A sci-fi collection explores extreme corporate futures, such as a Tinder-run city where you can swipe left or right for everything from sex to teachers

Many doctors are considering retiring, but fear they'll miss the patient interaction, mental stimulation, and income. There are ways to have it all.

The call for the European Respiratory Society (ERS) to change their e-cigarette and vaping policy, from honourable people with decades of experience fighting the evils of tobacco, is unfortunately misconceived. The three issues of greatest concern are acute toxicity, chronic toxicity and, most importantly, the effects on children and young people. The efficacy of e-cigarettes as an adjunct to smoking cessation are outwith the expertise of paediatric specialists, but we would ask for assurances that any benefits really do outweigh the risks to children and young people (below). Our comments on these key issues are as follows:

ABSTRACTIntroduction:Multimonth dispensing (MMD) of antiretroviral therapy (ART) is a differentiated model of care that can help overcome health system challenges and reduce the burden of HIV care on clients. Although 3-month dispensing has been the standard of care, interest has increased in extending refill intervals to 6 months. We explored client and provider experiences with MMD in Malawi as part of a cluster randomized trial evaluating 3- versus 6-month ART dispensing.Methods:Semi-structured in-depth interviews were conducted with 17 ART providers and 62 stable, adult clients with HIV on ART. Clients and providers were evenly divided by arm and were eligible for an interview if they had been participating in the study for 1 year (clients) or 6 months (providers). Questions focused on perceived challenges and benefits of the 3- or 6-month amount of ART dispensing. Interviews were transcribed, and data were coded and analyzed using constant comparison.Results:Both clients and providers reported that the larger medication supply had benefits. Clients reported decreased costs due to less frequent travel to the clinic and increased time for income-generating activities. Clients in the 6-month dispensing arm reported a greater sense of personal freedom and normalcy. Providers felt that the 6-month dispensing interval reduced their workload. They also expressed concerned about clients' challenges with ART storage at home, but clients reported no storage problems. Although providers mentioned the potential risk of clients sharing the larger medication supply with family or friends, clients emphasized the value of ART and reported only rare, short-term sharing, mostly with their spouses. Providers mentioned clients' lack of motivation to seek care for illnesses that might occur between refill appointments.Conclusions:The 6-month ART dispensing arm was particularly beneficial to clients for decreased costs, increased time for income generation, and a greater sense of normalcy. Providers' concerns about storage, sharing, and return visits to the facility did not emerge in client interviews. Further data are needed on the feasibility of implementing a large-scale program with 6-month dispensing.

Treating malaria in HIV-coinfected individuals should consider potential drug-drug interactions. Artemether-lumefantrine is the most widely recommended treatment for uncomplicated malaria globally. Lumefantrine is metabolized by CYP3A4, an enzyme that commonly used antiretrovirals often induce or inhibit. A population pharmacokinetic meta-analysis was conducted using individual participant data from 10 studies with 6,100 lumefantrine concentrations from 793 nonpregnant adult participants (41% HIV-malaria-coinfected, 36% malaria-infected, 20% HIV-infected, and 3% healthy volunteers). Lumefantrine exposure increased 3.4-fold with coadministration of lopinavir-ritonavir-based antiretroviral therapy (ART), while it decreased by 47% with efavirenz-based ART and by 59% in the patients with rifampin-based antituberculosis treatment. Nevirapine- or dolutegravir-based ART and malaria or HIV infection were not associated with significant effects. Monte Carlo simulations showed that those on concomitant efavirenz or rifampin have 49% and 80% probability of day 7 concentrations <200 ng/ml, respectively, a threshold associated with an increased risk of treatment failure. The risk of achieving subtherapeutic concentrations increases with larger body weight. An extended 5-day and 6-day artemether-lumefantrine regimen is predicted to overcome these drug-drug interactions with efavirenz and rifampin, respectively.

Etravirine (ETR) is a nonnucleoside reverse transcriptase inhibitor (NNRTI) used in treatment-experienced individuals. Genotypic resistance test-interpretation systems can predict ETR resistance; however, genotype-based algorithms are derived primarily from HIV-1 subtype B and may not accurately predict resistance in non-B subtypes. The frequency of ETR resistance among recombinant subtype C HIV-1 and the accuracy of genotypic interpretation systems were investigated. HIV-1_LAI containing full-length RT from HIV-1 subtype C-positive individuals experiencing virologic failure (>10,000 copies/ml and >1 NNRTI resistance-associated mutation) were phenotyped for ETR susceptibility. Fold change (FC) was calculated against a composite 50% effective concentration (EC₅₀) from treatment-naive individuals and three classifications were assigned: (i) <2.9-FC, susceptible; (ii) ≥2.9- to 10-FC, partially resistant; and (iii) >10-FC, fully resistant. The Stanford HIVdb-v8.4 was used for genotype predictions merging the susceptible/potential low-level and low-level/intermediate groups for 3 x 3 comparison. Fifty-four of a hundred samples had reduced ETR susceptibility (≥2.9-FC). The FC correlated with HIVdb-v8.4 (Spearman’s rho = 0.62; P < 0.0001); however, 44% of samples were partially (1 resistance classification difference) and 4% completely discordant (2 resistance classification differences). Of the 34 samples with an FC of >10, 26 were HIVdb-v8.4 classified as low-intermediate resistant. Mutations L100I, Y181C, or M230L were present in 27/34 (79%) of samples with an FC of >10 but only in 2/46 (4%) of samples with an FC of <2.9. No other mutations were associated with ETR resistance. Viruses containing the mutation K65R were associated with reduced ETR susceptibility, but 65R reversions did not increase ETR susceptibility. Therefore, genotypic interpretation systems were found to misclassify ETR susceptibility in HIV-1 subtype C samples. Modifications to genotypic algorithms are needed to improve the prediction of ETR resistance for the HIV-1 subtype C.

A sci-fi collection explores extreme corporate futures, such as a Tinder-run city where you can swipe left or right for everything from sex to teachers

A temporary coronavirus hospital ward in China is being staffed entirely by robots. Around 200 patients with mild symptoms will be fed and treated by machines, while medical staff issue commands from outside

Pluto’s ancient oceans may have come about just after the icy world was born, melting from ice in a process that suggests the dwarf planet took just 30,000 years to form

This uncanny story of preppy drug dealers has a touch of Heathers and a bit of Bret Easton Ellis, and an intriguing take on what high school is really like

Tayarisha Poe, like her partial namesake, has a gift for the uncanny. She is the photographer and film-maker behind this feature debut, which began as an online multimedia project and was developed as a conventional movie through the Sundance screenwriters and directors labs. What has emerged is an intriguing, opaque, tonally elusive story that seems weirdly unfinished. It is set in a privileged high school – a world of ivy-covered stone buildings and shady quadrangles where rich kids are separated into malign and mutually hostile cliques. It has a touch of Donna Tartt and Bret Easton Ellis, a hint of Heathers and a bit of the elegant, disdainful satire of Dear White People.

Somehow, though, it is odder, more stylised and contrived, always holding out the possibility that it is set in the future, or in an alternative present on some other planet, or inside the head of one of its characters who is having a disturbing dream – the kind that ends just as it is about to give up its meaning. Right until the closing credits, I half-expected the face of each person on screen to flip upwards, revealing a Stepford-like set of dials.

Chief Justice John G. Roberts on Friday declined to order a judicial misconduct investigation into a federal judge's retirement and whether Senate Majority Leader Mitch McConnell had anything to do with it.

D.C. Circuit Court of Appeals Judge Sri Srinavasan had previously asked the chief justice to assign a court ...

For years, those living and working in nursing and retirement homes across the country have struggled as overburdened caregivers tried to maintain a basic level of care and dignity for aging and ailing Canadians.

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The family of a London care home worker who died with Covid-19 today described how she "gave her life to nursing".

Stephanie Labbé, goalkeeper for the Canada's soccer team, and her long-time girlfriend Georgia Simmerling, a vital member for Canada's team pursuit in track cycling, have already qualified for the Tokyo Games. But the COVID-19 lockdown measures have rocked them. This Olympic couple had planned to retire. Now, instead of facing four months until retirement they face 16 months.

A three-year old girl is an internet sensation for her expert sheep wrangling.

Show promises a 'funny and hopeful look at the search for love, sex and connection during this time of social distancing'

(Pias)
Since his last outing, the south London musician and producer has eased up and moved to Margate. Yet this atmospheric return still carries the weight of the world

Ghostpoet – the brooding alias of south London-born Obaro Ejimiwe – is roughly a decade old this year. This dour bard has long been an artist ahead of his time. A track such as Cash and Carry Me Home, one of the highlights of his eclectic, jazz-inflected debut album – 2011’s Peanut Butter Blue and Melancholy Jam – defied genre as it mourned the self-inflicted pain of one drink too many. It now locates Ghostpoet as roughly adjacent to the south London jazz renaissance of the past few years – a multi-hyphenate scene in which most things go. Were it to be released today, its languorous, self-aware aperçus would find an even more receptive audience.

Searches for tracksuit bottoms are up 2000 per cent on last month, and fashion's high priestess has given her seal of approval

Follow our live updates here Coronavirus: the symptoms

Fans could be locked out of Premier League games until the end of the 2020-21 season.

Liverpool's success combined with the current enforced break from football may have convinced Jurgen Klopp to prolong any future retirement plans, according to football journalist Guillem Balague.

The true test of just how real Manchester United are prepared to get in the transfer market this summer will be their response to interest in Paul Pogba.

Sir Alex Ferguson retired at Manchester United after failing to sign Cristiano Ronaldo and Gareth Bale, according to Patrice Evra.

Andy Robertson insists he wants to retire at Liverpool but hasn't ruled out joining Celtic at the end of his career.

For this Colorado retirement community, living near a fracking site has been a nightmare. Now they can’t even leave.

The Labor Party has walked out of the NSW Legislative Assembly after Opposition Leader Jody McKay is thrown out by the Speaker.

South Sydney Rabbitohs forward Sam Burgess has been forced into early retirement from the NRL aged 30 due to a chronic shoulder injury.

Super funds and prominent professional investors warn that the mass withdrawal of funds from superannuation during the COVID-19 crisis risks undermining the whole retirement income system.

Huge flames are filmed shooting up the side of a Middle Eastern residential tower shortly after residents finish their nightly Ramadan meal.

The Liverpool defender says the current absence of football will have forced players to think about what they'll do when they have to stop playing

Australian Davis Cup star John Millman doubts the ATP and WTA Tours can resume at all in 2020 due to the extent of the coronavirus pandemic.

Chief Executive Mike Thompson is to retire from his role at the Association of the British Pharmaceutical Industry (ABPI) by the end of this year.

His decision to leave the association marks the end of a three-year run beginning in March 2016, when stepped in to take up the mantle from Alison Clough, who had served as the acting Chief Executive for much of 2015.

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An indictment was unsealed today charging Clark Alan Roberts, 46, and Sean Edward Howley, 38, both engineers with Wyko Tire Technology Inc., located in Greenback, Tenn., with conspiring to steal trade secrets from the Goodyear Tire and Rubber Company and scheming to defraud Goodyear of confidential and proprietary information.

A current Baltimore City Police Department officer and two retired officers were charged in a six-count federal indictment unsealed today with civil rights and obstruction of justice violations stemming from an April 2004 incident during which officers allegedly assaulted a handcuffed and shackled juvenile with a baton and pool stick.

Timothy Smith, a resident of Cullman, Ala., pleaded guilty today in federal court in Birmingham to one count of tax evasion, the Justice Department and Internal Revenue Service (IRS) announced.

John Reece Roth, 72, of Knoxville, Tenn., was sentenced to 48 months in prison for violating the Arms Export Control Act by conspiring to illegally export, and actually exporting, technical information relating to a U.S. Air Force (USAF) research and development contract.

A retired U.S. military official pleaded guilty to bribery and conspiracy charges relating to Department of Defense (DOD) contracts in Afghanistan. According to the plea agreement, which was filed in U.S. District Court in Chicago today, First Lieutenant Robert Moore (Ret.) pleaded guilty to conspiracy and bribery charges.

The operator and manager of the Rathbone Retirement Community in Evansville, Ind., has agreed to pay up to $116,000 to resolve a housing discrimination lawsuit. The November 2008 lawsuit alleged that the defendants violated the Fair Housing Act by prohibiting the use of motorized wheelchairs and scooters in residents’ apartments and in the home’s common dining room during meals.

Timothy Smith, a resident of Cullman, Ala., was sentenced today to 30 months in prison for tax evasion.

The United States has reached a settlement that will resolve its suit filed on behalf of retired Army service member King A. Gatten against Knight Protective Service Inc.

Christopher Murray pleaded guilty in January 2009 to four counts of bribery and one count of making a false statement.

The Department has reached a settlement, in the form of a consent decree, with the Goodyear Tire & Rubber Company that, if approved by the U.S. District Court in Oklahoma City, will resolve its lawsuit filed on behalf of Michael J. Ellis, a major in the U.S. Army Reserve.

A federal judge in St. Louis has permanently barred a Missouri attorney and his law firm from promoting any Individual Retirement Account-based arrangement.