ad have been unveiled.

The Jenny From The Block songstress, 50, was makeup-free and clad in a comfy red sweatsuit as she and fiance Alex Rodriguez strolled around. Her hair was tied into a messy top-knot.

Instagram model Kelly Kay Green, 27, was revealed as the Superbowl Streaker who was bruised and had her dress ripped as six security guards tackled her to the ground to arrest her.

The 38-year-old Grammy winner only collaborated with her pop rival once in 2004 for a Pepsi commercial, in which they played gladiators

Due to be held in front of the Bellagio Hotel, this life-changing event with a distinct gameshow aura will instead be held virtually. The best bit? It'll be unlike anything we've ever seen before.

On Saturday, ESPN reported that the NFL's 17-week season will commence on September 10 and come to a conclusion on February 7, when the Super Bowl will be held in Tampa, Florida.

Defending Super Bowl champions Kansas City Chiefs will host the Houston Texans for the opener, which will be played at Arrowhead Stadium.

The 31-year-old woman was 38 weeks pregnant when she was set upon by a stranger while with friends at Bay Vista cafe on Church Street, Parramatta.

AMP Capital chief economist Shane Oliver has said the bushfires engulfing Australia could wipe off up to 1 per cent of the nation's GDP growth this year - a staggering $13billion.

The Duke and Duchess of Cambridge's 2019 Christmas card featuring their children Princess Charlotte, Prince George and Prince Louis has been shared online.

The sportsman, 32, staved off stiff competition from fellow finalists Vicky Pattison and Neil Ruddock to be crowned the winner of Celebrity Masterchef 2019.

Hidden away by vast woodland and situated in Geres, the mansion - which includes a landing pad - was purchased for close to £3.5m seven years ago by the five-time Ballon d'Or winner.

KIT HOLDEN: In the end, Renato Sanches felt he was left with no other option but to pack his bags and leave Bayern Munich. He joined Ligue 1 side Lille this summer in a move worth £23million.

Cristiano Ronaldo took his goal-scoring career tally to an incredible 700 after netting in Portugal's 2-1 defeat against Ukraine. The five-time Ballon d'Or winner confidently slotted away a penalty.

The Juventus star was victorious on the international stage three years ago as Portugal beat France 1-0 after extra time. And now the 34-year-old has spoken out about the celebrations.

Chris Smalling has outlined his desire to win a place in Gareth Southgate's England squad, despite not having been capped for his country since 2017.

Not many football fans would have put Harvey Barnes in their England squad for Euro 2020 at the start of the season, yet the Leicester attacker is from a family who know all about defying the odds.

Manchester City star Raheem Sterling believes that a victorious England campaign in Euro 2020 could represent a significant step forward in the country's battle against racism.

Manchester United left back Luke Shaw hasn't featured in the last 15 England games under Gareth Southgate since playing against Spain in the Nations League 17 months ago.

FA chairman Greg Clarke says England will continue to prepare for next month's friendly against Italy at Wembley despite increasing fears over the spread of the coronavirus.

MATT HUGHES IN AMSTERDAM: Southgate warned Harry Kane and Marcus Rashford that they must prove their fitness by playing for their clubs before the end of the season.

Both sides had chances to open the scoring in the first half, with England's Nikita Parris failing to divert a header past Alyssa Naeher and Carly Telford equal to a dipping shot from Rose Lavelle.

Since the shambolic viewings four years ago, England have started to assemble a side capable of going all the way and Southgate deserves credit for putting faith in the next generation.

Leicester striker Jamie Vardy has refused to rule out making a return to the England squad for Euro 2020 with doubts over the fitness of Harry Kane and Marcus Rashford.