The 30-year-old had only played 13 games this season.

Penn State is on the verge of doing something that it hasn’t done in more than 40 years. The Nittany Lions can post three straight straight 10-win seasons for the first time since 1980-82 with its next two victories. It would be their sixth season with double-digit wins in nine years, the best such stretch since the program’s golden era from 1977-86. Yet some in the sellout crowd of 110,233 at ...

Tennessee Lady Vols basketball will open the 2025-26 season with a neutral-site matchup against NC State in Greensboro at First Horizon Coliseum

Lady Vols basketball relied on its best 3-point shooting night of the season to close out a win over Middle Tennessee State on Tuesday

Holly Oakley
Oct 4, 2006; 26:10129-10140
Neurobiology of Disease

Randy L. Buckner
Aug 24, 2005; 25:7709-7717
Neurobiology of Disease

Holly Oakley
Oct 4, 2006; 26:10129-10140
Neurobiology of Disease

Systemic study of pathogenic pathways and interrelationships underlying genes associated with Alzheimer's disease (AD) facilitates the identification of new targets for effective treatments. Recently available large-scale multiomics datasets provide opportunities to use computational approaches for such studies. Here, we devised a novel disease gene identification (digID) computational framework that consists of a semi-supervised deep learning classifier to predict AD-associated genes and a protein–protein interaction (PPI) network-based analysis to prioritize the importance of these predicted genes in AD. digID predicted 1,529 AD-associated genes and revealed potentially new AD molecular mechanisms and therapeutic targets including GNAI1 and GNB1, two G-protein subunits that regulate cell signaling, and KNG1, an upstream modulator of CDC42 small G-protein signaling and mediator of inflammation and candidate coregulator of amyloid precursor protein (APP). Analysis of mRNA expression validated their dysregulation in AD brains but further revealed the significant spatial patterns in different brain regions as well as among different subregions of the frontal cortex and hippocampi. Super-resolution STochastic Optical Reconstruction Microscopy (STORM) further demonstrated their subcellular colocalization and molecular interactions with APP in a transgenic mouse model of both sexes with AD-like mutations. These studies support the predictions made by digID while highlighting the importance of concurrent biological validation of computationally identified gene clusters as potential new AD therapeutic targets.

It’s a significant milestone – but what does the GFCM actually do? What has it achieved so far?

Since its creation, the GFCM has evolved into an efficient [...]

Mineralogist Bob Hazen talks about what he loves about walking along the coast of the Chesapeake Bay, hunting for fossils and shark teeth hidden in the sand

We're over here making podcasts, and you're over there listening. Let's bridge that gap! We want to know more about you, like: why you're listening, what your favorite topics are, and what Smithsonian magazine can do to make "There's More to That" even better. Tell us what you think at  smithsonianmag.com/podcastsurvey (https://www.smithsonianmag.com/podcastsurvey) .

Whether you're a passionate astronomer or a beginner eager to explore the cosmos, join us as we deep-dive into seasonal skywatching. Gain valuable insights into identifying meteors, stars, and fascinating deep-sky objects that grace the night sky. Interested in learning more? Check out this piece from Smithsonian Magazine on the celestial events to watch in 2024: https://www.smithsonianmag.com/science-nature/nine-dazzling-celestial-events-to-watch-in-2024-180983505/ And don't forget to subscribe to our channel for more exciting videos exploring the wonders of the natural world. --- Digital Editorial Director: Brian Wolly Supervising Producer & Scriptwriter: Michelle Mehrtens Video Editor: Sierra Theobald

The American Ingenuity Award winner is on the brink of using the human genome to provide better diagnostics for deadly diseases

The viewfinders are outfitted with special lenses that help people with red-green colorblindness distinguish between hues

While people gather around the Gore Park Cenotaph in his hometown of Hamilton, Tyrell will be one of nine Canadians serving as a peacekeeper in the United Nations mission in South Sudan.

LAFC opened the series with a narrow 2-1 victory in California and Vancouver replied with a decisive 3-0 win at home to set up a do-or-die matchup on Friday, but they failed to overcome L.A. and suffered a 1-0 defeat.

Make The Season Kind is a month of giving in support of The Food Bank of Waterloo Region. Join CBC K-W for a kick-off show on Friday, Dec. 6 at TheMuseum in downtown Kitchener with performances by I, The Mountain, singer-songwriter Mandippal, local chef Terry Salmond and more.

Two newly elected members of British Columbia's Green Party will officially take their seats in the legislature following the first of three swearing-in ceremonies since last month's provincial election. 

After playing her first season with the WNBA's Washington Mystics and representing Team Canada at the Olympics, forward Aaliyah Edwards held her second annual "You Got Knext" camp in her hometown over the weekend.

Canadian swingman RJ Barrett was upgraded to day-to-day and engaged in non-contact practise on Monday, two days before Toronto hosts the Cleveland Cavaliers at Scotiabank Arena.

Nine games into the Washington Capitals' season, Alex Ovechkin is scoring at a rate that would put him past Wayne Gretzky as soon as this spring.

The records just keep falling for the Jets under new head coach Scott Arniel.

The provincial government is seeking contractors to restore hundreds of kilometres of land where fireguards were created during the 2023 wildfire season.

After Canada Post workers gave a 72-hour notice to strike early Tuesday, some Calgary business owners are worried about what this means for holiday season sales. 

Global design firm cuts development time and costs in half

Robust design helps withstand challenging competitive conditions as team takes first round in America 's Cup qualifying races

Investment improves coordination and accuracy

Times are changing for OM Mexico, with new staff and a new office.

Veracruz, Mexico :: An overview of the various initiatives crewmembers have dispersed to while Logos Hope undergoes her annual maintenance.

A long-termer shares how she, as a childless woman, has been given opportunity to speak into local women’s lives in North Africa.

A church planting team shares their faith with Muslim friends and neighbours during a time set aside for sowing intentionally in people’s lives.

The first season of the Netflix political potboiler was rich with education-policy plotlines, and we're hoping for more of the same.

Both the AFT and the NEA vowed to engage their members more deeply this year in deciding who to back for the White House. How well have they done?

Medical imaging is no longer in Kansas, Toto, as a team led by Penn State researchers brings traditional black and white diagnostic images of X-rays and traditional CT scans into technicolor. The researchers developed novel contrast agents that target two proteins implicated in osteoarthritis, a degenerative joint disease commonly characterized as wear-and-tear arthritis.

Jack Saint Clair will bring his 17-piece jazz orchestra to Penn State Abington for a free concert at 7 p.m. Nov. 13 in Sutherland Auditorium.

As the cold weather approaches, it’s important to protect your family from the flu, COVID-19 and RSV. A Penn State Health pediatrician shares some simple tips to help keep everyone healthy.

Penn State School of Music announces the inaugural performance of its Opera Workshop, led by new faculty members Dawn Pierce and Parker Konkle. The performance, titled "Seasons of Love," will take place on Dec. 10, at 7:30 p.m. in the School of Music’s Recital Hall. This unique presentation will explore a range of lyric repertoire, offering an avant-garde experience that merges music, movement, and storytelling. 

The Penn State DuBois men’s basketball team started the 2024-25 season on a high note, winning its first two games over the weekend in strong showings against Bucks County Community College and Central Penn at Penn State Mont Alto.

The Penn State DuBois basketball season is off to a competitive start, with both the men’s and women’s teams showcasing their skills in early games. The women’s team began its campaign on a high note, capturing a commanding victory, while the men’s team fought a hard battle in a closely contested home opener.

During a decade in the Arabian Peninsula, one couple offers their home for different seasons of ministry.

WILMINGTON – After a one-year hiatus due to the COVID-19 pandemic, the Ferris School lacrosse team finished their Spring season strong. “It has been an incredible experience to see the youth not only in some cases learn a new sport, but also learn about themselves,” said Tanya Banks, Superintendent of Ferris School. “Lacrosse brings together […]

Cross, the new Prime Video crime-thriller series, debuts on November 14, 2024. Featuring Aldis Hodge as Alex Cross, this adaptation goes deeper into the detectives life than previous film versions. With 8 episodes in season 1, the show promises intense action and emotional depth as Cross faces a series of personal and professional challenges. The series marks a reimagined take on James Pattersons iconic character, with all episodes dropping on the same day for binge-watchers.

The study showed that low-medium fat dairy products may be protective, and should be preferred over high-fat dairy to prevent Metabolic dysfunction-associated steatotic liver disease (MASLD).

Love the custard apple's taste? We give you more reasons to get them home all the while they are in season.

Dover, Del—Natural gas prices have spiked in the past six months and are up more than 30 percent since the end of August 2021. This is largely due to increased U.S. demand and the ongoing energy crisis in Europe. According to the Energy Information Administration, about 43 percent of Delaware households rely on natural gas […]

Dover, Del.—Natural gas prices have continued to increase this year and are up nearly 60 percent year to date. This is largely due to increased U.S. demand and the ongoing energy crisis in Europe. According to the Energy Information Administration, about 42 percent of Delaware households rely on natural gas for home heating. “Due to […]

October 10, 2017 As part of its ongoing work monitoring and tracking the state’s Foreign Labor Certification and Migrant Seasonal Farm Worker activities, officials from the Delaware Department ofLabor paid a recent visit to Kent and Sussex County farms enrolled in the programs. DOL Secretary Dr. Patrice Gilliam-Johnson was joined by Deputy Secretary Karryl McManus, Division […]

Division of Revenue Director Jennifer R. Hudson has announced that the Delaware individual income tax season will begin on Monday, January 29, 2018, concurrently with the opening of the federal individual tax season announced by the IRS. While this is slightly later than previous years, the January 29 date was set to ensure the security […]

The Delaware Department of Agriculture (DDA) issued guidance today to help local U-Pick farms safely open to the public for the season. This guidance will help farm staff and visitors to U-Pick farm operations participate in a safe manner to reduce the spread of COVID-19.

The Department of Natural Resources and Environmental Control reminds visitors to Delaware State Parks that 2023 entrance fees will be in effect starting Wednesday, March 1 through Nov. 30.