The Document Object Model describes the structure of an XML or HTML document, a web page and allows access to each individual element.

Aria-body virus removal guide

What is Aria-body?

Aria-body is a piece of malicious software, also known as Aria-body RAT (Remote Access Trojan). RATs allow remote access and control over an infected machine. Aria-body malware has various abilities/features that enable likewise varied misuse. It has been observed being employed primarily for stealing information; this trojan can locate and exfiltrate specific data. This malicious program has been used for espionage, extensively targeting the APAC (Asia Pacific) region. Aria-body has been leveraged against governmental institutions (e.g. science and technology, foreign affairs ministries, government-owned companies, etc.) of Australia, Indonesia, Brunei, Philippines, Vietnam, Myanmar and Thailand.

  So I wrote an op-ed about the recent Macmillan/ebooks kerfuffle for CNN. Here’s how that all worked…. I got...

  From a Vermont librarian: VPNs are really important and I’d like to remind our patrons about them, but it...

  I am looking for someone who can help me find and clear out excess data on one of my...

From a friend: Please explain to me your enthusiasm for controlled digital lending. Please let me know what you think...

Subtitled: What’s the Yahoo! Internet Life for this generation? From a friend: A nice older lady asked for advice on...

I was wondering if you might give my little women’s (boomers) some guidance as to a beginning graphic novel for...

It’s been an odd set of months. I got busy with Drop-In Time and then very un-busy. I’ve been keeping...

Recent advancements in Machine Learning (ML) have taught us two main lessons: a large proportion of things that humans do can actually be automated, and that a substantial part of this automation can be done with minimal human supervision. One no longer needs to select features for models to use; in many cases people are … Continue reading Three Paper Thursday: Adversarial Machine Learning, Humans and everything in between →

Remember when all we had to complain about were crappy rail services?

Bork!Bork!Bork! Welcome to another in The Register's inexplicably long-lived series of digital signage suffering the odd public whoopsie.…

At last, we can write headlines with all the letters intact

For a company defined by design and attention to detail, the Butterfly keyboard was a tremendous humiliation for Apple. Conceived in 2015, it replaced the previous scissor-switch mechanism for one with a smaller profile, allowing Cupertino to continue shrinking already-svelte laptops.…

Levodopa-induced dyskinesia (LID) poses a significant health care challenge for Parkinson’s disease (PD) patients. Amantadine is currently the only drug proven to alleviate LID. Although its efficacy in treating LID is widely assumed to be mediated by blockade of N-methyl-D-aspartate (NMDA) glutamate receptors, our experiments demonstrate that at therapeutically relevant concentrations, amantadine preferentially blocks inward-rectifying K+ channel type 2 (Kir2) channels in striatal spiny projection neurons (SPNs) — not NMDA receptors. In so doing, amantadine enhances dendritic integration of excitatory synaptic potentials in SPNs and enhances — not antagonizes — the induction of long-term potentiation (LTP) at excitatory, axospinous synapses. Taken together, our studies suggest that the alleviation of LID in PD patients is mediated by diminishing the disparity in the excitability of direct- and indirect-pathway SPNs in the on state, rather than by disrupting LTP induction. This insight points to a pharmacological approach that could be used to effectively ameliorate LID and improve the quality of life for PD patients.

Arterial cardiovascular events are the leading cause of death in patients with JAK2V617F myeloproliferative neoplasms (MPNs). However, their mechanisms are poorly understood. The high prevalence of myocardial infarction without significant coronary stenosis or atherosclerosis in patients with MPNs suggests that vascular function is altered. The consequences of JAK2V617F mutation on vascular reactivity are unknown. We observe here increased responses to vasoconstrictors in arteries from Jak2V617F mice resulting from a disturbed endothelial NO pathway and increased endothelial oxidative stress. This response was reproduced in WT mice by circulating microvesicles isolated from patients carrying JAK2V617F and by erythrocyte-derived microvesicles from transgenic mice. Microvesicles of other cellular origins had no effect. This effect was observed ex vivo on isolated aortas, but also in vivo on femoral arteries. Proteomic analysis of microvesicles derived from JAK2V617F erythrocytes identified increased expression of myeloperoxidase as the likely mechanism accounting for their effect. Myeloperoxidase inhibition in microvesicles derived from JAK2V617F erythrocytes suppressed their effect on oxidative stress. Antioxidants such as simvastatin and N-acetyl cysteine improved arterial dysfunction in Jak2V617F mice. In conclusion, JAK2V617F MPNs are characterized by exacerbated vasoconstrictor responses resulting from increased endothelial oxidative stress caused by circulating erythrocyte-derived microvesicles. Simvastatin appears to be a promising therapeutic strategy in this setting.

BACKGROUND Preclinical experiments have shown that donor blood cells, modified in vitro by an alkylating agent (modified immune cells [MICs]), induced long-term specific immunosuppression against the allogeneic donor.METHODS In this phase I trial, patients received either 1.5 × 106 MICs per kg BW on day –2 (n = 3, group A), or 1.5 × 108 MICs per kg BW on day –2 (n = 3, group B) or day –7 (n = 4, group C) before living donor kidney transplantation in addition to post-transplantation immunosuppression. The primary outcome measure was the frequency of adverse events (AEs) until day 30 (study phase) with follow-up out to day 360.RESULTS MIC infusions were extremely well tolerated. During the study phase, 10 treated patients experienced a total of 69 AEs that were unlikely to be related or not related to MIC infusion. No donor-specific human leukocyte antigen Abs or rejection episodes were noted, even though the patients received up to 1.3 × 1010 donor mononuclear cells before transplantation. Group C patients with low immunosuppression during follow-up showed no in vitro reactivity against stimulatory donor blood cells on day 360, whereas reactivity against third-party cells was still preserved. Frequencies of CD19+CD24hiCD38hi transitional B lymphocytes (Bregs) increased from a median of 6% before MIC infusion to 20% on day 180, which was 19- and 68-fold higher, respectively, than in 2 independent cohorts of transplanted controls. The majority of Bregs produced the immunosuppressive cytokine IL-10. MIC-treated patients showed the Immune Tolerance Network operational tolerance signature.CONCLUSION MIC administration was safe and could be a future tool for the targeted induction of tolerogenic Bregs.TRIAL REGISTRATION EudraCT number: 2014-002086-30; ClinicalTrials.gov identifier: NCT02560220FUNDING Federal Ministry for Economic Affairs and Technology, Berlin, Germany, and TolerogenixX GmbH, Heidelberg, Germany.

Approximately half of the world’s population is infected with the stomach pathogen Helicobacter pylori. Infection with H. pylori is the main risk factor for distal gastric cancer. Bacterial virulence factors, such as the oncoprotein CagA, augment cancer risk. Yet despite high infection rates, only a fraction of H. pylori–infected individuals develop gastric cancer. This raises the question of defining the specific host and bacterial factors responsible for gastric tumorigenesis. To investigate the tumorigenic determinants, we analyzed gastric tissues from human subjects and animals infected with H. pylori bacteria harboring different CagA status. For laboratory studies, well-defined H. pylori strain B128 and its cancerogenic derivative strain 7.13, as well as various bacterial isogenic mutants were employed. We found that H. pylori compromises key tumor suppressor mechanisms: the host stress and apoptotic responses. Our studies showed that CagA induces phosphorylation of XIAP E3 ubiquitin ligase, which enhances ubiquitination and proteasomal degradation of the host proapoptotic factor Siva1. This process is mediated by the PI3K/Akt pathway. Inhibition of Siva1 by H. pylori increases survival of human cells with damaged DNA. It occurs in a strain-specific manner and is associated with the ability to induce gastric tumor.

The editors of JCI and JCI Insight are revisiting our editorial processes in light of the strain that the COVID-19 pandemic places on the worldwide scientific community. Here, we discuss adjustments to our decision framework in light of restrictions placed on laboratory working conditions for many of our authors.

Erowid Exp113948

CNN Brianna Keilar interviews Senator Bernie Sanders on State of the Union May 17 2015. Senator Bernie Sanders says the American people want and deserve a serious debate on the serious issues facing our country today instead of merely the same old, endless 30 second, ad hominem, attack ads. Continue reading →

Шестого мая BRIAN MAY опубликовал видео, как он на коляске передвигается по больнице и подписал это сообщение:

«Проверка реальности! Для меня... Нет, вирус меня пока не поймал — слава Богу. Надеюсь, что вы все в безопасности. Но решение ослабить контроль вовсе не означает, что опасность куда-то уходит. Но я??? Да, я молчал, а причины...

Так же, как и чрезмерное напряжение и беспокойство из-за слишком многих потребностей... Я умудрился порвать ягодичную мышцу в момент чрезмерного садоводческого энтузиазма. Так что внезапно я оказался в больнице, где меня просканировали, чтобы выяснить, насколько сильно я на самом деле повредил себя. Оказалось, что я проделал тщательную работу — это было пару дней назад — и я не смогу какое-то время ходить... Или спать без особой помощи, потому что боль не утихает.

Итак, ребята... Мне нужно немного уйти в сумрак, полностью отдохнуть дома.

Пожалуйста, пожалуйста, не посылайте мне слова сочувствия — мне просто нужно немного исцеляющей тишины на некоторое время. Я вернусь, но мне нужен полный перерыв. ХОРОШО?

Спасибо. Берегите себя там!» #Brian_May #BrianMay

Посмотреть эту публикацию в Instagram

Reality check ! For me. No - the Virus didn’t get me yet - thank God. Hope you’re all keeping extra-safe out there. A decision to relax controls doesn’t suddenly make the danger go away. But me ?? Yes, I’ve been quiet. Reason ? As well as getting over-stretched and harassed by too many demands ... I managed to rip my Gluteus Maximus to shreds in a moment of over-enthusiastic gardening. So suddenly I find myself in a hospital getting scanned to find out exactly how much I’ve actually damaged myself. Turns out I did a thorough job - this is a couple of days ago - and I won’t be able to walk for a while ... or sleep, without a lot of assistance, because the pain is relentless. So, folks ... I need to go dark for a while, getting some complete rest, at home. Please, please don’t send me sympathy - I just need some healing silence for a while. I’ll be back - but I need the complete break. OK ? Thanks. Take care out there. Bri

Публикация от Brian Harold May (@brianmayforreal) 6 Май 2020 в 6:44 PDT

Now that’s a name I haven’t heard in a long time…

The post Heads up: TEMUERA MORRISON will be THE MANDALORIAN’s Boba Fett appeared first on The Beat.

The pad thai recipe you're looking for! Try this simple trick to make a turmeric noodle version.

Continue reading Sunshine Pad Thai (Vegetarian) on 101 Cookbooks

Mayo Clinic and IBM Watson Health today unveiled results from early use of the Watson for Clinical Trial Matching, an IBM cognitive computing system. Use of this system in the Mayo Clinic oncology practice has been associated with more patients enrolled in Mayo’s breast cancer clinical trials.

IBM anunció una iniciativa pionera en la industria para construir sistemas de computación cuántica universal comercialmente disponibles. Los sistemas y servicios cuánticos “IBM Q” se entregarán mediante la plataforma IBM Cloud.

(NYSE: IBM) will strengthen Australia and New Zealand’s chances of co-hosting the world’s biggest radio telescope project (SKA), one of the largest scientific projects ever undertaken. The IBM SUR Award of IBM high performance Graphical Processor Unit (GPU) based computer hardware, management software and implementation services, will enable Victoria University to support the Murchison Widefield Array (MWA) project, a low frequency SKA pathfinder project hosted in Australia in collaboration with Curtin University, MIT, the Smithsonian Institute, and the Raman Research Institute.

IBM anunció que fue nombrada líder en el informe 2013 IDC MarketScape, que analiza a los proveedores de consultoría en movilidad empresarial a nivel mundial. El informe cita al recientemente anunciado Customer Experience Lab y la iniciativa Mobile First de IBM como ejemplos de su liderazgo en Consultoría en Movilidad Empresarial.

La empresa se afianza como líder de Proveedores Autorizados de Certificación (PAC) y logra procesar grandes volúmenes de transacciones de manera sencilla