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The multifaceted long-term effects of the COVID-19 pandemic on urology






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Novel targeted drugs approved by the NMPA and FDA in 2019




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Signal Transduction and Targeted Therapy




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Correction to: A universal pipeline for mobile mRNA detection and insights into heterografting advantages under chilling stress




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Targeted conservation genetics of the endangered chimpanzee




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Cardiovascular response and sequelae after minimally invasive surfactant therapy in growth-restricted preterm infants




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Do extremely preterm infants need retinopathy of prematurity screening earlier than 31 weeks postmenstrual age?




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Finding a unifying SLE expression signature in a sea of heterogeneity




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A methylation functional detection hepatic cell system validates correlation between DNA methylation and drug-induced liver injury




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Determination of RNA structural diversity and its role in HIV-1 RNA splicing




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Detection of metastable electronic states by Penning trap mass spectrometry




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Precise test of quantum electrodynamics and determination of fundamental constants with HD<sup>+</sup> ions




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Identification of type 2 diabetes loci in 433,540 East Asian individuals




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Autopsy slowdown hinders quest to determine how coronavirus kills




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Daily briefing: A dark-matter detector powered by the ‘fifth state of matter’




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Environmental determinants of cardiovascular disease: lessons learned from air pollution




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Antibody-free enzyme-assisted chemical approach for detection of <i>N</i><sup>6</sup>-methyladenosine




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A metabolic labeling method detects m<sup>6</sup>A transcriptome-wide at single base resolution




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Nucleation seed size determines amyloid clearance and establishes a barrier to prion appearance in yeast




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Clinical utility of serial analysis of circulating tumour cells for detection of minimal residual disease of metastatic nasopharyngeal carcinoma




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Author Correction: A complete domain-to-species taxonomy for Bacteria and Archaea




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Ex situ determination of freely dissolved concentrations of hydrophobic organic chemicals in sediments and soils: basis for interpreting toxicity and assessing bioavailability, risks and remediation necessity




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CRISPR off-target detection with DISCOVER-seq




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High rate of durable remissions post autologous stem cell transplantation for core-binding factor acute myeloid leukaemia in second complete remission




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Donor-derived DNA variability in fingernails of acute myeloid leukemia patients after allogeneic hematopoietic stem cell transplantation detected by direct PCR




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In vivo antitumor activity by dual stromal and tumor-targeted oncolytic measles viruses




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Oncolytic adenovirus encoding LIGHT (TNFSF14) inhibits tumor growth via activating anti-tumor immune responses in 4T1 mouse mammary tumor model in immune competent syngeneic mice




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TMB: a promising immune-response biomarker, and potential spearhead in advancing targeted therapy trials




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Two-dimensional optical edge detection




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Diabetes downregulates peptide transporter 1 in the rat jejunum: possible involvement of cholate-induced FXR activation




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New insights into K<sub>ATP</sub> channel gene mutations and neonatal diabetes mellitus




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Publisher Correction: Optomechanical detection of vibration modes of a single bacterium




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Single-cell RNA sequencing reveals the heterogeneity of liver-resident immune cells in human




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Peter Ward: 'Membership organisations can thrive and prosper'




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Evaluation of an AI system for the detection of diabetic retinopathy from images captured with a handheld portable fundus camera: the MAILOR AI study




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Central catheter removal timing and growth patterns in preterm infants




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Biallelic mutations in <i>SORD</i> cause a common and potentially treatable hereditary neuropathy with implications for diabetes




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Dystrophic calcification and heterotopic ossification in fibrocartilaginous tissues of the spine in diffuse idiopathic skeletal hyperostosis (DISH)




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Nonnutritive sweetener consumption during pregnancy, adiposity, and adipocyte differentiation in offspring: evidence from humans, mice, and cells




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Active travelling to school is not associated with increased total daily physical activity levels, or reduced obesity and cardiovascular/pulmonary health parameters in 10–12-year olds: a cross-sectional cohort study




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Subduction megathrust heterogeneity characterized from 3D seismic data




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Hamilton: I was in complete control

Lewis Hamilton admits he always had something extra in his pocket throughout the Australian Grand Prix after leading home a dominant Mercedes one-two in Melbourne




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Pakistan teeters on the edge of potential disaster with the coronavirus

As of March 26, coronavirus cases in Pakistan — the world’s fifth most populous country — climbed to 1,190; nine people have died. Pakistan currently has the highest number of cases in South Asia, more even than its far larger neighbor, India. In this densely populated country of more than 210 million, with megacities Lahore…

       




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Escaping Jurassic Government : How to Recover America’s Lost Commitment to Competence


Brookings Institution Press 2016 233pp.

Why big government is not the problem

The Progressive government movement, founded on support from Republicans and Democrats alike, reined in corporate trusts and improved the lives of sweatshop workers. It created modern government, from the Federal Reserve to the nation’s budgetary and civil service policies, and most of the programs on which we depend.

Ask Americans today and they will tell you that our government has hit a wall of low performance and high distrust, with huge implications for governance in the country. Instead of a focus on government effectiveness, the movement that spawned the idea of government for the people has become known for creating a big government disconnected from citizens. Donald F. Kettl finds that both political parties have contributed to the decline of the Progressive ideal of a commitment to competence. They have both fed gridlock and created a government that does not work the way citizens expect and deserve.

Kettl argues for a rebirth of the original Progressive spirit, not in pursuit of bigger government but with a bipartisan dedication to better government, one that works on behalf of all citizens and that delivers services effectively. He outlines the problems in today’s government, including political pressures, proxy tools, and managerial failures. Escaping Jurassic Government details the strategies, evidence, and people that can strengthen governmental effectiveness and shut down gridlock.


Donald F. Kettl is a professor and former dean of the School of Public Policy at the University of Maryland. He is also a nonresident senior fellow at the Brookings Institution.

ABOUT THE AUTHOR

Donald F. Kettl

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Seattle Uniquely Placed to Compete on Global Stage, but Success is Not Inevitable

In an increasingly international and interconnected economy, Seattle was global before global was cool.

The region’s competitive global assets include internationally competitive firms, strategically important ports and one of the nation’s largest foreign-born populations.

Still, today’s unique economic moment demands an extra measure of purposeful global engagement.

As cities and metropolitan areas begin to emerge from the Great Recession, leaders are realizing the need to restructure the economy — to move from one based on debt and consumption to one powered by production and innovation.

At the same time, most economic growth over the next decade will occur outside of America’s borders. As of 2009, the combined economies of Brazil, India and China eclipsed that of the United States and now account for more than one-fifth of the global economy. By 2018, their share is expected to surpass one-quarter.

The developing world, with a rapidly rising middle class, represents a huge market opportunity for American firms. China and India alone are expected to increase their urban populations by more than 500 million over the next 20 years, which naturally leads to a rise in their consumer classes. By 2050, Chinese and Indian consumers will account for more than half of all middle-class consumption worldwide, up from just 2 percent in 2000.

These growing metropolises will also require massive investments in infrastructure and face huge challenges as they expand, challenges that U.S. firms have the expertise to solve — in transportation and mobility, in sustainability and clean energy, in information technology and software.

America’s metropolitan areas are uniquely positioned to take advantage of this dual challenge through increased trade and investment. The top 100 metro areas not only produce three-quarters of our gross domestic product, they also concentrate our most innovative firms, our research institutions and universities, and the majority of our skilled workers.

So how does the central Puget Sound region stack up? Recently, I came to Seattle as part of the Global Cities Initiative, a joint project of the Brookings Institution and JPMorgan Chase. This initiative aims to catalyze a shift in economic development priorities and practices that would result in more globally connected metropolitan areas and more sustainable economic growth.

The metro area has a strong platform for trade: firms such as Boeing, Microsoft, and Amazon; world-class research assets including the University of Washington and the Fred Hutchinson Cancer Research Center; and a strong legacy of globally oriented leadership, with a wide coalition, including public, private and civic leaders, actively promoting a regional strategy for global engagement.

The data bear this out: While Seattle is the 15th largest metro area in the United States, it has the sixth highest export total, sending more than $47 billion in goods and services abroad in 2012. These exports are overwhelmingly driven by globally competitive clusters in aerospace and information technology.

Partly due to this industry specialty, Seattle’s economy is also highly innovative and uniquely oriented toward science, technology, engineering and math: More than one-quarter of jobs in the metro are in STEM occupations, the fourth highest share of any metropolitan area in the country.

Still, in such a competitive and dynamic global economy, no metro area can afford complacency. In order to maintain its position in the global economy, Seattle needs to get serious about global engagement.

First, focus on global trade and investment. Continue the collaborative efforts of your public, private and civic leaders to focus economic development strategies on growth abroad. In Seattle earlier this month, regional leaders committed to expanding these efforts, joining the Global Cities Initiative’s Exchange, through which the metro area will develop a strategy to increase foreign direct investment in key industries.

Second, invest in what matters. To compete globally, metro areas must be strong at home. In Seattle, this means shoring up your workforce-development pipeline so that local residents have a path to good jobs in advanced industries. It also calls for a regional approach to financing and delivering transportation solutions that not only reduce congestion at home, but also improve your connections abroad.

Finally, metropolitan leaders must look beyond their own borders, identify their trading partners, and build relationships to increase both trade and investment. For example, as part of the Global Cities Initiative, Chicago and Mexico City entered into a first-of-its-kind economic partnership that builds on the extensive economic, social, cultural linkages between the two metros to make both more prosperous.

There are promising efforts under way in the region, as the King County Aerospace Alliance has started collaborating with Aéro Montréal so that the two aerospace clusters can be more competitive.

Simply put, in today’s economic landscape, every city is a global city. The success of regional economies hinges on their engagement throughout the global economy. Seattle has an enviable hand to play; but success is not inevitable.

This opinion piece originally appeared in the Seattle Times.

Authors

      
 
 




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Preventing targeted violence against communities of faith

The right to practice religion free of fear is one of our nation’s most indelible rights. But over the last few years, the United States has experienced a significant increase in mass casualty attacks targeting houses of worship and their congregants. Following a string of attacks on synagogues, temples, churches, and mosques in 2019, the…

       




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Hope in heterogeneity: Big data, opportunity and policy

“Big data” is particularly useful for demonstrating variation across large groups. Using administrative tax data, for example, Stanford economist Raj Chetty and his colleagues have shown big differences in upward mobility rates by geography, by the economic background of students at different colleges, by the earnings of students taught by different teachers, and so on.…

       




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Israel’s Arab parties may help determine who runs the next government.