“What does it take to live on the moon?” That was the question put forward by Sebastian Aristotelis and Karl-Johan Sørensen, the founders of SAGA Space Architects and the analog astronauts behind Lunark, a prototype moon habitat. Designed in collaboration with scientists, engineers and polar experts, Lunark will be tested over three months in northern Greenland as part of the first Arctic-simulated moon mission. In addition to its resilience to extreme temperatures, the habitat will be engineered for a zero-waste ecosystem and will draw power from solar panels.[...]

Take a look at the bottom right-hand corner of that phone, the reflection tells the story of a guy who's going to get a severe talking to.

♐ Sagittarius - Archer (Thighs)

Seeds planted now will do poorly and yield little.

The Moon's current percentage of illumination is 92%.

Mijn eerste blog vanuit Leiden In dit tijdperk van Covid19 met iets minder bewegingsvrijheid dan we gewend zijn leek het mij leuk eens terug te kijken op al die bijzondere voettochten die ik heb gedaan. Je moet toch wat als die tocht van deze week niet

I will try a few jokes to entertain you as well as lighten the mood. I hate being cooped up during the shelter in place but at least I can go to work a few days a week. Thanks to my dear friend Barry the V I once knew a grape which could have been

The feathery glint startles their rodent prey, making them easier to catch.

Astronomers discovered 20 new moons around Saturn, bringing its total to 82.

Dusty Imoo, former goalie development coach for the Kings, took a job in Beijing this season and got a close look at how the coronavirus affected China.

With one heartfelt speech, Mookie Betts established himself as a Dodgers leader by emphasizing the focus needed to win a World Series must begin in the spring.

Dodgers right fielder Mookie Betts didn't report to spring training on Saturday because of a stomach ailment. He could be back in the lineup Monday.

Mookie Betts wasn't too worried when he became ill at the end of last week. While the country was dealing with the growing COVID-19 outbreak, he was dealing with food poisoning.

Superstar acquisition Mookie Betts could leave the Dodgers without ever playing a game for them if the season is canceled because of the coronavirus crisis.

It doesn't take a lot of fancy equipment. A modern camera with a longer lens can help you capture the heavens.

Worden performed the first deep-space spacewalk — nearly 200,000 miles from Earth

L.A. school chief says district is moving fast to set everything up and racing to find unconnected students. The number drops substantially in a week.

A after visiting every U.S. county in the lower 48, William Least Heat-Moon is the master of the topographical journey. Now 80, he takes another trip through his new novel — into the imperfect history of American democracy.

Captain Tom Moore has been invited to deliver a team talk by England cricket captain Joe Root in the wake of his remarkable achievements in raising money for the NHS.

Captain Tom Moore was made an honorary cricket player by former England captain Michael Vaughan on his 100th birthday.

ALIEN hunters believe they have spotted a fleet of UFOs zooming past the Moon in images from the 1969 Apollo 9 mission.

ASTRONAUTS could use their own wee to construct a Moon base, the European Space Agency has astonishingly announced.

MICHAEL COLLINS made a candid confession over his role in the Moon landings after 50 years, admitting he "had some regrets" about the way things played out.

Dramatic, fiery and different every night, you'll never tire of looking at them. You'll bore everyone with photos of them. One of your friends proposed underneath one, while another made them the backdrop to her honeymoon. One thing's for sure, Santorini sure does a good sunset.

Allison Bosse scored 23 points to lift the Bulldogs over Mooresville, 51-42, in Tuesday's sectional opener.

The Boilermakers have seven commitments in the 2021 recruiting class, including two from Mooresville

DES MOINES-Iowa Firearms Coalition President Barry Snell shared their mission of protecting Second Amendment Rights for Iowans at the Bull Moose Club luncheon in Des Moines on Tuesday.  He explained how the IFC was formed and gave an update on their legislative achievements since their formation in 2010. “IFC got […]

Indiana women's basketball roster retooling has hit overdrive the past few days.

Nearly 70 acts, including Valee and Black Moon, will perform at fourth annual Chreece hip-hop festival in Fountain Square.

Simon Bogg says it took him 10 days to make the sculpture in tribute to the "absolute legend".

F1 driver Lando Norris calls McLaren fan Captain Tom Moore after the 99-year-old raised more than £27m for the NHS by completing 100 laps of his garden.

The space agency announces the companies that will work on landers to return astronauts to the Moon.

How the outside world can be good for body and mind - with expert tips on making the most of it.

In 1961 John F Kennedy made a promise to our country that we would walk on the moon before the end of the decade, and in 1969 the promise held true.

Sure, a lot of countries have been to the moon. They’ve or..

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Record-breaking high and low temperatures were recorded in parts of Canada going into the weekend, including the nearly 28 C recorded in the Squamish area of British Columbia and the -4.2 C recorded in Kitchener, Ont.

Work(out) From Home is a weekly column where we review smart fitness machines and apps in the wake of the coronavirus outbreak. Thanks to technology, there are still plenty of ways to exercise if your gym is closed. Read more...

Takahito Kashiwabara and Tomoya Kemmochi
Math. Comp. 89 (2020), 1647-1679.
Abstract, references and article information

Weimin Chen
Proc. Amer. Math. Soc. 148 (2020), 2707-2716.
Abstract, references and article information

Hong Kong has, for the first time, held the Willem C Vis (East) International Commercial Arbitration Moot (VEM) through an online platform amidst the COVID-19 pandemic. While most of the competitions in other jurisdictions have been cancelled or postponed due to challenges posed by the pandemic, the 17th VEM was the only international mooting which went ahead as scheduled through an online dispute resolution (ODR) platform.

Though the outbreak of COVID-19 has changed our travel patterns and presented many challenges, advance in modern technology has helped us to address them. For the first time in the moot’s history, the mooting competition was conducted completely online with the support of Electronic Business Related Arbitration & Mediation (eBRAM). The platform supported by eBRAM accommodated 71 teams from 21 jurisdictions and about 250 arbitrators from 52 jurisdictions to take part in the moot which started on March 22. This exemplifies the importance of technological developments in the legal field.

The audience, with the latest lawtech support by eBRAM, watched the lively and intensive oral arguments online with participants of the finalists showing considerable flair and aptitude in trying their best to present their case to an international panel of distinguished arbitrators. The Chinese University of Hong Kong won the competition after rounds of rigorous and remarkable oral submissions before the panel.

The Government has always been supportive of the development of lawtech spearheaded by, amongst others, eBRAM, which is expected to be launched this year to resolve cross-boundary disputes online. If funding is approved by the Legislative Council Finance Committee on time, eBRAM would be able to provide an efficient, cost-effective and safe online platform for deal-making and resolution of cross-boundary commercial and investment disputes. We understand that eBRAM also plans to develop an online dispute resolution platform to support cross-boundary business-to-business transactions in the Asia-Pacific Economic Cooperation region.

We would continue to offer our support to the VEM as part of our legal education campaign. However, the VEM would not have been held smoothly without the technical support provided by eBRAM and also the tenacity and determination displayed by the Vis East Moot Foundation. The successful conclusion of the moot proved that Hong Kong has the capability of developing lawtech.

Changes are inevitable, including technological changes. The COVID-19 pandemic posed new challenges to Hong Kong, but it also provides an opportunity for us to explore lawtech in the provision of legal services. We all should join hands to make the best use of the technologies to develop ODR to assist all parties in resolving disputes in an efficient, effective and fair manner with a view to bringing rule of law and justice for all.

Secretary for Justice Teresa Cheng wrote this article and posted it on her blog on March 31.

(Brown University) Strange spots scattered across the moon's nearside where bedrock is conspicuously exposed are evidence of seismic activity set in motion 4.3 billion years ago that could be ongoing today, the researchers say.

(Rutgers University) Rutgers Professor Gregory W. Moore, a renowned physicist who seeks a unified understanding of the basic forces and fundamental particles in the universe, has been elected to the prestigious National Academy of Sciences.

Eyes popped and mouths dropped wide open this week when it was reported in this newspaper that a British woman is using sperm smoothies to build her immune system. Tracy Kiss, 32, said she takes the sperm straight from the source - her boyfriend...

Purpose: To determine the effect of smooth filter and partial volume correction (PVC) method on measured prostate-specific membrane antigen (PSMA) activity in small metastatic lesions and to determine the impact of these changes on the molecular imaging (mi) PSMA scoring. Materials & Methods: Men with biochemical recurrence of prostate cancer with negative CT and bone scintigraphy were referred for ¹⁸F-DCFPyL PET/CT. Examinations were performed on one of 2 PET/CT scanners (GE Discovery 610 or Siemens mCT40). All suspected tumor sites were manually contoured on co-registered CT and PET images, and each was assigned a miPSMA score as per the PROMISE criteria. The PVC factors were calculated for every lesion using the anatomical CT and then applied to the unsmoothed PET images. The miPSMA scores, with and without the corrections, were compared, and a simplified "rule of thumb" (RoT) correction factor (CF) was derived for lesions at various sizes (<4mm, 4-7mm, 7-9mm, 9-12mm). This was then applied to the original dataset and miPSMA scores obtained using the RoT CF were compared to those found using the actual corrections. Results: There were 75 men (median age, 69 years; median serum PSA of 3.69 ug/L) with 232 metastatic nodes < 12 mm in diameter (mean lesion volume of 313.5 ± 309.6 mm³). Mean SUV_max before and after correction was 11.0 ± 9.3 and 28.5 ± 22.8, respectively (p<0.00001). The mean CF for lesions <4mm (n = 22), 4-7mm (n = 140), 7-9mm (n = 50), 9-12 mm (n = 20) was 4 (range: 2.5-6.4), 2.8 (range: 1.6-4.9), 2.3 (range: 1.6-3.3) and 1.8 (range 1.4-2.4), respectively. Overall miPSMA scores were concordant between the corrected dataset and RoT in 205/232 lesions (88.4%). Conclusion: There is a significant effect of smooth filter and partial volume correction on measured PSMA activity in small nodal metastases, impacting the miPSMA score.

Mustafa Yalcinkaya
Apr 1, 2020; 61:492-504
Research Articles

Loss of pancreatic β-cell mass and function as a result of sustained ER stress is a core step in the pathogenesis of diabetes mellitus type 2. The complex control of β-cells and insulin production involves hedgehog (Hh) signaling pathways as well as cholesterol-mediated effects. In fact, data from studies in humans and animal models suggest that HDL protects against the development of diabetes through inhibition of ER stress and β-cell apoptosis. We investigated the mechanism by which HDL inhibits ER stress and apoptosis induced by thapsigargin, a sarco/ER Ca²⁺-ATPase inhibitor, in β-cells of a rat insulinoma cell line, INS1e. We further explored effects on the Hh signaling receptor Smoothened (SMO) with pharmacologic agonists and inhibitors. Interference with sterol synthesis or efflux enhanced β-cell apoptosis and abrogated the anti-apoptotic activity of HDL. During ER stress, HDL facilitated the efflux of specific oxysterols, including 24-hydroxycholesterol (OHC). Supplementation of reconstituted HDL with 24-OHC enhanced and, in cells lacking ABCG1 or the 24-OHC synthesizing enzyme CYP46A1, restored the protective activity of HDL. Inhibition of SMO countered the beneficial effects of HDL and also LDL, and SMO agonists decreased β-cell apoptosis in the absence of ABCG1 or CYP46A1. The translocation of the SMO-activated transcription factor glioma-associated oncogene GLI-1 was inhibited by ER stress but restored by both HDL and 24-OHC. In conclusion, the protective effect of HDL to counter ER stress and β-cell death involves the transport, generation, and mobilization of oxysterols for activation of the Hh signaling receptor SMO